SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

Journal of Biological Chemistry

Volumn 285, Issue 11, 2010, Pages 8340-8351

  Pacholec, Michelle ^a   Bleasdale, John E ^a   Chrunyk, Boris ^a   Cunningham, David ^a   Flynn, Declan ^a   Garofalo, Robert S ^a   Griffith, David ^a   Griffor, Matt ^a   Loulakis, Pat ^a   Pabst, Brandon ^a   Qiu, Xiayang ^a   Stockman, Brian ^a,b   Thanabal, Venkataraman ^a   Varghese, Alison ^a   Ward, Jessica ^a   Withka, Jane ^a   Ahn, Kay ^a  

^a PFIZER INC   (United States)

^b ADELPHI UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL-COA; AGE-RELATED DISEASE; APOPTOSIS; BENEFICIAL EFFECTS; BIOCHEMICAL ASSAY; CALORIE RESTRICTION; DEACETYLATION; FULL-LENGTH PROTEINS; HIGH-FAT DIET; ION CHANNEL; ISOTHERMAL CALORIMETRY; OVER-EXPRESSION; PEPTIDE SUBSTRATES; PLASMA GLUCOSE; RELATED COMPOUNDS; RESVERATROL; RODENT MODELS; SMALL MOLECULES; TARGET ACTIVITY; THERAPEUTIC TARGETS; TRANSGENICS; TYPE-2 DIABETES;

ACETYLATION; CELL DEATH; FLUOROPHORES; GLUCOSE; ION EXCHANGE; LEAD COMPOUNDS; PEPTIDES; SURFACE PLASMON RESONANCE; TRANSCRIPTION;

SUBSTRATES;

ACETYL COENZYME A SYNTHETASE; CARRIER PROTEIN; ENZYME ACTIVATOR; GLUCOSE; ION CHANNEL; PEPTIDE; PROTEIN P53; RECEPTOR PROTEIN; RESVERATROL; SIRTUIN 1; SRT 1460; SRT 1720; SRT 2183; UNCLASSIFIED DRUG; 5 CARBOXYTETRAMETHYLRHODAMINE SUCCINIMIDYL ESTER; 5-CARBOXYTETRAMETHYLRHODAMINE SUCCINIMIDYL ESTER; ENZYME INHIBITOR; FUSED HETEROCYCLIC RINGS; RHODAMINE; SIRT1 PROTEIN, HUMAN; SRT1460; SRT1720; SRT2183; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; COVALENT BOND; ENZYME ACTIVATION; ENZYME SUBSTRATE; GLUCOSE BLOOD LEVEL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN TARGETING; ACETYLATION; ALLOSTERISM; ANIMAL; CALORIMETRY; CHEMISTRY; DRUG EFFECT; ENZYME SPECIFICITY; FAT INTAKE; HUMAN; METABOLISM; MOUSE MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE; SURFACE PLASMON RESONANCE;

MUS; RODENTIA;

ACETYLATION; ALLOSTERIC REGULATION; ANIMALS; BLOOD GLUCOSE; CALORIMETRY; DIABETES MELLITUS, TYPE 2; DIETARY FATS; ENZYME ACTIVATION; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; MICE; MICE, OBESE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RHODAMINES; SIRTUIN 1; STILBENES; SUBSTRATE SPECIFICITY; SURFACE PLASMON RESONANCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77950246109     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.088682     Document Type: Article

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