메뉴 건너뛰기




Volumn 19, Issue 4, 2008, Pages 113-121

Do the cholesterol-lowering properties of statins affect cancer risk?

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANDROGEN; ANTINEOPLASTIC AGENT; ATORVASTATIN; CANDICIDIN; FILIPIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; ISOPRENOID; MEVINOLIN; NYSTATIN; PLACEBO; PRAVACOL; PRAVASTATIN; SIMVASTATIN;

EID: 42949170875     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2007.12.004     Document Type: Article
Times cited : (103)

References (98)
  • 1
    • 0036771113 scopus 로고    scopus 로고
    • Pleiotropic effects of HMG-CoA reductase inhibitors
    • Bocan T.M. Pleiotropic effects of HMG-CoA reductase inhibitors. Curr. Opin. Investig. Drugs 3 (2002) 1312-1317
    • (2002) Curr. Opin. Investig. Drugs , vol.3 , pp. 1312-1317
    • Bocan, T.M.1
  • 2
    • 18444374227 scopus 로고    scopus 로고
    • Clinical significance of statin pleiotropic effects: hypotheses versus evidence
    • Davidson M.H. Clinical significance of statin pleiotropic effects: hypotheses versus evidence. Circulation 111 (2005) 2280-2281
    • (2005) Circulation , vol.111 , pp. 2280-2281
    • Davidson, M.H.1
  • 3
    • 0346690415 scopus 로고    scopus 로고
    • The pleiotropic effects of HMG-CoA reductase inhibitors: their role in osteoporosis and dementia
    • Waldman A., and Kritharides L. The pleiotropic effects of HMG-CoA reductase inhibitors: their role in osteoporosis and dementia. Drugs 63 (2003) 139-152
    • (2003) Drugs , vol.63 , pp. 139-152
    • Waldman, A.1    Kritharides, L.2
  • 4
    • 0032985265 scopus 로고    scopus 로고
    • Effect of inhibition of cholesterol synthetic pathway on the activation of Ras and MAP kinase in mesangial cells
    • Bassa B.V., et al. Effect of inhibition of cholesterol synthetic pathway on the activation of Ras and MAP kinase in mesangial cells. Biochim. Biophys. Acta 1449 (1999) 137-149
    • (1999) Biochim. Biophys. Acta , vol.1449 , pp. 137-149
    • Bassa, B.V.1
  • 5
    • 9144236957 scopus 로고    scopus 로고
    • Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia
    • Bi X., et al. Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. J. Biol. Chem. 279 (2004) 48238-48245
    • (2004) J. Biol. Chem. , vol.279 , pp. 48238-48245
    • Bi, X.1
  • 6
    • 0036192275 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation
    • Blanco-Colio L.M., et al. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. Atherosclerosis 161 (2002) 17-26
    • (2002) Atherosclerosis , vol.161 , pp. 17-26
    • Blanco-Colio, L.M.1
  • 7
    • 0036357938 scopus 로고    scopus 로고
    • Statin drugs and dietary isoprenoids downregulate protein prenylation in signal transduction and are antithrombotic and prothrombolytic agents
    • Fenton II J.W., et al. Statin drugs and dietary isoprenoids downregulate protein prenylation in signal transduction and are antithrombotic and prothrombolytic agents. Biochemistry (Mosc.) 67 (2002) 85-91
    • (2002) Biochemistry (Mosc.) , vol.67 , pp. 85-91
    • Fenton II, J.W.1
  • 8
    • 16344370063 scopus 로고    scopus 로고
    • Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases
    • Ghittoni R., et al. Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases. FASEB J. 19 (2005) 605-607
    • (2005) FASEB J. , vol.19 , pp. 605-607
    • Ghittoni, R.1
  • 9
    • 0033980025 scopus 로고    scopus 로고
    • ras p21 Isoprenylation inhibition induces flat colon tumors in Wistar rats
    • Iishi H., et al. ras p21 Isoprenylation inhibition induces flat colon tumors in Wistar rats. Dis. Colon Rectum 43 (2000) 70-75
    • (2000) Dis. Colon Rectum , vol.43 , pp. 70-75
    • Iishi, H.1
  • 10
    • 0035929257 scopus 로고    scopus 로고
    • Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts
    • Ohnaka K., et al. Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. Biochem. Biophys. Res. Commun. 287 (2001) 337-342
    • (2001) Biochem. Biophys. Res. Commun. , vol.287 , pp. 337-342
    • Ohnaka, K.1
  • 11
    • 0037178736 scopus 로고    scopus 로고
    • 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA
    • Park H.J., et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA. Circ. Res. 91 (2002) 143-150
    • (2002) Circ. Res. , vol.91 , pp. 143-150
    • Park, H.J.1
  • 13
    • 2942705774 scopus 로고    scopus 로고
    • Safety of statins: focus on clinical pharmacokinetics and drug interactions
    • Bellosta S., et al. Safety of statins: focus on clinical pharmacokinetics and drug interactions. Circulation 109 (2004) III50-III57
    • (2004) Circulation , vol.109
    • Bellosta, S.1
  • 14
    • 0026567257 scopus 로고
    • Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: comparison with selected HMG-CoA reductase inhibitors
    • Bocan T.M., et al. Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: comparison with selected HMG-CoA reductase inhibitors. Biochim. Biophys. Acta 1123 (1992) 133-144
    • (1992) Biochim. Biophys. Acta , vol.1123 , pp. 133-144
    • Bocan, T.M.1
  • 15
    • 0028929401 scopus 로고
    • Pharmacology of competitive inhibitors of HMG-CoA reductase
    • Corsini A., et al. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol. Res. 31 (1995) 9-27
    • (1995) Pharmacol. Res. , vol.31 , pp. 9-27
    • Corsini, A.1
  • 16
    • 0029957678 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors
    • Desager J.P., and Horsmans Y. Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. Clin. Pharmacokinet. 31 (1996) 348-371
    • (1996) Clin. Pharmacokinet. , vol.31 , pp. 348-371
    • Desager, J.P.1    Horsmans, Y.2
  • 17
    • 0024513882 scopus 로고
    • The physiological disposition of lovastatin
    • Duggan D.E., et al. The physiological disposition of lovastatin. Drug Metab. Dispos. 17 (1989) 166-173
    • (1989) Drug Metab. Dispos. , vol.17 , pp. 166-173
    • Duggan, D.E.1
  • 18
    • 0024508358 scopus 로고
    • Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo
    • Germershausen J.I., et al. Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo. Biochem. Biophys. Res. Commun. 158 (1989) 667-675
    • (1989) Biochem. Biophys. Res. Commun. , vol.158 , pp. 667-675
    • Germershausen, J.I.1
  • 19
    • 0025286202 scopus 로고
    • Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor
    • Koga T., et al. Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Biochim. Biophys. Acta 1045 (1990) 115-120
    • (1990) Biochim. Biophys. Acta , vol.1045 , pp. 115-120
    • Koga, T.1
  • 20
    • 0141560665 scopus 로고    scopus 로고
    • Comparative pharmacology of rosuvastatin
    • McTaggart F. Comparative pharmacology of rosuvastatin. Atheroscler. Suppl. 4 (2003) 9-14
    • (2003) Atheroscler. Suppl. , vol.4 , pp. 9-14
    • McTaggart, F.1
  • 21
    • 0025348680 scopus 로고
    • Selective inhibition of cholesterol synthesis in liver versus extrahepatic tissues by HMG-CoA reductase inhibitors
    • Parker R.A., et al. Selective inhibition of cholesterol synthesis in liver versus extrahepatic tissues by HMG-CoA reductase inhibitors. J. Lipid Res. 31 (1990) 1271-1282
    • (1990) J. Lipid Res. , vol.31 , pp. 1271-1282
    • Parker, R.A.1
  • 22
    • 13444251203 scopus 로고    scopus 로고
    • Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update
    • Schachter M. Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update. Fundam. Clin. Pharmacol. 19 (2005) 117-125
    • (2005) Fundam. Clin. Pharmacol. , vol.19 , pp. 117-125
    • Schachter, M.1
  • 23
    • 0027819738 scopus 로고
    • Tissue selectivity of hydroxymethylglutaryl coenzyme A (HMG CoA) reductase inhibitors
    • Sirtori C.R. Tissue selectivity of hydroxymethylglutaryl coenzyme A (HMG CoA) reductase inhibitors. Pharmacol. Ther. 60 (1993) 431-459
    • (1993) Pharmacol. Ther. , vol.60 , pp. 431-459
    • Sirtori, C.R.1
  • 25
    • 0025240977 scopus 로고
    • Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug
    • Vickers S., et al. Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug. Drug Metab. Dispos. 18 (1990) 138-145
    • (1990) Drug Metab. Dispos. , vol.18 , pp. 138-145
    • Vickers, S.1
  • 26
    • 0036708020 scopus 로고    scopus 로고
    • A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin
    • White C.M. A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin. J. Clin. Pharmacol. 42 (2002) 963-970
    • (2002) J. Clin. Pharmacol. , vol.42 , pp. 963-970
    • White, C.M.1
  • 27
    • 34147152963 scopus 로고    scopus 로고
    • Rosuvastatin displays anti-atherothrombotic and anti-inflammatory properties in apoE-deficient mice
    • Monetti M., et al. Rosuvastatin displays anti-atherothrombotic and anti-inflammatory properties in apoE-deficient mice. Pharmacol. Res. 55 (2007) 441-449
    • (2007) Pharmacol. Res. , vol.55 , pp. 441-449
    • Monetti, M.1
  • 28
    • 33947526805 scopus 로고    scopus 로고
    • Attenuation of contractile dysfunction by atorvastatin after intestinal ischemia reperfusion injury in rats
    • Ozacmak V.H., et al. Attenuation of contractile dysfunction by atorvastatin after intestinal ischemia reperfusion injury in rats. Eur. J. Pharmacol. 562 (2007) 138-147
    • (2007) Eur. J. Pharmacol. , vol.562 , pp. 138-147
    • Ozacmak, V.H.1
  • 29
    • 0022837973 scopus 로고
    • Serum cholesterol and the incidence of cancer in a large cohort
    • Hiatt R.A., and Fireman B.H. Serum cholesterol and the incidence of cancer in a large cohort. J. Chronic Dis. 39 (1986) 861-870
    • (1986) J. Chronic Dis. , vol.39 , pp. 861-870
    • Hiatt, R.A.1    Fireman, B.H.2
  • 30
    • 0023895001 scopus 로고
    • Serum cholesterol and risk of cancer in a cohort of 39,000 men and women
    • Knekt P., et al. Serum cholesterol and risk of cancer in a cohort of 39,000 men and women. J. Clin. Epidemiol. 41 (1988) 519-530
    • (1988) J. Clin. Epidemiol. , vol.41 , pp. 519-530
    • Knekt, P.1
  • 31
    • 0026718746 scopus 로고
    • Serum cholesterol and cancer risk: an epidemiologic perspective
    • Kritchevsky S.B., and Kritchevsky D. Serum cholesterol and cancer risk: an epidemiologic perspective. Annu. Rev. Nutr. 12 (1992) 391-416
    • (1992) Annu. Rev. Nutr. , vol.12 , pp. 391-416
    • Kritchevsky, S.B.1    Kritchevsky, D.2
  • 33
    • 84965811594 scopus 로고
    • The cholesterol content of normal and enlarged prostates
    • Swyer G.I. The cholesterol content of normal and enlarged prostates. Cancer Res. 2 (1942) 372-375
    • (1942) Cancer Res. , vol.2 , pp. 372-375
    • Swyer, G.I.1
  • 34
    • 0014321808 scopus 로고
    • The effect of polyene macrolides on the prostate gland and canine prostatic hyperplasia
    • Gordon H.W., and Schaffner C.P. The effect of polyene macrolides on the prostate gland and canine prostatic hyperplasia. Proc. Natl. Acad. Sci. U. S. A. 60 (1968) 1201-1208
    • (1968) Proc. Natl. Acad. Sci. U. S. A. , vol.60 , pp. 1201-1208
    • Gordon, H.W.1    Schaffner, C.P.2
  • 35
    • 0015773662 scopus 로고
    • Effect of candicidin on the human benign hypertrophied prostate gland
    • Keshin J.G. Effect of candicidin on the human benign hypertrophied prostate gland. Int. Surg. 58 (1973) 116-122
    • (1973) Int. Surg. , vol.58 , pp. 116-122
    • Keshin, J.G.1
  • 36
    • 0015627095 scopus 로고
    • Therapeutic action of levorin in adenoma of the prostate
    • Klijucharev B.V., et al. Therapeutic action of levorin in adenoma of the prostate. Urol. Nefrol. (Mosk.) 38 (1973) 40-43
    • (1973) Urol. Nefrol. (Mosk.) , vol.38 , pp. 40-43
    • Klijucharev, B.V.1
  • 37
    • 0347321080 scopus 로고
    • Efficacy of candicidin in benign prostatic hyperplasia
    • Orkin L.A. Efficacy of candicidin in benign prostatic hyperplasia. Urology 4 (1974) 80-84
    • (1974) Urology , vol.4 , pp. 80-84
    • Orkin, L.A.1
  • 38
    • 0019761279 scopus 로고
    • Prostatic cholesterol metabolism: regulation and alteration
    • Schaffner C.P. Prostatic cholesterol metabolism: regulation and alteration. Prog. Clin. Biol. Res. 75A (1981) 279-324
    • (1981) Prog. Clin. Biol. Res. , vol.75 A , pp. 279-324
    • Schaffner, C.P.1
  • 39
    • 0017120335 scopus 로고
    • Effect of candicidin and colestipol on the testes and prostate glands of BIO 87.20 hamsters
    • Wang G.M., and Schaffner C.P. Effect of candicidin and colestipol on the testes and prostate glands of BIO 87.20 hamsters. Invest. Urol. 14 (1976) 66-71
    • (1976) Invest. Urol. , vol.14 , pp. 66-71
    • Wang, G.M.1    Schaffner, C.P.2
  • 40
    • 0014325851 scopus 로고
    • The hypocholesterolemic activity of orally administered polyene macrolides
    • Schaffner C.P., and Gordon H.W. The hypocholesterolemic activity of orally administered polyene macrolides. Proc. Natl. Acad. Sci. U. S. A. 61 (1968) 36-41
    • (1968) Proc. Natl. Acad. Sci. U. S. A. , vol.61 , pp. 36-41
    • Schaffner, C.P.1    Gordon, H.W.2
  • 41
    • 0035796796 scopus 로고    scopus 로고
    • The interactions of amphotericin B with various sterols in relation to its possible use in anticancer therapy
    • Charbonneau C., et al. The interactions of amphotericin B with various sterols in relation to its possible use in anticancer therapy. Biophys. Chem. 91 (2001) 125-133
    • (2001) Biophys. Chem. , vol.91 , pp. 125-133
    • Charbonneau, C.1
  • 42
    • 0016818236 scopus 로고
    • Candicidin: physiologic effect on prostate
    • Sporer A., et al. Candicidin: physiologic effect on prostate. Urology 6 (1975) 298-304
    • (1975) Urology , vol.6 , pp. 298-304
    • Sporer, A.1
  • 43
    • 0029743674 scopus 로고    scopus 로고
    • Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP
    • Swinnen J.V., et al. Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP. Endocrinology 137 (1996) 4468-4474
    • (1996) Endocrinology , vol.137 , pp. 4468-4474
    • Swinnen, J.V.1
  • 44
    • 0034791515 scopus 로고    scopus 로고
    • Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway
    • Heemers H., et al. Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway. Mol. Endocrinol. 15 (2001) 1817-1828
    • (2001) Mol. Endocrinol. , vol.15 , pp. 1817-1828
    • Heemers, H.1
  • 45
    • 0142124790 scopus 로고    scopus 로고
    • Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo
    • Heemers H., et al. Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo. Mol. Cell. Endocrinol. 205 (2003) 21-31
    • (2003) Mol. Cell. Endocrinol. , vol.205 , pp. 21-31
    • Heemers, H.1
  • 46
    • 12344287240 scopus 로고    scopus 로고
    • Androgens, lipogenesis and prostate cancer
    • Swinnen J.V., et al. Androgens, lipogenesis and prostate cancer. J. Steroid Biochem. Mol. Biol. 92 (2004) 273-279
    • (2004) J. Steroid Biochem. Mol. Biol. , vol.92 , pp. 273-279
    • Swinnen, J.V.1
  • 47
    • 0037015040 scopus 로고    scopus 로고
    • The program of androgen-responsive genes in neoplastic prostate epithelium
    • Nelson P.S., et al. The program of androgen-responsive genes in neoplastic prostate epithelium. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 11890-11895
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 11890-11895
    • Nelson, P.S.1
  • 48
    • 10044271037 scopus 로고    scopus 로고
    • SREBP transcription factors: master regulators of lipid homeostasis
    • Eberle D., et al. SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 86 (2004) 839-848
    • (2004) Biochimie , vol.86 , pp. 839-848
    • Eberle, D.1
  • 49
    • 0142027805 scopus 로고    scopus 로고
    • Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    • Horton J.D., et al. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 12027-12032
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 12027-12032
    • Horton, J.D.1
  • 50
    • 1542615071 scopus 로고    scopus 로고
    • Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence
    • Ettinger S.L., et al. Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence. Cancer Res. 64 (2004) 2212-2221
    • (2004) Cancer Res. , vol.64 , pp. 2212-2221
    • Ettinger, S.L.1
  • 51
    • 0035195361 scopus 로고    scopus 로고
    • Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2
    • Chen Y., and Hughes-Fulford M. Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2. Int. J. Cancer 91 (2001) 41-45
    • (2001) Int. J. Cancer , vol.91 , pp. 41-45
    • Chen, Y.1    Hughes-Fulford, M.2
  • 52
    • 26244464326 scopus 로고    scopus 로고
    • PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
    • Porstmann T., et al. PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24 (2005) 6465-6481
    • (2005) Oncogene , vol.24 , pp. 6465-6481
    • Porstmann, T.1
  • 53
    • 15444349266 scopus 로고    scopus 로고
    • Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
    • Cairns P., et al. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res. 57 (1997) 4997-5000
    • (1997) Cancer Res. , vol.57 , pp. 4997-5000
    • Cairns, P.1
  • 54
    • 0033152165 scopus 로고    scopus 로고
    • Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN
    • Davies M.A., et al. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res. 59 (1999) 2551-2556
    • (1999) Cancer Res. , vol.59 , pp. 2551-2556
    • Davies, M.A.1
  • 55
    • 0033564514 scopus 로고    scopus 로고
    • The phosphatidylinositol 3′-kinase pathway is a dominant growth factor- activated cell survival pathway in LNCaP human prostate carcinoma cells
    • Lin J., et al. The phosphatidylinositol 3′-kinase pathway is a dominant growth factor- activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res. 59 (1999) 2891-2897
    • (1999) Cancer Res. , vol.59 , pp. 2891-2897
    • Lin, J.1
  • 56
    • 0034742120 scopus 로고    scopus 로고
    • AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells
    • Sun M., et al. AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am. J. Pathol. 159 (2001) 431-437
    • (2001) Am. J. Pathol. , vol.159 , pp. 431-437
    • Sun, M.1
  • 57
    • 29944446607 scopus 로고    scopus 로고
    • Statins and cancer risk: a meta-analysis
    • Dale K.M., et al. Statins and cancer risk: a meta-analysis. JAMA 295 (2006) 74-80
    • (2006) JAMA , vol.295 , pp. 74-80
    • Dale, K.M.1
  • 58
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Baigent C., et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 366 (2005) 1267-1278
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1
  • 59
    • 33846604584 scopus 로고    scopus 로고
    • Statins and risk of cancer: a systematic review and metaanalysis
    • Browning D.R., and Martin R.M. Statins and risk of cancer: a systematic review and metaanalysis. Int. J. Cancer 120 (2007) 833-843
    • (2007) Int. J. Cancer , vol.120 , pp. 833-843
    • Browning, D.R.1    Martin, R.M.2
  • 60
    • 33745256796 scopus 로고    scopus 로고
    • Statins and the risk of cancer
    • Freeman M.R., et al. Statins and the risk of cancer. JAMA 295 (2006) 2720-2721
    • (2006) JAMA , vol.295 , pp. 2720-2721
    • Freeman, M.R.1
  • 61
    • 34547736129 scopus 로고    scopus 로고
    • Risk factors for prostate cancer incidence and progression in the health professionals follow-up study
    • Giovannucci E., et al. Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. Int. J. Cancer 121 (2007) 1571-1578
    • (2007) Int. J. Cancer , vol.121 , pp. 1571-1578
    • Giovannucci, E.1
  • 62
    • 0037420492 scopus 로고    scopus 로고
    • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
    • Sever P.S., et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 361 (2003) 1149-1158
    • (2003) Lancet , vol.361 , pp. 1149-1158
    • Sever, P.S.1
  • 63
    • 85136450947 scopus 로고    scopus 로고
    • (2002) Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). JAMA 288, 2998-3007
    • (2002) Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). JAMA 288, 2998-3007
  • 64
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360 (2002) 7-22
    • (2002) Lancet , vol.360 , pp. 7-22
    • Heart Protection Study Collaborative Group1
  • 65
    • 0036227123 scopus 로고    scopus 로고
    • Statin use and the risk of breast and prostate cancer
    • Coogan P.F., et al. Statin use and the risk of breast and prostate cancer. Epidemiology 13 (2002) 262-267
    • (2002) Epidemiology , vol.13 , pp. 262-267
    • Coogan, P.F.1
  • 66
    • 14844292583 scopus 로고    scopus 로고
    • Cancer risk among statin users: a population-based cohort study
    • Friis S., et al. Cancer risk among statin users: a population-based cohort study. Int. J. Cancer 114 (2005) 643-647
    • (2005) Int. J. Cancer , vol.114 , pp. 643-647
    • Friis, S.1
  • 67
    • 2942754163 scopus 로고    scopus 로고
    • The risk of cancer in users of statins
    • Graaf M.R., et al. The risk of cancer in users of statins. J. Clin. Oncol. 22 (2004) 2388-2394
    • (2004) J. Clin. Oncol. , vol.22 , pp. 2388-2394
    • Graaf, M.R.1
  • 68
    • 33845864688 scopus 로고    scopus 로고
    • Statin drugs and risk of advanced prostate cancer
    • Platz E.A., et al. Statin drugs and risk of advanced prostate cancer. J. Natl. Cancer Inst. 98 (2006) 1819-1825
    • (2006) J. Natl. Cancer Inst. , vol.98 , pp. 1819-1825
    • Platz, E.A.1
  • 69
    • 38849123455 scopus 로고    scopus 로고
    • Statin use and risk of prostate cancer in the California Men's Health Study Cohort
    • Flick E.D., et al. Statin use and risk of prostate cancer in the California Men's Health Study Cohort. Cancer Epidemiol. Biomarkers Prev. 16 (2007) 2218-2225
    • (2007) Cancer Epidemiol. Biomarkers Prev. , vol.16 , pp. 2218-2225
    • Flick, E.D.1
  • 70
    • 38849159872 scopus 로고    scopus 로고
    • Cholesterol-lowering drugs and advanced prostate cancer incidence in a large U.S. cohort
    • Jacobs E.J., et al. Cholesterol-lowering drugs and advanced prostate cancer incidence in a large U.S. cohort. Cancer Epidemiol. Biomarkers Prev. 16 (2007) 2213-2217
    • (2007) Cancer Epidemiol. Biomarkers Prev. , vol.16 , pp. 2213-2217
    • Jacobs, E.J.1
  • 71
    • 38849208358 scopus 로고    scopus 로고
    • Cholesterol-lowering drugs and prostate cancer risk: a population-based case-control study
    • Murtola T.J., et al. Cholesterol-lowering drugs and prostate cancer risk: a population-based case-control study. Cancer Epidemiol. Biomarkers Prev. 16 (2007) 2226-2232
    • (2007) Cancer Epidemiol. Biomarkers Prev. , vol.16 , pp. 2226-2232
    • Murtola, T.J.1
  • 72
    • 0345491598 scopus 로고    scopus 로고
    • Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A
    • Li L., et al. Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. Mol. Cell. Biol. 23 (2003) 9389-9404
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 9389-9404
    • Li, L.1
  • 73
    • 0036784311 scopus 로고    scopus 로고
    • The role of caveolin-1 in androgen insensitive prostate cancer
    • Mouraviev V., et al. The role of caveolin-1 in androgen insensitive prostate cancer. J. Urol. 168 (2002) 1589-1596
    • (2002) J. Urol. , vol.168 , pp. 1589-1596
    • Mouraviev, V.1
  • 74
    • 0031872767 scopus 로고    scopus 로고
    • Elevated expression of caveolin is associated with prostate and breast cancer
    • Yang G., et al. Elevated expression of caveolin is associated with prostate and breast cancer. Clin. Cancer Res. 4 (1998) 1873-1880
    • (1998) Clin. Cancer Res. , vol.4 , pp. 1873-1880
    • Yang, G.1
  • 75
    • 14744275841 scopus 로고    scopus 로고
    • Combined c-Myc and caveolin-1 expression in human prostate carcinoma predicts prostate carcinoma progression
    • Yang G., et al. Combined c-Myc and caveolin-1 expression in human prostate carcinoma predicts prostate carcinoma progression. Cancer 103 (2005) 1186-1194
    • (2005) Cancer , vol.103 , pp. 1186-1194
    • Yang, G.1
  • 77
    • 0029204576 scopus 로고
    • Caveolae, transmembrane signalling and cellular transformation
    • Lisanti M.P., et al. Caveolae, transmembrane signalling and cellular transformation. Mol. Membr. Biol. 12 (1995) 121-124
    • (1995) Mol. Membr. Biol. , vol.12 , pp. 121-124
    • Lisanti, M.P.1
  • 78
    • 0032723268 scopus 로고    scopus 로고
    • Caveolins, liquid-ordered domains, and signal transduction
    • Smart E.J., et al. Caveolins, liquid-ordered domains, and signal transduction. Mol. Cell. Biol. 19 (1999) 7289-7304
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7289-7304
    • Smart, E.J.1
  • 79
    • 0035069676 scopus 로고    scopus 로고
    • The caveolin triad: caveolae biogenesis, cholesterol trafficking, and signal transduction
    • Schlegel A., and Lisanti M.P. The caveolin triad: caveolae biogenesis, cholesterol trafficking, and signal transduction. Cytokine Growth Factor Rev. 12 (2001) 41-51
    • (2001) Cytokine Growth Factor Rev. , vol.12 , pp. 41-51
    • Schlegel, A.1    Lisanti, M.P.2
  • 80
    • 0035477058 scopus 로고    scopus 로고
    • Ligand-independent activation of oestrogen receptor alpha by caveolin-1
    • Schlegel A., et al. Ligand-independent activation of oestrogen receptor alpha by caveolin-1. Biochem. J. 359 (2001) 203-210
    • (2001) Biochem. J. , vol.359 , pp. 203-210
    • Schlegel, A.1
  • 81
    • 0033571471 scopus 로고    scopus 로고
    • Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker
    • Yang G., et al. Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker. Cancer Res. 59 (1999) 5719-5723
    • (1999) Cancer Res. , vol.59 , pp. 5719-5723
    • Yang, G.1
  • 82
    • 21644452110 scopus 로고    scopus 로고
    • Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice
    • Williams T.M., et al. Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice. J. Biol. Chem. 280 (2005) 25134-25145
    • (2005) J. Biol. Chem. , vol.280 , pp. 25134-25145
    • Williams, T.M.1
  • 83
    • 0035971086 scopus 로고    scopus 로고
    • Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control
    • Parpal S., et al. Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control. J. Biol. Chem. 276 (2001) 9670-9678
    • (2001) J. Biol. Chem. , vol.276 , pp. 9670-9678
    • Parpal, S.1
  • 84
    • 0034532063 scopus 로고    scopus 로고
    • PC12 cells have caveolae that contain TrkA. Caveolae-disrupting drugs inhibit nerve growth factor-induced, but not epidermal growth factor- induced, MAPK phosphorylation
    • Peiro S., et al. PC12 cells have caveolae that contain TrkA. Caveolae-disrupting drugs inhibit nerve growth factor-induced, but not epidermal growth factor- induced, MAPK phosphorylation. J. Biol. Chem. 275 (2000) 37846-37852
    • (2000) J. Biol. Chem. , vol.275 , pp. 37846-37852
    • Peiro, S.1
  • 85
    • 0032575524 scopus 로고    scopus 로고
    • Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover
    • Pike L.J., and Miller J.M. Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J. Biol. Chem. 273 (1998) 22298-22304
    • (1998) J. Biol. Chem. , vol.273 , pp. 22298-22304
    • Pike, L.J.1    Miller, J.M.2
  • 86
    • 0027997787 scopus 로고
    • Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules
    • Schnitzer J.E., et al. Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules. J. Cell Biol. 127 (1994) 1217-1232
    • (1994) J. Cell Biol. , vol.127 , pp. 1217-1232
    • Schnitzer, J.E.1
  • 87
    • 33845312826 scopus 로고    scopus 로고
    • Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells
    • Williams T.M., et al. Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells. Am. J. Pathol. 169 (2006) 1784-1801
    • (2006) Am. J. Pathol. , vol.169 , pp. 1784-1801
    • Williams, T.M.1
  • 88
    • 33845338025 scopus 로고    scopus 로고
    • Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers
    • Sotgia F., et al. Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers. Cancer Res. 66 (2006) 10647-10651
    • (2006) Cancer Res. , vol.66 , pp. 10647-10651
    • Sotgia, F.1
  • 89
    • 30344437854 scopus 로고    scopus 로고
    • Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness
    • Sotgia F., et al. Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness. Am. J. Pathol. 168 (2006) 292-309
    • (2006) Am. J. Pathol. , vol.168 , pp. 292-309
    • Sotgia, F.1
  • 90
    • 33744776333 scopus 로고    scopus 로고
    • Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status
    • Li T., et al. Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status. Am. J. Pathol. 168 (2006) 1998-2013
    • (2006) Am. J. Pathol. , vol.168 , pp. 1998-2013
    • Li, T.1
  • 91
    • 21244451436 scopus 로고    scopus 로고
    • Caveolin-1 in breast cancer
    • Bouras T., et al. Caveolin-1 in breast cancer. Cancer Biol. Ther. 3 (2004) 931-941
    • (2004) Cancer Biol. Ther. , vol.3 , pp. 931-941
    • Bouras, T.1
  • 92
    • 7644227012 scopus 로고    scopus 로고
    • Caveolin-1 inhibits breast cancer growth and metastasis
    • Sloan E.K., et al. Caveolin-1 inhibits breast cancer growth and metastasis. Oncogene 23 (2004) 7893-7897
    • (2004) Oncogene , vol.23 , pp. 7893-7897
    • Sloan, E.K.1
  • 93
    • 0037089486 scopus 로고    scopus 로고
    • Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells
    • Zhuang L., et al. Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells. Cancer Res. 62 (2002) 2227-2231
    • (2002) Cancer Res. , vol.62 , pp. 2227-2231
    • Zhuang, L.1
  • 94
    • 0032431032 scopus 로고    scopus 로고
    • The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
    • Wu X., et al. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 15587-15591
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 15587-15591
    • Wu, X.1
  • 95
    • 34447134174 scopus 로고    scopus 로고
    • Cholesterol sensitivity of endogenous and myristoylated Akt
    • Adam R.M., et al. Cholesterol sensitivity of endogenous and myristoylated Akt. Cancer Res. 67 (2007) 6238-6246
    • (2007) Cancer Res. , vol.67 , pp. 6238-6246
    • Adam, R.M.1
  • 96
    • 16844372930 scopus 로고    scopus 로고
    • Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts
    • Zhuang L., et al. Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J. Clin. Invest. 115 (2005) 959-968
    • (2005) J. Clin. Invest. , vol.115 , pp. 959-968
    • Zhuang, L.1
  • 97
    • 0035843962 scopus 로고    scopus 로고
    • Structural mechanism for statin inhibition of HMG-CoA reductase
    • Istvan E.S., and Deisenhofer J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292 (2001) 1160-1164
    • (2001) Science , vol.292 , pp. 1160-1164
    • Istvan, E.S.1    Deisenhofer, J.2
  • 98
    • 42949110862 scopus 로고    scopus 로고
    • Platz et al. (2006) Association between plasma cholesterol and prostate cancer. AACR Frontiers in Cancer Prevention Research, Boston, MA, [abstract A179]
    • Platz et al. (2006) Association between plasma cholesterol and prostate cancer. AACR Frontiers in Cancer Prevention Research, Boston, MA, [abstract A179]


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.