Analysis of Rho GTPase expression in T-ALL identifies RhoU as a target for Notch involved in T-ALL cell migration

Oncogene

Volumn 32, Issue 2, 2013, Pages 198-208

  Bhavsar, P J ^a   Infante, E ^a,b   Khwaja, A ^c   Ridley, A J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

acute lymphoblastic leukaemia; cell migration; cytoskeleton; Notch1; Rho GTPases; RhoU

Indexed keywords

GAMMA SECRETASE INHIBITOR; NOTCH1 RECEPTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CELL ADHESION; CELL MIGRATION; CHEMOTAXIS; DELTEX 1 GENE; GENE; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHOU GENE; RNA INTERFERENCE; T CELL ACUTE LYMPHOBLASTIC LEUKEMIA; T LYMPHOCYTE; UPREGULATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; HUMANS; OLIGOPEPTIDES; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECEPTOR, NOTCH1; RHO GTP-BINDING PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84872175646     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.42     Document Type: Article

References (53)

1. Pieters R, Carroll WL. Biology and treatment of acute lymphoblastic leukemia. Pediatr Clin North Am 2008; 55: 1-20. (Pubitemid 351173191)
2. Aifantis I, Raetz E, Buonamici S. Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol 2008; 8: 380-390. (Pubitemid 351595220)
3. Crazzolara R, Kreczy A, Mann G, Heitger A, Eibl G, Fink FM et al. High expression of the chemokine receptor CXCR4 predicts extramedullary organ infiltration in childhood acute lymphoblastic leukaemia. Br J Haematol 2001; 115: 545-553. (Pubitemid 34015643)
4. Bhojwani D, Howard SC, Pui CH. High-risk childhood acute lymphoblastic leukemia. Clin Lymphoma Myeloma 2009; 9 (Suppl 3): S222-S230.
5. Weng AP, Ferrando AA, Lee W, Morris 4th JP, Silverman LB, Sanchez-Irizarry C et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306: 269-271. (Pubitemid 39336870)
6. van Grotel M, Meijerink JP, van Wering ER, Langerak AW, Beverloo HB, Buijs-Gladdines JG et al. Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences. Leukemia 2008; 22: 124-131.
7. Hayday AC, Pennington DJ. Key factors in the organized chaos of early T cell development. Nat Immunol 2007; 8: 137-144. (Pubitemid 46152644)
8. Vicente R, Swainson L, Marty-Gres S, De Barros SC, Kinet S, Zimmermann VS et al. Molecular and cellular basis of T cell lineage commitment. Semin Immunol 2010; 22: 270-275.
9. Aster JC, Blacklow SC, Pear WS. Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. J Pathol 2011; 223: 262-273.
10. Ferrando AA. The role of NOTCH1 signaling in T-ALL. Hematology Am Soc Hematol Educ Program 2009; 353-361.
11. Buonamici S, Trimarchi T, Ruocco MG, Reavie L, Cathelin S, Mar BG et al. CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature 2009; 459: 1000-1004.
12. Van Hennik PB, Hordijk PL. Rho GTPases in hematopoietic cells. Antioxid Redox Signal 2005; 7: 1440-1455. (Pubitemid 41767979)
13. Tybulewicz VL, Henderson RB. Rho family GTPases and their regulators in lymphocytes. Nat Rev Immunol 2009; 9: 630-644.
14. Boureux A, Vignal E, Faure S, Fort P. Evolution of the Rho family of ras-like GTPases in eukaryotes. Mol Biol Evol 2007; 24: 203-216. (Pubitemid 46026295)
15. Chang FK, Sato N, Kobayashi-Simorowski N, Yoshihara T, Meth JL, Hamaguchi M. DBC2 is essential for transporting vesicular stomatitis virus glycoprotein. J Mol Biol 2006; 364: 302-308. (Pubitemid 44715940)
16. Aspenstrom P, Ruusala A, Pacholsky D. Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases. Exp Cell Res 2007; 313: 3673-3679. (Pubitemid 47464235)
17. Vega FM, Ridley AJ. Rho GTPases in cancer cell biology. FEBS Lett 2008; 582: 2093-2101.
18. Ellenbroek SI, Collard JG. Rho GTPases: Functions and association with cancer. Clin Exp Metastasis 2007; 24: 657-672.
19. Symons M, Segall JE. Rac and Rho driving tumor invasion: Who's at the wheelGenome Biol 2009; 10: 213.
20. Parri M, Chiarugi P. Rac and Rho GTPases in cancer cell motility control. Cell Commun Signal 2010; 8: 23.
21. Heasman SJ, Carlin LM, Cox S, Ng T, Ridley AJ. Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration. J Cell Biol 2010; 190: 553-563.
22. O'Neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C et al. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gammasecretase inhibitors. J Exp Med 2007; 204: 1813-1824. (Pubitemid 47236319)
23. Palomero T, Odom DT, O'Neil J, Ferrando AA, Margolin A, Neuberg DS et al. Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. Blood 2006; 108: 986-992. (Pubitemid 44154635)
24. Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med 2007; 13: 1203-1210. (Pubitemid 47530629)
25. Wolfe MS. Secretase in biology and medicine. Semin Cell Dev Biol 2009; 20: 219-224.
26. Heasman SJ, Ridley AJ. Mammalian Rho GTPases: New insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 2008; 9: 690-701.
27. Takesono A, Heasman SJ, Wojciak-Stothard B, Garg R, Ridley AJ. Microtubules regulate migratory polarity through Rho/ROCK signaling in T cells. PLoS One 2010; 5: E8774.
28. Infante E, Heasman SJ, Ridley AJ. Statins inhibit T-Acute lymphoblastic leukemia cell adhesion and migration through Rap1b. J Leukoc Biol 2011; 89: 577-586.
29. Aspenstrom P, Fransson A, Saras J. Rho GTPases have diverse effects on the organization of the actin filament system. Biochem J 2004; 377: 327-337. (Pubitemid 38142188)
30. Chuang YY, Valster A, Coniglio SJ, Backer JM, Symons M. The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration. J Cell Sci 2007; 120: 1927-1934. (Pubitemid 46979784)
31. Aronheim A, Broder YC, Cohen A, Fritsch A, Belisle B, Abo A. Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton. Curr Biol 1998; 8: 1125-1128. (Pubitemid 28501376)
32. Brazier H, Pawlak G, Vives V, Blangy A. The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration. Int J Biochem Cell Biol 2009; 41: 1391-1401.
33. Fort P, Guemar L, Vignal E, Morin N, Notarnicola C, de Santa Barbara P et al. Activity of the RhoU/Wrch1 GTPase is critical for cranial neural crest cell migration. Dev Biol 2011; 350: 451-463.
34. Weisz Hubsman M, Volinsky N, Manser E, Yablonski D, Aronheim A. Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp. Biochem J 2007; 404: 487-497. (Pubitemid 46953923)
35. Arias-Romero LE, Chernoff J. A tale of two Paks. Biol Cell 2008; 100: 97-108. (Pubitemid 351266767)
36. Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 2002; 1: 75-87. (Pubitemid 41039178)
37. Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC et al. Direct inhibition of the NOTCH transcription factor complex. Nature 2009; 462: 182-188.
38. Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev 2001; 15: 1796-1807. (Pubitemid 32905637)
39. Weerkamp F, van Dongen JJ, Staal FJ. Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia. Leukemia 2006; 20: 1197-1205. (Pubitemid 43905820)
40. Fueller F, Kubatzky KF. The small GTPase RhoH is an atypical regulator of haematopoietic cells. Cell Commun Signal 2008; 6: 6.
41. Wang H, Zeng X, Fan Z, Lim B. RhoH plays distinct roles in T-cell migrations induced by different doses of SDF1a. Cell Signal 2010; 22: 1022-1032.
42. Berthold J, Schenkova K, Rivero F. Rho GTPases of the RhoBTB subfamily and tumorigenesis. Acta Pharmacol Sin 2008; 29: 285-295. (Pubitemid 351316996)
43. Berthold J, Schenkova K, Ramos S, Miura Y, Furukawa M, Aspenstrom P et al. Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes-evidence for an autoregulatory mechanism. Exp Cell Res 2008; 314: 3453-3465.
44. Riou P, Villalonga P, Ridley AJ. Rnd proteins: Multifunctional regulators of the cytoskeleton and cell cycle progression. Bioessays 2010; 32: 986-992.
45. Gomez del Pulgar T, Benitah SA, Valeron PF, Espina C, Lacal JC. Rho GTPase expression in tumourigenesis: Evidence for a significant link. Bioessays 2005; 27: 602-613. (Pubitemid 40896091)
46. Ridley AJ. Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol 2006; 16: 522-529. (Pubitemid 44444995)
47. Huang M, Prendergast GC. RhoB in cancer suppression. Histol Histopathol 2006; 21: 213-218. (Pubitemid 43033730)
48. Ono Y, Fukuhara N, Yoshie O. Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. J Biol Chem 1997; 272: 4576-4581. (Pubitemid 27078539)
49. Graux C, Cools J, Michaux L, Vandenberghe P, Hagemeijer A. Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: From thymocyte to lymphoblast. Leukemia 2006; 20: 1496-1510. (Pubitemid 44264091)
50. Yanez-Mo M, Barreiro O, Gordon-Alonso M, Sala-Valdes M, Sanchez-Madrid F. Tetraspanin-enriched microdomains: A functional unit in cell plasma membranes. Trends Cell Biol 2009; 19: 434-446.
51. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008; 3: 1101-1108. (Pubitemid 351818697)
52. de Hoon MJ, Imoto S, Nolan J, Miyano S. Open source clustering software. Bioinformatics 2004; 20: 1453-1454. (Pubitemid 38931415)
53. Saldanha AJ. Java Treeview-extensible visualization of microarray data. Bioinformatics 2004; 20: 3246-3248. (Pubitemid 39619217)