Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease

Journal of Neurochemistry

Volumn 87, Issue 1, 2003, Pages 172-181

  Ono, Kenjiro ^a   Yoshiike, Yuji ^b   Takashima, Akihiko ^b   Hasegawa, Kazuhiro ^c   Naiki, Hironobu ^c   Yamada, Masahito ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c UNIVERSITY OF FUKUI   (Japan)

Author keywords

amyloid fibrils; Alzheimer's disease; Cytotoxicity; Electron microscopy; Polyphenols; Thioflavin T

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMYLOID BETA PROTEIN; BROMINE DERIVATIVE; CATECHIN; EPICATECHIN; KAEMPFEROL; MORIN; MYRICETIN; POLYPHENOL DERIVATIVE; QUERCETIN;

ALZHEIMER DISEASE; ARTICLE; CELL PH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ELECTRON MICROSCOPY; EMBRYO; HUMAN; HUMAN CELL; IN VITRO STUDY; NERVE CELL CULTURE; NEUROPROTECTION; PRIORITY JOURNAL; SPECTROFLUOROMETRY; WINE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; HUMANS; KIDNEY; KINETICS; MICROSCOPY, ELECTRON; PEPTIDE FRAGMENTS; PHENOLS; POLYMERS; QUERCETIN; SPECTROMETRY, FLUORESCENCE; TETRAZOLIUM SALTS; THIAZOLES;

EID: 0141642253     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01976.x     Document Type: Article

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