Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents

Pulmonary Pharmacology and Therapeutics

Volumn 27, Issue 1, 2014, Pages 10-16

  Capra, Valérie ^a   Rovati, G Enrico ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

3 Hydroxy 3 methylglutaryl coenzyme A (HMG CoA) inhibitor; Airway smooth muscle; Asthma; Cysteinyl leukotrienes; Remodeling; Thromboxane

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 3 HYDROXY 3 METHYLGLUTARYL COENZYME A; EPIDERMAL GROWTH FACTOR; FARNESOL; GERANYLGERANIOL; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; ICOSANOID; ISOPRENOID; MEVALONIC ACID; MITOGENIC AGENT; PEPTIDOLEUKOTRIENE; PROSTANOID; ROSUVASTATIN; THROMBOXANE A2;

AIRWAY REMODELING; AIRWAY SMOOTH MUSCLE CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; ASTHMA; BRONCHUS MUSCLE; CELL GROWTH; CELL PROLIFERATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHILICITY; IC 50; MITOGENESIS; MITOSIS INHIBITION; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN PRENYLATION; SMOOTH MUSCLE FIBER;

3-HYDROXY-3-METHYLGLUTARYL COENZYME A (HMG-COA) INHIBITOR; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME-A; AIRWAY SMOOTH MUSCLE; ASM; ASTHMA; BOVINE SERUM ALBUMIN; BSA; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; COPD; CYSTEINYL-LEUKOTRIENE D(4); CYSTEINYL-LEUKOTRIENES; EGF; EPIDERMAL GROWTH FACTOR; FBS; FETAL BOVINE SERUM; GERANYLGERANYLTRANSFERASE I; GGTASE I; HMG-COA; LTD(4); MEM; MODIFIED EAGLE'S MEDIUM; REACTIVE OXYGEN SPECIES; REMODELING; ROS; THROMBOXANE; THROMBOXANE A(2); TXA(2);

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; AIRWAY REMODELING; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSANOIDS; EPIDERMAL GROWTH FACTOR; FLUOROBENZENES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEUKOTRIENE D4; MEVALONIC ACID; MITOGENS; MYOCYTES, SMOOTH MUSCLE; PYRIMIDINES; RECEPTORS, LEUKOTRIENE; SERUM ALBUMIN, BOVINE; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 84892442322     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2013.06.005     Document Type: Article

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