Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity

Journal of Biological Chemistry

Volumn 279, Issue 32, 2004, Pages 33079-33084

  Duncan, Robin E ^a   El Sohemy, Ahmed ^a   Archer, Michael C ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; SYNTHESIS (CHEMICAL); TUMORS;

MEVALONATE; PROLIFERATION RATE;

BIOCHEMISTRY;

CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYCLIN E; DNA; HISTONE H1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVALONIC ACID; PROTAMINE KINASE; PROTEIN P21; PROTEIN P27;

ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL PROLIFERATION; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME REGULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TUMOR GROWTH; WESTERN BLOTTING;

ANIMALS; CDC2-CDC28 KINASES; CELL DIVISION; CYCLIN A; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; FLOW CYTOMETRY; G1 PHASE; GENE EXPRESSION; HUMANS; IMMUNOSORBENT TECHNIQUES; MEVALONIC ACID; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASES; S PHASE; TUMOR CELLS, CULTURED;

ANIMALIA; MUS MUSCULUS;

EID: 4043114237     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400732200     Document Type: Article

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