Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress

Free Radical Biology and Medicine

Volumn 51, Issue 11, 2011, Pages 2073-2081

  Yang, Ya Chen ^a   Lii, Chong Kuei ^b   Lin, Ai Hsuan ^c   Yeh, Yu Wen ^b   Yao, Hsien Tsung ^b   Li, Chien Chun ^c   Liu, Kai Li ^c   Chen, Haw Wen ^b  

^a ASIA UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Butein; CCl 4; ERK; Free radicals; Glutamate cysteine ligase; Heme oxygenase 1; Nrf2; Phloretin; tBHP

Indexed keywords

BUTEIN; FLAVONOID; HEME OXYGENASE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 3; PHLORETIN; PROTOPORPHYRIN ZINC; TERT BUTYL HYDROPEROXIDE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GLUTATHIONE METABOLISM; LIVER CELL; LIVER TOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; UPREGULATION;

ANIMALS; CARBON TETRACHLORIDE; CELLS, CULTURED; CHALCONES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTATHIONE; HEME OXYGENASE (DECYCLIZING); HEPATOCYTES; MALE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHLORETIN; RATS; RATS, SPRAGUE-DAWLEY; TERT-BUTYLHYDROPEROXIDE;

ANIMALIA; RATTUS;

EID: 80255126225     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.09.007     Document Type: Article

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