-
1
-
-
0034213327
-
Rho GTPases and their effector proteins
-
A.L. Bishop, and A. Hall Rho GTPases and their effector proteins Biochem. J. 348 2000 241 255
-
(2000)
Biochem. J.
, vol.348
, pp. 241-255
-
-
Bishop, A.L.1
Hall, A.2
-
2
-
-
0033929471
-
Fluvastatin: Effects beyond cholesterol lowering
-
A. Corsini Fluvastatin: effects beyond cholesterol lowering J. Cardiovasc. Pharmacol. Therapeut. 5 2000 161 175
-
(2000)
J. Cardiovasc. Pharmacol. Therapeut.
, vol.5
, pp. 161-175
-
-
Corsini, A.1
-
3
-
-
2642536741
-
Inflammation, immunity, and HMG-CoA reductase inhibitors. Statins as anti-inflammatory agents?
-
U. Schonbeck, and P. Libby Inflammation, immunity, and HMG-CoA reductase inhibitors. Statins as anti-inflammatory agents? Circulation 109 Suppl. II 2004 II18 II26
-
(2004)
Circulation
, vol.109
, Issue.2 SUPPL.
-
-
Schonbeck, U.1
Libby, P.2
-
4
-
-
0035988910
-
Inhibition of proliferation and signaling mechanisms in human lymphocytes by fluvastatin
-
D.Z. Hillyard, A.J. Cameron, A.H. McIntyre, M.H. Hadden, H.E. Marshall, N. Johnston, and A.G. Jardine Inhibition of proliferation and signaling mechanisms in human lymphocytes by fluvastatin Clin. Exp. Pharmacol. Physiol. 29 2002 673 678
-
(2002)
Clin. Exp. Pharmacol. Physiol.
, vol.29
, pp. 673-678
-
-
Hillyard, D.Z.1
Cameron, A.J.2
McIntyre, A.H.3
Hadden, M.H.4
Marshall, H.E.5
Johnston, N.6
Jardine, A.G.7
-
5
-
-
0034948339
-
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site
-
G. Weitz-Schmidt, K. Welzenbach, V. Brinkmann, T. Kamata, J. Kallen, C. Bruns, S. Cottens, Y. Takada, and U. Hommel Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site Nat. Med. 7 2001 687 692
-
(2001)
Nat. Med.
, vol.7
, pp. 687-692
-
-
Weitz-Schmidt, G.1
Welzenbach, K.2
Brinkmann, V.3
Kamata, T.4
Kallen, J.5
Bruns, C.6
Cottens, S.7
Takada, Y.8
Hommel, U.9
-
6
-
-
0034533147
-
Statins as a newly recognized type of immunomodulator
-
B. Kwak, F. Mulhaupt, S. Myit, and F. Mach Statins as a newly recognized type of immunomodulator Nat. Med. 6 2000 1399 1402
-
(2000)
Nat. Med.
, vol.6
, pp. 1399-1402
-
-
Kwak, B.1
Mulhaupt, F.2
Myit, S.3
MacH, F.4
-
7
-
-
0042804908
-
Targeting inflammatory diseases via apoptotic mechanisms
-
F.J. Murphy, I. Hayes, and T.G. Cotter Targeting inflammatory diseases via apoptotic mechanisms Curr. Opin. Pharmacol. 3 2003 412 419
-
(2003)
Curr. Opin. Pharmacol.
, vol.3
, pp. 412-419
-
-
Murphy, F.J.1
Hayes, I.2
Cotter, T.G.3
-
8
-
-
0242493030
-
All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells
-
S. Kaneta, K. Satoh, S. Kano, M. Kanda, and K. Ichihara All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells Atherosclerosis 170 2003 237 243
-
(2003)
Atherosclerosis
, vol.170
, pp. 237-243
-
-
Kaneta, S.1
Satoh, K.2
Kano, S.3
Kanda, M.4
Ichihara, K.5
-
9
-
-
0037013293
-
Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells
-
X. Li, L. Liu, J.C. Tupper, D.D. Bannerman, R.K. Winn, S.M. Sebti, A.D. Hamilton, and J.M. Harlan Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells J. Biol. Chem. 277 2002 15309 15316
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 15309-15316
-
-
Li, X.1
Liu, L.2
Tupper, J.C.3
Bannerman, D.D.4
Winn, R.K.5
Sebti, S.M.6
Hamilton, A.D.7
Harlan, J.M.8
-
10
-
-
0036192275
-
3-Hydroxy-3-methyl-glutaryl coenzyme a reductase inhibitors, atrovastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho prenylation
-
L.M. Blanco-Colio, A. Villa, M. Ortego, M.A. Hernandez-Presa, A. Pascual, J.J. Plaza, and J. Egido 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atrovastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho prenylation Atherosclerosis 161 2002 17 26
-
(2002)
Atherosclerosis
, vol.161
, pp. 17-26
-
-
Blanco-Colio, L.M.1
Villa, A.2
Ortego, M.3
Hernandez-Presa, M.A.4
Pascual, A.5
Plaza, J.J.6
Egido, J.7
-
11
-
-
0032494101
-
3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture
-
C. Guijarro, L.M. Blanco-Colio, M. Ortego, C. Alonso, A. Ortiz, J.J. Plaza, C. Diaz, G. Hernandez, and J. Egido 3-Hydroxy-3-methylglutaryl coenzyme A reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture Circ. Res. 83 1998 490 500
-
(1998)
Circ. Res.
, vol.83
, pp. 490-500
-
-
Guijarro, C.1
Blanco-Colio, L.M.2
Ortego, M.3
Alonso, C.4
Ortiz, A.5
Plaza, J.J.6
Diaz, C.7
Hernandez, G.8
Egido, J.9
-
12
-
-
0037309378
-
A novel anti-inflammatory role for simvastatin in inflammatory arthritis
-
B.P. Leung, N. Sattar, A. Crilly, M. Prach, D.W. McCarey, H. Payne, R. Madhok, C. Campbell, J.A. Gracie, F.Y. Liew, and I.B. McInnes A novel anti-inflammatory role for simvastatin in inflammatory arthritis J. Immunol. 170 2003 1524 1530
-
(2003)
J. Immunol.
, vol.170
, pp. 1524-1530
-
-
Leung, B.P.1
Sattar, N.2
Crilly, A.3
Prach, M.4
McCarey, D.W.5
Payne, H.6
Madhok, R.7
Campbell, C.8
Gracie, J.A.9
Liew, F.Y.10
McInnes, I.B.11
-
13
-
-
1342282244
-
A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma
-
A. McKay, B.P. Leung, I.B. McInnes, N.C. Thomson, and F.Y. Liew A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma J. Immunol. 172 2004 2903 2908
-
(2004)
J. Immunol.
, vol.172
, pp. 2903-2908
-
-
McKay, A.1
Leung, B.P.2
McInnes, I.B.3
Thomson, N.C.4
Liew, F.Y.5
-
14
-
-
2942571817
-
Statin-induced immunomodulatory effects on human T cells in vivo
-
T. Fehr, C. Kahlert, W. Fierz, H.I. Joller-Jemelka, W.F. Riesen, H. Rickli, R.P. Wuthrich, and P. Ammann Statin-induced immunomodulatory effects on human T cells in vivo Atherosclerosis 175 2004 83 90
-
(2004)
Atherosclerosis
, vol.175
, pp. 83-90
-
-
Fehr, T.1
Kahlert, C.2
Fierz, W.3
Joller-Jemelka, H.I.4
Riesen, W.F.5
Rickli, H.6
Wuthrich, R.P.7
Ammann, P.8
-
15
-
-
0033575198
-
Effect of suplatast tosilate (IPD-1151T) on cytokine production by allergen-specific human Th1 and Th2 cell lines
-
N. Oda, K. Minoguchi, T. Yokoe, T. Hashimoto, K. Wada, M. Miyamoto, A. Tanaka, Y. Kohno, and M. Adachi Effect of suplatast tosilate (IPD-1151T) on cytokine production by allergen-specific human Th1 and Th2 cell lines Life Sci. 65 1999 763 770
-
(1999)
Life Sci.
, vol.65
, pp. 763-770
-
-
Oda, N.1
Minoguchi, K.2
Yokoe, T.3
Hashimoto, T.4
Wada, K.5
Miyamoto, M.6
Tanaka, A.7
Kohno, Y.8
Adachi, M.9
-
16
-
-
0032743259
-
Annexin V used for measuring apoptosis in the early events of cellular toxicity
-
J.P. Aubry, A. Blaecke, S. Lecoanet-Henchoz, P. Jeannin, N. Herbault, G. Caron, V. Moine, and J.Y. Bonnefoy Annexin V used for measuring apoptosis in the early events of cellular toxicity Cytometry 37 1999 197 204
-
(1999)
Cytometry
, vol.37
, pp. 197-204
-
-
Aubry, J.P.1
Blaecke, A.2
Lecoanet-Henchoz, S.3
Jeannin, P.4
Herbault, N.5
Caron, G.6
Moine, V.7
Bonnefoy, J.Y.8
-
17
-
-
0034018781
-
Differential regulation of activation-induced cell death in individual human T cell clones
-
O. Janssen, A. Stocker, R. Sanzenbacher, H.H. Oberg, M.A. Siddiqi, and D. Kabelitz Differential regulation of activation-induced cell death in individual human T cell clones Int. Arch. Allergy Immnol. 121 2000 183 193
-
(2000)
Int. Arch. Allergy Immnol.
, vol.121
, pp. 183-193
-
-
Janssen, O.1
Stocker, A.2
Sanzenbacher, R.3
Oberg, H.H.4
Siddiqi, M.A.5
Kabelitz, D.6
-
18
-
-
0037339680
-
Simvastatin reduces the expression of adhesion molecules in circulating monocytes from hypercholesterolemic patients
-
A. Rezaie-Majd, G.W. Prager, R.A. Bucek, G.H. Schernthaner, T. Maca, H.G. Kress, P. Valent, B.R. Binder, E. Minar, and M. Baghestanian Simvastatin reduces the expression of adhesion molecules in circulating monocytes from hypercholesterolemic patients Arterioscler. Thromb. Vasc. Biol. 23 2003 397 403
-
(2003)
Arterioscler. Thromb. Vasc. Biol.
, vol.23
, pp. 397-403
-
-
Rezaie-Majd, A.1
Prager, G.W.2
Bucek, R.A.3
Schernthaner, G.H.4
MacA, T.5
Kress, H.G.6
Valent, P.7
Binder, B.R.8
Minar, E.9
Baghestanian, M.10
-
19
-
-
0033826581
-
The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
-
Y. Kureishi, Z. Luo, I. Shiojima, A. Bialik, D. Fulton, D.J. Lefer, W.C. Sessa, and K. Walsh The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals Nat. Med. 6 2000 1004 1010
-
(2000)
Nat. Med.
, vol.6
, pp. 1004-1010
-
-
Kureishi, Y.1
Luo, Z.2
Shiojima, I.3
Bialik, A.4
Fulton, D.5
Lefer, D.J.6
Sessa, W.C.7
Walsh, K.8
-
20
-
-
0038216660
-
Statin use is associated with improved function and survival of lung allografts
-
B.A. Johnson, A.T. Iacono, A. Zeevi, K.R. McCurry, and S.R. Duncan Statin use is associated with improved function and survival of lung allografts Am. J. Respir. Crit. Care Med. 167 2003 1271 1278
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.167
, pp. 1271-1278
-
-
Johnson, B.A.1
Iacono, A.T.2
Zeevi, A.3
McCurry, K.R.4
Duncan, S.R.5
-
21
-
-
0029119711
-
Effect of pravastatin on outcomes after cardiac transplantation
-
J.A. Kobashigawa, S. Katznelson, H. Laks, J.A. Johnson, L. Yeatman, X.M. Wang, D. Chia, P.I. Terasaki, A. Sabad, G.A. Cogert, K. Trosian, M.A. Hamilton, J.D. Moriguchi, N. Kawata, A. Hage, D.C. Drinkwater, and L.W. Stevenson Effect of pravastatin on outcomes after cardiac transplantation N. Engl. J. Med. 333 1995 621 627
-
(1995)
N. Engl. J. Med.
, vol.333
, pp. 621-627
-
-
Kobashigawa, J.A.1
Katznelson, S.2
Laks, H.3
Johnson, J.A.4
Yeatman, L.5
Wang, X.M.6
Chia, D.7
Terasaki, P.I.8
Sabad, A.9
Cogert, G.A.10
Trosian, K.11
Hamilton, M.A.12
Moriguchi, J.D.13
Kawata, N.14
Hage, A.15
Drinkwater, D.C.16
Stevenson, L.W.17
-
22
-
-
0034778828
-
Effect of fluvastatin on acute renal allograft rejection: A randomized multicenter trial
-
H. Holdaas, A.G. Jardine, D.C. Wheeler, I.B. Brekke, P.J. Conlon, B. Fellstrom, A. Hammad, I. Holme, H. Isoniemi, R. Moore, P.A. Rowe, P. Sweny, D.A. Talbot, J. Wadstrom, and O. Ostraat Effect of fluvastatin on acute renal allograft rejection: a randomized multicenter trial Kidney Int. 60 2001 1990 1997
-
(2001)
Kidney Int.
, vol.60
, pp. 1990-1997
-
-
Holdaas, H.1
Jardine, A.G.2
Wheeler, D.C.3
Brekke, I.B.4
Conlon, P.J.5
Fellstrom, B.6
Hammad, A.7
Holme, I.8
Isoniemi, H.9
Moore, R.10
Rowe, P.A.11
Sweny, P.12
Talbot, D.A.13
Wadstrom, J.14
Ostraat, O.15
-
23
-
-
2342481172
-
Programmed cell death: Apoptosis and alternative deathstyles
-
C.A. Guimaraes, and R. Linden Programmed cell death: apoptosis and alternative deathstyles Eur. J. Biochem. 271 2004 1638 1650
-
(2004)
Eur. J. Biochem.
, vol.271
, pp. 1638-1650
-
-
Guimaraes, C.A.1
Linden, R.2
-
24
-
-
0035366202
-
Activation-induced cell death
-
R.C. Budd Activation-induced cell death Curr. Opin. Immunol. 13 2001 356 362
-
(2001)
Curr. Opin. Immunol.
, vol.13
, pp. 356-362
-
-
Budd, R.C.1
-
25
-
-
0038171513
-
Overview: Apoptotic signaling pathways in immune system
-
D.R. Green Overview: apoptotic signaling pathways in immune system Immunol. Rev. 193 2003 5 9
-
(2003)
Immunol. Rev.
, vol.193
, pp. 5-9
-
-
Green, D.R.1
-
26
-
-
2442434564
-
Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors
-
T. Kubota, K. Fujisaki, Y. Itoh, T. Yano, T. Sendo, and R. Oishi Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors Biochem. Pharmacol. 67 2004 2175 2186
-
(2004)
Biochem. Pharmacol.
, vol.67
, pp. 2175-2186
-
-
Kubota, T.1
Fujisaki, K.2
Itoh, Y.3
Yano, T.4
Sendo, T.5
Oishi, R.6
-
27
-
-
0037380579
-
Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system
-
K. Newton, and A. Strasser Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system Genes Dev. 17 2003 819 825
-
(2003)
Genes Dev.
, vol.17
, pp. 819-825
-
-
Newton, K.1
Strasser, A.2
-
28
-
-
0034283536
-
Inhibitors of HMG-CoA reductase sensitize human smooth muscle cells to Fas-ligand and cytokine-induced cell death
-
A.C. Knapp, J. Huang, G. Starling, and P.A. Kiener Inhibitors of HMG-CoA reductase sensitize human smooth muscle cells to Fas-ligand and cytokine-induced cell death Atherosclerosis 152 2000 217 227
-
(2000)
Atherosclerosis
, vol.152
, pp. 217-227
-
-
Knapp, A.C.1
Huang, J.2
Starling, G.3
Kiener, P.A.4
-
29
-
-
0141615830
-
3-Hydroxy-3-methylglutaryl coenzyme a reductase inhibitors decrease Fas ligand expression and cytotoxicity in activated human T lymphocytes
-
L.M. Blanco-Colio, B. Munoz-Garcia, L. Martin-Ventura, C. Lorz, C. Diaz, G. Hernandez, and J. Egido 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors decrease Fas ligand expression and cytotoxicity in activated human T lymphocytes Circulation 108 2003 1506 1513
-
(2003)
Circulation
, vol.108
, pp. 1506-1513
-
-
Blanco-Colio, L.M.1
Munoz-Garcia, B.2
Martin-Ventura, L.3
Lorz, C.4
Diaz, C.5
Hernandez, G.6
Egido, J.7
-
30
-
-
2942744672
-
Fas-mediated apoptosome formation is dependent on reactive oxygen species derived from mitochondrial permeability transition in Jurkat cells
-
T. Sato, T. Machida, S. Takahashi, S. Iyama, Y. Sato, K. Kuribayashi, K. Takada, T. Oku, Y. Kawano, T. Okamoto, R. Takimoto, T. Matsunaga, T. Takayama, M. Takahashi, J. Kato, and Y. Niitsu Fas-mediated apoptosome formation is dependent on reactive oxygen species derived from mitochondrial permeability transition in Jurkat cells J. Immunol. 173 2004 285 296
-
(2004)
J. Immunol.
, vol.173
, pp. 285-296
-
-
Sato, T.1
MacHida, T.2
Takahashi, S.3
Iyama, S.4
Sato, Y.5
Kuribayashi, K.6
Takada, K.7
Oku, T.8
Kawano, Y.9
Okamoto, T.10
Takimoto, R.11
Matsunaga, T.12
Takayama, T.13
Takahashi, M.14
Kato, J.15
Niitsu, Y.16
-
31
-
-
0034440818
-
Proteases for cell suicide: Functions and regulations of caspases
-
H.Y. Chang, and X. Yang Proteases for cell suicide: Functions and regulations of caspases Microbiol. Mol. Biol. Rev. 64 2000 821 846
-
(2000)
Microbiol. Mol. Biol. Rev.
, vol.64
, pp. 821-846
-
-
Chang, H.Y.1
Yang, X.2
-
32
-
-
0034280579
-
Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways
-
X.M. Yin Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways Cell Res. 10 2000 161 167
-
(2000)
Cell Res.
, vol.10
, pp. 161-167
-
-
Yin, X.M.1
-
33
-
-
1442310922
-
Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death
-
M. Donovan, and T.G. Cotter Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death Biochim. Biophys. Acta 1644 2004 133 147
-
(2004)
Biochim. Biophys. Acta
, vol.1644
, pp. 133-147
-
-
Donovan, M.1
Cotter, T.G.2
-
34
-
-
0037057629
-
Apoptosis initiated by Bcl-2-regulated caspases activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
-
V.S. Marsden, L. O'Connor, L.A. O'Reilly, J. Silke, D. Metcalf, P.G. Ekert, D.C.S. Huang, F. Cecconi, K. Kuida, K.J. Tomaselli, S. Roy, D.W. Nicholson, D.L. Vaux, P. Bouillet, J.M. Adams, and A. Strasser Apoptosis initiated by Bcl-2-regulated caspases activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome Nature 419 2002 634 637
-
(2002)
Nature
, vol.419
, pp. 634-637
-
-
Marsden, V.S.1
O'Connor, L.2
O'Reilly, L.A.3
Silke, J.4
Metcalf, D.5
Ekert, P.G.6
Huang, D.C.S.7
Cecconi, F.8
Kuida, K.9
Tomaselli, K.J.10
Roy, S.11
Nicholson, D.W.12
Vaux, D.L.13
Bouillet, P.14
Adams, J.M.15
Strasser, A.16
-
35
-
-
0037833742
-
Caspase-activation pathways in apoptosis and immunity
-
E.M. Creagh, H. Conroy, and S.J. Martin Caspase-activation pathways in apoptosis and immunity Immunol. Rev. 193 2003 10 21
-
(2003)
Immunol. Rev.
, vol.193
, pp. 10-21
-
-
Creagh, E.M.1
Conroy, H.2
Martin, S.J.3
-
36
-
-
0036847338
-
3-Hydroxy-3-methylglutaryl-CoA reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells
-
A.H. Wagner, M. Gebauer, B. Guldenzoph, and M. Hecker 3-Hydroxy-3-methylglutaryl-CoA reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells Arterioscler. Thromb. Vasc. Biol. 22 2002 1784 1789
-
(2002)
Arterioscler. Thromb. Vasc. Biol.
, vol.22
, pp. 1784-1789
-
-
Wagner, A.H.1
Gebauer, M.2
Guldenzoph, B.3
Hecker, M.4
-
37
-
-
1842367878
-
Rho prevents apoptosis through Bcl-2 expression: Implications for interleukin-2 receptor signal transduction
-
J. Gomez, C. Martinez, M. Giry, A. Garcia, and A. Rebolla Rho prevents apoptosis through Bcl-2 expression: implications for interleukin-2 receptor signal transduction Eur. J. Immunol. 27 1997 2793 2799
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 2793-2799
-
-
Gomez, J.1
Martinez, C.2
Giry, M.3
Garcia, A.4
Rebolla, A.5
-
38
-
-
0002493538
-
Phase I study of fluvastatin, a new synthetic HMG-CoA reductase inhibitor.-Pharmacokinetics of fluvastatin in healthy male volunteers after single and multiple oral administrations
-
N. Masuda, I. Akasaka, J. Suzuki, A. Fujino, M. Ohtawa, N. Nakaya, Y. Goto, N. Takahashi, H. Sekino, T. Amamoto, A. Urae, A. Maeda, and S. Irie Phase I study of fluvastatin, a new synthetic HMG-CoA reductase inhibitor.- Pharmacokinetics of fluvastatin in healthy male volunteers after single and multiple oral administrations Rinshouiyaku 11 Suppl. 1 1995 65 81
-
(1995)
Rinshouiyaku
, vol.11
, Issue.1 SUPPL.
, pp. 65-81
-
-
Masuda, N.1
Akasaka, I.2
Suzuki, J.3
Fujino, A.4
Ohtawa, M.5
Nakaya, N.6
Goto, Y.7
Takahashi, N.8
Sekino, H.9
Amamoto, T.10
Urae, A.11
Maeda, A.12
Irie, S.13
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