Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease

Journal of Nutritional Biochemistry

Volumn 24, Issue 1, 2013, Pages 360-370

  Vepsäläinen, Saila ^a   Koivisto, Henna ^a   Pekkarinen, Elina ^a   Mäkinen, Petra ^a   Dobson, Gary ^b   McDougall, Gordon J ^b   Stewart, Derek ^b,c   Haapasalo, Annakaisa ^a   Karjalainen, Reijo O ^a   Tanila, Heikki ^a,d   Hiltunen, Mikko ^a,d  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b SCOTTISH CROP RESEARCH INSTITUTE   (United Kingdom)

^c HERIOT WATT UNIVERSITY   (United Kingdom)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Amyloid precursor protein; Anthocyanin; APdE9 mice; Apoptosis; Bilberry; Blackcurrant; Cell viability; Cognitive impairment; Flavonols

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTHOCYANIN; BILBERRY FRUIT EXTRACT; BLACK CURRANT EXTRACT; CASPASE 3; MENADIONE; MYRICETIN; PLANT EXTRACT; QUERCETIN; REACTIVE OXYGEN METABOLITE; STAUROSPORINE; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BEHAVIOR DISORDER; BILBERRY; BLACK CURRANT; BRAIN CORTEX; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOTOXICITY; DIETARY INTAKE; ENZYME ACTIVATION; FRUIT; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MALE; MOUSE; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; TRANSGENIC MOUSE; WORKING MEMORY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTHOCYANINS; BEHAVIOR, ANIMAL; BRAIN; CELL LINE; DISEASE MODELS, ANIMAL; FLAVONOIDS; HUMANS; MALE; MEMORY, SHORT-TERM; MICE; MICE, TRANSGENIC; PLANT EXTRACTS; PRESENILIN-1; QUERCETIN; REACTIVE OXYGEN SPECIES; RIBES; TAU PROTEINS; VACCINIUM MYRTILLUS; VITAMIN K 3;

MUS; VACCINIUM MYRTILLUS;

EID: 84870397190     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2012.07.006     Document Type: Article

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