Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Nature

Volumn 425, Issue 6954, 2003, Pages 191-196

  Howitz, Konrad T ^a   Bitterman, Kevin J ^b   Cohen, Halm Y ^b   Lamming, Dudley W ^b   Lavu, Siva ^b   Wood, Jason G ^b   Zipkin, Robert E ^a   Chung, Phuong ^a   Kisielewski, Anne ^a   Zhang, Li Li ^a   Scherer, Brandy ^a   Sinclair, David A ^b  

^a BIOMOL Research Laboratories Inc   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; DNA; MOLECULAR BIOLOGY; YEAST;

DEACETYLATION;

ENZYME KINETICS;

ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE; POLYPHENOL; PROTEIN P53; RESVERATROL; SIRTUIN; UNCLASSIFIED DRUG; FLAVONOID; HISTONE DEACETYLASE; PHENOL DERIVATIVE; POLYMER; POLYPHENOLS; SILENT INFORMATION REGULATOR PROTEIN; SIR2 PROTEIN, S CEREVISIAE; SIRT1 PROTEIN, HUMAN; STILBENE DERIVATIVE;

CALORIMETRY; LONGEVITY; PROTEIN; YEAST;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CALORIC RESTRICTION; CELL SURVIVAL; DEACETYLATION; ENZYME REGULATION; GENETIC CONSERVATION; LIFESPAN; LONGEVITY; MICHAELIS CONSTANT; MOLECULAR MIMICRY; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TUMOR SUPPRESSOR GENE; YEAST; ACETYLATION; CATALYSIS; CELL AGING; CELL LINE; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; GENETIC RECOMBINATION; GENETICS; HUMAN; KINETICS; METABOLISM; WINE;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

ACETYLATION; CALORIC RESTRICTION; CATALYSIS; CELL AGING; CELL LINE; CELL SURVIVAL; FLAVONOIDS; HISTONE DEACETYLASES; HUMANS; KINETICS; LONGEVITY; PHENOLS; POLYMERS; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; STILBENES; TUMOR SUPPRESSOR PROTEIN P53; WINE;

EID: 0141719702     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01960     Document Type: Article

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