The mevalonate cascade as a target to suppress extracellular matrix synthesis by human airway smooth muscle

American Journal of Respiratory Cell and Molecular Biology

Volumn 44, Issue 3, 2011, Pages 394-403

  Schaafsma, Dedmer ^a,b   Dueck, Gordon ^a,b   Ghavami, Saeid ^a,b   Kroeker, Andrea ^a,b   Mutawe, Mark M ^a,b   Hauff, Kristin ^a   Xu, Fred Y ^a   McNeill, Karol D ^a,b   Unruh, Helmut ^a   Hatch, Grant M ^a   Halayko, Andrew J ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b MANITOBA INSTITUTE OF CHILD HEALTH   (Canada)

Author keywords

Airway remodeling; Asthma; Collagen; Geranylgeranyl transferase; Statins

Indexed keywords

BETA ACTIN; CHOLESTEROL; COLLAGEN TYPE 1; FARNESYL DIPHOSPHATE; FARNESYL TRANSFERASE; FIBRONECTIN; GERANYLGERANYL PYROPHOSPHATE; GERANYLGERANYL TRANSFERASE 1; GERANYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVALONIC ACID; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SCLEROPROTEIN; SIMVASTATIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

AIRWAY; AIRWAY REMODELING; ARTICLE; CELL PROLIFERATION; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LUNG FIBROSIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; SYNTHESIS;

ALKYL AND ARYL TRANSFERASES; COLLAGEN; COLLAGEN TYPE I; EXTRACELLULAR MATRIX; FARNESYLTRANSTRANSFERASE; GENE EXPRESSION REGULATION; HUMANS; LEUCINE; MEVALONIC ACID; MODELS, BIOLOGICAL; PROTEIN PROCESSING, POST-TRANSLATIONAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIMVASTATIN; TRACHEA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79952237366     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2010-0052OC     Document Type: Article

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