Membrane-bound enzymes of cholesterol synthesis from lanosterol

Biochemical and Biophysical Research Communications

Volumn 292, Issue 5, 2002, Pages 1139-1146

  Gaylor, James L ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLYASE; CHOLESTEROL; ISOMERASE; LANOSTEROL; OXIDOREDUCTASE;

CHOLESTEROL SYNTHESIS; DEMETHYLATION; HUMAN; ISOMERISM; NONHUMAN; PRIORITY JOURNAL; REDUCTION; REVIEW;

EID: 0036085695     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.2008     Document Type: Article

References (72)

1. Preparation and partial purification of a microsomal prenol pyrophosphate pyrophospho-hydrolase
2. The biological synthesis of cholesterol
3. Function of cytochrome P-450 of microsomes
4. Formation of sterols in animals
5. Lanosterol 14-alpha methyl demethylase: Isolation and characterization of the third metabolically generated oxidative demethylation intermediate
6. Cholesterol biosynthesis from lanosterol: Development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase
7. Total enzymic synthesis of cholesterol from lanosterol: Cytochrome b5-dependence of 4-methyl sterol oxidase
8. Biosynthesis of skin sterols. VI. Enzymatic demethylation of lanosterol and lanosta-7, 24-dien-3 beta-01 by homogenates of rat liver
9. Removal of nonionic detergents from proteins by chromatography on Sephadex LH-20
10. Effect of cholestyramine on the terminal reactions of sterol biosynthesis
11. Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme from liver microsomes
12. Existence and separation of three forms of cytochrome P-450 from rat liver microsomes
13. Kinetic investigation of rat liver microsomal electron transport from NADH to cytochrome P-450
14. Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis: Microsomal electron transport and C-32 demethylation
15. Oxidative demethylation of lanosterol in cholesterol biosynthesis: Accumulation of sterol intermediates
16. Microsomal enzymes of cholesterol biosynthesis. Purification of lanosterol 14 alpha-demethylase cytochrome P-450 from hepatic microsomes
17. Modulation of 3-hydroxy-3 methylgutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3-beta-01: A mechanism-based inhibitor of cholesterol biosynthesis
18. In situ accumulation of 3 beta-hydroxylanost-8-en-32-aldehyde in hepatocyte cultures. A putative regulator of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity
19. Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase I: Assessment of inhibitor structure-activity relationship and cholesterol biosynthesis inhibition properties
20. Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase II. Time-dependent enzyme inactivation by selected oxylanosterol analogs
21. Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent delta 8, 14-steroid 14-reductase
22. Cholesterol biosynthesis from lanosterol: Regulation and purification of rat hepatic sterol 14-reductase
23. Investigation of the component reactions of oxidative sterol demethylation. Study of the aerobic and anaerobic processes
24. Investigation of the component reactions of oxidative sterol demethylation: Oxidation of a 4, 4-dimethyl sterol to a 4 beta-methyl-4 alpha-carboxylic acid during cholesterol biosynthesis
25. Electron transfer from alpha-reduced nicotinamide of adenine dinucleotide to flavoprotein, cytochromes, and mixed function of oxidases of rat liver nicrosomes
26. Affinity chromatography of microsomal enzymes on immobilized detergent-solubilized cytochrome b5
27. Investigation of the component reactions of oxidative sterol demethylation: Evidence against participation of cytochrome P-450
28. Assay and isolation of a cyanide-binding protein of rat liver microsomes
29. Stoichiometry of 4-methyl sterol oxidase of rat liver microsomes
30. Investigation of the component reactions of oxidative demethylation of sterols: Metabolism of 4 alpha-hydroxymethyl steroids
31. Investigation of the component reactions of oxidative sterol demethylation: Alcohol dehydrogenase
32. Investigation of the component reactions of oxidative sterol demethylation: Oxidation of a 4 alpha-methyl sterol to a 4 alpha-carboxylic acid during cholesterol biosynthesis
33. Investigation of the component reactions of oxidative sterol demethylation: Partial purification of a microsomal sterol 4alpha-carboxylic acid decarboxylase
34. Investigation of the component reactions of oxidative sterol demethylation: Formation and metabolism of 3-ketosteroid intermediates
35. Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis
36. Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis
37. Enzymatic isomerization (delta 8-delta 7) of intermediates of sterol biosynthesis
38. Investigation of the component reactions of oxidative sterol demethylation: Role of an endogenous microsomal source of reducing equivalents
39. Characterization of the microsomal steroid-8-ene isomerase of cholesterol biosynthesis
40. Microsomal enzymes of cholesterol biosynthesis from lanosterol: Solubilization and purification of steroid 8-isomerase
41. Cholesterol biosynthesis from lanosterol: Regulation and purification of rat hepatic sterol 8-isomerase
42. Noncytochrome P-450-dependent oxidase of liver microsomes; oxidation of methyl sterols and stearyl coenzyme A
43. Microsomal enzymes of sterol biosynthesis
44. Investigation of microsomal oxygenases of biosynthetic processes: Stearyl-CoA desaturase of adipose tissue and liver
45. Enzymes of sterol biosynthesis
46. Total enzymic synthesis of cholesterol from lanosterol: Solubilization, resolution and reconstitution of delta 7-sterol 5-desaturase
47. Microsomal enzymes of cholesterol biosynthesis from lanosterol: Purification and characterization of delta 7-sterol 5-desaturase of rat liver microsomes
48. Complete resolution and reconstitution of cholesterol synthesis from lanosterol: Nonoxi-dative enzymes
49. Localization and biosynthesis of 7-dehydrocholesterol in rat skin
50. Cytosolic modulators of activities of microsomal enzymes of cholesterol biosynthesis: Purification and characterization of a non-specific lipid-transfer protein
51. Delta 7-sterol delta 5-dehydrogenase and delta 5, 7-sterol delta 7-reductase of rat liver
52. Membrane-bound enzymes of cholesterol biosynthesis: Resolution and identification of the components required for cholesterol synthesis from squalene
53. Cholesterol biosynthesis from lanosterol: Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome related protein
54. Biosynthesis of skin sterols. II. Reduction of delta 24-unsaturated sterols of rat skin
55. Inhibition of cholesterol biosynthesis. N. Y. State
56. Testicular sterols. IV. End-product steroid inhibition of lanosterol demethylation
57. Investigation of the multienzymic system of microsomal cholesterol biosynthesis
58. Oxylanosterols as modifiers of cholesterol biosynthesis
59. Regulation of hepatic lanosterol 14alpha-demethylase gene expression by dietary cholesterol and cholesterol-lowering agents
60. Executive summary of the third report of the national cholesterol education program (ncep) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (ATP III)
61. Isolation and purification of a 5alpha-hydroxysterol dehydrase of yeast
62. Cytosolic modulators of activities of microsomal enzymes of cholesterol biosynthesis: Role of a cytosolic protein with properties similar to Z-protein (fatty acid-binding protein)
63. Yeast sterol C8-C7-isomerase: Identification and characterization of a high-affinity binding site for enzyme inhibitors
64. Cholesterol biosynthesis from lanosterol: Differential inhibition of sterol delta8-isomerase and other lanosterol-converting enzymes by Tamoxifen
65. Meiosis-activating sterols: Background, discovery, and possible use
66. Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase: Substrate specificity, competitive and non-competitive inhibition, and phosphorylation/dephosphorylation
67. Molecular cloning and expression of the human delta7-sterol reductase
68. Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis
69. Sterol Biosynthesis Inhibitors: Potential chemotherapeutics against Chagas Disease
70. Cholesterol inhibition, cancer, and chemotherapy
71. Lanosterol 14-demethylase activity expressed in rat brain microsomes
72. Recent advances in brain cholesterol dynamics: Transport, domains, and Alzheimer's disease