Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

EMBO Journal

Volumn 21, Issue 10, 2002, Pages 2383-2396

  Langley, Emma ^a   Pearson, Mark ^a   Faretta, Mario ^a   Bauer, Uta Maria ^b   Frye, Roy A ^c   Minucci, Saverio ^d   Pelicci, Pier Giuseppe ^e   Kouzarides, Tony ^e  

^a DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c RESEARCH AND DEVELOPMENT   (Australia)

^d College of Chemistry and Molecular Engineering ^*  (China)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

NAD dependent deacetylase; p53; PML nuclear bodies; Senescence; SIRT1

Indexed keywords

FUNGAL PROTEIN; HISTONE DEACETYLASE; PROTEIN P53; SILENT INFORMATION REGULATOR PROTEIN 2; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CELL AGING; CELL NUCLEUS INCLUSION BODY; CHROMATIN; CONTROLLED STUDY; DEACETYLATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MAMMAL CELL; ONCOGENE RAS; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN LOCALIZATION; TRANSACTIVATION; WORM; YEAST;

ANIMALS; CELL AGING; CELL LINE; FIBROBLASTS; HELA CELLS; HISTONE DEACETYLASES; HUMANS; MALE; MICE; NEOPLASM PROTEINS; NUCLEAR PROTEINS; RECOMBINANT PROTEINS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; TESTIS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

MAMMALIA; SACCHAROMYCETALES;

EID: 0037093346     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.10.2383     Document Type: Article

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