Procyanidins from apples (Malus pumila Mill.) Extend the lifespan of caenorhabditis elegans

Planta Medica

Volumn 77, Issue 2, 2011, Pages 122-127

  Sunagawa, Tadahiro ^a   Shimizu, Takahiko ^b   Kanda, Tomomasa ^a   Tagashira, Motoyuki ^a   Sami, Manabu ^a   Shirasawa, Takuji ^b,c  

^a ASAHI BREWERIES LTD   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

Author keywords

ageing; Caenorhabditis elegans; lifespan; Malus pumila Mill.; polyphenol; procyanidin; Rosaceae

Indexed keywords

EPICATECHIN; PROCYANIDIN; RESVERATROL; SIRTUIN 2;

APPLE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; FOOD INTAKE; GROWTH; LIFESPAN; NONHUMAN; OXIDATIVE STRESS; WILD TYPE;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; LONGEVITY; MALUS; MUTATION; PROANTHOCYANIDINS; SIRTUINS; STILBENES; SUCCINATE DEHYDROGENASE; TEMPERATURE;

CAENORHABDITIS ELEGANS; MALUS PUMILA; MALUS X DOMESTICA; ROSACEAE;

EID: 78651476135     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1250204     Document Type: Article

References (34)

1. Ohnishi-Kameyama M, Yanagida A, Kanda T, Nagata T. Identification of catechin oligomers from apple (Malus pumila cv. Fuji) in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and fast-atom bombardment mass spectrometry. Rapid Commun Mass Spectrom 1997 11 31-36
2. Santos-Buelga C, Scalbert A. Proanthocyanidins and tannin-like compounds: nature, occurrence, dietary intake and effects on nutrition and health. J Sci Food Agric 2000 80 1094-1117
3. Shahat A A., Cos P, De Bruyne T, Apers S, Hammouda F M., Ismail S I., Azzam S, Claeys M, Goovaerts E, Pieters L, Vanden Berghe D, Vlietinck A J. Antiviral and antioxidant activity of flavonoids and proanthocyanidins from Crataegus sinaica. Planta Med 2002 68 539-541
4. van Beek T A. Chemical analysis of Ginkgo biloba leaves and extracts. J Chromatogr A 2002 967 21-55
5. Vennat B, Bos M A., Pourrat A, Bastide P. Procyanidins from tormentil: fractionation and study of the anti-radical activity towards superoxide anion. Biol Pharm Bull 1994 17 1613-1615
6. Pallenbach E, Scholz E, Knig M, Rimpler H. Proanthocyanidins from Quercus petraea Bark. Planta Med 1993 59 264-268
7. Leontowicz H, Gorinstein S, Lojek A, Leontowicz M, M, Soliva-Fortuny R, Park Y S., Jung S T., Trakhtenberg S, Martin-Belloso O. Comparative content of some bioactive compounds in apples, peaches and pears and their influence on lipids and antioxidant capacity in rats. J Nutr Biochem 2002 13 603-610
8. Akiyama H, Sato Y, Watanabe T, Nagaoka M H., Yoshioka Y, Shoji T, Kanda T, Yamada K, Totsuka M, Teshima R, Sawada J, Goda Y, Maitani T. Dietary unripe apple polyphenol inhibits the development of food allergies in murine models. FEBS Lett 2005 579 4485-4491
9. Hibasami H, Shoji T, Shibuya I, Higo K, Kanda T. Induction of apoptosis by three types of procyanidin isolated from apple (Rosaceae Malus pumila) in human stomach cancer KATO III cells. Int J Mol Med 2004 13 795-799
10. Miura T, Chiba M, Kasai K, Nozaka H, Nakamura T, Shoji T, Kanda T, Ohtake Y, Sato T. Apple procyanidins induce tumor cell apoptosis through mitochondrial pathway activation of caspase-3. Carcinogenesis 2008 29 585-593
11. Osada K, Funayama M, Fuchi S. Effects of dietary procyanidins and tea polyphenols on adipose tissue mass and fatty acid metabolism in rats on a high fat diet. J Oleo Sci 2006 55 79-89
12. Sugiyama H, Akazome Y, Shoji T, Yamaguchi A, Yasue M, Kanda T, Ohtake Y. Oligomeric procyanidins in apple polyphenol are main active components for inhibition of pancreatic lipase and triglyceride absorption. J Agric Food Chem 2007 55 4604-4609
13. Shoji T, Masumoto S, Moriichi N, Akiyama H, Kanda T, Ohtake Y, Goda Y. Apple procyanidin oligomers absorption in rats after oral administration: analysis of procyanidins in plasma using the porter method and high-performance liquid chromatography/tandem mass spectrometry. J Agric Food Chem 2006 54 884-892
14. Lakowski B, Hekimi S. The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci USA 1998 95 13091-13096
15. Harrington L A., Harley C B. Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegans. Mech Ageing Dev 1988 43 71-78
16. Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974 77 71-94
17. Emmons S W., Klass M R., Hirsh D. Analysis of the constancy of DNA sequences during development and evolution of the nematode Caenorhabditis elegans. Proc Natl Acad Sci USA 1979 76 1333-1337
18. Shoji T, Masumoto S, Moriichi N, Kanda T, Ohtake Y. Apple (Malus pumila) procyanidins fractionated according to the degree of polymerization using normal-phase chromatography and characterized by HPLC-ESI/MS and MALDI-TOF/MS. J Chromatogr A 2006 1102 206-213
19. Wood J G., Regina B, Lavu S, Hewitz K, Helfand S L., Tatar M, Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 2004 430 686-689
20. Bauer J H., Goupil S, Garber G B., Helfand S L. An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proc Natl Acad Sci USA 2004 101 12980-12985
21. Valenzano D R., Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol 2006 16 296-300
22. Wilson M A., Shukitt-Hale B, Kalt W, Ingram D K., Joseph J A., Wolkow C A. Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 2006 5 59-68
23. Shoji T, Masumoto S, Moriichi N, Kobori M, Kanda T, Shinmoto H, Tsushida T. Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells. J Agric Food Chem 2005 53 6105-6111
24. Ottaviani J I., Actis-Goretta L, Villordo J J., Fraga C G. Procyanidin structure defines the extent and specificity of angiotensin I converting enzyme inhibition. Biochimie 2006 88 359-365
25. Wink M. Evolutionary advantage and molecular modes of action of multi-component mixtures used in phytomedicine. Curr Drug Metab 2008 9 996-1009
26. Kim J, Takahashi M, Shimizu T, Shirasawa T, Kajita M, Kanayama A, Miyamoto Y. Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans. Mech Ageing Dev 2008 129 322-331
27. Abbas S, Wink M. Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. Planta Med 2009 75 216-221
28. Senoo-Matsuda N, Yasuda K, Tsuda M, Ohkubo T, Yoshimura S, Nakazawa H, Hartman P S., Ishii N. A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans. J Biol Chem 2001 276 41553-41558
29. Schulz T J., Zarse K, Voigt A, Urban N, Birringer M, Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab 2007 6 280-293
30. Howitz K T., Bitterman K J., Cohen H Y., Lamming D W., Lavu S, Wood J G., Zipkin R E., Chung P, Kisielewski A, Zhang L L., Scherer B, Sinclair D A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003 425 191-196
31. Tissenbaum H A., Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001 410 227-230
32. Mrck C, Pilon M. C. elegans feeding defective mutants have shorter body lengths and increased autophagy. BMC Dev Biol 2006 6 39
33. Corder R, Mullen W, Khan N Q., Marks S C., Wood E G., Carrier M J., Crozier A. Oenology: red wine procyanidins and vascular health. Nature 2006 444 566
34. Oszmiaski J, Wojdyo A, Kolniak J. Effect of enzymatic mash treatment and storage on phenolic composition, antioxidant activity, and turbidity of cloudy apple juice. J Agric Food Chem 2009 57 7078-7085