Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin

Investigational New Drugs

Volumn 29, Issue 5, 2011, Pages 945-952

  Hwang, Ki Eun ^a   Na, Kyoung Suk ^a   Park, Do Sim ^b   Choi, Keum Ha ^b   Kim, Byoung Ryun ^b   Shim, Hyeok ^a   Jeong, Eun Taik ^a   Kim, Hak Ryul ^a,b  

^a Wonkwang University School of Medicine   (South Korea)

^b Wonkwang University   (South Korea)

Author keywords

Akt; Lung cancer; Simvastatin; Survivin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; MESSENGER RNA; PROTEIN KINASE B; SIMVASTATIN; SURVIVIN; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; BIRC5 PROTEIN, HUMAN; CASPASE; CHROMONE DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INHIBITOR OF APOPTOSIS PROTEIN; MORPHOLINE DERIVATIVE; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CONTENT; DNA FRAGMENTATION; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; LUNG CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGICAL STRESS; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHROMONES; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INHIBITOR OF APOPTOSIS PROTEINS; LUNG NEOPLASMS; MORPHOLINES; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SIMVASTATIN; STRESS, PHYSIOLOGICAL;

EID: 84856074926     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-010-9450-2     Document Type: Article

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