Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

Trends in Pharmacological Sciences

Volumn 22, Issue 1, 2001, Pages 32-39

  Fukata, Yuko ^a   Kaibuchi, Kozo ^a,b   Amano, Mutsuki ^b  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALCIUM ION; FASUDIL; MYOSIN LIGHT CHAIN; RHO FACTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE;

ARTERIOSCLEROSIS; BRAIN ARTERY; CELL MIGRATION; CORONARY ARTERY; CYTOKINESIS; CYTOSKELETON; HUMAN; HYPERTENSION; NONHUMAN; PATHOPHYSIOLOGY; PHOSPHORYLATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SENSITIZATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTION; VASOSPASM;

ANIMALS; CYTOSKELETON; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PROTEIN-SERINE-THREONINE KINASES; RHO GTP-BINDING PROTEINS;

EID: 0035150402     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01596-0     Document Type: Review

References (61)

1. Cell calcium and its regulation in smooth muscle
2. Signal transduction and regulation in smooth muscle
3. The function of myosin and myosin light chain kinase phosphorylation in smooth muscle
4. From pharmacomechanical coupling to G-proteins and myosin phosphatase
5. G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle
6. Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction
7. 2+ sensitization of smooth muscle
8. Involvement of rho in GTP γS-induced enhancement of phosphorylation of 20 kDa myosin light chain in vascular smooth muscle cells: Inhibition of phosphatase activity
9. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
10. Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm
11. Inhibition of myosin phosphatase by upregulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β
12. Regulation and function of the Rho subfamily of small GTPases
13. Rho as a mediator of G protein-coupled receptor signaling
14. p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13
15. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Gα13
16. Rho GTPases and signaling networks
17. Rho GTPases and the actin cytoskeleton
18. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells
19. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho
20. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes
21. ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice
22. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase
23. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
24. The p160 RhoA-binding kinase ROKa is a member of a kinase family and is involved in the reorganization of the cytoskeleton
25. Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase
26. The COOH terminus of Rho-kinase negatively regulates Rho-kinase activity
27. p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions
28. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells
29. Myosin light chain phosphatase: Subunit composition, interactions and regulation
30. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
31. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
32. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation
33. 2+ sensitization through inhibition of myosin phosphatase in rabbit trachea
34. Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase
35. Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase during cell migration and cytokinesis
36. Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activity
37. Rho-associated kinase of chicken gizzard smooth muscle
38. 2+ sensitization of smooth muscle contraction through activation of Rho-kinase
39. 2+-sensitization of smooth muscle
40. Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility
41. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase
42. Activation of moesin and adducin by Rho-kinase downstream of Rho
43. Identification of calponin as a novel substrate of Rho-kinase
44. Role for G(12)/G(13) in agonist-induced vascular smooth muscle cell contraction
45. 2+ sensitization of smooth muscle
46. Inhibition of RhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric toxin DC3B
47. Cellular and molecular mechanisms of coronary artery spasm: Lessons from animal models
48. Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm
49. The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells
50. Gene transfer of dominant negative Rho-kinase suppresses neointimal formation after balloon injury in pigs
51. Inhibition of Rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries
52. Rho-kinase is involved in the macrophage-mediated formation of coronary arteriosclerotic lesions in pigs in vivo
53. Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase
54. Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rho-kinase
55. Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho-Kinase in human endothelial cells
56. Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells
57. Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse
58. + exchange
59. Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop