Inhibition of Rho and Rac Geranylgeranylation by Atorvastatin Is Critical for Preservation of Endothelial Junction Integrity

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Xiao, Hongbing ^a   Qin, Xiong ^a   Ping, Ding ^a   Zuo, Keqiang ^a  

^a TONGJI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; GERANYLGERANYL PYROPHOSPHATE; GUANOSINE TRIPHOSPHATASE; INTERLEUKIN 6; INTERLEUKIN 8; MEVALONIC ACID; PROTEIN CDC42; RAC PROTEIN; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; VASCULAR ENDOTHELIAL CADHERIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL JUNCTION; CELL MEMBRANE PERMEABILITY; CELL MIGRATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; CYTOSOL; DRUG EFFECT; EMBRYO; GENE SILENCING; HUMAN; HUMAN CELL; INHIBITION KINETICS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PRENYLATION; PROTEIN PROCESSING; PROTEIN TARGETING; PROTEIN TRANSPORT; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTIGENS, CD; CADHERINS; CDC42 GTP-BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; HEPTANOIC ACIDS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERCELLULAR JUNCTIONS; INTERLEUKIN-6; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; MEVALONIC ACID; POLYISOPRENYL PHOSPHATES; PRENYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLES; RHO-ASSOCIATED KINASES; SESQUITERPENES; THROMBIN;

EID: 84874875218     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059233     Document Type: Article

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