Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts

Cell Death and Disease

Volumn 3, Issue 6, 2012, Pages

  Ghavami, S ^a   Yeganeh, B ^a   Stelmack, G L ^a   Kashani, H H ^a   Sharma, P ^a   Cunnington, R ^a   Rattan, S ^a   Bathe, K ^a   Klonisch, T ^a   Dixon, I M C ^a   Freed, D H ^a   Halayko, A J ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

cardiac remodeling; heart; lysosome; simvastatin; unfolded protein response

Indexed keywords

AUTOPHAGY PROTEIN 5; BAFILOMYCIN A1; CASPASE 4; CASPASE 7; CATHEPSIN B; CATHEPSIN L; MEVALONIC ACID; PROTEIN BCL 2; SIMVASTATIN; STRESS ACTIVATED PROTEIN KINASE; CASP4 PROTEIN, HUMAN; CASPASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INITIATOR CASPASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; FIBROBLAST; HEART ATRIUM; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UNFOLDED PROTEIN RESPONSE; CELL CULTURE; CYTOLOGY; ENZYME ACTIVATION; HEART MUSCLE; METABOLISM; SIGNAL TRANSDUCTION;

APOPTOSIS; AUTOPHAGY; CASPASE 7; CASPASE INHIBITORS; CASPASES, INITIATOR; CELL DEATH; CELLS, CULTURED; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FIBROBLASTS; HEART ATRIA; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEVALONIC ACID; MYOCARDIUM; SIGNAL TRANSDUCTION; SIMVASTATIN; UNFOLDED PROTEIN RESPONSE;

EID: 84863425318     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.61     Document Type: Article

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