Simvastatin abrogates inflamed neutrophil adhesive properties, in association with the inhibition of Mac-1 integrin expression and modulation of Rho kinase activity

Inflammation Research

Volumn 62, Issue 2, 2013, Pages 127-132

  Silveira, Angélica Aparecida Antoniellis ^a   Dominical, Venina Marcela ^a   Lazarini, Mariana ^a   Costa, Fernando Ferreira ^a   Conran, Nicola ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Adhesion; Inflammation; Neutrophil; Rho GTPase; Statin

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CD11B ANTIGEN; CD26L ANTIGEN; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; ISOPRENOID; LYMPHOCYTE ANTIGEN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; RHO KINASE; SIMVASTATIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ANTIGEN ACTIVATION; ANTIGEN FUNCTION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE INHIBITION; LEUKOCYTE MIGRATION INHIBITION; NEUTROPHIL CHEMOTAXIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; CELL ADHESION; CELL ADHESION MOLECULES; CELLS, CULTURED; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MACROPHAGE-1 ANTIGEN; MIDDLE AGED; NEUTROPHILS; SIMVASTATIN; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84873716166     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-012-0579-7     Document Type: Article

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