Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages

Journal of Biological Chemistry

Volumn 276, Issue 51, 2001, Pages 48213-48222

  Coxon, Fraser P ^a,f   Helfrich, Miep H ^a   Larijani, Banafshe ^b,e   Muzylak, Mariusz ^c   Dunford, James E ^a   Marshall, Deborah ^a   McKinnon, Alastair D ^a   Nesbitt, Stephen A ^c   Horton, Michael A ^c   Seabra, Miguel C ^b   Ebetino, Frank H ^d   Rogers, Michael J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^e IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^f UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BONE; CELLS; DRUG PRODUCTS; LIPIDS; NITROGEN;

MACROPHAGES;

ENZYMES;

BISPHOSPHONIC ACID DERIVATIVE; CARBON 14; F ACTIN; GERANYLTRANSFERASE; GGTI 298; ISOPRENOID; MEVALONIC ACID; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; NE 10790; NITROGEN; PROTEIN FARNESYLTRANSFERASE; RAB GERANYLGERANYLTRANSFERASE; RAB PROTEIN; RAB6 PROTEIN; RAP PROTEIN; RISEDRONIC ACID; UNCLASSIFIED DRUG; ENZYME INHIBITOR; PYRIDINE DERIVATIVE; TRANSFERASE;

ANIMAL CELL; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; MACROPHAGE; MEMBRANE TRANSPORT; MICROVILLUS; MOLECULAR WEIGHT; NONHUMAN; ONCOGENE H RAS; OSTEOCLAST; OSTEOLYSIS; PRENYLATION; PRIORITY JOURNAL; ANIMAL; CELL LINE; DRUG EFFECT; ELECTRON MICROSCOPY; METABOLISM; PROTEIN PROCESSING; RABBIT; ULTRASTRUCTURE;

ANIMALIA;

ALKYL AND ARYL TRANSFERASES; ANIMAL; CELL LINE; DIPHOSPHONATES; ENZYME INHIBITORS; MACROPHAGES; MICROSCOPY, ELECTRON; OSTEOCLASTS; PROTEIN ISOPRENYLATION; PYRIDINES; RABBITS; SUPPORT, NON-U.S. GOV'T;

EID: 0035930612     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106473200     Document Type: Article

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