3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA

Circulation Research

Volumn 91, Issue 2, 2002, Pages 143-150

  Park, Ho Jin ^a   Kong, Dequan ^a   Iruela Arispe, Luisa ^b   Begley, Ulrike ^a   Tang, Dongjiang ^a   Galper, Jonas B ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A reductase inhibitors; Angiogenesis; RhoA

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; COMPACTIN; ENZYME INHIBITOR; EXOTOXIN; GERANYLGERANIOL; GERANYLGERANYL PYROPHOSPHATE; GERANYLGERANYL TRANSFERASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PYROPHOSPHATE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADENOVIRUS; ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CAPILLARY PROLIFERATION; CARCINOGENESIS; CHICKEN; CHOLESTEROL METABOLISM; CHORIOALLANTOIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORNEA; CORONARY ARTERY DISEASE; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME MECHANISM; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPID METABOLISM; MICROVASCULARIZATION; MOUSE; NONHUMAN; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; VIRUS EXPRESSION;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL MEMBRANE; CELLS, CULTURED; COLLAGEN; CORNEA; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; FIBROBLAST GROWTH FACTOR 2; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LYMPHOKINES; MICE; MUTATION; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEIN ISOPRENYLATION; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SIMVASTATIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0037178736     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000028149.15986.4C     Document Type: Article

References (28)

1. Angiogenesis in cancer, vascular, rheumatoid and other disease
2. Therapeutic angiogenesis for ischemic cardiovascular disease
3. Regulation of the mevalonate pathway
4. Statin trials and goals of cholesterol-lowering therapy
5. Inhibition of the mevalonate pathway: Benefits beyond cholesterol reduction?
6. Relationship between plasma LDL concentrations during treatment with pravastatin and recurrent coronary events in the Cholesterol and Recurrent Events trial
7. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
8. Tyrosine phosphorylation of the vascular endothelial-growth-factor receptor-2 (VEGFR-2) is modulated by Rho proteins
9. Integrinmediated signals regulated by members of the rho family of GTPases
10. Edg1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes
11. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
12. Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10β-trimethyl-trans-decal-3β-o1: A specific 2,3-oxidosqualene cyclase inhibitor
13. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes
14. Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts
15. Bacterial inhibition of phagocytosis
16. Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors
17. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
18. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI3-kinase/Akt pathway
19. HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells
20. Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: Contribution to its antiangiogenic effect
21. The putative convergent and divergent natures of angiogenesis and arteriogenesis
22. Role of ischemia and of hypoxia-inducible genes in arteriogenesis after femoral artery occlusion in the rabbit
23. Lovastatin and tumor necrosis factor-α exhibit potentiated antitumor effects against Ha-ras-transformed murine tumor via inhibition of tumor-induced angiogenesis
24. Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys
25. Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering
26. The effects of lipid lowering on diabetic retinopathy
27. Statins have biphasic effects on angiogenesis
28. Double-edged role of statins in angiogenesis signaling