Oxidative damage is the earliest event in Alzheimer disease

Journal of Neuropathology and Experimental Neurology

Volumn 60, Issue 8, 2001, Pages 759-767

  Nunomura, Akihiko ^a,b   Perry, George ^a   Aliev, Gjumrakch ^a   Hirai, Keisuke ^a,e   Takeda, Atsushi ^a   Balraj, Elizabeth K ^a,c   Jones, Paul K ^a   Ghanbari, Hossein ^d   Wataya, Takafumi ^f   Shimohama, Shun ^f   Chiba, Shigeru ^b   Atwood, Craig S ^a   Petersen, Robert B ^a   Smith, Mark A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

^c Cuyahoga County Coroner's Office   (United States)

^d Panacea Pharmaceuticals   (United States)

^e TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^f KYOTO UNIVERSITY   (Japan)

Author keywords

8 hydroxyguanosine; Alzheimer disease; Amyloid ; Apolipoprotein E; Neurofibrillary tangle; Nitrotyrosine; Oxidative stress

Indexed keywords

3 NITROTYROSINE; APOLIPOPROTEIN E; NUCLEOSIDE; REACTIVE OXYGEN METABOLITE; RNA;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENOTYPE; HETEROZYGOTE; HUMAN; HUMAN TISSUE; MALE; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUANTITATIVE ASSAY;

EID: 0034923434     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/60.8.759     Document Type: Article

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