Rho family proteins: Coordinating cell responses

Trends in Cell Biology

Volumn 11, Issue 12, 2001, Pages 471-477

  Ridley, Anne J ^a,b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; EZRIN; GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; LYSOPHOSPHATIDIC ACID; MOESIN; PROTEIN; PROTEIN CDC24; PROTEIN WASP; RAC PROTEIN; RAC1 PROTEIN; RAC2 PROTEIN; RADIXIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RHO FACTOR; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

CELL FUNCTION; CELL INTERACTION; CELL MIGRATION; CELL SURVIVAL; CYTOSKELETON; ENZYME ACTIVATION; GENE SEQUENCE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ACTINS; ANIMALS; CYTOSKELETON; GTPASE-ACTIVATING PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NADPH OXIDASE; PROTEIN-SERINE-THREONINE KINASES; RAC GTP-BINDING PROTEINS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 0035575585     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(01)02153-5     Document Type: Review

References (75)

1. The ras superfamily proteins
2. A novel ras-related gene family
3. Clostridium botulinum C3 ADP-ribosyltransferase
4. Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells
5. Microinjection of recombinant p21rho induces rapid changes in cell morphology
6. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
7. Intracellular localization of the P21rho proteins
8. Post-translational modifications of p21rho proteins
9. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
10. Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1
11. Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2
12. NADPH oxidase: An update
13. Rac inserts its way into the immune response
14. Phagocytosis and the actin cytoskeleton
15. Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins
16. Rho guanine dissociation inhibitors: Pivotal molecules in cellular signalling
17. Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI
18. Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
19. Protein kinase C-α signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function
20. Association of the Rho family small GTP-binding proteins with Rho GDP dissociation inhibitor (Rho GDI) in Saccharomyces cerevisiae
21. Molecular characterization of the Caenorhabditis elegans Rho GDP-dissociation inhibitor
22. Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product
23. Signaling to Rho GTPases
24. Comparative genomics of the eukaryotes
25. Nuclear sequestration of the exchange factor Cdc24 by Far1 regulates cell polarity during yeast mating
26. Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAP
27. Identification of the human platelet GTPase activating protein for the CDC42Hs protein
28. GAPs for rho-related GTPases
29. Phosphorylation of p190 on Tyr1105 by c-Src is necessary but not sufficient for EGF-induced actin disassembly in C3H10T1/2 fibroblasts
30. A brain serine/threonine protein kinase activated by Cdc42 and Rac1
31. Raf meets Ras: Completing the framework of a signal transduction pathway
32. Rho GTPases and their effector proteins
33. Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain
34. Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
35. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
36. The p160 RhoA-binding kinase ROK α is a member of a kinase family and is involved in the reorganization of the cytoskeleton
37. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
38. Stress fibres take shape
39. Disease mechanism: Unravelling Wiskott-Aldrich syndrome
40. Rho GTPases and the actin cytoskeleton
41. Actin polymerization: Where the WASP stings
42. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
43. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling
44. Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin
45. Branching out: Cortactin stabilizes actin networks generated by the Arp2/3 complex
46. Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states
47. Temporal and spatial regulation of Rho-type guanine-nucleotide exchange factors: The yeast perspective
48. Spatial regulation of the exocyst complex by Rho1 GTPase
49. Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-β-glucan synthase
50. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF
51. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
52. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
53. Rho signals to cell growth and apoptosis
54. Signal-regulated activation of serum response factor is mediated by changes in actin dynamics
55. A direct interaction between JNK1 and CrkII is critical for Rac1 induced JNK activation
56. Molecular signaling mechanisms of cell migration and invasion
57. The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization
58. Rho proteins: Linking signaling with membrane trafficking
59. Epithelial cell shape: Cadherins and small GTPases
60. Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior
61. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
62. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK
63. Localized Rac activation dynamics visualized in living cells
64. Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation
65. The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1
66. Structure of the TPR domain of p67phox in complex with Rac.GTP
67. The structuralbasis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways
68. Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein
69. Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK
70. Structure of Cdc42 bound to the GTPase binding domain of PAK
71. Residues in Cdc42 that specify binding to individual CRIB effector proteins
72. The Dictyostelium discoideum family of Rho-related proteins
73. Crystal structure of the BTB domain from PLZF
74. Rho GTPases and cell migration
75. A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38δ