The nature of small-airway obstruction in chronic obstructive pulmonary disease

New England Journal of Medicine

Volumn 350, Issue 26, 2004, Pages 2645-2653

  Hogg, James C ^a,d   Chu, Fanny ^a   Utokaparch, Soraya ^a   Woods, Ryan ^a   Elliott, W Mark ^a   Buzatu, Liliana ^a   Cherniack, Ruben M ^b   Rogers, Robert M ^c   Sciurba, Frank C ^c   Coxson, Harvey O ^a   Paré, Peter D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Natl Jewish Res and Medical Center   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^d ST PAUL S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

TOXIC GAS;

ADULT; AGED; AIRWAY OBSTRUCTION; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; FEMALE; FORCED EXPIRATORY VOLUME; HISTOPATHOLOGY; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INFLAMMATORY CELL; LONG TERM EXPOSURE; LUNG CLEARANCE; LUNG FUNCTION; LYMPH FOLLICLE; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; PRIORITY JOURNAL; RISK ASSESSMENT; SMALL AIRWAY DISEASE;

AGED; AIRWAY OBSTRUCTION; ANALYSIS OF VARIANCE; B-LYMPHOCYTES; BRONCHI; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DISEASE PROGRESSION; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LEUKOCYTE COUNT; MACROPHAGES; MALE; MIDDLE AGED; NEUTROPHILS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 2942720573     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa032158     Document Type: Article

References (40)

1. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease; NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001;163:1256-76.
2. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease NHLBI/WHO Workshop report. Rev. ed. 2003. (NIH publication no. 2701.) (Accessed May 3, 2004, at http://www.goldcopd.com.)
3. Mead J, Turner JM, Macklem PT, Little J. Significance of the relationship between lung recoil and maximum expiratory flow. J Appl Physiol 1967;22:95-108.
4. Hogg JC, Macklem PT, Thurlbeck WM. Site and nature of airway obstruction in chronic obstructive lung disease. N Engl J Med 1968;278:1355-60.
5. Van Brabandt H, Cauberghs M, Verbeken E, Moerman P, Lauweryns JM, Van de Woestijne KP. Partitioning of pulmonary impedance in excised human and canine lungs. J Appl Physiol 1983;55:1733-42.
6. Yanai M, Sekizawa K, Ohrui T, Sasaki H, Takishima T. Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure. J Appl Physiol 1992; 72:1016-23.
7. Innate immunity. In: Abbas AK, Lichtman AH, Pober JS. Cellular and molecular immunology. 4th ed. Philadelphia: W.B. Saunders, 2000:270-90.
8. Lymphocyte maturation and expression of antigen receptor genes. In: Abbas AK, Lichtman AH, Pober JS. Cellular and molecular immunology. 4th ed. Philadelphia: W.B. Saunders, 2000:125-60.
9. Knowles MR, Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 2002; 109:571-7.
10. Simani AS, Inoue S, Hogg JC. Penetration of respiratory epithelium of guinea pigs following exposure to cigarette smoke. Lab Invest 1974;31:75-81.
11. Jones JG, Minty BD, Lawler P, Hulands G, Crawley JCW, Veal N. Increased alveolar epithelial permeability in cigarette smokers. Lancet 1980;1:66-8.
12. Weibel ER. The morphometry of the human lung. New York: Academic Press, 1963: 110-35.
13. Wright JL, Lawson LM, Paré PD, Kennedy S, Wiggs B, Hogg JC. The detection of small airways disease. Am Rev Respir Dis 1984; 129:989-94.
14. Kuwano K, Bosken CH, Paré PD, Bai TR, Wiggs BR, Hogg JC. Small airways dimensions in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1993; 148:1220-5.
15. Hogg JC, Wright JL, Wiggs BR, Coxson HO, Opazo Saez A, Pare PD. Lung structure and function in cigarette smokers. Thorax 1994;49:473-8.
16. National Emphysema Treatment Trial Research Group. Rationale and design of the National Emphysema Treatment Trial: a prospective randomized trial of lung volume reduction surgery. Chest 1999;116: 1750-61.
17. Idem. Patients at high risk of death after lung-volume-reduction surgery. N Engl J Med 2001;345:1075-83.
18. Idem. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N Engl J Med 2003;348:2059-73.
19. Movat HZ. Demonstration of all connective tissue elements in a single section: pentachrome stains. AMA Arch Pathol 1955; 60:289-95.
20. James AL, Hogg JC, Dunn LA, Paré PD. The use of the internal perimeter to compare airway size and to calculate smooth muscle shortening. Am Rev Respir Dis 1988;138: 136-9.
21. Bosken CH, Wiggs BR, Paré PD, Hogg JC. Small airway dimensions in smokers with obstruction to airflow. Am Rev Respir Dis 1990;142:563-72.
22. Coxson HO, Hogg JC, Mayo JR, et al. Quantification of idiopathic pulmonary fibrosis using computed tomography and histology. Am J Respir Crit Care Med 1997;155: 1649-56.
23. Retamales I, Elliott WM, Meshi B, et al. Amplification of inflammation in emphysema and its association with latent adenoviral infection. Am J Respir Crit Care Med 2001; 164:469-73.
24. Cruz-Orive LM, Weibel ER. Sampling designs for stereology. J Microsc 1981;122: 235-57.
25. Dobson AJ. An introduction to generalized linear models. 2nd ed. New York: Chapman & Hall, 2002.
26. Fisher LD, van Belle G. Biostatistics: a methodology for the health sciences. New York: John Wiley, 1993.
27. Mullen JBM, Wright JL, Wiggs BR, Paré PD, Hogg JC. Reassessment of inflammation of airways in chronic bronchitis. Br Med J (Clin Res Ed) 1985;291:1235-9.
28. Saetta M, Turato G, Facchini FM, et al. Inflammatory cells in the bronchial glands of smokers with chronic bronchitis. Am J Respir Crit Care Med 1997;156:1633-9.
29. Fletcher C, Peto R, Thaker C, Speizer FE. The natural history of chronic bronchitis and emphysema: an eight-year study of early chronic obstructive lung disease in working men in London. Oxford, England: Oxford University Press, 1976:93.
30. Vestbo J, Lange P. Can GOLD Stage 0 provide information of prognostic value in chronic obstructive pulmonary disease? Am J Respir Crit Care Med 2002;66:329-32.
31. Di Stefano A, Turato G, Maestrelli P, et al. Airflow limitation in chronic bronchitis is associated with T-lymphocyte and macrophage infiltration in the bronchial mucosa. Am J Respir Crit Care Med 1996;153: 629-32.
32. O'Shaughnessy TC, Ansari TW, Barnes NC, Jeffery PK. Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1. Am J Respir Crit Care Med 1997; 155:852-7.
33. Bosken CH, Hards J, Gatter K, Hogg JC. Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers using immunocytochemistry. Am Rev Respir Dis 1992;145:911-7.
34. Lamm ME. Interaction between antigens and antibodies at mucosal surfaces. Annu Rev Microbiol 1997;5:311-40.
35. Neutra MR, Mantis NJ, Kraehenbuhl JP. Collaboration of epithelial cells with organized mucosal lymphoid tissues. Nat Immunol 2001;11:1004-9.
36. Sethi S, Murphy TF. Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review. Clin Microbiol Rev 2001;14:336-63.
37. Wiggs BR, Moreno R, Hogg JC, Hilliam C, Pare PD. A model of the mechanics of airway narrowing. J Appl Physiol 1990;69: 849-60.
38. Tashkin DP, Altose MD, Connett JE, Kanner RE, Lee WW, Wise RA. Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996;153:1802-11.
39. Matsuba K, Thurlbeck WM. The number and dimensions of small airways in emphysematous lungs. Am J Pathol 1972;67: 265-75.
40. Lee CG, Homer RJ, Zhu Z, et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med 2001;194: 809-21.