Effects of the dietary flavonoid quercetin upon performance and health

Current Sports Medicine Reports

Volumn 8, Issue 4, 2009, Pages 206-213

  Davis, J Mark ^a   Murphy, E Angela ^a   Carmichael, Martin D ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGLYCONE; FLAVONOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PLACEBO; QUERCETIN; REACTIVE OXYGEN METABOLITE; SIRTUIN 1;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; ATHLETE; CANCER PREVENTION; CARDIOVASCULAR DISEASE; DEGENERATIVE DISEASE; DIABETES MELLITUS; DIET SUPPLEMENTATION; ENDURANCE; EPILEPSY; GENE EXPRESSION; HEALTH PROMOTION; HEART PROTECTION; HUMAN; IMMUNE SYSTEM; INFECTION; INGESTION; INSULIN RESISTANCE; NEOPLASM; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PARKINSON DISEASE; PHYSICAL PERFORMANCE; REVIEW; SPORT; STRESS; STROKE; ATHLETIC PERFORMANCE; EVIDENCE BASED MEDICINE; FITNESS; PHYSIOLOGY;

ATHLETIC PERFORMANCE; DIETARY SUPPLEMENTS; EVIDENCE-BASED MEDICINE; HUMANS; PHYSICAL FITNESS; QUERCETIN;

EID: 70349234008     PISSN: 1537890X     EISSN: 15378918     Source Type: Journal    
DOI: 10.1249/JSR.0b013e3181ae8959     Document Type: Review

References (56)

1. Alexander SP. Flavonoids as antagonists at A1 adenosine receptors. Phytother. Res. 2006; 20:1009-12.
2. Alvarez P, Alvarado C, Puerto M, et al. Improvement of leukocyte functions in prematurely aging mice after five weeks of diet supplementation with polyphenol-rich cereals. Nutrition. 2006; 22:913-21.
3. Angeloni C, Spencer JP, Leoncini E, et al. Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress. Biochimie. 2007; 89:73-82.
4. Ansari MA, Abdul HM, Joshi G, et al. Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease. J. Nutr. Biochem. 2008.
5. Booyse FM, Pan W, Grenett HE, et al. Mechanism by which alcohol and wine polyphenols affect coronary heart disease risk. Ann. Epidemiol. 2007; 17:S24-31.
6. Chen L, Li J, Luo C, et al. Binding interaction of quercetin-3- betagalactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features. Bioorganic Medicinal Chemistry. 2006; 14:8295-306.
7. Cheuvront SN, Ely BR, Kenefick RW, et al. No effect of nutritional adenosine receptor antagonists on exercise performance in the heat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009; 296:R394-401.
8. Chiang LC, Chiang W, Liu MC, Lin CC. In vitro antiviral activities of Caesalpinia pulcherrima and its related flavonoids. J. Antimicrob. Chemother. 2003; 52:194-8.
9. Cogolludo A, Frazziano G, Briones AM, et al. The dietary flavonoid quercetin activates BKCa currents in coronary arteries via production of H2O2. Role in vasodilatation. Cardiovasc. Res. 2007; 73:424-31.
10. Cohen HY, Miller C, Bitterman KJ, et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004; 305:390-2.
11. Cushnie TP, Lamb AJ. Antimicrobial activity of flavonoids. Int. J. Antimicrob. Agents. 2005; 26:343-56.
12. Davis JM CC, Chen S, Carmichael MD, Murphy EA. The dietary flavonoid quercetin increases VO2max and endurance capacity. Int. J. Sport Nutr. Exerc. Metab. 2009 (in press).
13. Davis JM, Murphy EA, Carmichael MD, Davis B. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009; 296:R1071-7.
14. Davis JM, Murphy EA, McClellan JL, et al. Quercetin reduces susceptibility to influenza infection following stressful exercise. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008; 295:R505-9.
15. Davis JM, Zhao Z, Stock HS, et al. Central nervous system effects of caffeine and adenosine on fatigue. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003; 284:R399-404.
16. De Boer VC, Dihal AA, van der Woude H, et al. Tissue distribution of quercetin in rats and pigs. J. Nutr. 2005; 135:1718-25.
17. Debiaggi M, Tateo F, Pagani L, et al. Effects of propolis flavonoids on virus infectivity and replication. Microbiologica. 1990; 13:207-13.
18. Deschner EE, Ruperto J, Wong G, Newmark HL. Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis. 1991; 12:1193-6.
19. Dietrich-Muszalska A, Olas B. Inhibitory effects of polyphenol compounds on lipid peroxidation caused by antipsychotics (haloperidol and amisulpride) in human plasma in vitro. World J. Biol. Psychiatry. 2009; Feb 19:1-6 [Epub ahead of print].
20. Eckert A, Hauptmann S, Scherping I, et al. Oligomeric and fibrillar species of beta-amyloid (Abeta42) both impair mitochondrial function in P301L tau transgenic mice. J. Mol. Med. 2008; 86:1255-67.
21. Edwards RL, Lyon T, Litwin SE, et al. Quercetin reduces blood pressure in hypertensive subjects. J. Nutr. 2007; 137:2405-11.
22. Egert S, Wolffram S, Bosy-Westphal A, et al. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J. Nutr. 2008; 138:1615-21.
23. Granado-Serrano AB, Martin MA, Bravo L, et al. Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). J. Nutr. 2006; 136:2715-21.
24. Harwood M, Danielewska-Nikiel B, Borzelleca JF, et al. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem. Toxicol. 2007; 45:2179-205.
25. Henson D, Nieman D, Davis JM, et al. Post-160-km race illness rates and decreases in granulocyte respiratory burst and salivary IgA output are not countered by quercetin ingestion. Int. J. Sports Med. 2008; 29:856-63.
26. Heo HJ, Lee CY. Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration. J. Agric. Food Chem. 2004; 52:7514-7.
27. Katula KS, McCain JA, Radewicz AT. Relative ability of dietary compounds to modulate nuclear factor-kappaB activity as assessed in a cell-based reporter system. J. Med. Food. 2005; 8:269-74.
28. Kaul TN, Middleton E, Ogra PL. Antiviral effect of flavonoids on human viruses. J. Med. Virol. 1985; 15:71-9.
29. Kaur G, Rao LV, Agrawal A, Pendurthi UR. Effect of wine phenolics on cytokine-induced C-reactive protein expression. J. Thromb. Haemost. 2007; 5:1309-17.
30. Khanduja KL, Gandhi RK, Pathania V, Syal N. Prevention of Nnitrosodiethylamine- induced lung tumorigenesis by ellagic acid and quercetin in mice. Food Chem. Toxicol. 1999; 37:313-8.
31. Kim H, Park BS, Lee KG, et al. Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. J. Agric. Food Chem. 2005; 53:8537-41.
32. Knekt P, Kumpulainen J, Jarvinen R, et al. Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr. 2002; 76:560-8.
33. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006; 127:1109-22.
34. MacRae HS, Mefferd KM. Dietary antioxidant supplementation combined with quercetin improves cycling time trial performance. Int. J. Sport Nutr. Exerc. Metab. 2006; 16:405-19.
35. Mahmoud NN, Carothers AM, Grunberger D, et al. Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. Carcinogenesis. 2000; 21:921-7.
36. McAnulty SR, McAnulty LS, Nieman DC, et al. Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation. Appl. Physiol. Nutr. Metab. 2008; 33:254-62.
37. Nair MP, Kandaswami C, Mahajan S, et al. The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Biochimica Biophysica Acta. 2002; 1593:29-36.
38. Nieman DC. Immunonutrition support for athletes. Nutr. Rev. 2008; 66:310-20.
39. Nieman DC, Henson DA, Davis JM, et al. Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA. J. Appl. Physiol. 2007; 103:1728-35.
40. Nieman DC, Henson DA, Davis JM, et al. Quercetin ingestion does not alter cytokine changes in athletes competing in the Western States Endurance Run. J. Interferon Cytokine Res. 2007; 27:1003-1011
41. Nieman DC, Henson DA, Gross SJ, et al. Quercetin reduces illness but not immune perturbations after intensive exercise. Med. Sci. Sports Exerc. 2007; 39:1561-9.
42. Nuraliev Iu N, Avezov GA. [The efficacy of que rcetin in alloxan diabetes]. Eksp. Klin. Farmakol. 1992; 55:42-4.
43. O'Leary KA, de Pascual-Tereasa S, Needs PW, et al. Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutation Res. 2004; 551:245-54.
44. Quindry JC, McAnulty SR, Hudson MB, et al. Oral quercetin supplementation and blood oxidative capacity in response to ultramarathon competition. Int. J. Sport Nutr. Exerc. Metab. 2008; 18: 601-16.
45. Ranelletti FO, Maggiano N, Serra FG, et al. Quercetin inhibits p21- RAS expression in human colon cancer cell lines and in primary colorectal tumors. Int. J. Cancer. 2000; 85:438-45.
46. Rasbach K, Schnellmann RG. Isoflavones promote mitochondrial biogenesis. J. Pharmacol. Exp. Ther. 2008; 325:536-43.
47. Reid MB. Free radicals and muscle fatigue: of ROS, canaries, and the IOC. Free Radic. Biol. Med. 2008; 44:169-79.
48. Rivera L, Moron R, Sanchez M, et al. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity. 2008; 16:2081-7.
49. Sagara Y, Vanhnasy J, Maher P. Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation. J. Neurochem. 2004; 90:1144-55.
50. Sharma V, Mishra M, Ghosh S, et al. Modulation of interleukin- 1beta mediated inflammatory response in human astrocytes by flavonoids: implications in neuroprotection. Brain Res. Bull. 2007; 73: 55-63.
51. Snijman PW, Swanevelder S, Joubert E, et al. The antimutagenic activity of the major flavonoids of rooibos (Aspalathus linearis): some dose-response effects on mutagen activation-flavonoid interactions. Mutat. Res. 2007; 631:111-23.
52. Song Y, Manson JE, Buring JE, et al. Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis. J. Am. Coll. Nutr. 2005; 24:376-84.
53. Steerenberg PA, Garssen J, Dortant P, et al. Quercetin prevents UVinduced local immunosuppression, but does not affect UV-induced tumor growth in SKH-1 hairless mice. Photochem. Photobiol. 1997; 65:736-44.
54. Stewart LK, Wang Z, Ribnicky D, et al. Failure of dietary quercetin to alter the temporal progression of insulin resistance among tissues of C57BL/6J mice during the development of diet-induced obesity. Diabetologia. 2009; 52:514-23.
55. Utesch D, Feige K, Dasenbrock J, et al. Evaluation of the potential in vivo genotoxicity of quercetin. Mutat. Res. 2008; 654:38-44.
56. Vauzour D, Vafeiadou K, Rodriguez-Mateos A, et al. The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr. 2008; 3:115-26. Volume