Activation of the TLR4 signaling pathway and abnormal cholesterol efflux lead to emphysema in ApoE-deficient mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 302, Issue 11, 2012, Pages

  Goldklang, Monica ^a   Golovatch, Polina ^a   Zelonina, Tina ^a   Trischler, Jordis ^a   Rabinowitz, Daniel ^b   Lemaître, Vincent ^a   D'Armiento, Jeanine ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Apolipoprotein E; Atherosclerosis; Proteases; Toll like receptor

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; GELATINASE B; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; LOW DENSITY LIPOPROTEIN RECEPTOR; MACROPHAGE ELASTASE; OXIDIZED LOW DENSITY LIPOPROTEIN; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CELL INFILTRATION; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE OVEREXPRESSION; HYPERCHOLESTEROLEMIA; LIPID DIET; LUNG EMPHYSEMA; LYMPHOCYTE; MACROPHAGE; MOUSE; NONHUMAN; PHENOTYPE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ANIMALS; APOLIPOPROTEINS E; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CHOLESTEROL; DIET, ATHEROGENIC; DIET, HIGH-FAT; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; HYPERCHOLESTEROLEMIA; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LIPOPROTEINS, LDL; LUNG; LYMPHOCYTES; MACROPHAGES; MATRIX METALLOPROTEINASE 12; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY EMPHYSEMA; RECEPTORS, LDL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84861889744     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00454.2010     Document Type: Article

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