Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA

American Journal of Respiratory and Critical Care Medicine

Volumn 179, Issue 11, 2009, Pages 1011-1021

  Richens, Tiffany R ^a   Linderman, Derek J ^a   Horstmann, Sarah A ^a   Lambert, Cherie ^a   Xiao, Yi Qun ^a   Keith, Robert L ^b   Boé, Darren M ^a   Morimoto, Konosuke ^c   Bowler, Russell P ^d   Day, Brian J ^d   Janssen, William J ^d   Henson, Peter M ^d   Vandivier, R William ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c NAGASAKI UNIVERSITY   (Japan)

^d DEPARTMENT OF MEDICINE   (United States)

Author keywords

Chronic obstructive; Macrophages, alveolar; Phagocytosis; Pulmonary disease; Rho associated kinases; Superoxides

Indexed keywords

CIGARETTE SMOKE; FC RECEPTOR; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VIVO STUDY; INSTITUTE FOR CANCER RESEARCH MOUSE; LONG TERM EXPOSURE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PHAGOCYTOSIS; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; HUMANS; MACROPHAGES, ALVEOLAR; MALE; MICE; MICE, INBRED ICR; MICE, KNOCKOUT; NEUTROPHILS; OXIDATIVE STRESS; PHAGOCYTOSIS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; SMOKING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 66249127897     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200807-1148OC     Document Type: Article

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