A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase

ACS Chemical Biology

Volumn 6, Issue 6, 2011, Pages 540-546

  Taylor, David M ^a   Balabadra, Uma ^b   Xiang, Zhongmin ^d   Woodman, Ben ^c   Meade, Sarah ^d   Amore, Allison ^d   Maxwell, Michele M ^d,e   Reeves, Steven ^d   Bates, Gillian P ^e   Luthi Carter, Ruth ^a   Lowden, Philip A S ^b   Kazantsev, Aleksey G ^d,e  

^a EPFL   (Switzerland)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (1 AZEPANYLSULFONYL) N (3 BROMPHENYL)BENZAMIDE; AK 7; CHOLESTEROL; HUNTINGTIN; NEUROPROTECTIVE AGENT; PROTEIN INHIBITOR; SIRTUIN 2; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BIOSYNTHESIS; BRAIN SLICE; CONFERENCE PAPER; CORPUS STRIATUM; CYTOPLASM; DEACETYLATION; DRUG ELIMINATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; HUNTINGTON CHOREA; IC 50; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSCRIPTION REGULATION;

ANIMALS; BRAIN; CHOLESTEROL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; MICE; MODELS, NEUROLOGICAL; MOLECULAR STRUCTURE; NEURONS; PERMEABILITY; SIRTUIN 2; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

MUS;

EID: 79961053798     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb100376q     Document Type: Conference Paper

References (18)

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