Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract

Experimental and Molecular Medicine

Volumn 41, Issue 4, 2009, Pages 277-287

  Kim, Sang Eun ^a   Thuy, Tran Thi Thanh ^a   Lee, Ji Hyun ^b   Ro, Jai Youl ^a   Bae, Young An ^a   Kong, Yoon ^a   Ahn, Jee Yin ^a   Lee, Dong Soon ^c   Oh, Yeon Mock ^d   Lee, Sang Do ^d   Lee, Yun Song ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b CHA University   (South Korea)

^c Seoul National University   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

Author keywords

Macrophages, alveolar; Matrix metalloproteinases 9; Pulmonary disease, chronic obstructive; Pulmonary emphysema; Simvastatin; Smoking

Indexed keywords

CIGARETTE SMOKE CONDENSATE; FARNESYL DIPHOSPHATE; GELATINASE B; GERANYLGERANYL PYROPHOSPHATE; GGTI 2133; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN; SIMVASTATIN; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR AP 1; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; EMPHYSEMA; ENZYME INDUCTION; ENZYME INHIBITION; LUNG ALVEOLUS MACROPHAGE; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PRENYLATION; RAT;

RATTUS;

EID: 65949088332     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2009.41.4.031     Document Type: Article

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