Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 6, 2008, Pages 1889-1892

  Maynor, Michelle ^a   Scott, Sarah A ^a   Rickert, Emily L ^a   Gibbs, Richard A ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Geranylgeranylation; Isoprenoids; Palladium catalyzed coupling; Post translational modification

Indexed keywords

DIMETHYLALLYLTRANSFERASE; FARNESYL TRANS TRANSFERASE; GERANYLGERANYL PYROPHOSPHATE DERIVATIVE; GERANYLGERANYLTRANSFERASE I INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PYROPHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; EVALUATION; MAMMAL; NONHUMAN; PRENYLATION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; FARNESYLTRANSTRANSFERASE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR STRUCTURE; POLYISOPRENYL PHOSPHATES; PROTEIN PRENYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL;

MAMMALIA;

EID: 40749147583     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.02.014     Document Type: Article

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