The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease

Ageing Research Reviews

Volumn 12, Issue 4, 2013, Pages 867-883

  Jayasena, T ^a   Poljak, A ^b   Smythe, G ^b   Braidy, N ^a,d   Munch G ^c   Sachdev, P ^a,d  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF WESTERN SYDNEY   (Australia)

^d PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

Alzheimer's disease; Phenolics; Polyphenol; Sirtuin

Indexed keywords

APIGENIN; BUTEIN; CAFFEIC ACID; CURCUMIN; DAIDZEIN; DIOSMETIN; ESCULETIN; FERULIC ACID; FISETIN; GALLIC ACID; GENISTEIN; GLYCITEIN; KAEMPFEROL; LUTEOLIN; MANGIFERIN; MATAIRESINOL; MYRICETIN; NARINGENIN; OLEUROPEIN; PHLORIZIN; PICEATANNOL; POLYPHENOL; QUERCETIN; RESVERATROL; SCOPOLETIN; SECOISOLARICIRESINOL; SIRTUIN; TYROSOL; UMBELLIFERONE; UNINDEXED DRUG;

AGING; ALZHEIMER DISEASE; CELL NUCLEUS; CYTOPLASM; DRUG STRUCTURE; HUMAN; INFLAMMATION; LONGEVITY; MITOCHONDRION; MOLECULAR MECHANICS; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; TELOMERE HOMEOSTASIS;

ALZHEIMER'S DISEASE; PHENOLICS; POLYPHENOL; SIRTUIN;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; HUMANS; LONGEVITY; POLYPHENOLS; SIGNAL TRANSDUCTION; SIRTUINS;

EID: 84882779240     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2013.06.003     Document Type: Review

References (308)

1. Agarwal B., Baur J.A. Resveratrol and life extension. Annals of the New York Academy of Sciences 2011, 1215:138-143.
2. Ahmed S., Rahman A., Hasnain A., Lalonde M., Goldberg V.M., Haqqi T.M. Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Free Radical Biology and Medicine 2002, 33:1097-1105.
3. Ahmed T., Enam S.A., Gilani A.H. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience 2010, 169:1296-1306.
4. Akaishi T., Morimoto T., Shibao M., Watanabe S., Sakai-Kato K., Utsunomiya-Tate N., Abe K. Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid beta protein. Neuroscience Letters 2008, 444:280-285.
5. Akieda-Asai S., Zaima N., Ikegami K., Kahyo T., Yao I., Hatanaka T., Iemura S., Sugiyama R., Yokozeki T., Eishi Y., Koike M., Ikeda K., Chiba T., Yamaza H., Shimokawa I., Song S.Y., Matsuno A., Mizutani A., Sawabe M., Chao M.V., Tanaka M., Kanaho Y., Natsume T., Sugimura H., Date Y., McBurney M.W., Guarente L., Setou M. SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. PLoS One 2010, 5:e11755.
6. Aksenov M.Y., Aksenova M.V., Butterfield D.A., Geddes J.W., Markesbery W.R. Protein oxidation in the brain in Alzheimer's disease. Neuroscience 2001, 103:373-383.
7. Alonso Á.M., Castro R., Rodríguez M.C., Guillén D.A., Barroso C.G. Study of the antioxidant power of brandies and vinegars derived from Sherry wines and correlation with their content in polyphenols. Food Research International 2004, 37:715-721.
8. Alvarez-Suarez J.M., Dekanski D., Ristic S., Radonjic N.V., Petronijevic N.D., Giampieri F., Astolfi P., Gonzalez-Paramas A.M., Santos-Buelga C., Tulipani S., Quiles J.L., Mezzetti B., Battino M. Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase. PLoS One 2011, 6:e25878.
9. Ansari M.A., Abdul H.M., Joshi G., Opii W.O., Butterfield D.A. Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease. Journal of Nutritional Biochemistry 2009, 20:269-275.
10. Arai S. Studies on functional foods in Japan--state of the art. Bioscience, Biotechnology, and Biochemistry 1996, 60:9-15.
11. Arts I.C., van de Putte B., Hollman P.C. Catechin contents of foods commonly consumed in The Netherlands. 1. Fruits, vegetables, staple foods, and processed foods. Journal of Agricultural and Food Chemistry 2000, 48:1746-1751.
12. Arts I.C., van De Putte B., Hollman P.C. Catechin contents of foods commonly consumed in The Netherlands. 2. Tea, wine, fruit juices, and chocolate milk. Journal of Agricultural and Food Chemistry 2000, 48:1752-1757.
13. Asha Devi S., Sagar Chandrasekar B.K., Manjula K.R., Ishii N. Grape seed proanthocyanidin lowers brain oxidative stress in adult and middle-aged rats. Experimental Gerontology 2011, 46:958-964.
14. Atwood C.S., Obrenovich M.E., Liu T., Chan H., Perry G., Smith M.A., Martins R.N. Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta. Brain Research. Brain Research Reviews 2003, 43:1-16.
15. Barger J.L., Kayo T., Pugh T.D., Prolla T.A., Weindruch R. Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart. Experimental Gerontology 2008, 43:859-866.
16. Barger J.L., Kayo T., Vann J.M., Arias E.B., Wang J., Hacker T.A., Wang Y., Raederstorff D., Morrow J.D., Leeuwenburgh C., Allison D.B., Saupe K.W., Cartee G.D., Weindruch R., Prolla T.A. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One 2008, 3:e2264.
17. Barnham K.J., Masters C.L., Bush A.I. Neurodegenerative diseases and oxidative stress. Nature Reviews Drug Discovery 2004, 3:205-214.
18. Bastianetto S., Krantic S., Chabot J.G., Quirion R. Possible involvement of programmed cell death pathways in the neuroprotective action of polyphenols. Current Alzheimer Research 2011, 8:445-451.
19. Baur J.A., Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nature Reviews Drug Discovery 2006, 5:493-506.
20. Beirowski B., Gustin J., Armour S.M., Yamamoto H., Viader A., North B.J., Michan S., Baloh R.H., Golden J.P., Schmidt R.E., Sinclair D.A., Auwerx J., Milbrandt J. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proceedings of the National Academy of Sciences of the United States of America 2011, 108:E952-E961.
21. Belinha I., Amorim M.A., Rodrigues P., de Freitas V., Moradas-Ferreira P., Mateus N., Costa V. Quercetin increases oxidative stress resistance and longevity in Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry 2007, 55:2446-2451.
22. Bell E.L., Guarente L. The SirT3 divining rod points to oxidative stress. Molecular Cell 2011, 42:561-568.
23. Bernardes de Jesus B., Schneeberger K., Vera E., Tejera A., Harley C.B., Blasco M.A. The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell 2011, 10:604-621.
24. Bhardwaj A., Sethi G., Vadhan-Raj S., Bueso-Ramos C., Takada Y., Gaur U., Nair A.S., Shishodia S., Aggarwal B.B. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood 2007, 109:2293-2302.
25. Bieschke J., Russ J., Friedrich R.P., Ehrnhoefer D.E., Wobst H., Neugebauer K., Wanker E.E. EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:7710-7715.
26. Biradar S.M., Joshi H., Chheda T.K. Neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer's disease. European Journal of Pharmacology 2012, 683:140-147.
27. Bisson J.F., Nejdi A., Rozan P., Hidalgo S., Lalonde R., Messaoudi M. Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats. British Journal of Nutrition 2008, 100:94-101.
28. Bonda D.J., Liu G., Men P., Perry G., Smith M.A., Zhu X. Nanoparticle delivery of transition-metal chelators to the brain: Oxidative stress will never see it coming!. CNS & Neurological Disorders: Drug Targets 2012, 11:81-85.
29. Bordone L., Cohen D., Robinson A., Motta M.C., van Veen E., Czopik A., Steele A.D., Crowe H., Marmor S., Luo J., Gu W., Guarente L. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 2007, 6:759-767.
30. Borra M.T., Smith B.C., Denu J.M. Mechanism of human SIRT1 activation by resveratrol. Journal of Biological Chemistry 2005, 280:17187-17195.
31. 2+ ions: implications for their antioxidant properties. The Biochemical Journal 1998, 330(Pt 3):1173-1178.
32. Brown V.A., Patel K.R., Viskaduraki M., Crowell J.A., Perloff M., Booth T.D., Vasilinin G., Sen A., Schinas A.M., Piccirilli G., Brown K., Steward W.P., Gescher A.J., Brenner D.E. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Research 2010, 70:9003-9011.
33. Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., Lin Y., Tran H., Ross S.E., Mostoslavsky R., Cohen H.Y., Hu L.S., Cheng H.L., Jedrychowski M.P., Gygi S.P., Sinclair D.A., Alt F.W., Greenberg M.E. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004, 303:2011-2015.
34. Buettner G.R., Jurkiewicz B.A. Catalytic metals, ascorbate and free radicals: combinations to avoid. Radiation research 1996, 145:532-541.
35. Burnett C., Valentini S., Cabreiro F., Goss M., Somogyvari M., Piper M.D., Hoddinott M., Sutphin G.L., Leko V., McElwee J.J., Vazquez-Manrique R.P., Orfila A.M., Ackerman D., Au C., Vinti G., Riesen M., Howard K., Neri C., Bedalov A., Kaeberlein M., Soti C., Partridge L., Gems D. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 2011, 477:482-485.
36. Burns J., Gardner P.T., O'Neil J., Crawford S., Morecroft I., McPhail D.B., Lister C., Matthews D., MacLean M.R., Lean M.E., Duthie G.G., Crozier A. Relationship among antioxidant activity, vasodilation capacity, and phenolic content of red wines. Journal of Agricultural and Food Chemistry 2000, 48:220-230.
37. Butterfield D.A. Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review. Free Radical Research 2002, 36:1307-1313.
38. Capiralla H., Vingtdeux V., Zhao H., Sankowski R., Al-Abed Y., Davies P., Marambaud P. Resveratrol mitigates lipopolysaccharide- and Abeta-mediated microglial inflammation by inhibiting the TLR4/NF-kappaB/STAT signaling cascade. Journal of Neurochemistry 2012, 120:461-472.
39. Carrasco-Pozo C., Gotteland M., Speisky H. Apple peel polyphenol extract protects against indomethacin-induced damage in Caco-2 cells by preventing mitochondrial complex I inhibition. Journal of Agricultural and Food Chemistry 2011, 59:11501-11508.
40. Carrasco-Pozo C., Mizgier M.L., Speisky H., Gotteland M. Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells. Chemico-Biological Interactions 2012, 195:199-205.
41. Casley C.S., Canevari L., Land J.M., Clark J.B., Sharpe M.A. Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. Journal of neurochemistry 2002, 80:91-100.
42. Cawthon R.M., Smith K.R., O'Brien E., Sivatchenko A., Kerber R.A. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003, 361:393-395.
43. Chan R., Woo J., Suen E., Leung J., Tang N. Chinese tea consumption is associated with longer telomere length in elderly Chinese men. British Journal of Nutrition 2010, 103:107-113.
44. Chandrashekara K.T., Shakarad M.N. Aloe vera or resveratrol supplementation in larval diet delays adult aging in the fruit fly, Drosophila melanogaster. Journals of Gerontology, Series A: Biological Sciences and Medical Sciences 2011, 66:965-971.
45. Chen J., Zhou Y., Mueller-Steiner S., Chen L.F., Kwon H., Yi S., Mucke L., Gan L. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. Journal of Biological Chemistry 2005, 280:40364-40374.
46. Cheng I.F., Breen K. On the ability of four flavonoids, baicilein, luteolin, naringenin, and quercetin, to suppress the Fenton reaction of the iron-ATP complex. Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine 2000, 13:77-83.
47. Cho N., Choi J.H., Yang H., Jeong E.J., Lee K.Y., Kim Y.C., Sung S.H. Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 2012, 50:1940-1945.
48. Choi K.C., Jung M.G., Lee Y.H., Yoon J.C., Kwon S.H., Kang H.B., Kim M.J., Cha J.H., Kim Y.J., Jun W.J., Lee J.M., Yoon H.G. Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation. Cancer Research 2009, 69:583-592.
49. Chukwumah Y., Walker L., Vogler B., Verghese M. Changes in the phytochemical composition and profile of raw, boiled, and roasted peanuts. Journal of Agricultural and Food Chemistry 2007, 55:9266-9273.
50. Chung S., Yao H., Caito S., Hwang J.W., Arunachalam G., Rahman I. Regulation of SIRT1 in cellular functions: role of polyphenols. Archives of Biochemistry and Biophysics 2010, 501:79-90.
51. Cohen D.E., Supinski A.M., Bonkowski M.S., Donmez G., Guarente L.P. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes and Development 2009, 23:2812-2817.
52. Crujeiras A.B., Parra D., Goyenechea E., Martinez J.A. Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction. European Journal of Clinical Investigation 2008, 38:672-678.
53. D'Archivio M., Filesi C., Di Benedetto R., Gargiulo R., Giovannini C., Masella R. Polyphenols, dietary sources and bioavailability. Annali dell Istituto Superiore di Sanita 2007, 43:348-361.
54. Dave M., Attur M., Palmer G., Al-Mussawir H.E., Kennish L., Patel J., Abramson S.B. The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production. Arthritis and Rheumatism 2008, 58:2786-2797.
55. Davis J.M., Murphy E.A., Carmichael M.D. Effects of the dietary flavonoid quercetin upon performance and health. Current sports medicine reports 2009, 8:206-213.
56. Davis J.M., Murphy E.A., Carmichael M.D., Davis B. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2009, 296:R1071-R1077.
57. De Bacquer D., Clays E., Delanghe J., De Backer G. Epidemiological evidence for an association between habitual tea consumption and markers of chronic inflammation. Atherosclerosis 2006, 189:428-435.
58. Desideri G., Kwik-Uribe C., Grassi D., Necozione S., Ghiadoni L., Mastroiacovo D., Raffaele A., Ferri L., Bocale R., Lechiara M.C., Marini C., Ferri C. Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study. Hypertension 2012, 60:794-801.
59. Dhanasekaran M., Holcomb L.A., Hitt A.R., Tharakan B., Porter J.W., Young K.A., Manyam B.V. Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer's disease animal model. Phytotherapy Research 2009, 23:14-19.
60. Do Carmo Barbosa Mendes De Vasconcelos M., Bennett R.N., Rosa E.A., Ferreira Cardoso J.V. Primary and secondary metabolite composition of kernels from three cultivars of Portuguese chestnut (Castanea sativa Mill.) at different stages of industrial transformation. Journal of Agricultural and Food Chemistry 2007, 55:3508-3516.
61. Doggui S., Dao L., Ramassamy C. Potential of drug-loaded nanoparticles for Alzheimer's disease: diagnosis, prevention and treatment. Therapeutic delivery 2012, 3:1025-1027.
62. Donmez G., Wang D., Cohen D.E., Guarente L. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 2010, 142:320-332.
63. Dragicevic N., Smith A., Lin X., Yuan F., Copes N., Delic V., Tan J., Cao C., Shytle R.D., Bradshaw P.C. Green tea epigallocatechin-3-gallate (EGCG) and other flavonoids reduce Alzheimer's amyloid-induced mitochondrial dysfunction. Journal of Alzheimer's disease: JAD 2011, 26:507-521.
64. Ehala S., Vaher M., Kaljurand M. Characterization of phenolic profiles of Northern European berries by capillary electrophoresis and determination of their antioxidant activity. Journal of Agricultural and Food Chemistry 2005, 53:6484-6490.
65. Fernandez A.F., Fraga M.F. The effects of the dietary polyphenol resveratrol on human healthy aging and lifespan. Epigenetics 2011, 6:870-874.
66. Fontana L., Meyer T.E., Klein S., Holloszy J.O. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:6659-6663.
67. Fontana L., Partridge L., Longo V.D. Extending healthy life span--from yeast to humans. Science 2010, 328:321-326.
68. Ford E., Voit R., Liszt G., Magin C., Grummt I., Guarente L. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes and Development 2006, 20:1075-1080.
69. Frei B., Higdon J.V. Antioxidant activity of tea polyphenols in vivo: evidence from animal studies. Journal of Nutrition 2003, 133:3275S-3284S.
70. Frydman-Marom A., Levin A., Farfara D., Benromano T., Scherzer-Attali R., Peled S., Vassar R., Segal D., Gazit E., Frenkel D., Ovadia M. Orally administrated cinnamon extract reduces beta-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models. PLoS One 2011, 6:e16564.
71. Gertz M., Nguyen G.T., Fischer F., Suenkel B., Schlicker C., Franzel B., Tomaschewski J., Aladini F., Becker C., Wolters D., Steegborn C. A molecular mechanism for direct sirtuin activation by resveratrol. PLoS One 2012, 7:e49761.
72. Giunta B., Hou H., Zhu Y., Salemi J., Ruscin A., Shytle R.D., Tan J. Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice. Neuroscience Letters 2010, 471:134-138.
73. Glorioso C., Oh S., Douillard G.G., Sibille E. Brain molecular aging, promotion of neurological disease and modulation by sirtuin 5 longevity gene polymorphism. Neurobiology of Disease 2011, 41:279-290.
74. Greilberger J., Koidl C., Greilberger M., Lamprecht M., Schroecksnadel K., Leblhuber F., Fuchs D., Oettl K. Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease. Free Radical Research 2008, 42:633-638.
75. Gu L., Kelm M.A., Hammerstone J.F., Beecher G., Holden J., Haytowitz D., Gebhardt S., Prior R.L. Concentrations of proanthocyanidins in common foods and estimations of normal consumption. Journal of Nutrition 2004, 134:613-617.
76. Guan J.Z., Maeda T., Sugano M., Oyama J., Higuchi Y., Suzuki T., Makino N. A percentage analysis of the telomere length in Parkinson's disease patients. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2008, 63:467-473.
77. Guarente L. Mitochondria--a nexus for aging, calorie restriction, and sirtuins?. Cell 2008, 132:171-176.
78. Gutierrez-Zepeda A., Santell R., Wu Z., Brown M., Wu Y., Khan I., Link C.D., Zhao B., Luo Y. Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans. BMC Neuroscience 2005, 6:54.
79. Hafner A.V., Dai J., Gomes A.P., Xiao C.Y., Palmeira C.M., Rosenzweig A., Sinclair D.A. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY) 2010, 2:914-923.
80. Haigis M.C., Mostoslavsky R., Haigis K.M., Fahie K., Christodoulou D.C., Murphy A.J., Valenzuela D.M., Yancopoulos G.D., Karow M., Blander G., Wolberger C., Prolla T.A., Weindruch R., Alt F.W., Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 2006, 126:941-954.
81. Halaschek-Wiener J., Amirabbasi-Beik M., Monfared N., Pieczyk M., Sailer C., Kollar A., Thomas R., Agalaridis G., Yamada S., Oliveira L., Collins J.A., Meneilly G., Marra M.A., Madden K.M., Le N.D., Connors J.M., Brooks-Wilson A.R. Genetic variation in healthy oldest-old. PLoS One 2009, 4:e6641.
82. Harman D. Aging: a theory based on free radical and radiation chemistry. Journal of Gerontology 1956, 11:298-300.
83. Harting K., Knoll B. SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology. European Journal of Cell Biology 2010, 89:262-269.
84. Hasegawa T., Baba T., Kobayashi M., Konno M., Sugeno N., Kikuchi A., Itoyama Y., Takeda A. Role of TPPP/p25 on alpha-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy. Neurochemistry International 2010, 57:857-866.
85. Heilbronn L.K., de Jonge L., Frisard M.I., DeLany J.P., Larson-Meyer D.E., Rood J., Nguyen T., Martin C.K., Volaufova J., Most M.M., Greenway F.L., Smith S.R., Deutsch W.A., Williamson D.A., Ravussin E., Pennington C.T. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA 2006, 295:1539-1548.
86. Hensley K., Maidt M.L., Yu Z., Sang H., Markesbery W.R., Floyd R.A. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. Journal of Neuroscience 1998, 18:8126-8132.
87. Heo H.J., Lee C.Y. Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration. Journal of Agricultural and Food Chemistry 2004, 52:7514-7517.
88. Herbig U., Jobling W.A., Chen B.P., Chen D.J., Sedivy J.M. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Molecular Cell 2004, 14:501-513.
89. Hider R.C., Liu Z.D., Khodr H.H. Metal chelation of polyphenols. Methods in Enzymology 2001, 335:190-203.
90. Hirschey M.D., Shimazu T., Goetzman E., Jing E., Schwer B., Lombard D.B., Grueter C.A., Harris C., Biddinger S., Ilkayeva O.R., Stevens R.D., Li Y., Saha A.K., Ruderman N.B., Bain J.R., Newgard C.B., Farese R.V., Alt F.W., Kahn C.R., Verdin E. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 2010, 464:121-125.
91. Holloszy J.O., Fontana L. Caloric restriction in humans. Experimental Gerontology 2007, 42:709-712.
92. Honda K., Casadesus G., Petersen R.B., Perry G., Smith M.A. Oxidative stress and redox-active iron in Alzheimer's disease. Annals of the New York Academy of Sciences 2004, 1012:179-182.
93. Horio Y., Hayashi T., Kuno A., Kunimoto R. Cellular and molecular effects of sirtuins in health and disease. Clinical Science (London) 2011, 121:191-203.
94. Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.L., Scherer B., Sinclair D.A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003, 425:191-196.
95. Huang H.C., Chang P., Dai X.L., Jiang Z.F. Protective effects of curcumin on amyloid-beta-induced neuronal oxidative damage. Neurochemical Research 2012, 37:1584-1597.
96. Jena S., Dandapat J., Chainy G.B. Curcumin differentially regulates the expression of superoxide dismutase in cerebral cortex and cerebellum of L: -thyroxine (T(4))-induced hyperthyroid rat brain. Neurological Sciences 2012.
97. Johnston H., Boutin H., Allan S.M. Assessing the contribution of inflammation in models of Alzheimer's disease. Biochemical Society Transactions 2011, 39:886-890.
98. Jomova K., Vondrakova D., Lawson M., Valko M. Metals, oxidative stress and neurodegenerative disorders. Molecular and Cellular Biochemistry 2010, 345:91-104.
99. Julien C., Tremblay C., Emond V., Lebbadi M., Salem N., Bennett D.A., Calon F. Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. Journal of Neuropathology & Experimental Neurology 2009, 68:48-58.
100. Justesen U., Knuthsen P., Leth T. Quantitative analysis of flavonols, flavones, and flavanones in fruits, vegetables and beverages by high-performance liquid chromatography with photo-diode array and mass spectrometric detection. Journal of Chromatography A 1998, 799:101-110.
101. Kaeberlein M., McVey M., Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes and Development 1999, 13:2570-2580.
102. Kaeberlein M., McDonagh T., Heltweg B., Hixon J., Westman E.A., Caldwell S.D., Napper A., Curtis R., DiStefano P.S., Fields S., Bedalov A., Kennedy B.K. Substrate-specific activation of sirtuins by resveratrol. Journal of Biological Chemistry 2005, 280:17038-17045.
103. Kampkotter A., Gombitang Nkwonkam C., Zurawski R.F., Timpel C., Chovolou Y., Watjen W., Kahl R. Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans. Archives of toxicology 2007, 81:849-858.
104. Kang H.T., Lee H.I., Hwang E.S. Nicotinamide extends replicative lifespan of human cells. Aging Cell 2006, 5:423-436.
105. Karuppagounder S.S., Pinto J.T., Xu H., Chen H.L., Beal M.F., Gibson G.E. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochemistry International 2009, 54:111-118.
106. Kawahara T.L., Michishita E., Adler A.S., Damian M., Berber E., Lin M., McCord R.A., Ongaigui K.C., Boxer L.D., Chang H.Y., Chua K.F. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 2009, 136:62-74.
107. Kawahara T.L., Rapicavoli N.A., Wu A.R., Qu K., Quake S.R., Chang H.Y. Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks. PLoS Genet 2011, 7:e1002153.
108. Khan N., Afaq F., Saleem M., Ahmad N., Mukhtar H. Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Research 2006, 66:2500-2505.
109. Khurana S., Jain S., Mediratta P.K., Banerjee B.D., Sharma K.K. Protective role of curcumin on colchicine-induced cognitive dysfunction and oxidative stress in rats. Human and Experimental Toxicology 2012, 31:686-697.
110. Kim T.S., Pae C.U., Yoon S.J., Jang W.Y., Lee N.J., Kim J.J., Lee S.J., Lee C., Paik I.H., Lee C.U. Decreased plasma antioxidants in patients with Alzheimer's disease. International Journal of Geriatric Psychiatry 2006, 21:344-348.
111. Kim D., Nguyen M.D., Dobbin M.M., Fischer A., Sananbenesi F., Rodgers J.T., Delalle I., Baur J.A., Sui G., Armour S.M., Puigserver P., Sinclair D.A., Tsai L.H. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO Journal 2007, 26:3169-3179.
112. Kim J.K., Choi S.J., Cho H.Y., Hwang H.J., Kim Y.J., Lim S.T., Kim C.J., Kim H.K., Peterson S., Shin D.H. Protective effects of kaempferol (3,4',5,7-tetrahydroxyflavone) against amyloid beta peptide (Abeta)-induced neurotoxicity in ICR mice. Bioscience, Biotechnology, and Biochemistry 2010, 74:397-401.
113. Kim S.H., Lu H.F., Alano C.C. Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture. PLoS One 2011, 6:e14731.
114. Kitani K., Osawa T., Yokozawa T. The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice. Biogerontology 2007, 8:567-573.
115. Kojro E., Fahrenholz F. The non-amyloidogenic pathway: structure and function of alpha-secretases. Sub-Cellular Biochemistry 2005, 38:105-127.
116. Ksiezak-Reding H., Ho L., Santa-Maria I., Diaz-Ruiz C., Wang J., Pasinetti G.M. Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols. Neurobiology of Aging 2012, 33:1427-1439.
117. Kumar A., Prakash A., Dogra S. Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by D-galactose in mice. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 2010, 48:626-632.
118. Kumari M.V., Yoneda T., Hiramatsu M. Effect of "beta CATECHIN" on the life span of senescence accelerated mice (SAM-P8 strain). Biochemistry and molecular biology international 1997, 41:1005-1011.
119. Ladiwala A.R., Lin J.C., Bale S.S., Marcelino-Cruz A.M., Bhattacharya M., Dordick J.S., Tessier P.M. Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers. Journal of Biological Chemistry 2010, 285:24228-24237.
120. Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., Geny B., Laakso M., Puigserver P., Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006, 127:1109-1122.
121. Langley E., Pearson M., Faretta M., Bauer U.M., Frye R.A., Minucci S., Pelicci P.G., Kouzarides T. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO Journal 2002, 21:2383-2396.
122. Lee K.W., Kundu J.K., Kim S.O., Chun K.S., Lee H.J., Surh Y.J. Cocoa polyphenols inhibit phorbol ester-induced superoxide anion formation in cultured HL-60 cells and expression of cyclooxygenase-2 and activation of NF-kappaB and MAPKs in mouse skin in vivo. Journal of Nutrition 2006, 136:1150-1155.
123. Lee K.S., Lee B.S., Semnani S., Avanesian A., Um C.Y., Jeon H.J., Seong K.M., Yu K., Min K.J., Jafari M. Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster. Rejuvenation Research 2010, 13:561-570.
124. Lei H., Wang B., Li W.P., Yang Y., Zhou A.W., Chen M.Z. Anti-aging effect of astragalosides and its mechanism of action. Acta Pharmacologica Sinica 2003, 24:230-234.
125. Li X., Kazgan N. Mammalian sirtuins and energy metabolism. International Journal of Biological Sciences 2011, 7:575-587.
126. Li W., Zhang B., Tang J., Cao Q., Wu Y., Wu C., Guo J., Ling E.A., Liang F. Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin. Journal of Neuroscience 2007, 27:2606-2616.
127. Li Y., Xu W., McBurney M.W., Longo V.D. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab 2008, 8:38-48.
128. Li Y.M., Chan H.Y., Yao X.Q., Huang Y., Chen Z.Y. Green tea catechins and broccoli reduce fat-induced mortality in Drosophila melanogaster. Journal of Nutritional Biochemistry 2008, 19:376-383.
129. Li Q., Zhao H.F., Zhang Z.F., Liu Z.G., Pei X.R., Wang J.B., Li Y. Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing Abeta1-42 oligomers and upregulating synaptic plasticity-related proteins in the hippocampus. Neuroscience 2009, 163:741-749.
130. Li W., Yin Y., Gong H., Wu G., Zhu F. [Protective effects of AST and ASI on memory impairment and its mechanism in senescent rats treated by GC]. Zhongguo Zhong Yao Za Zhi 2009, 34:199-203.
131. Lim G.P., Chu T., Yang F., Beech W., Frautschy S.A., Cole G.M. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. Journal of Neuroscience 2001, 21:8370-8377.
132. Lin S.J., Kaeberlein M., Andalis A.A., Sturtz L.A., Defossez P.A., Culotta V.C., Fink G.R., Guarente L. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 2002, 418:344-348.
133. Lin S.J., Ford E., Haigis M., Liszt G., Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes and Development 2004, 18:12-16.
134. Liu C., Shi Z., Fan L., Zhang C., Wang K., Wang B. Resveratrol improves neuron protection and functional recovery in rat model of spinal cord injury. Brain Research 2011, 1374:100-109.
135. Liu L., Arun A., Ellis L., Peritore C., Donmez G. Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein. Journal of Biological Chemistry 2012, 287:32307-32311.
136. Lodovici M., Guglielmi F., Casalini C., Meoni M., Cheynier V., Dolara P. Antioxidant and radical scavenging properties in vitro of polyphenolic extracts from red wine. European Journal of Nutrition 2001, 40:74-77.
137. Lombard D.B., Schwer B., Alt F.W., Mostoslavsky R. SIRT6 in DNA repair, metabolism and ageing. Journal of Internal Medicine 2008, 263:128-141.
138. Long J., Gao H., Sun L., Liu J., Zhao-Wilson X. Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model. Rejuvenation Research 2009, 12:321-331.
139. Lopes G.K., Schulman H.M., Hermes-Lima M. Polyphenol tannic acid inhibits hydroxyl radical formation from Fenton reaction by complexing ferrous ions. Biochimica et Biophysica Acta 1999, 1472:142-152.
140. Lovell M.A., Markesbery W.R. Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease. Nucleic Acids Research 2007, 35:7497-7504.
141. Lovell M.A., Robertson J.D., Teesdale W.J., Campbell J.L., Markesbery W.R. Copper, iron and zinc in Alzheimer's disease senile plaques. Journal of the Neurological Sciences 1998, 158:47-52.
142. Luceri C., Caderni G., Sanna A., Dolara P. Red wine and black tea polyphenols modulate the expression of cycloxygenase-2, inducible nitric oxide synthase and glutathione-related enzymes in azoxymethane-induced f344 rat colon tumors. Journal of Nutrition 2002, 132:1376-1379.
143. Luczaj W., Waszkiewicz E., Skrzydlewska E., Roszkowska-Jakimiec W. Green tea protection against age-dependent ethanol-induced oxidative stress. Journal of Toxicology and Environmental Health, Part A 2004, 67:595-606.
144. Luthi-Carter R., Taylor D.M., Pallos J., Lambert E., Amore A., Parker A., Moffitt H., Smith D.L., Runne H., Gokce O., Kuhn A., Xiang Z., Maxwell M.M., Reeves S.A., Bates G.P., Neri C., Thompson L.M., Marsh J.L., Kazantsev A.G. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:7927-7932.
145. Ma W.W., Xiang L., Yu H.L., Yuan L.H., Guo A.M., Xiao Y.X., Li L., Xiao R. Neuroprotection of soyabean isoflavone co-administration with folic acid against beta-amyloid 1-40-induced neurotoxicity in rats. British Journal of Nutrition 2009, 102:502-505.
146. Maher P. Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin. Genes Nutr 2009, 4:297-307.
147. Manach C., Scalbert A., Morand C., Remesy C., Jimenez L. Polyphenols: food sources and bioavailability. American Journal of Clinical Nutrition 2004, 79:727-747.
148. Mandel S.A., Amit T., Kalfon L., Reznichenko L., Weinreb O., Youdim M.B. Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate (EGCG). Journal of Alzheimer's Disease 2008, 15:211-222.
149. Mandel S.A., Amit T., Kalfon L., Reznichenko L., Youdim M.B. Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins. Journal of Nutrition 2008, 138:1578S-1583S.
150. Mandel S.A., Amit T., Weinreb O., Reznichenko L., Youdim M.B. Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases. CNS Neuroscience & Therapeutics 2008, 14:352-365.
151. Mandel S.A., Amit T., Weinreb O., Youdim M.B. Understanding the broad-spectrum neuroprotective action profile of green tea polyphenols in aging and neurodegenerative diseases. Journal of Alzheimer's Disease 2011, 25:187-208.
152. Mantyh P.W., Ghilardi J.R., Rogers S., DeMaster E., Allen C.J., Stimson E.R., Maggio J.E. Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide. Journal of Neurochemistry 1993, 61:1171-1174.
153. Mao Z., Hine C., Tian X., Van Meter M., Au M., Vaidya A., Seluanov A., Gorbunova V. SIRT6 promotes DNA repair under stress by activating PARP1. Science 2011, 332:1443-1446.
154. Mao Z., Tian X., Van Meter M., Ke Z., Gorbunova V., Seluanov A. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:11800-11805.
155. Marfe G., Tafani M., Indelicato M., Sinibaldi-Salimei P., Reali V., Pucci B., Fini M., Russo M.A. Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction. Journal of Cellular Biochemistry 2009, 106:643-650.
156. Marquez-Valadez B., Lugo-Huitron R., Valdivia-Cerda V., Miranda-Ramirez L.R., Perez-De La Cruz V., Gonzalez-Cuahutencos O., Rivero-Cruz I., Mata R., Santamaria A., Pedraza-Chaverri J. The natural xanthone alpha-mangostin reduces oxidative damage in rat brain tissue. Nutritional Neuroscience 2009, 12:35-42.
157. Mattson M.P. Dietary factors, hormesis and health. Ageing Research Reviews 2008, 7:43-48.
158. Maxwell M.M., Tomkinson E.M., Nobles J., Wizeman J.W., Amore A.M., Quinti L., Chopra V., Hersch S.M., Kazantsev A.G. The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS. Human Molecular Genetics 2011, 20:3986-3996.
159. Maynard C.J., Bush A.I., Masters C.L., Cappai R., Li Q.X. Metals and amyloid-beta in Alzheimer's disease. International Journal of Experimental Pathology 2005, 86:147-159.
160. Merry B.J. Oxidative stress and mitochondrial function with aging--the effects of calorie restriction. Aging Cell 2004, 3:7-12.
161. Michan S., Li Y., Chou M.M., Parrella E., Ge H., Long J.M., Allard J.S., Lewis K., Miller M., Xu W., Mervis R.F., Chen J., Guerin K.I., Smith L.E., McBurney M.W., Sinclair D.A., Baudry M., de Cabo R., Longo V.D. SIRT1 is essential for normal cognitive function and synaptic plasticity. Journal of Neuroscience 2010, 30:9695-9707.
162. Michishita E., McCord R.A., Berber E., Kioi M., Padilla-Nash H., Damian M., Cheung P., Kusumoto R., Kawahara T.L., Barrett J.C., Chang H.Y., Bohr V.A., Ried T., Gozani O., Chua K.F. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 2008, 452:492-496.
163. Michishita E., McCord R.A., Boxer L.D., Barber M.F., Hong T., Gozani O., Chua K.F. Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. Cell Cycle 2009, 8:2664-2666.
164. Miller R.A., Harrison D.E., Astle C.M., Baur J.A., Boyd A.R., de Cabo R., Fernandez E., Flurkey K., Javors M.A., Nelson J.F., Orihuela C.J., Pletcher S., Sharp Z.D., Sinclair D., Starnes J.W., Wilkinson J.E., Nadon N.L., Strong R. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2011, 66:191-201.
165. Minagawa S., Araya J., Numata T., Nojiri S., Hara H., Yumino Y., Kawaishi M., Odaka M., Morikawa T., Nishimura S.L., Nakayama K., Kuwano K. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-beta-induced senescence of human bronchial epithelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 2011, 300:L391-L401.
166. Mirabello L., Huang W.Y., Wong J.Y., Chatterjee N., Reding D., Crawford E.D., De Vivo I., Hayes R.B., Savage S.A. The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer. Aging Cell 2009, 8:405-413.
167. Montine T.J., Neely M.D., Quinn J.F., Beal M.F., Markesbery W.R., Roberts L.J., Morrow J.D. Lipid peroxidation in aging brain and Alzheimer's disease. Free Radical Biology and Medicine 2002, 33:620-626.
168. Moongkarndi P., Srisawat C., Saetun P., Jantaravinid J., Peerapittayamongkol C., Soi-ampornkul R., Junnu S., Sinchaikul S., Chen S.T., Charoensilp P., Thongboonkerd V., Neungton N. Protective effect of mangosteen extract against beta-amyloid-induced cytotoxicity, oxidative stress and altered proteome in SK-N-SH cells. Journal of Proteome Research 2010, 9:2076-2086.
169. Morgan T.E., Wong A.M., Finch C.E. Anti-inflammatory mechanisms of dietary restriction in slowing aging processes. Interdisciplinary Topics in Gerontology 2007, 35:83-97.
170. Mori T., Rezai-Zadeh K., Koyama N., Arendash G.W., Yamaguchi H., Kakuda N., Horikoshi-Sakuraba Y., Tan J., Town T. Tannic acid is a natural beta-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice. Journal of Biological Chemistry 2012, 287:6912-6927.
171. Moridani M.Y., Pourahmad J., Bui H., Siraki A., O'Brien P.J. Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers. Free Radical Biology and Medicine 2003, 34:243-253.
172. Moriya J., Chen R., Yamakawa J., Sasaki K., Ishigaki Y., Takahashi T. Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells. Biological and Pharmaceutical Bulletin 2011, 34:354-359.
173. Moskaug J.O., Carlsen H., Myhrstad M.C., Blomhoff R. Polyphenols and glutathione synthesis regulation. American Journal of Clinical Nutrition 2005, 81:277S-283S.
174. Mostoslavsky R., Chua K.F., Lombard D.B., Pang W.W., Fischer M.R., Gellon L., Liu P., Mostoslavsky G., Franco S., Murphy M.M., Mills K.D., Patel P., Hsu J.T., Hong A.L., Ford E., Cheng H.L., Kennedy C., Nunez N., Bronson R., Frendewey D., Auerbach W., Valenzuela D., Karow M., Hottiger M.O., Hursting S., Barrett J.C., Guarente L., Mulligan R., Demple B., Yancopoulos G.D., Alt F.W. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006, 124:315-329.
175. Mouchiroud L., Molin L., Dalliere N., Solari F. Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging. Biofactors 2010, 36:377-382.
176. Mrak R.E., Griffin W.S. Potential inflammatory biomarkers in Alzheimer's disease. Journal of Alzheimer's Disease 2005, 8:369-375.
177. Mukherjee S., Lekli I., Gurusamy N., Bertelli A.A., Das D.K. Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. Free Radical Biology and Medicine 2009, 46:573-578.
178. Mukhopadhyay P., Mukherjee S., Ahsan K., Bagchi A., Pacher P., Das D.K. Restoration of altered microRNA expression in the ischemic heart with resveratrol. PLoS One 2010, 5:e15705.
179. Munch G., Keis R., Wessels A., Riederer P., Bahner U., Heidland A., Niwa T., Lemke H.D., Schinzel R. Determination of advanced glycation end products in serum by fluorescence spectroscopy and competitive ELISA. European Journal of Clinical Chemistry and Clinical Biochemistry: Journal of the Forum of European Clinical Chemistry Societies 1997, 35:669-677.
180. Nakagawa T., Lomb D.J., Haigis M.C., Guarente L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 2009, 137:560-570.
181. Nakamura Y., Ogura M., Ogura K., Tanaka D., Inagaki N. SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice. FEBS Letters 2012, 586:4076-4081.
182. Narala S.R., Allsopp R.C., Wells T.B., Zhang G., Prasad P., Coussens M.J., Rossi D.J., Weissman I.L., Vaziri H. SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity. Molecular Biology of the Cell 2008, 19:1210-1219.
183. Narita K., Hisamoto M., Okuda T., Takeda S. Differential neuroprotective activity of two different grape seed extracts. PLoS One 2011, 6:e14575.
184. Nasrin N., Wu X., Fortier E., Feng Y., Bare O.C., Chen S., Ren X., Wu Z., Streeper R.S., Bordone L. SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells. Journal of Biological Chemistry 2010, 285:31995-32002.
185. Nerurkar P.V., Johns L.M., Buesa L.M., Kipyakwai G., Volper E., Sato R., Shah P., Feher D., Williams P.G., Nerurkar V.R. Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. Journal of Neuroinflammation 2011, 8:64.
186. Nunomura A., Perry G., Aliev G., Hirai K., Takeda A., Balraj E.K., Jones P.K., Ghanbari H., Wataya T., Shimohama S., Chiba S., Atwood C.S., Petersen R.B., Smith M.A. Oxidative damage is the earliest event in Alzheimer disease. Journal of Neuropathology and Experimental Neurology 2001, 60:759-767.
187. Obregon D.F., Rezai-Zadeh K., Bai Y., Sun N., Hou H., Ehrhart J., Zeng J., Mori T., Arendash G.W., Shytle D., Town T., Tan J. ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein. Journal of Biological Chemistry 2006, 281:16419-16427.
188. Ogura M., Nakamura Y., Tanaka D., Zhuang X., Fujita Y., Obara A., Hamasaki A., Hosokawa M., Inagaki N. Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1. Biochemical and Biophysical Research Communications 2010, 393:73-78.
189. Oliva J., French B.A., Li J., Bardag-Gorce F., Fu P., French S.W. Sirt1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol. Experimental and Molecular Pathology 2008, 85:155-159.
190. Omodei D., Fontana L. Calorie restriction and prevention of age-associated chronic disease. FEBS Letters 2011, 585:1537-1542.
191. Ono K., Yoshiike Y., Takashima A., Hasegawa K., Naiki H., Yamada M. Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease. Journal of Neurochemistry 2003, 87:172-181.
192. Ono K., Hasegawa K., Naiki H., Yamada M. Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro. Biochimica et Biophysica Acta 2004, 1690:193-202.
193. Ornish D., Lin J., Daubenmier J., Weidner G., Epel E., Kemp C., Magbanua M.J., Marlin R., Yglecias L., Carroll P.R., Blackburn E.H. Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncology 2008, 9:1048-1057.
194. Outeiro T.F., Kontopoulos E., Altmann S.M., Kufareva I., Strathearn K.E., Amore A.M., Volk C.B., Maxwell M.M., Rochet J.C., McLean P.J., Young A.B., Abagyan R., Feany M.B., Hyman B.T., Kazantsev A.G. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 2007, 317:516-519.
195. Pacholec M., Bleasdale J.E., Chrunyk B., Cunningham D., Flynn D., Garofalo R.S., Griffith D., Griffor M., Loulakis P., Pabst B., Qiu X., Stockman B., Thanabal V., Varghese A., Ward J., Withka J., Ahn K. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. Journal of Biological Chemistry 2010, 285:8340-8351.
196. Palacios J.A., Herranz D., De Bonis M.L., Velasco S., Serrano M., Blasco M.A. SIRT1 contributes to telomere maintenance and augments global homologous recombination. Journal of Cell Biology 2010, 191:1299-1313.
197. Panickar K.S., Anderson R.A. Effect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemia. International Journal of Molecular Sciences 2011, 12:8181-8207.
198. Panossian L.A., Porter V.R., Valenzuela H.F., Zhu X., Reback E., Masterman D., Cummings J.L., Effros R.B. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiology of Aging 2003, 24:77-84.
199. Parachikova A., Green K.N., Hendrix C., LaFerla F.M. Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease. PLoS One 2010, 5:e14015.
200. Parihar M.S., Brewer G.J. Mitoenergetic failure in Alzheimer disease. American Journal of Physiology: Cell Physiology 2007, 292:C8-C23.
201. Partridge L., Piper M.D., Mair W. Dietary restriction in Drosophila. Mechanisms of Ageing and Development 2005, 126:938-950.
202. Patel N.V., Gordon M.N., Connor K.E., Good R.A., Engelman R.W., Mason J., Morgan D.G., Morgan T.E., Finch C.E. Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models. Neurobiology of Aging 2005, 26:995-1000.
203. Patil C.S., Singh V.P., Satyanarayan P.S., Jain N.K., Singh A., Kulkarni S.K. Protective effect of flavonoids against aging- and lipopolysaccharide-induced cognitive impairment in mice. Pharmacology 2003, 69:59-67.
204. Pearson K.J., Baur J.A., Lewis K.N., Peshkin L., Price N.L., Labinskyy N., Swindell W.R., Kamara D., Minor R.K., Perez E., Jamieson H.A., Zhang Y., Dunn S.R., Sharma K., Pleshko N., Woollett L.A., Csiszar A., Ikeno Y., Le Couteur D., Elliott P.J., Becker K.G., Navas P., Ingram D.K., Wolf N.S., Ungvari Z., Sinclair D.A., de Cabo R. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metabolism 2008, 8:157-168.
205. Pedrielli P., Skibsted L.H. Antioxidant synergy and regeneration effect of quercetin, (-)-epicatechin, and (+)-catechin on alpha-tocopherol in homogeneous solutions of peroxidating methyl linoleate. Journal of Agricultural and Food Chemistry 2002, 50:7138-7144.
206. Pellegrini N., Simonetti P., Gardana C., Brenna O., Brighenti F., Pietta P. Polyphenol content and total antioxidant activity of vini novelli (young red wines). Journal of Agricultural and Food Chemistry 2000, 48:732-735.
207. Penalvo J.L., Haajanen K.M., Botting N., Adlercreutz H. Quantification of lignans in food using isotope dilution gas chromatography/mass spectrometry. Journal of Agricultural and Food Chemistry 2005, 53:9342-9347.
208. Peng X., Ma J., Chao J., Sun Z., Chang R.C., Tse I., Li E.T., Chen F., Wang M. Beneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption. Journal of Agricultural and Food Chemistry 2010, 58:6692-6696.
209. Peng C., Chan H.Y., Huang Y., Yu H., Chen Z.Y. Apple polyphenols extend the mean lifespan of Drosophila melanogaster. Journal of Agricultural and Food Chemistry 2011, 59:2097-2106.
210. Perez-Jimenez J., Neveu V., Vos F., Scalbert A. Systematic analysis of the content of 502 polyphenols in 452 foods and beverages: an application of the phenol-explorer database. Journal of Agricultural and Food Chemistry 2010, 58:4959-4969.
211. Peterson D.W., George R.C., Scaramozzino F., LaPointe N.E., Anderson R.A., Graves D.J., Lew J. Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro. Journal of Alzheimer's Disease 2009, 17:585-597.
212. Pietsch K., Saul N., Menzel R., Sturzenbaum S.R., Steinberg C.E. Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43. Biogerontology 2009, 10:565-578.
213. Porquet D., Casadesus G., Bayod S., Vicente A., Canudas A.M., Vilaplana J., Pelegri C., Sanfeliu C., Camins A., Pallas M., Del Valle J. Dietary resveratrol prevents Alzheimer's markers and increases life span in SAMP8. Age 2012.
214. Qin W., Chachich M., Lane M., Roth G., Bryant M., de Cabo R., Ottinger M.A., Mattison J., Ingram D., Gandy S., Pasinetti G.M. Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). Journal of Alzheimer's Disease 2006, 10:417-422.
215. Qin W., Yang T., Ho L., Zhao Z., Wang J., Chen L., Zhao W., Thiyagarajan M., MacGrogan D., Rodgers J.T., Puigserver P., Sadoshima J., Deng H., Pedrini S., Gandy S., Sauve A.A., Pasinetti G.M. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. Journal of Biological Chemistry 2006, 281:21745-21754.
216. Qin W., Zhao W., Ho L., Wang J., Walsh K., Gandy S., Pasinetti G.M. Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration. Annals of the New York Academy of Sciences 2008, 1147:335-347.
217. Qiu X., Brown K., Hirschey M.D., Verdin E., Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metabolism 2010, 12:662-667.
218. Quideau S. Plant "polyphenolic" small molecules can induce a calorie restriction-mimetic life-span extension by activating sirtuins: will "polyphenols" someday be used as chemotherapeutic drugs in Western medicine?. Chembiochem 2004, 5:427-430.
219. Ramadori G., Fujikawa T., Anderson J., Berglund E.D., Frazao R., Michan S., Vianna C.R., Sinclair D.A., Elias C.F., Coppari R. SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. Cell Metabolism 2011, 14:301-312.
220. Rasbach K.A., Schnellmann R.G. Isoflavones promote mitochondrial biogenesis. Journal of Pharmacology and Experimental Therapeutics 2008, 325:536-543.
221. Rayalam S., Yang J.Y., Ambati S., Della-Fera M.A., Baile C.A. Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes. Phytotherapy Research 2008, 22:1367-1371.
222. Reiter R.J. Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB Journal 1995, 9:526-533.
223. Reynolds A., Laurie C., Mosley R.L., Gendelman H.E. Oxidative stress and the pathogenesis of neurodegenerative disorders. International Review of Neurobiology 2007, 82:297-325.
224. Rezai-Zadeh K., Shytle D., Sun N., Mori T., Hou H., Jeanniton D., Ehrhart J., Townsend K., Zeng J., Morgan D., Hardy J., Town T., Tan J. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. Journal of Neuroscience 2005, 25:8807-8814.
225. Rezai-Zadeh K., Arendash G.W., Hou H., Fernandez F., Jensen M., Runfeldt M., Shytle R.D., Tan J. Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain Research 2008, 1214:177-187.
226. Rezai-Zadeh K., Douglas Shytle R., Bai Y., Tian J., Hou H., Mori T., Zeng J., Obregon D., Town T., Tan J. Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. Journal of Cellular and Molecular Medicine 2009, 13:574-588.
227. Richards J.B., Valdes A.M., Gardner J.P., Paximadas D., Kimura M., Nessa A., Lu X., Surdulescu G.L., Swaminathan R., Spector T.D., Aviv A. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. American Journal of Clinical Nutrition 2007, 86:1420-1425.
228. Richards J.B., Valdes A.M., Gardner J.P., Kato B.S., Siva A., Kimura M., Lu X., Brown M.J., Aviv A., Spector T.D. Homocysteine levels and leukocyte telomere length. Atherosclerosis 2008, 200:271-277.
229. Robak J., Gryglewski R.J. Flavonoids are scavengers of superoxide anions. Biochemical Pharmacology 1988, 37:837-841.
230. Roberts B.R., Ryan T.M., Bush A.I., Masters C.L., Duce J.A. The role of metallobiology and amyloid-beta peptides in Alzheimer's disease. Journal of Neurochemistry 2012, 120(Suppl. 1):149-166.
231. Rogina B., Helfand S.L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:15998-16003.
232. Rojanathammanee L., Puig K.L., Combs C.K. Pomegranate polyphenols and extract inhibit nuclear factor of activated T-cell activity and microglial activation in vitro and in a transgenic mouse model of Alzheimer disease. Journal of Nutrition 2013, 143:597-605.
233. Romano A.D., Serviddio G., de Matthaeis A., Bellanti F., Vendemiale G. Oxidative stress and aging. Journal of Nephrology 2010, 23(Suppl. 15):S29-S36.
234. Rose G., Dato S., Altomare K., Bellizzi D., Garasto S., Greco V., Passarino G., Feraco E., Mari V., Barbi C., BonaFe M., Franceschi C., Tan Q., Boiko S., Yashin A.I., De Benedictis G. Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Experimental Gerontology 2003, 38:1065-1070.
235. Roth A., Schaffner W., Hertel C. Phytoestrogen kaempferol (3,4',5,7-tetrahydroxyflavone) protects PC12 and T47D cells from beta-amyloid-induced toxicity. Journal of Neuroscience Research 1999, 57:399-404.
236. Sahni J.K., Doggui S., Ali J., Baboota S., Dao L., Ramassamy C. Neurotherapeutic applications of nanoparticles in Alzheimer's disease. Journal of Controlled Release 2011, 152:208-231.
237. Salah N., Miller N.J., Paganga G., Tijburg L., Bolwell G.P., Rice-Evans C. Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants. Archives of Biochemistry and Biophysics 1995, 322:339-346.
238. Sanbongi C., Suzuki N., Sakane T. Polyphenols in chocolate, which have antioxidant activity, modulate immune functions in humans in vitro. Cellular Immunology 1997, 177:129-136.
239. Santa-Maria I., Diaz-Ruiz C., Ksiezak-Reding H., Chen A., Ho L., Wang J., Pasinetti G.M. GSPE interferes with tau aggregation in vivo: implication for treating tauopathy. Neurobiology of Aging 2012, 33:2072-2081.
240. Santangelo C., Vari R., Scazzocchio B., Di Benedetto R., Filesi C., Masella R. Polyphenols, intracellular signalling and inflammation. Annali dell Istituto Superiore di Sanita 2007, 43:394-405.
241. Sasaki N., Fukatsu R., Tsuzuki K., Hayashi Y., Yoshida T., Fujii N., Koike T., Wakayama I., Yanagihara R., Garruto R., Amano N., Makita Z. Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases. American Journal of Pathology 1998, 153:1149-1155.
242. Saul N., Pietsch K., Menzel R., Sturzenbaum S.R., Steinberg C.E. Catechin induced longevity in C. elegans: from key regulator genes to disposable soma. Mechanisms of Ageing and Development 2009, 130:477-486.
243. Scheepens A., Tan K., Paxton J.W. Improving the oral bioavailability of beneficial polyphenols through designed synergies. Genes & Nutrition 2010, 5:75-87.
244. Schirmer H., Pereira T.C., Rico E.P., Rosemberg D.B., Bonan C.D., Bogo M.R., Souto A.A. Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4, PGC1alpha and NAMPT gene expression profiles in wild-type adult zebrafish liver. Molecular Biology Reports 2012, 39:3281-3289.
245. Schulz T.J., Zarse K., Voigt A., Urban N., Birringer M., Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metabolism 2007, 6:280-293.
246. Schwer B., Schumacher B., Lombard D.B., Xiao C., Kurtev M.V., Gao J., Schneider J.I., Chai H., Bronson R.T., Tsai L.H., Deng C.X., Alt F.W. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:21790-21794.
247. Selkoe D.J. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends in Cell Biology 1998, 8:447-453.
248. Shan B., Cai Y.Z., Sun M., Corke H. Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents. Journal of Agricultural and Food Chemistry 2005, 53:7749-7759.
249. Sheng R., Gu Z.L., Xie M.L. Epigallocatechin gallate, the major component of polyphenols in green tea, inhibits telomere attrition mediated cardiomyocyte apoptosis in cardiac hypertrophy. International Journal of Cardiology 2011.
250. Shimmyo Y., Kihara T., Akaike A., Niidome T., Sugimoto H. Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features. Biochimica et Biophysica Acta 2008, 1780:819-825.
251. Smith M.A., Perry G., Richey P.L., Sayre L.M., Anderson V.E., Beal M.F., Kowall N. Oxidative damage in Alzheimer's. Nature 1996, 382:120-121.
252. Smith M.A., Harris P.L., Sayre L.M., Perry G. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:9866-9868.
253. Smith M.A., Richey Harris P.L., Sayre L.M., Beckman J.S., Perry G. Widespread peroxynitrite-mediated damage in Alzheimer's disease. Journal of Neuroscience 1997, 17:2653-2657.
254. Smith M.A., Rottkamp C.A., Nunomura A., Raina A.K., Perry G. Oxidative stress in Alzheimer's disease. Biochimica et Biophysica Acta 2000, 1502:139-144.
255. Smith A., Giunta B., Bickford P.C., Fountain M., Tan J., Shytle R.D. Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease. International Journal of Pharmaceutics 2010, 389:207-212.
256. Smith A.J., Kavuru P., Wojtas L., Zaworotko M.J., Shytle R.D. Cocrystals of quercetin with improved solubility and oral bioavailability. Molecular Pharmaceutics 2011, 8:1867-1876.
257. Someya S., Yu W., Hallows W.C., Xu J., Vann J.M., Leeuwenburgh C., Tanokura M., Denu J.M., Prolla T.A. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 2010, 143:802-812.
258. Souto E.B., Severino P., Basso R., Santana M.H. Encapsulation of antioxidants in gastrointestinal-resistant nanoparticulate carriers. Methods in Molecular Biology 2013, 1028:37-46.
259. Spires-Jones T.L., Fox L.M., Rozkalne A., Pitstick R., Carlson G.A., Kazantsev A.G. Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia. Frontiers in Pharmacology 2012, 3:42.
260. Sulaiman S.F., Ooi K.L. Polyphenolic and Vitamin C Contents and Antioxidant Activities of Aqueous Extracts from Mature-Green and Ripe Fruit Fleshes of Mangifera sp. Journal of Agricultural and Food Chemistry 2012, 60:11832-11838.
261. Sunagawa T., Shimizu T., Kanda T., Tagashira M., Sami M., Shirasawa T. Procyanidins from apples (Malus pumila Mill.) extend the lifespan of Caenorhabditis elegans. Planta Medica 2011, 77:122-127.
262. Suzuki K., Koike T. Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation. Neuroscience 2007, 147:599-612.
263. Suzuki K., Koike T. Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (WldS) mice: activation of SIRT2, an NAD-dependent tubulin deacetylase. Biochemical and Biophysical Research Communications 2007, 359:665-671.
264. Takubo K., Aida J., Izumiyama-Shimomura N., Ishikawa N., Sawabe M., Kurabayashi R., Shiraishi H., Arai T., Nakamura K. Changes of telomere length with aging. Geriatrics & Gerontology International 2010, 10(Suppl. 1):S197-S206.
265. Taylor D.M., Balabadra U., Xiang Z., Woodman B., Meade S., Amore A., Maxwell M.M., Reeves S., Bates G.P., Luthi-Carter R., Lowden P.A., Kazantsev A.G. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chemical Biology 2011, 6:540-546.
266. Thomas P., Wang Y.J., Zhong J.H., Kosaraju S., O'Callaghan N.J., Zhou X.F., Fenech M. Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease. Mutation Research 2009, 661:25-34.
267. Thornton E., Vink R., Blumbergs P.C., Van Den Heuvel C. Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats. Brain Research 2006, 1094:38-46.
268. Tissenbaum H.A., Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001, 410:227-230.
269. Tohda C., Tamura T., Matsuyama S., Komatsu K. Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus. British Journal of Pharmacology 2006, 149:532-541.
270. Truelsen T., Thudium D., Gronbaek M. Amount and type of alcohol and risk of dementia: the Copenhagen City Heart Study. Neurology 2002, 59:1313-1319.
271. Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients 2010, 2:1231-1246.
272. Uchiumi F., Watanabe T., Hasegawa S., Hoshi T., Higami Y., Tanuma S. The effect of resveratrol on the Werner syndrome RecQ helicase gene and telomerase activity. Current Aging Science 2011, 4:1-7.
273. Unno K., Takabayashi F., Yoshida H., Choba D., Fukutomi R., Kikunaga N., Kishido T., Oku N., Hoshino M. Daily consumption of green tea catechin delays memory regression in aged mice. Biogerontology 2007, 8:89-95.
274. Vakhrusheva O., Braeuer D., Liu Z., Braun T., Bober E. Sirt7-dependent inhibition of cell growth and proliferation might be instrumental to mediate tissue integrity during aging. Journal of Physiology and Pharmacology 2008, 59(Suppl. 9):201-212.
275. Vakhrusheva O., Smolka C., Gajawada P., Kostin S., Boettger T., Kubin T., Braun T., Bober E. Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circulation Research 2008, 102:703-710.
276. Valenzano D.R., Terzibasi E., Genade T., Cattaneo A., Domenici L., Cellerino A. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Current Biology: CB 2006, 16:296-300.
277. Veerendra Kumar M.H., Gupta Y.K. Effect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer's disease in rats. Clinical and Experimental Pharmacology and Physiology 2003, 30:336-342.
278. Vepsalainen S., Koivisto H., Pekkarinen E., Makinen P., Dobson G., McDougall G.J., Stewart D., Haapasalo A., Karjalainen R.O., Tanila H., Hiltunen M. Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease. Journal of Nutrition Biochemistry 2013, 24:360-370.
279. Vitrac X., Bornet A., Vanderlinde R., Valls J., Richard T., Delaunay J.C., Merillon J.M., Teissedre P.L. Determination of stilbenes (delta-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, epsilon-viniferin) in Brazilian wines. Journal of Agricultural and Food Chemistry 2005, 53:5664-5669.
280. Vrhovsek U., Rigo A., Tonon D., Mattivi F. Quantitation of polyphenols in different apple varieties. Journal of Agricultural and Food Chemistry 2004, 52:6532-6538.
281. Walker E.B. HPLC analysis of selected xanthones in mangosteen fruit. Journal of Separation Science 2007, 30:1229-1234.
282. Walsh D.M., Selkoe D.J. A beta oligomers - a decade of discovery. Journal of Neurochemistry 2007, 101:1172-1184.
283. Wang Q., Rowan M.J., Anwyl R. Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide. Journal of Neuroscience 2004, 24:6049-6056.
284. Wang F., Nguyen M., Qin F.X., Tong Q. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 2007, 6:505-514.
285. Wang J., Santa-Maria I., Ho L., Ksiezak-Reding H., Ono K., Teplow D.B., Pasinetti G.M. Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease 2010, 22:653-661.
286. Wang P., Zhang Z., Sun Y., Liu X., Tong T. The two isomers of HDTIC compounds from Astragali Radix slow down telomere shortening rate via attenuating oxidative stress and increasing DNA repair ability in human fetal lung diploid fibroblast cells. DNA and Cell Biology 2010, 29:33-39.
287. Wang H., Yang Y.J., Qian H.Y., Zhang Q., Xu H., Li J.J. Resveratrol in cardiovascular disease: what is known from current research?. Heart Failure Reviews 2012, 17:437-448.
288. Weir H.J., Murray T.K., Kehoe P.G., Love S., Verdin E.M., O'Neill M.J., Lane J.D., Balthasar N. CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease. PLoS One 2012, 7:e48225.
289. Wilson M.A., Shukitt-Hale B., Kalt W., Ingram D.K., Joseph J.A., Wolkow C.A. Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 2006, 5:59-68.
290. Witte A.V., Fobker M., Gellner R., Knecht S., Floel A. Caloric restriction improves memory in elderly humans. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:1255-1260.
291. Wood J.G., Rogina B., Lavu S., Howitz K., Helfand S.L., Tatar M., Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 2004, 430:686-689.
292. Wu Z.Q., Guo Q.L., You Q.D., Zhao L., Gu H.Y. Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells. Biological and Pharmaceutical Bulletin 2004, 27:1769-1774.
293. Wu A., Ying Z., Gomez-Pinilla F. Oxidative stress modulates Sir2alpha in rat hippocampus and cerebral cortex. European Journal of Neuroscience 2006, 23:2573-2580.
294. Xiang L., Sun K., Lu J., Weng Y., Taoka A., Sakagami Y., Qi J. Anti-aging effects of phloridzin, an apple polyphenol, on yeast via the SOD and Sir2 genes. Bioscience, Biotechnology, and Biochemistry 2011, 75:854-858.
295. Xie B., Shi H., Chen Q., Ho C.T. Antioxidant properties of fractions and polyphenol constituents from green, oolong and black teas. Proceedings of the National Science Council, Republic of China. Part B, Life sciences 1993, 17:77-84.
296. Xu Q., Parks C.G., DeRoo L.A., Cawthon R.M., Sandler D.P., Chen H. Multivitamin use and telomere length in women. American Journal of Clinical Nutrition 2009, 89:1857-1863.
297. Xu J., Rong S., Xie B., Sun Z., Deng Q., Bao W., Wang D., Yao P., Huang F., Liu L. Changes in the nitric oxide system contribute to effect of procyanidins extracted from the lotus seedpod ameliorating memory impairment in cognitively impaired aged rats. Rejuvenation Research 2011, 14:33-43.
298. Yamamoto A., Shin R.W., Hasegawa K., Naiki H., Sato H., Yoshimasu F., Kitamoto T. Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease. Journal of Neurochemistry 2002, 82:1137-1147.
299. Yamamoto H., Schoonjans K., Auwerx J. Sirtuin functions in health and disease. Molecular Endocrinology 2007, 21:1745-1755.
300. Yang H., Jin G.-F., Ren D.-D., Luo S.-J., Zhou T.-H. Neuro-protective Mechanism of Isoflavones on Senescence-accelerated Mice. Chinese Journal of Natural Medicines 2010, 8:280-284.
301. Yang Y.C., Lii C.K., Lin A.H., Yeh Y.W., Yao H.T., Li C.C., Liu K.L., Chen H.W. Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress. Free Radical Biology and Medicine 2011, 51:2073-2081.
302. Yao J., Gao X., Sun W., Yao T., Shi S., Ji L. Molecular hairpin: a possible model for inhibition of tau aggregation by tannic acid. Biochemistry 2013, 52:1893-1902.
303. Yeung F., Hoberg J.E., Ramsey C.S., Keller M.D., Jones D.R., Frye R.A., Mayo M.W. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO Journal 2004, 23:2369-2380.
304. Yokozawa T., Lee Y.A., Zhao Q., Matsumoto K., Cho E.J. Persimmon oligomeric proanthocyanidins extend life span of senescence-accelerated mice. Journal of Medicinal Food 2009, 12:1199-1205.
305. Yokozawa T., Lee Y.A., Cho E.J., Matsumoto K., Park C.H., Shibahara N. Anti-aging effects of oligomeric proanthocyanidins isolated from persimmon fruits. Drug discoveries & therapeutics 2011, 5:109-118.
306. Yu W., Fu Y.C., Zhou X.H., Chen C.J., Wang X., Lin R.B., Wang W. Effects of resveratrol on H(2)O(2)-induced apoptosis and expression of SIRTs in H9c2 cells. Journal of Cellular Biochemistry 2009, 107:741-747.
307. Zhang L., Jie G., Zhang J., Zhao B. Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress. Free Radical Biology and Medicine 2009, 46:414-421.
308. Zhang C., Browne A., Child D., Tanzi R.E. Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. Journal of Biological Chemistry 2010, 285:28472-28480.