Inhibition of sirtuin 2 with sulfobenzoic acid derivative AK1 is non-toxic and potentially neuroprotective in a mouse model of frontotemporal dementia

Frontiers in Pharmacology

Volumn 3 MAR, Issue , 2012, Pages

  Spires Jones, Tara L ^a   Fox, Leora M ^a,c   Rozkalne, Anete ^a   Pitstick, Rose ^b   Carlson, George A ^b   Kazantsev, Aleksey G ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MCLAUGHLIN RESEARCH INSTITUTE   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Alzheimer; Frontotemporal dementia; Neuroprotection; Sirtuin; Tauopathy

Indexed keywords

3 (1 AZEPANYLSULFONYL) N (3 NITROPHENYL)BENZAMIDE; ABC TRANSPORTER A1; AK 1; HYDROLASE INHIBITOR; NEUROPROTECTIVE AGENT; SIRTUIN 2; TAU PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; DISEASE MODEL; DRUG ACTIVITY; DRUG SAFETY; EMBRYO; ENZYME INHIBITION; FEMALE; FRONTOTEMPORAL DEMENTIA; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OSMOTIC MINIPUMP; PROTEIN EXPRESSION; UPREGULATION; WILD TYPE;

EID: 84865987956     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2012.00042     Document Type: Article

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