The functional role of Rho and Rho-associated coiled-coil forming protein kinase in eotaxin signaling of eosinophils

Journal of Immunology

Volumn 167, Issue 8, 2001, Pages 4609-4615

  Adachi, T ^a   Vita, R ^a   Sannohe, S ^a   Stafford, S ^a   Alam, R ^a   Kayaba, H ^a   Chihara, J ^a  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; BETA CHEMOKINE; EOTAXIN; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN P21; REACTIVE OXYGEN METABOLITE; RHO FACTOR; RHO KINASE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EOSINOPHIL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION;

EID: 0035887743     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.8.4609     Document Type: Article

References (43)

1. Mechanisms of eosinophil-associated inflammation
2. Updates on cells and cytokines: Chemokines in allergic inflammation
3. Cloning and functional expression of a human eosinophil CC chemokine receptor
4. Cloning, expression, and characterization of the human eosinophil eotaxin receptor
5. Activation of mitogen-activated protein kinase regulates eotaxin-induced eosinophil migration
6. Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-ctivated protein kinase
7. Rho effectors and reorganization of actin cytoskeleton
8. Signal transduction and regulation in smooth muscle
9. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
10. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
11. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation
12. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
13. 2+ sensitization through inhibition of myosin phosphatase in rabbit trachea
14. The p160 RhoA-binding kinase ROKα is a member of a kinase family and is involved in the reorganization of the cytoskeleton
15. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
16. ROCK, a Rho-associated coiled coil forming protein kinase, works downstream of Rho and induces focal adhesions
17. Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility
18. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins
19. Rho-kinase in human neutrophils: A role in signalling for myosin light chain phosphorylation and cell migration
20. An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils
21. Rho controls cortical F-actin disassembly in addition to, but independently of, secretion in mast cells
22. 2-adrenergic receptor to different G proteins by protein kinase A
23. Eosinophil activation by eotaxin: Eotaxin primes the production of reactive oxygen species from eosinophils
24. Human eotaxin represents a potent activator of the respiratory burst of human eosinophils
25. 2+-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein
26. Rho GTPases and the actin cytoskeleton
27. p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
28. Cooperation between mDial and ROCK in Rho-induced actin reorganization
29. Distinct actions and cooperative roles of ROCK and mDia in Rho small G protein-induced reorganization of the actin cytoskeleton in Madin-Darby canine kidney cells
30. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
31. Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2
32. Novel association of the src family kinases, Hck and c-Fgr, with CCR3 receptor stimulation: A possible mechanism for eotaxin-induced human eosinophil chemotaxis
33. Ras and Rho GTPases: A family reunion
34. Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members
35. ADP-ribosylation of Rho by C3 ribosyltransferase inhibits IL-2 production and sustained calcium influx in activated T cells
36. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
37. Rho family GTPases regulate p38 mitogen-activated protein kinase through the down stream mediator Pakl
38. A role for Cdc42 in macrophage chemotaxis
39. The effect of a Rho kinase inhibitor Y-27632 on superoxide production, aggregation and adhesion in human polymorphonuclear leukocytes
40. The role of small GTP-binding proteins in leukocyte function
41. Regulation of p21 rac activation in human neutrophils
42. Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways
43. Expression and translocation of Rac2 in eosinophils during superoxide generation