Potential Inflammatory biomarkers in Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 8, Issue 4, 2005, Pages 369-375

  Mrak, Robert E ^a,c   Griffin, W Sue T ^a,b,c,d  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

Alzheimer's disease; And S100B; Biomarkers; Blood; CSF; Cytokines; Interleukin 1 (IL 1); Neuroinflammation

Indexed keywords

AMYLOID BETA PROTEIN; BIOLOGICAL MARKER; CYTOKINE; HYDROCORTISONE; INTERLEUKIN 1; INTERLEUKIN 6; PROTEIN S100B; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ARTICLE; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DISEASE COURSE; DNA POLYMORPHISM; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INFLAMMATION; INNATE IMMUNITY; MACROPHAGE ACTIVATION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

EID: 33645082486     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/jad-2005-8406     Document Type: Article

References (96)

1. A. Adunsky, D. Baram, M. Hershkowitz and Y.A. Mekori, Increased cytosolic free calcium in lymphocytes of Alzheimer patients, J. Neuroimmunology 33 (1991), 167-172.
2. H. Akiyama, K. Ikeda, M. Katoh, E.G. McGeer and P.L. McGeer, Expression of MRP14, 27E10, interferon-alpha and leukocyte common antigen by reactive microglia in post-mortem human brain tissue, J. Neuroimmunol. 50 (1994), 195-201.
3. X.A. Alvarez, A. Franco, L. Fernandez-Novoa and R. Cacabelos, Blood levels of histamine, IL-1 beta, and TNF-alpha in patients with mild to moderate Alzheimer disease, Molec. & Chem. Neuropath. 29 (1996), 237-252.
4. P. Angelis, S. Scharf, A. Mander, F. Vajda and N. Christophidis, Serum interleukin-6 and interleukin-6 soluble receptor in Alzheimer's disease, Neurosci. Lett. 244 (1998), 106-108.
5. D.M. Araujo and P.A. Lapchak, Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: selective effects on specific interleukins and interleukin receptors, Neurosci 61 (1994), 745-754.
6. M. Bagli, A. Papassotiropoulos, H. Hampel, K. Becker, F. Jessen, K. Burger, U. Ptok, M.L. Rao, H.J. Moller, W. Maier and R. Heun, Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study, Eur. Arch. Psychiatry Clin. Neurosci. 253 (2003), 44-48.
7. S.W. Barger and L.J. Van Eldik, S100β stimulates calcium fluxes in glial and neuronal cells, J. Biol. Chem. 267 (1992), 9689-9694.
8. S.W. Barger and M.P. Mattson, Secreted form of the Alzheimer's amyloid precursor protein stimulates a membrane-associated guanylate cyclase, J. Biochem. 311 (1995), 45-47.
9. J. Bauer, S. Strauss, U. Schreiter-Gasser, U. Ganter, P. Schlegel, I. Witt, B. Yolk and M. Berger, Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices, FEBS Lett 285 (1991), 111-114.
10. W.C. Benzing, J.R. Wujek, E.K. Ward, D. Shaffer, K.H. Ashe, S.G. Younkin and K.R. Brunden, Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice, Neurobiol. Aging 20 (1999), 581-589.
11. F. Berkenbosch, J. Van Oers, A. Del Rey, F. Tilders and H. Besedovsky, Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1, Sci 238 (1987), 524-526.
12. E.W. Bernton, J.E. Beach, J.W. Holaday, R.C. Smallridge and H.G. Fein, Release of multiple hormones by a direct action of Interleukin-1 on pituitary cells, Sci 238 (1987), 519-521.
13. L. Bertram, D. Blacker, A. Crystal, K. Mullin, D. Keeney, J. Jones, S. Basu, S. Yhu, S. Guenette, M. McInnis, R. Go and R. Tanzi, Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies, Exp. Gerontol. 35 (2000), 2353-2361.
14. T.J. Bhojak, S.T. DeKosky, M. Ganguli and M.I. Kamboh, Genetic polymorphisms in the cathespin D and interleukin-6 genes and the risk of Alzheimer's disease, Neurosci. Lett. 288 (2000), 21-24.
15. D. Blum-Degen, T. Muller, W. Kuhn, M. Gerlach, H. Przuntek and P. Riederer, Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients, Neurosci. Lett. 202 (1995), 17-20.
16. H. Bruunsgaard, K. Andersen-Ranberg, B. Jeune, A.N. Pedersen, P. Skinhoj and B.K. Pedersen, A high plasma concentration of TNF-alpha is associated with dementia in centenarians, J. Gerontol. A. Biol. Sci. Med. Sci. 54 (1999), M357-364.
17. J.D. Buxbaum, M. Oishi, H.I. Chen, R. Pinkas-Kramarski, E.A. Jaffe, S.E. Gandy and P. Greengard, Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor, Proc. Natl. Acad. Sci. USA. 89 (1992), 10075-10078.
18. C.C. Chao, T.A. Ala, S. Hu, K.B. Crossley, R.E. Sherman, P.K. Peterson and W.H. Frey 2nd, Serum cytokine levels in patients with Alzheimer's disease, Clin. Diagn. Lab. Immunol. 1 (1994), 433-436.
19. J.S. Collins, R.T. Perry, B. Watson Jr, L.E. Harrell, R.T. Acton, D. Blacker, M.S. Albert and R.E. Tanzi, Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative, Am. J. Med. Genet. 96 (2000) 823-830.
20. D. Culpan, S.H. MacGowan, J.M. Ford, J.A. Nicoll, W.S. Griffin, D. Dewar, N.J. Cairns, A. Hughes, P.G. Kehoe and G.K. Wilcock, Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease, Neurosci. Lett. 350 (2003), 61-65.
21. A. Da Cunha, J.A. Jefferson, R.W. Jackson and L. Vitkovic, Glial cell-specific mechanisms of TGF-β1 induction by IL-1 in cerebral cortex, J. Neuroimmunol. 42 (1993), 71-86.
22. A. De Luigi, C. Fragiacomo, U. Lucca, P. Quadri, M. Tettamanti and M. Grazia De Simoni, Inflammatory markers in Alzheimer's disease and multi-infarct dementia, Mech. Ageing Dev. 122 (2001), 1985-1995.
23. A. De Luigi, S. Pizzimenti, P. Quadri, U. Lucca, M. Tettamanti, C. Fragiacomo and M.G. De Simoni, Peripheral inflammatory response in Alzheimer's disease and multiinfarct dementia, Neurobiol. Dis. 11 (2002), 308-314.
24. R. Del Bo, N. Angeretti, E. Lucca, M.G. De Simoni and G. Forloni, Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and beta-amyloid production in cultures, Neurosci. Lett. 188 (1995), 70-74.
25. C.A. Dinarello, Proinflammatory cytokines, Chest 118 (2000), 503-508.
26. Y. Du, R.C. Dodel, B.J. Eastwood, K.R. Bales, F. Gao, F. Lohmuller, U. Muller, A. Kurz, R. Zimmer, R.M. Evans, A. Hake, T. Gasser, W.H. Oertel, W.S. Griffin, S.M. Paul and M.R. Farlow, Association of an interleukin 1α polymorphism with Alzheimer's disease, Neurol 55 (2000), 480-483.
27. S. Du Yan, H. Zhu, J. Fu, S.F. Yan, A. Roher, W.W. Tourtellotte, T. Rajavashisth, X. Chen, G.C. Godman, D. Stern and A.M. Schmidt, Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease, Proc. Natl. Acad. Sci. USA. 94 (1997), 5296-5301.
28. S. Engelborghs, M. De Brabander, J. De Cree, R. D'Hooge, H. Geerts, H. Verhaegen and P.P. De Deyn, Unchanged levels of interleukins, neopterin, interferon-gamma and tumor necrosis factor-alpha in cerebrospinal fluid of patients with dementia of the Alzheimer type, Neurochem. Int. 34 (1999), 523-530.
29. G. Fano, M.A. Mariggio, P. Angelella, I. Nicoletti, A. Antonica, S. Fulle and P. Calissano, The S-100 protein causes an increase of intracellular calcium and death of PC12 cells, Neurosci 53 (1993), 919-925.
30. K.C. Flanders, C.F. Lippa, T.W. Smith, D.A. Pollen and M.B. Sporn, Altered expression of transforming growth factor-beta in Alzheimer's disease, Neurol 45 (1995), 1561-1569.
31. G. Forloni, F. Demicheli, S. Giorgi, C. Bendotti and N. Angeretti, Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1, Brain Res. Molec. Brain Res. 16 (1992) 128-134.
32. B.D. Gitter, L.M. Cox, R.E. Rydel and P.C. May, Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells, Proc. Natl. Acad. Sci. USA. 92 (1995), 10738-10741.
33. D. Goldgaber, H.W. Harris, T. Hla, T. Maciag, R.G. Donnelly, J.S.Jacobsen, M.P. Vitek and D.C. Gajdusek, Interleukin 1 regulates synthesis of amyloid β-protein precursor mRNA in human endothelial cells, Proc. Natl. Acad. Sci. USA. 86 (1989), 7606-7610.
34. W.S.T. Griffin, L.C. Stanley, C. Ling, L. White, V. MacLeod, L.J. Perrot, C.L.White, III and C. Araoz, Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease, Proc. Natl. Acad. Sci. USA. 86 (1989), 7611-7615.
35. W.S.T. Griffin, J.G. Sheng, G.W. Roberts and R.E. Mrak, Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution, J. Neuropathol. Exp. Neurol. 54 (1995), 276-281.
36. L.M. Grimaldi, V.M. Casadei, C. Ferri, F. Veglia, F. Licastro, G. Annoni, I. Biunno, G. De Bellis, S. Sorbi, C. Mariani, N. Canal, W.S. Griffin and M. Franceschi, Association of early-onset Alzheimer's disease with an interleukin-1β gene polymorphism, Ann. Neurol. 47 (2000), 361-365.
37. A. Grossmann, W.A. Kukull, J.C. Jinneman, T.D. Bird, E.C. Villacres, E.B. Larson and P.S. Rabinovitch, Intracellular calcium response is reduced in CD4+ lymphocytes in Alzheimer's disease and in older persons with Down's syndrome, Neurobiol. Aging 14 (1993), 177-185.
38. Y. Hasegawa, M. Sawada, N. Ozaki, T. Inagaki and A. Suzumura, Increased soluble tumor necrosis factor receptor levels in the serum of elderly people, Gerontology 46 (2000), 185-188.
39. K. Ishizuka, T. Kimura, R. Igata-yi, S. Katsuragi, J. Takamatsu and T. Miyakawa, Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease, Psychiatr. Clin. Neurosci. 51 (1997), 135-138.
40. R.N. Kalaria, D.L. Cohen, D.R. Premkumar, S. Nag, J.C. LaManna and W.D. Lust, Vascular endothelial growth factor in Alzheimer's disease and experimental cerebral ischemia, Brain Res. Molec. Brain Res. 62 (1998), 101-105.
41. D. Kligman and D.R. Marshak, Purification and characterization of a neurite extension factor from bovine brain, Proc. Natl. Acad. Sci. USA. 82 (1985), 7136-7139.
42. Q.L. Kong, J.M. Zhang, Z.X. Zhang, P.J. Ge, Y.J. Xu, R.S. Mi, Y.H. Zhao, Y.P. Sui and W. He, Serum levels of macrophage colony stimulating factor in the patients with Alzheimer's disease, Chung-Kuo i Hsueh Ko Hsueh Yuan Hsueh Pao Acta Academiae Medicinae Sinicae 24 (2002), 298-301.
43. T. Kordula, R.E. Rydel, E.F. Brigham, F. Horn, P.C. Heinrich and J. Travis, Oncostatin M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes, J. Biol. Chem. 273 (1998), 4112-4118.
44. L. Kusdra, H. Rempel, K. Yaffe and L. Pulliam, Elevation of CD69+ monocyte/macrophages in patients with Alzheimer's disease, Immunobiology 202 (2000), 26-33.
45. A.S. Lanzrein, C.M. Johnston, V.H. Perry, K.A. Jobst, E. M. King and A.D. Smith, Longitudinal study of inflammatory factors in serum, cerebrospinal fluid, and brain tissue in Alzheimer disease: interleukin-1beta, interleukin-6, interleukin-1 receptor antagonist, tumor necrosis factor-alpha, the soluble tumor necrosis factor receptors I and II, and alpha1-antichymotrypsin, Alzh. Dis. Assoc. Dis. 12 (1998), 215-227.
46. F. Leblhuber, J. Walli, G.P. Tilz, H. Wachter and D. Fuchs, Systemic changes of the immune system in patients with Alzheimer's dementia, Deutsche Medizinische Wochenschrift 123 (1998), 787-791.
47. S.C. Lee, W. Liu, D.W. Dickson, C.F. Brosnan, J.W. Berman, Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL1β, J. Immunol. 150 (1993), 2659-2667.
48. Y. Li, S.W. Barger, L. Liu, R.E. Mrak and W.S.T. Griffin, S100β induction of the pro-inflammatory cytokine interleukin-6 in neurons: Implications for Alzheimer pathogenesis, J. Neurochem. 74 (2000), 143-150.
49. Y. Li, L. Liu, J. Kang, J.G. Sheng, S.W. Barger, R.E. Mrak and W.S.T. Griffin, Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression, J. Neurosci. 20 (2000), 149-155.
50. X.Q. Li, J.W. Zhang, Z.X. Zhang, D. Chen and Q.M. Qu, Interleukin-1 gene cluster polymorphisms and risk of Alzheimer's disease in Chinese Han population, J. Neural. Transm. 111 (2004), 1183-1190.
51. V.R. Lombardi, M. Garcia, L. Rey and R. Cacabelos, Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's Disease (AD) individuals, J. Neuroimmunol. 97 (1999), 163-171.
52. E.K. Luedecking, S.T. DeKosky, H. Mehdi, M. Ganguli and M.I. Kamboh, Analysis of genetic polymorphisms in the transforming growth factor-beta1 gene and the risk of Alzheimer's disease, Hum. Genet. 106 (2000), 565-569.
53. J.D. Luterman, V. Haroutunian, S. Yemul, L. Ho, D. Purohit, P.S. Aisen, R. Mohs and G.M. Pasinetti, Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia, Arch. Neurol. 57 (2000), 1153-1160.
54. M. Maes, N. DeVos, A. Wauters, P. Demedts, V.W. Maurits, H. Neels, E. Bosmans C. Altamura, A. Lin, C. Song, M. Vandenbroucke and S. Scharpe, Inflammatory markers in younger vs elderly normal volunteers and in patients with Alzheimer's disease, J. Psychiatr. Res. 33 (1999), 397-405.
55. M. Martinez, E. Fernandez-Vivancos, A. Frank, M. De la Fuente and A. Hernanz, Increased cerebrospinal fluid fas (Apo-1) levels in Alzheimer's disease. Relationship with IL-6 concentrations, Brain Res 869 (2000), 216-219.
56. P. Marz, K. Heese, C. Hock, S. Golombowski, F. Muller-Spahn, S. Rose-John and U. Otten, Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients, Neurosci. Lett. 239 (1997), 29-32.
57. S.M. McCusker, M.D. Curran, K.B. Dynan, C.D. McCullagh, D.D. Urquhart and D. Middleton, Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia: a case-control study, Lancet 357 (2001), 436-439.
58. G. Mehlhorn, M. Hollborn and R. Schliebs, Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology, Int. J. Develop. Neurosci. 18 (2000), 423-431.
59. T.P. Miller, J. Taylor, S. Rogerson, M. Mauricio, Q. Kennedy, A. Schatzberg, J. Tinklenberg and J. Yesavage, Cognitive and noncognitive symptoms in dementia patients: relationship to cortisol and dehydroepiandrosterone, Int. Psychogeriatr. 10 (1998), 85-96.
60. A. Mocali, S. Cedrola, N. Della Malva, M. Bontempelli, V.A. Mitidieri, A. Bavazzano, R. Comolli, F. Paoletti and C.A. La Porta, Increased plasma levels of soluble CD40, together with the decrease of TGF beta 1, as possible differential markers of Alzheimer disease, Exp. Gerontol. 39 (2004), 1555-1561.
61. R.E. Mrak and W.S.T. Griffin, Glia and their cytokines in progression of neurodegeneration, Neurobiol Aging. Neurobiol Aging 26 (2005), 349-354.
62. G.M. Murphy Jr, L. Yang and B. Cordell, Macrophage colony-stimulating factor augments beta-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells, J. Biol. Chem. 273 (1998), 20967-20971.
63. S. Nakamura, K. Arima, S. Haga, T. Aizawa, Y. Motoi, M. Otsuka, A. Ueki and K. Ikeda, Fibroblast growth factor (FGF)-9 immunoreactivity in senile plaques, Brain Res 814 (1998), 222-225.
64. J.A. Nicoll, R.E. Mrak, D.I. Graham, J. Stewart, G. Wilcock, S. MacGowan, M.M. Esiri, L.S. Murray, D. Dewar, S. Love, T. Moss and W.S.T. Griffin, Association of interleukin-1 gene polymorphisms with Alzheimer's disease, Ann. Neurol. 47 (2000), 365-368.
65. A. Papassotiropoulos, M. Bagli, F. Jessen, T.A. Bayer, W. Maier, M.L. Rao and R. Heun, A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease, Ann. Neurol. 45 (1999), 666-668.
66. E.R. Peskind, W.S. Griffin, K.T. Akama, M.A. Raskind and L.J. Van Eldik, Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease, Neurochem. Int. 39 (2001), 409-413.
67. T. Pirttila, P.D. Mehta, H. Frey and H.M. Wisniewski, Alpha 1-antichymotrypsin and IL-1 beta are not increased in CSF or serum in Alzheimer's disease, Neurobiol. Aging 15 (1994), 313-317.
68. R. Pola, A. Flex, E. Gaetani, A.S. Proia, P. Papaleo, A.D. Giorgio, G. Straface, G. Pecorini, M. Serricchio and P. Pola, Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism and risk of Alzheimer's disease in Italians, Exp. Gerontol. 39 (2004), 1249-1252.
69. I. Rainero, M. Bo, M. Ferrero, W. Valfre, G. Vaula and L. Pinessi, Association between the interleukin-1 alpha gene and Alzheimer's disease: a meta analysis, Neurobiol. Aging 25 (2004), 1293-1298.
70. G.W. Rebeck, Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease, Neurosci. Lett. 293 (2000), 75-77.
71. G.E. Ringheim, A.M. Szczepanik, W. Petko, K.L. Burgher, S.Z. Zhu and C.C. Chao, Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex, Brain Res. Molec. Brain Res. 55 (1998), 35-44.
72. G. Sala, G. Galimberti, C. Canevari, M.E. Raggi, V. Isella, M. Facheris, I. Appollonio and C. Ferrarese, Peripheral cytokine release in Alzheimer patients: correlation with disease severity, Neurobiol. Aging 24 (2003), 909-914.
73. R. Sapolsky, C. Rivier, G. Yamamoto, P. Plotsky and W. Vale, Interleukin-1 stimulates the secretion of hypothalamic corticotrophin-releasing factor, Sci 238 (1987), 522-524.
74. G. Sebire, D. Emilie, C. Wallon, C. Hery, O. Devergne, J.F. Delfraissy, P. Galanaud and M. Tardieu, In vitro production of IL6, IL1α, and tumor necrosis factorα by human embryonic microglial and neural cells, J. Immunol. 150 (1993), 1517-1523.
75. R.H. Selinfreund, S.W. Barger, W.J. Pledger and L.J. Van Eldik, Neurotrophic protein S100β stimulates glial cell proliferation, Proc. Nat. Acad. Sci. USA 88 (1991), 3554-3558.
76. D. Seripa, M.G. Matera, G. Dal Forno, C. Gravina, C. Masullo, A. Daniele, G. Binetti, C. Bonvicini, R. Squitti, M.T. Palermo, D.G. Davis, P. Antuono, D.R. Wekstein, A. Dobrina, M. Gennarelli and V.M. Fazio, Genotypes and haplotypes in the IL-1 gene cluster: analysis of two genetically and diagnostically distinct groups of Alzheimer patients, Neurobiol. Aging 26 (2005), 455-464.
77. J.G. Sheng, K. Ito, R.D. Skinner, R.E. Mrak, C.R. Rovnaghi, L.J. Van Eldik and W.S.T. Griffin, In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis, Neurobiol. Aging 17 (1996), 761-766.
78. J.G. Sheng, R.A. Jones, X.Q. Zhou, J.M. McGinness, L.J. Van Eldik, R.E. Mrak and W.S.T. Griffin, Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation, Neurochem. Intl. 39 (2001), 341-348.
79. + astrocytes with neurofibrillary tangle stages, J. Neuropathol. Exp. Neurol. 56 (1997), 285-290.
80. J.G. Sheng, S.G. Zhu, W.S.T. Griffin and R.E. Mrak, Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo, Exp. Neurol. 163 (2000), 388-391.
81. Y.X. Sun, L. Minthon, A. Wallmark, S. Warkentin, K. Blennow and S. Janciauskiene, Inflammatory markers in matched plasma and cerebrospinal fluid from patients wi th Alzheimer's disease, Dement. Geriatr. Cogn. Disord. 16 (2003), 136-144.
82. E. Tarkowski, K. Blennow, A. Wallin and A. Tarkowski, Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia, J. Clin. Immunol. 19 (1999), 223-230.
83. C.E. Teunissen, M.P. van Boxtel, H. Bosma, J. Jolles, D. Lutjohann, K. von Bergmann, A. Wauters, E. Bosmans, M. Maes, J. Delanghe, C. De Bruijn, H.W. Steinbusch, H.J. Blom and J. de Vente, Serum markers in relation to cognitive functioning in an aging population: results of the Maastricht Aging Study (MAAS), Tijdschrift voor Gerontologie en Geriatrie 34 (2003), 6-12.
84. H. Umegaki, H. Ikari, H. Nakahata, H. Endo, Y. Suzuki, O. Ogawa, A. Nakamura, T. Yamamoto and A. Iguchi, Plasma cortisol levels in elderly female subjects with Alzheimer's disease: a cross-sectional and longitudinal study, Brain Res 881 (2000), 241-243.
85. E.A. van der Wal, F. Gomez-Pinilla and C.W. Cotman, Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies, Neuroreport 4 (1993), 69-72.
86. M.N. Wallace, J.G. Geddes, D.A. Farquhar and M.R. Masson, Nitric oxide synthase in reactive astrocytes adjacent to beta-amyloid plaques, Exp. Neurol. 144 (1997), 266-272.
87. F. Winningham-Major, J.L. Staecher, S.W. Barger, S. Coats and L.J. Van Eldik, Neurite extension and neuronal survival activities of recombinant S100β proteins that differ in the content and position of cysteine residues, J. Cell. Biol. 109 (1989), 3036-3071.
88. T. Wisniewski, M. Lalowski, M. Baumann, H. Rauvala, E. Raulo, R. Nolo and B. Frangione, HB-GAM is a cytokine present in Alzheimer's and Down's syndrome lesions, Neuroreport 7 (1996), 667-671.
89. B. Wolozin, P. Lesch, R. Lebovics, T. Sunderland and A.E. Bennett Research Award 1993, Olfactory neuroblasts from Alzheimer donors: studies on APP processing and cell regulation, Biol. Psychiat. 34 (1993), 824-838.
90. J.A. Wood, P.L. Wood, R. Ryan, N.R. Graff-Radford, C. Pilapil, Y. Robitaille and R. Quirion, Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1 beta or IL-1RA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein, Brain Res 629 (1993), 245-252.
91. T. Wyss-Coray, E. Masliah, M. Mallory, L. McConlogue, K. Johnson-Wood, C. Lin and L. Mucke, Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease, Nature 389 (1997), 603-606.
92. M. Xia, S. Qin, M. McNamara, C. Mackay and B.T. Hyman, Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease, Am. J. Pathol. 150 (1997), 1267-1274.
93. M.Q. Xia, S.X. Qin, L.J. Wu, C.R. Mackay and B.T. Hyman, Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains, Am. J. Pathol. 153 (1998), 31-37.
94. M.Q. Xia, B.J. Bacskai, R.B. Knowles, S.X. Qin and B.T. Hyman, Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease, J. Neuroimmunol. 108 (2000), 227-235.
95. T. Yamada, M.A. Horisberger, N. Kawaguchi, I. Moroo and T. Toyoda, Immunohistochemistry using antibodies to alpha-interferon and its induced protein, MxA, in Alzheimer's and Parkinson's disease brain tissues, Neurosci. Lett. 181 (1999), 61-64.
96. K. Yamada, K. Kono, H. Umegaki, K. Yamada, A. Iguchi, T. Fukatsu, N. Nakashima, H. Nishiwaki, Y. Shimada and Y. Sugita, Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia, Neurosci. Lett. 186 (1995), 219-221.