Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

Nature Medicine

Volumn 7, Issue 6, 2001, Pages 687-692

  Weitz Schmidt, Gabriele ^a   Welzenbach, Karl ^a   Brinkmann, Volker ^a   Kamata, Tetsji ^b   Kallen, Joerg ^a   Bruns, Christian ^a   Cottens, Sylvain ^a   Takada, Yoshikazu ^b   Hommel, Ulrich ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPACTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INTEGRIN; LFA 703; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MEVINOLIN; PRAVASTATIN; SIMVASTATIN; STATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; BINDING SITE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; GRAFT REJECTION; HYPERCHOLESTEROLEMIA; INFLAMMATION; ISCHEMIA; LEUKOCYTE ADHERENCE; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PERITONITIS; PRIORITY JOURNAL; PSORIASIS; REPERFUSION; RHEUMATOID ARTHRITIS;

ALLOSTERIC SITE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL ADHESION; DISEASE MODELS, ANIMAL; DRUG DESIGN; HUMANS; INTEGRIN ALPHA4BETA1; INTEGRINS; INTERCELLULAR ADHESION MOLECULE-1; LOVASTATIN; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; NAPHTHALENES; PERITONITIS; PRAVASTATIN; PROTEIN BINDING; RECEPTORS, LYMPHOCYTE HOMING; T-LYMPHOCYTES;

ANIMALIA; MURINAE;

EID: 0034948339     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/89058     Document Type: Article

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