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Volumn 452, Issue 7186, 2008, Pages 492-496

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; PROTEIN SIRT6; UNCLASSIFIED DRUG;

EID: 41349090663     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06736     Document Type: Article
Times cited : (924)

References (32)
  • 1
    • 0034705129 scopus 로고    scopus 로고
    • The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
    • Landry, J. et al. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl Acad. Sci. USA 97, 5807-5811 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 5807-5811
    • Landry, J.1
  • 2
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • Imai, S., Armstrong, C. M., Kaeberlein, M. & Guarente, L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800 (2000).
    • (2000) Nature , vol.403 , pp. 795-800
    • Imai, S.1    Armstrong, C.M.2    Kaeberlein, M.3    Guarente, L.4
  • 3
    • 31044445366 scopus 로고    scopus 로고
    • Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
    • Mostoslavsky, R. et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124, 315-329 (2006).
    • (2006) Cell , vol.124 , pp. 315-329
    • Mostoslavsky, R.1
  • 4
    • 34547931623 scopus 로고    scopus 로고
    • Werner syndrome protein: Functions in the response to DNA damage and replication stress in S-phase
    • Cheng, W. H., Muftuoglu, M. & Bohr, V. A. Werner syndrome protein: Functions in the response to DNA damage and replication stress in S-phase. Exp. Gerontol. 42, 871-878 (2007).
    • (2007) Exp. Gerontol , vol.42 , pp. 871-878
    • Cheng, W.H.1    Muftuoglu, M.2    Bohr, V.A.3
  • 5
    • 34047178427 scopus 로고    scopus 로고
    • WRN at telomeres: Implications for aging and cancer
    • Multani, A. S. & Chang, S. WRN at telomeres: implications for aging and cancer. J. Cell Sci. 120, 713-721 (2007).
    • (2007) J. Cell Sci , vol.120 , pp. 713-721
    • Multani, A.S.1    Chang, S.2
  • 6
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
    • Campisi, J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120, 513-522 (2005).
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 7
    • 34250841785 scopus 로고    scopus 로고
    • Replication and protection of telomeres
    • Verdun, R. E. & Karlseder, J. Replication and protection of telomeres. Nature 447, 924-931 (2007).
    • (2007) Nature , vol.447 , pp. 924-931
    • Verdun, R.E.1    Karlseder, J.2
  • 8
    • 33745652501 scopus 로고    scopus 로고
    • Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase
    • van Overbeek, M. & de Lange, T. Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase. Curr. Biol. 16, 1295-1302 (2006).
    • (2006) Curr. Biol , vol.16 , pp. 1295-1302
    • van Overbeek, M.1    de Lange, T.2
  • 9
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai, H., Smogorzewska, A. & de Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556 (2003).
    • (2003) Curr. Biol , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 10
    • 0344441890 scopus 로고    scopus 로고
    • A DNA damage checkpoint response in telomere-initiated senescence
    • d'Adda di Fagagna, F. et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426, 194-198 (2003).
    • (2003) Nature , vol.426 , pp. 194-198
    • d'Adda di Fagagna, F.1
  • 11
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel, B., Smogorzewska, A. & de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 92, 401-413 (1998).
    • (1998) Cell , vol.92 , pp. 401-413
    • van Steensel, B.1    Smogorzewska, A.2    de Lange, T.3
  • 12
    • 0034682721 scopus 로고    scopus 로고
    • Cellular senescence: Mitotic clock or culture shock?
    • Sherr, C. J. & DePinho, R. A. Cellular senescence: mitotic clock or culture shock? Cell 102, 407-410 (2000).
    • (2000) Cell , vol.102 , pp. 407-410
    • Sherr, C.J.1    DePinho, R.A.2
  • 13
    • 10344256183 scopus 로고    scopus 로고
    • Defective telomere lagging strand synthesis in cells lacking WRN helicase activity
    • Crabbe, L., Verdun, R. E., Haggblom, C. I. & Karlseder, J. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 306, 1951-1953 (2004).
    • (2004) Science , vol.306 , pp. 1951-1953
    • Crabbe, L.1    Verdun, R.E.2    Haggblom, C.I.3    Karlseder, J.4
  • 14
    • 27644443332 scopus 로고    scopus 로고
    • Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway
    • Laud, P. R. et al. Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev. 19, 2560-2570 (2005).
    • (2005) Genes Dev , vol.19 , pp. 2560-2570
    • Laud, P.R.1
  • 16
    • 0033987424 scopus 로고    scopus 로고
    • Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
    • Wyllie, F. S. et al. Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts. Nature Genet. 24, 16-17 (2000).
    • (2000) Nature Genet , vol.24 , pp. 16-17
    • Wyllie, F.S.1
  • 17
    • 2942637828 scopus 로고    scopus 로고
    • The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
    • Opresko, P. L. et al. The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol. Cell 14, 763-774 (2004).
    • (2004) Mol. Cell , vol.14 , pp. 763-774
    • Opresko, P.L.1
  • 18
    • 0038451396 scopus 로고    scopus 로고
    • POT1 as a terminal transducer of TRF1 telomere length control
    • Loayza, D. & De Lange, T. POT1 as a terminal transducer of TRF1 telomere length control. Nature 423, 1013-1018 (2003).
    • (2003) Nature , vol.423 , pp. 1013-1018
    • Loayza, D.1    De Lange, T.2
  • 19
    • 33846590977 scopus 로고    scopus 로고
    • Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres
    • Benetti, R., Garcia-Cao, M. & Blasco, M. A. Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nature Genet. 39, 243-250 (2007).
    • (2007) Nature Genet , vol.39 , pp. 243-250
    • Benetti, R.1    Garcia-Cao, M.2    Blasco, M.A.3
  • 20
    • 34249993770 scopus 로고    scopus 로고
    • Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells
    • Ariyoshi, K., Suzuki, K., Goto, M., Watanabe, M. & Kodama, S. Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells. J. Radiat. Res. (Tokyo) 48, 219-231 (2007).
    • (2007) J. Radiat. Res. (Tokyo) , vol.48 , pp. 219-231
    • Ariyoshi, K.1    Suzuki, K.2    Goto, M.3    Watanabe, M.4    Kodama, S.5
  • 21
    • 0020306698 scopus 로고
    • Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts
    • Takeuchi, F., Hanaoka, F., Goto, M., Yamada, M. & Miyamoto, T. Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts. Exp. Gerontol. 17, 473-480 (1982).
    • (1982) Exp. Gerontol , vol.17 , pp. 473-480
    • Takeuchi, F.1    Hanaoka, F.2    Goto, M.3    Yamada, M.4    Miyamoto, T.5
  • 22
    • 0026702210 scopus 로고
    • Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines
    • Poot, M., Hoehn, H., Runger, T. M. & Martin, G. M. Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp. Cell Res. 202, 267-273 (1992).
    • (1992) Exp. Cell Res , vol.202 , pp. 267-273
    • Poot, M.1    Hoehn, H.2    Runger, T.M.3    Martin, G.M.4
  • 24
    • 33947317206 scopus 로고    scopus 로고
    • The epigenetic regulation of mammalian telomeres
    • Blasco, M. A. The epigenetic regulation of mammalian telomeres. Nature Rev. Genet. 8, 299-309 (2007).
    • (2007) Nature Rev. Genet , vol.8 , pp. 299-309
    • Blasco, M.A.1
  • 25
    • 3543043128 scopus 로고    scopus 로고
    • Essential role of limiting telomeres in the pathogenesis of Werner syndrome
    • Chang, S. et al. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nature Genet. 36, 877-882 (2004).
    • (2004) Nature Genet , vol.36 , pp. 877-882
    • Chang, S.1
  • 27
    • 33845419422 scopus 로고    scopus 로고
    • MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres
    • Dimitrova, N. & de Lange, T. MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes Dev. 20, 3238-3243 (2006).
    • (2006) Genes Dev , vol.20 , pp. 3238-3243
    • Dimitrova, N.1    de Lange, T.2
  • 28
    • 0035107553 scopus 로고    scopus 로고
    • Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms
    • Padilla-Nash, H. M. et al. Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms. Genes Chromosom. Cancer 30, 349-363 (2001).
    • (2001) Genes Chromosom. Cancer , vol.30 , pp. 349-363
    • Padilla-Nash, H.M.1
  • 29
    • 26244436281 scopus 로고    scopus 로고
    • Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
    • Michishita, E., Park, J. Y., Burneskis, J. M., Barrett, J. C. & Horikawa, I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell 16, 4623-4635 (2005).
    • (2005) Mol. Biol. Cell , vol.16 , pp. 4623-4635
    • Michishita, E.1    Park, J.Y.2    Burneskis, J.M.3    Barrett, J.C.4    Horikawa, I.5
  • 30
    • 27244435939 scopus 로고    scopus 로고
    • Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
    • Chua, K. F. et al. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab. 2, 67-76 (2005).
    • (2005) Cell Metab , vol.2 , pp. 67-76
    • Chua, K.F.1
  • 31
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri, G. P. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363-9367 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 9363-9367
    • Dimri, G.P.1
  • 32
    • 0038214755 scopus 로고    scopus 로고
    • Multicolor spectral karyotyping of human chromosomes
    • Schrock, E. et al. Multicolor spectral karyotyping of human chromosomes. Science 273, 494-497 (1996).
    • (1996) Science , vol.273 , pp. 494-497
    • Schrock, E.1


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