Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung

Thorax

Volumn 64, Issue 1, 2009, Pages 44-49

  Imamura, M ^a   Okunishi, K ^a   Ohtsu, H ^a   Nakagome, K ^a   Harada, H ^a   Tanaka, R ^a   Yamamoto, K ^a   Dohi, M ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ALUMINUM HYDROXIDE; ANTIGEN; IMMUNOGLOBULIN E; INTERLEUKIN 17; INTERLEUKIN 5; OVALBUMIN; PRAVASTATIN;

AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; ASTHMA; BAGG ALBINO MOUSE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; EX VIVO STUDY; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; IN VITRO STUDY; LUNG LAVAGE; LYMPH NODE; LYMPH NODE CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; SPLEEN CELL; TH2 CELL;

EID: 58349103693     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thx.2007.094540     Document Type: Article

References (35)

1. Nakamura H, Arakawa K, Itakura H, et al. Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trial. MEGA Study Group. Lancet 2006;368:1155-63.
2. Greenwood J, Steinman L, Zamvil SS. Statin therapy and autoimmune disease: from protein prenylation to immunomodulation. Nat Rev Immunol 2006;6:358-70.
3. Yilmaz A, Reiss C, Tantawi 0, et al. HMG-CoA reductase inhibitors suppress maturation of human dendritic cells; new implications for atherosclerosis, Atherosclerosis 2004;172:85-93.
4. Yilmaz A, Reiss C, Weng A, et al. Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukocyte Biol 2006;79:529-38.
5. Youssef S, Stuve O, Patarroyo JC, et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 2002;420:78-84.
6. Lawman S, Mauri C, Jury EC, et al. Atorvastatin inhibits autoreactive B cell activation and delays lupus development in New Zealand black/white F1 mice. J Immunol 2004;173:7641-6.
7. Hakamada-Taguchi R, Uehara Y, Kuribayashi K, et al. Inhibition of hydroxymethylglutaryl-coenzyme A reductase reduces Th1 development and promotes Th2 development. Circ Res 2003;93:948-56.
8. Dunn SE, Youssef S, Goldstein MJ, et al. Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. J Exp Med 2006;20:401-12.
9. Leung BP, Sattar N, Crilly A, et al. A novel anti-inflammatory role for simvastatin in inflammatory arthritis. J Immunol 2003;170:1524-30.
10. Mckay A, Leung BP, Mclnnes IB, et al. A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma. J Immunol 2004;172:2903-8.
11. Kim DY, Byu SY, Lim JE, et al. Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model. Eur J Pharmacol 2007;557:76-86.
12. Yeh YF, Huang SL. Enhancing effect of dietary cholesterol and inhibitory effect of pravastatin on allergic pulmonary inflammation. J Biomed Sci 2004;11:599-606.
13. Hothersall E, McSharry C, Thomson NC. Potential therapeutic role for statins in respiratory disease. Thorax 2006;61:729-34.
14. Weaver CT, Hatton RD, Mangan PR, et al. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007;25:821-52.
15. + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005;6:1123- 32.
16. H17 and regulatory T cells. Nature 2006;441;235-8.
17. Happel Kl, Oubin PJ, Zheng M, et al. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med 2005;202:761-9.
18. + T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 2007;8:369-77.
19. Cua DJ, Sherlock J, Chen Y, et al. lnterleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003;421:744-8.
20. Murphy CA, Langrish CL, Chen Y, et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 2003;198:1951-7.
21. Laan M, Cui ZH, Hoshino H, et al. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol 1999;162:2347-52.
22. Barczyk A, Pierzchala W, Sozanska E. Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med 2003;97:726-33.
23. Schnyder-Candrian S, Togbe D, Couillin l, et al. lnterleukin-17 is a negative regulator of established allergic asthma. J Exp Med 2006;203:2715-25.
24. Nakae S, Komiyama Y, Nambu A, et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 2002;17:375-87.
25. Hellings PW, Kasran A, Liu Z, et al. lnterleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am J Respir Cell Mol Biol 2003;28:42-50.
26. Molet S, Hamid Q, Davoine F, et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol 2001;108:430-8.
27. Dragon S, Rahman MS, Yang J, et al. IL-17 enhances IL-1β-mediated CXCL-8 release from human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2007;292:L1023-9.
28. Okunishi K, Dohi M, Nakagome K, et al. A novel role of cysteinyl leukotrienes to promote dendritic cell activation in the antigen-induced immune responses in the lung. J Immunol 2004;173:6393-402.
29. Okunishi K, Dohi M, Nakagome K, et al. A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function. J Immunol 2005;175:4745-53.
30. Nakagome K, Dohi M, Okunishi K, et al. In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specific systemic immune response in a mouse model of allergic airway inflammation. J Immunol 2005;174:6955-66.
31. Brandt EB, Strait RT, Hershko D, et al. Mast cells are required for experimental oral allergen-induced diarrhea. J Clin Invest 2003;112:1666-77.
32. + lymphocytes. J Immunol 2008;180:6988-96.
33. Pahan K, Sheikh FG, Namboodiri AM, et al. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. J Clin Invest 1997;100:2671-9.
34. Kwak B, Mulhaupt F, Myit S, et al. Statins as a newly recognized type of immunomodulator. imNat Med 2000;6:1399-402.
35. Menzies D, Nair A, Meldrum KT, et al. Simvastatin does not exhibit therapeutic antiinflammatory effects in asthma. J Allergy Clin Immunol 2007;119:328-35.