The role of RhoA and cytoskeleton in myofibroblast transformation in hyperoxic lung fibrosis

Free Radical Biology and Medicine

Volumn 61, Issue , 2013, Pages 26-39

  Ni, Jixiang ^a,b,c   Dong, Zheng ^a   Han, Weihong ^a   Kondrikov, Dmitry ^a   Su, Yunchao ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b First People's Hospital of Yichang   (China)

^c CHINA THREE GORGES UNIVERSITY   (China)

Author keywords

Collagen; Fibroblasts; Free radicals; Lung; MRTF A; Oxygen toxicity; Reactive oxygen species

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; CYTOCHALASIN D; EXOENZYME C3; F ACTIN; G ACTIN; MYOCARDIN RELATED TRANSCRIPTION FACTOR A; REACTIVE OXYGEN METABOLITE; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TIRON; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL TRANSFORMATION; CHROMATIN IMMUNOPRECIPITATION; COLLAGEN SYNTHESIS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; ENZYME SYNTHESIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPEROXIA; INHIBITION KINETICS; LUNG FIBROSIS; MALE; MOUSE; MUTANT; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; PROTEIN STABILITY; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; WESTERN BLOTTING;

EID: 84878829007     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.03.012     Document Type: Article

References (38)

1. B. Meyrick Pathology of the adult respiratory distress syndrome Crit. Care Clin. 2 1986 405 428 (Pubitemid 17171072)
2. W.B. Davis, S.I. Rennard, P.B. Bitterman, and R.G. Crystal Pulmonary oxygen toxicity: early reversible changes in human alveolar structures induced by hyperoxia N. Engl. J. Med. 309 1983 878 883 (Pubitemid 13014027)
3. D.J. Riley, J.S. Kerr, and S.Y. Yu Effect of proline analogs on oxygen toxicity-induced pulmonary fibrosis in the rat Toxicol. Appl. Pharmacol. 75 1984 554 560 (Pubitemid 14017224)
4. B. Weinberger, D.L. Laskin, D.E. Heck, and J.D. Laskin Oxygen toxicity in premature infants Toxicol. Appl. Pharmacol. 181 2002 60 67 (Pubitemid 34615412)
5. N. Chen, J.J. Li, and X.D. Xue [Effect of losartan on lung fibrosis in neonatal rats with hyperoxia-induced chronic lung disease] Zhongguo Dang Dai Er Ke Za Zhi 9 2007 591 594
6. D. Kondrikov, R.B. Caldwell, Z. Dong, and Y. Su Reactive oxygen species-dependent RhoA activation mediates collagen synthesis in hyperoxic lung fibrosis Free Radic. Biol. Med. 50 2011 1689 1698
7. I.I. Ekekezie, D.W. Thibeault, M.H. Rezaeikhaligh, S.M. Mabry, M. Norberg, G.K. Reddy, J. Youssef, and W.E. Truog High-dose inhaled nitric oxide and hyperoxia increases lung collagen accumulation in piglets Biol. Neonate 78 2000 198 206
8. C.M. Chen, L.F. Wang, H.C. Chou, Y.D. Lang, and Y.P. Lai Up-regulation of connective tissue growth factor in hyperoxia-induced lung fibrosis Pediatr. Res. 62 2007 128 133
9. Y.D. Lang, C.L. Hung, T.Y. Wu, L.F. Wang, and C.M. Chen The renin-angiotensin system mediates hyperoxia-induced collagen production in human lung fibroblasts Free Radic. Biol. Med. 49 2010 88 95
10. B. Hinz, S.H. Phan, V.J. Thannickal, A. Galli, M.L. Bochaton-Piallat, and G. Gabbiani The myofibroblast: one function, multiple origins Am. J. Pathol. 170 2007 1807 1816 (Pubitemid 47339255)
11. V. Rehan, and J. Torday Hyperoxia augments pulmonary lipofibroblast-to- myofibroblast transdifferentiation Cell Biochem. Biophys. 38 2003 239 250
12. M. Raftopoulou, and A. Hall Cell migration: Rho GTPases lead the way Dev. Biol. 265 2004 23 32 (Pubitemid 38018819)
13. F. Peng, B. Zhang, D. Wu, A.J. Ingram, B. Gao, and J.C. Krepinsky TGFbeta-induced RhoA activation and fibronectin production in mesangial cells require caveolae Am. J. Physiol. Renal Physiol 295 2008 F153 F164
14. P.J. O'Reilly, J.M. Hickman-Davis, I.C. Davis, and S. Matalon Hyperoxia impairs antibacterial function of macrophages through effects on actin Am. J. Respir. Cell Mol. Biol. 28 2003 443 450 (Pubitemid 36399366)
15. D. Kondrikov, S. Elms, D. Fulton, and Y. Su eNOS-beta-actin interaction contributes to increased peroxynitrite formation during hyperoxia in pulmonary artery endothelial cells and mouse lungs J. Biol. Chem 285 2010 35479 35487
16. D. Kondrikov, H.R. Han, E.R. Block, and Y. Su Growth and density-dependent regulation of NO synthase by the actin cytoskeleton in pulmonary artery endothelial cells Am. J. Physiol. Lung Cell. Mol. Physiol 290 2006 L41 L50
17. S. Pendyala, P.V. Usatyuk, I.A. Gorshkova, J.G. Garcia, and V. Natarajan Regulation of NADPH oxidase in vascular endothelium: the role of phospholipases, protein kinases, and cytoskeletal proteins Antioxid. Redox Signaling 11 2009 841 860
18. E.N. Olson, and A. Nordheim Linking actin dynamics and gene transcription to drive cellular motile functions Nat. Rev. Mol. Cell Biol. 11 2010 353 365
19. M.C. Subauste, H.M. Von, V. Benard, C.E. Chamberlain, T.H. Chuang, K. Chu, G.M. Bokoch, and K.M. Hahn Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas J. Biol. Chem. 275 2000 9725 9733 (Pubitemid 30185206)
20. G.Q. Cai, C.F. Chou, M. Hu, A. Zheng, L.F. Reichardt, J.L. Guan, H. Fang, T.R. Luckhardt, Y. Zhou, V.J. Thannickal, and Q. Ding Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of alpha-smooth muscle actin filaments during myofibroblast differentiation Am. J. Physiol. Lung Cell. Mol. Physiol 303 2012 L692 L702
21. B. Hinz Mechanical aspects of lung fibrosis: a spotlight on the myofibroblast Proc. Am. Thorac. Soc 9 2012 137 147
22. K.D. Salazar, S.M. Lankford, and A.R. Brody Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts Am. J. Physiol. Lung Cell. Mol. Physiol 297 2009 L1002 L1011
23. M. Nonaka, R. Pawankar, A. Fukumoto, and T. Yagi Heterogeneous response of nasal and lung fibroblasts to transforming growth factor-beta 1 Clin. Exp. Allergy 38 2008 812 821 (Pubitemid 351550671)
24. A.N. Lekkerkerker, J. Aarbiou, T. van Es, and R.A. Janssen Cellular players in lung fibrosis Curr. Pharm. Des 18 2012 4093 4102
25. R. Pawlowski, E.K. Rajakyla, M.K. Vartiainen, and R. Treisman An actin-regulated importin alpha/beta-dependent extended bipartite NLS directs nuclear import of MRTF-A EMBO J. 29 2010 3448 3458
26. S. Nakamura, K. Hayashi, K. Iwasaki, T. Fujioka, H. Egusa, H. Yatani, and K. Sobue Nuclear import mechanism for myocardin family members and their correlation with vascular smooth muscle cell phenotype J. Biol. Chem. 285 2010 37314 37323
27. Y. Lu, N. Azad, L. Wang, A.K. Iyer, V. Castranova, B.H. Jiang, and Y. Rojanasakul Phosphatidylinositol-3-kinase/akt regulates bleomycin-induced fibroblast proliferation and collagen production Am. J. Respir. Cell Mol. Biol. 42 2010 432 441
28. H.Y. Cho, and S.R. Kleeberger Genetic mechanisms of susceptibility to oxidative lung injury in mice Free Radic. Biol. Med. 42 2007 433 445 (Pubitemid 46164879)
29. B. Manoury, S. Nenan, O. Leclerc, I. Guenon, E. Boichot, J.M. Planquois, C.P. Bertrand, and V. Lagente The absence of reactive oxygen species production protects mice against bleomycin-induced pulmonary fibrosis Respir. Res. 6 2005 11
30. K.C. Teixeira, F.S. Soares, L.G. Rocha, P.C. Silveira, L.A. Silva, S.S. Valenca, P.F. Dal, E.L. Streck, and R.A. Pinho Attenuation of bleomycin-induced lung injury and oxidative stress by N-acetylcysteine plus deferoxamine Pulm. Pharmacol. Ther. 21 2008 309 316 (Pubitemid 351312673)
31. H.C. Yen, H.M. Chang, H.J. Majima, F.Y. Chen, and S.H. Li Levels of reactive oxygen species and primary antioxidant enzymes in WI38 versus transformed WI38 cells following bleomycin treatment Free Radic. Biol. Med. 38 2005 950 959 (Pubitemid 40321086)
32. M.T. Conconi, S. Baiguera, D. Guidolin, C. Furlan, A.M. Menti, S. Vigolo, A.S. Belloni, P.P. Parnigotto, and G.G. Nussdorfer Effects of hyperbaric oxygen on proliferative and apoptotic activities and reactive oxygen species generation in mouse fibroblast 3T3/J2 cell line J. Invest. Med. 51 2003 227 232 (Pubitemid 36870446)
33. P.A. Singleton, S. Pendyala, I.A. Gorshkova, N. Mambetsariev, J. Moitra, J.G. Garcia, and V. Natarajan Dynamin 2 and c-Abl are novel regulators of hyperoxia-mediated NADPH oxidase activation and reactive oxygen species production in caveolin-enriched microdomains of the endothelium J. Biol. Chem. 284 2009 34964 34975
34. J. Li, X. Gao, M. Qian, and J.W. Eaton Mitochondrial metabolism underlies hyperoxic cell damage Free Radic. Biol. Med. 36 2004 1460 1470 (Pubitemid 38596806)
35. N.L. Parinandi, M.A. Kleinberg, P.V. Usatyuk, R.J. Cummings, A. Pennathur, A.J. Cardounel, J.L. Zweier, J.G. Garcia, and V. Natarajan Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells Am. J. Physiol. Lung Cell. Mol. Physiol 284 2003 L26 L38
36. P.V. Usatyuk, L.H. Romer, D. He, N.L. Parinandi, M.E. Kleinberg, S. Zhan, J.R. Jacobson, S.M. Dudek, S. Pendyala, J.G. Garcia, and V. Natarajan Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin J. Biol. Chem. 282 2007 23284 23295 (Pubitemid 47311961)
37. A. Andersson-Sjoland, C.G. de Alba, K. Nihlberg, C. Becerril, R. Ramirez, A. Pardo, G. Westergren-Thorsson, and M. Selman Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis Int. J. Biochem. Cell Biol. 40 2008 2129 2140
38. B. Mehrad, M.D. Burdick, D.A. Zisman, M.P. Keane, J.A. Belperio, and R.M. Strieter Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease Biochem. Biophys. Res. Commun. 353 2007 104 108 (Pubitemid 44958347)