Resveratrol and life extension

Annals of the New York Academy of Sciences

Volumn 1215, Issue 1, 2011, Pages 138-143

  Agarwal, Beamon ^a   Baur, Joseph A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Caloric restriction; Longevity; Resveratrol; SIRT1; Sirtuins

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PEROXISOME PROLIFERATOR ACTIVATOR GAMMA COACTIVATOR 1 ALPHA; RESVERATROL; SIRTUIN 1; SIRTUIN 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOMIMETICS; CALORIC INTAKE; CALORIC RESTRICTION; CATARACT; CHEMOPROPHYLAXIS; DRUG MECHANISM; ENDURANCE; ENZYME ACTIVATION; ENZYME ACTIVITY; FLY; HEALTH STATUS; IN VITRO STUDY; IN VIVO STUDY; INSULIN SENSITIVITY; LIFE EXTENSION; LIFESPAN; LIPID DIET; METABOLISM; MOLECULE; MOTOR PERFORMANCE; NERVE DEGENERATION; NONHUMAN; OBESITY; OVERALL SURVIVAL; PROTEIN PHOSPHORYLATION; RODENT; WORM; YEAST;

MUS; RODENTIA;

EID: 78851470225     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05850.x     Document Type: Article

References (66)

1. Weindruch, R. & R.L. Walford 1988. The Retardation of Aging and Disease by Dietary Restriction. Charles C. Thomas. Springfield, IL.
2. McCay, C.M., M.F. Crowell & L.A. Maynard 1935. The effect of retarded growth upon the length of life span and upon the ultimate body size. J. Nutr. 10: 63-79.
3. Forster, M.J., P. Morris & R.S. Sohal 2003. Genotype and age influence the effect of caloric intake on mortality in mice. Faseb J. 17: 690-692.
4. Shanley, D.P. & T.B. Kirkwood 2006. Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans. Biogerontology 7: 165-168.
5. Liao, C.Y. et al 2010. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell 9: 92-95.
6. Colman, R.J. et al 2009. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325: 201-204.
7. Weiss, E.P. et al 2006. Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am. J. Clin. Nutr. 84: 1033-1042.
8. Lefevre, M. et al 2009. Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals. Atherosclerosis 203: 206-213.
9. Ingram, D.K. et al 2006. Calorie restriction mimetics: an emerging research field. Aging Cell 5: 97-108.
10. Anderson, R.M. et al 2003. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423: 181-185.
11. Bonkowski, M.S. et al 2006. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc. Natl. Acad. Sci. USA 103: 7901-7905.
12. Panowski, S.H. et al 2007. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 447: 550-555.
13. Holloszy, J.O. et al 1985. Effect of voluntary exercise on longevity of rats. J. Appl. Physiol. 59: 826-831.
14. Frye, R.A. 2000. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273: 793-798.
15. Kaeberlein, M., M. McVey & L. Guarente 1999. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13: 2570-2580.
16. Rogina, B. & S.L. Helfand 2004. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. USA 101: 15998-16003.
17. Tissenbaum, H.A. & L. Guarente 2001. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230.
18. Imai, S. et al 2000. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795-800.
19. Vaziri, H. et al 2001. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159.
20. Lin, S.J., P.A. Defossez & L. Guarente 2000. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126-2128.
21. Wang, Y. & H.A. Tissenbaum 2006. Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Mech. Ageing Dev. 127: 48-56.
22. Greer, E.L. & A. Brunet 2009. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell. 8: 113-127.
23. Lamming, D.W. et al 2006. Response to Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". Science 312: 1312c.
24. Chen, D. et al 2005. Increase in activity during calorie restriction requires Sirt1. Science 310: 1641.
25. Boily, G. et al 2008. SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS ONE 3: e1759.
26. Bordone, L. et al 2007. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell. 6: 759-767.
27. Haigis, M.C. et al 2006. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126: 941-954.
28. Chen, D. et al 2008. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 22: 1753-1757.
29. Li, Y. et al 2008. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab. 8: 38-48.
30. Howitz, K.T. et al 2003. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191-196.
31. Jang, M. et al 1997. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275: 218-220.
32. Wood, J.G. et al 2004. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430: 686-689.
33. Jarolim, S. et al 2004. A novel assay for replicative lifespan in Saccharomyces cerevisiae. FEMS Yeast Res. 5: 169-177.
34. Kaeberlein, M. et al 2005. Substrate specific activation of sirtuins by resveratrol. J. Biol. Chem. 280: 17038-17045.
35. Yang, H. et al 2007. Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell 6: 35-43.
36. Bass, T.M. et al 2007. Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech. Ageing Dev. 128: 546-552.
37. Gruber, J., S.Y. Tang & B. Halliwell 2007. Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans. Ann. N.Y. Acad. Sci. 1100: 530-542.
38. Sunagawa, T. et al Procyanidins from Apples (Malus pumila Mill.) Extend the Lifespan of Caenorhabditis elegans. Planta Med. 2010 Aug 17 [Epub ahead of print] doi:.
39. Viswanathan, M. et al 2005. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell. 9: 605-615.
40. Zarse, K. et al 2010. Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans. Horm. Metab. Res. 42: 837-839.
41. Valenzano, D.R. et al 2006. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr. Biol. 16: 296-300.
42. Baur, J.A. et al 2006. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342.
43. Pearson, K.J. et al 2008. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 8: 157-168.
44. Miller, R.A., D.E. Harrison, C. Astle, et al 2010. Rapamycin, but not resveratrol or simvastatin, extends lifespan of genetically heterogeneous mice. J. Gerontology: Biol. Sci. In press.
45. Bauer, J.H. et al 2004. An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 101: 12980-12985.
46. Zou, S. et al 2009. The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly. Exp. Gerontol. 44: 472-476.
47. Pearson, K.J. et al 2008. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life Span. Cell Metab. 8: 157-168.
48. Barger, J.L. et al 2008. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE 3: e2264.
49. Weindruch, R. & R.L. Walford 1982. Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science 215: 1415-1418.
50. Lagouge, M. et al 2006. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127: 1109-1122.
51. Zang, M. et al 2006. Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes 55: 2180-2191.
52. Dasgupta, B. & J. Milbrandt 2007. Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci USA 104: 7217-7222.
53. Canto, C. et al 2010. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab. 11: 213-219.
54. Fulco, M. et al 2008. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell 14: 661-673.
55. Csiszar, A. et al 2009. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 297: H13-H20.
56. Gracia-Sancho, J. et al 2010. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype. Cardiovasc. Res. 85: 514-519.
57. Picard, F. et al 2004. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429: 771-776.
58. Feige, J.N. et al 2008. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab. 8: 347-358.
59. Banks, A.S. et al 2008. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 8: 333-341.
60. Pfluger, P.T. et al 2008. Sirt1 protects against high-fat diet-induced metabolic damage. Proc. Natl. Acad. Sci. USA 105: 9793-9798.
61. Borra, M.T., B.C. Smith & J.M. Denu 2005. Mechanism of human SIRT1 activation by resveratrol. J. Biol. Chem. 280: 17187-17195.
62. Pacholec, M. et al 2010. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J. Biol. Chem. 285: 8340-8351.
63. Dai, H. et al 2010. SIRT1 activation by small molecules - kinetic and biophysical evidence for direct interaction of enzyme and activator. J. Biol. Chem. 285: 32695-32703.
64. Cheng, H.L. et al 2003. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl. Acad. Sci. USA 100: 10794-10799.
65. McBurney, M.W. et al 2003. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol. Cell Biol. 23: 38-54.
66. Boily, G. et al 2009. SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol. Oncogene 28: 2882-2893.