Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: A dual role for p53

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Ghavami, Saeid ^a,b   Mutawe, Mark M ^a,b   Sharma, Pawan ^a,b   Yeganeh, Behzad ^a,b   McNeill, Karol D ^a,b   Klonisch, Thomas ^a   Unruh, Helmut ^a   Kashani, Hessam H ^a,b   Schaafsma, Dedmer ^a,b   Los, Marek ^c   Halayko, Andrew J ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b MANITOBA INSTITUTE OF CHILD HEALTH   (Canada)

^c LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 12; AUTOPHAGY PROTEIN 5; CASPASE; CELL PROTEIN; DAMAGE REGULATED AUTOPHAGY MODULATOR; MEVALONIC ACID; PIFITHRIN ALPHA; PROTEIN NOXA; PROTEIN P53; PUMA PROTEIN; SHORT HAIRPIN RNA; SIMVASTATIN; UNCLASSIFIED DRUG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; AUTOPHAGY; BIOACCUMULATION; CELL CULTURE; CONTROLLED STUDY; CYTOCHEMISTRY; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LUNG FIBROBLAST; LYSOSOME; MESENCHYME CELL; NUCLEOTIDE SEQUENCE; PHAGOSOME; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RESPIRATORY EPITHELIUM; RNA INTERFERENCE; TRACHEA MUSCLE; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; CYTOLOGY; DRUG EFFECT; MESODERM; PHYSIOLOGY; RESPIRATORY SYSTEM;

APOPTOSIS; AUTOPHAGY; CELLS, CULTURED; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MESODERM; MEVALONIC ACID; RESPIRATORY SYSTEM; SIMVASTATIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79551622901     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016523     Document Type: Article

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