Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1β-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes

Free Radical Biology and Medicine

Volumn 33, Issue 8, 2002, Pages 1097-1105

  Ahmed, Salahuddin ^a   Rahman, Ayesha ^b   Hasnain, Absarul ^b   Lalonde, Matthew ^b   Goldberg, Victor M ^a   Haqqi, Tariq M ^b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chondrocytes; COX 2; Free radicals; IL 1 ; iNOS; Nitric oxide; Osteoarthritis

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 1; LACTATE DEHYDROGENASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POLYPHENOL DERIVATIVE; POLYPHENOL EPIGALLOCATECHIN 3 GALLATE; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ARTICLE; CARTILAGE CELL; CATALYSIS; CELL PROTECTION; CELL STIMULATION; CHONDROLYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; TEA;

ANTIOXIDANTS; CATECHIN; CELLS, CULTURED; CHONDROCYTES; CYCLOOXYGENASE 2; DEPRESSION, CHEMICAL; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; HUMANS; INTERLEUKIN-1; ISOENZYMES; L-LACTATE DEHYDROGENASE; MEMBRANE PROTEINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OSTEOARTHRITIS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REACTIVE OXYGEN SPECIES; TEA;

EID: 0037108115     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)01004-3     Document Type: Article

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