-
1
-
-
4043165678
-
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
-
DOI 10.1126/science.1098014
-
T. Araki, Y. Sasaki, and J. Milbrandt Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration Science 305 2004 1010 1013 (Pubitemid 39071777)
-
(2004)
Science
, vol.305
, Issue.5686
, pp. 1010-1013
-
-
Araki, T.1
Sasaki, Y.2
Milbrandt, J.3
-
2
-
-
52749091816
-
SirT1 gain of function increases energy efficiency and prevents diabetes in mice
-
A.S. Banks, N. Kon, C. Knight, M. Matsumoto, R. Gutiérrez- Juárez, L. Rossetti, W. Gu, and D. Accili SirT1 gain of function increases energy efficiency and prevents diabetes in mice Cell Metab. 8 2008 333 341
-
(2008)
Cell Metab.
, vol.8
, pp. 333-341
-
-
Banks, A.S.1
Kon, N.2
Knight, C.3
Matsumoto, M.4
Gutiérrez-Juárez, R.5
Rossetti, L.6
Gu, W.7
Accili, D.8
-
3
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
DOI 10.1038/nature05354, PII NATURE05354
-
J.A. Baur, K.J. Pearson, N.L. Price, H.A. Jamieson, C. Lerin, A. Kalra, V.V. Prabhu, J.S. Allard, G. Lopez-Lluch, and K. Lewis Resveratrol improves health and survival of mice on a high-calorie diet Nature 444 2006 337 342 (Pubitemid 44764104)
-
(2006)
Nature
, vol.444
, Issue.7117
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
Pistell, P.J.11
Poosala, S.12
Becker, K.G.13
Boss, O.14
Gwinn, D.15
Wang, M.16
Ramaswamy, S.17
Fishbein, K.W.18
Spencer, R.G.19
Lakatta, E.G.20
Le Couteur, D.21
Shaw, R.J.22
Navas, P.23
Puigserver, P.24
Ingram, D.K.25
De Cabo, R.26
Sinclair, D.A.27
more..
-
4
-
-
70350524083
-
Resveratrol is not a direct activator of SIRT1 enzyme activity
-
D. Beher, J. Wu, S. Cumine, K.W. Kim, S.C. Lu, L. Atangan, and M. Wang Resveratrol is not a direct activator of SIRT1 enzyme activity Chem. Biol. Drug Des. 74 2009 619 624
-
(2009)
Chem. Biol. Drug Des.
, vol.74
, pp. 619-624
-
-
Beher, D.1
Wu, J.2
Cumine, S.3
Kim, K.W.4
Lu, S.C.5
Atangan, L.6
Wang, M.7
-
5
-
-
42449086900
-
Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome
-
DOI 10.1210/en.2007-1200
-
N.C. Bingham, K.K. Anderson, A.L. Reuter, N.R. Stallings, and K.L. Parker Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome Endocrinology 149 2008 2138 2148 (Pubitemid 351574486)
-
(2008)
Endocrinology
, vol.149
, Issue.5
, pp. 2138-2148
-
-
Bingham, N.C.1
Anderson, K.K.2
Reuter, A.L.3
Stallings, N.R.4
Parker, K.L.5
-
6
-
-
0033588184
-
Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
-
DOI 10.1016/S0092-8674(00)81973-X
-
R.M. Chemelli, J.T. Willie, C.M. Sinton, J.K. Elmquist, T. Scammell, C. Lee, J.A. Richardson, S.C. Williams, Y. Xiong, and Y. Kisanuki Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation Cell 98 1999 437 451 (Pubitemid 29402482)
-
(1999)
Cell
, vol.98
, Issue.4
, pp. 437-451
-
-
Chemelli, R.M.1
Willie, J.T.2
Sinton, C.M.3
Elmquist, J.K.4
Scammell, T.5
Lee, C.6
Richardson, J.A.7
Clay Williams, S.8
Xiong, Y.9
Kisanuki, Y.10
Fitch, T.E.11
Nakazato, M.12
Hammer, R.E.13
Saper, C.B.14
Yanagisawa, M.15
-
7
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
DOI 10.1073/pnas.1934713100
-
H.L. Cheng, R. Mostoslavsky, S. Saito, J.P. Manis, Y. Gu, P. Patel, R. Bronson, E. Appella, F.W. Alt, and K.F. Chua Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice Proc. Natl. Acad. Sci. USA 100 2003 10794 10799 (Pubitemid 37140107)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.19
, pp. 10794-10799
-
-
Cheng, H.-L.1
Mostoslavsky, R.2
Saito, S.3
Manis, J.P.4
Gu, Y.5
Patel, P.6
Bronson, R.7
Appella, E.8
Alt, F.W.9
Chua, K.F.10
-
8
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
DOI 10.1126/science.1099196
-
H.Y. Cohen, C. Miller, K.J. Bitterman, N.R. Wall, B. Hekking, B. Kessler, K.T. Howitz, M. Gorospe, R. de Cabo, and D.A. Sinclair Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science 305 2004 390 392 (Pubitemid 38938153)
-
(2004)
Science
, vol.305
, Issue.5682
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
Kessler, B.6
Howitz, K.T.7
Gorospe, M.8
De Cabo, R.9
Sinclair, D.A.10
-
9
-
-
0030876952
-
Valvular heart disease associated with fenfluramine phentermine
-
DOI 10.1056/NEJM199708283370901
-
H.M. Connolly, J.L. Crary, M.D. McGoon, D.D. Hensrud, B.S. Edwards, W.D. Edwards, and H.V. Schaff Valvular heart disease associated with fenfluramine-phentermine N. Engl. J. Med. 337 1997 581 588 (Pubitemid 27360757)
-
(1997)
New England Journal of Medicine
, vol.337
, Issue.9
, pp. 581-588
-
-
Connolly, H.M.1
Crary, J.L.2
McGoon, M.D.3
Hensrud, D.D.4
Edwards, B.S.5
Edwards, W.D.6
Schaff, H.V.7
-
10
-
-
17844389670
-
The hypothalamic arcuate nucleus: A key site for mediating leptin's effects on glucose homeostasis and locomotor activity
-
DOI 10.1016/j.cmet.2004.12.004, PII S1550413104000105
-
R. Coppari, M. Ichinose, C.E. Lee, A.E. Pullen, C.D. Kenny, R.A. McGovern, V. Tang, S.M. Liu, T. Ludwig, and S.C. Chua Jr. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity Cell Metab. 1 2005 63 72 (Pubitemid 43960588)
-
(2005)
Cell Metabolism
, vol.1
, Issue.1
, pp. 63-72
-
-
Coppari, R.1
Ichinose, M.2
Lee, C.E.3
Pullen, A.E.4
Kenny, C.D.5
McGovern, R.A.6
Tang, V.7
Liu, S.M.8
Ludwig, T.9
Chua Jr., S.C.10
Lowell, B.B.11
Elmquist, J.K.12
-
11
-
-
27844463517
-
Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
-
DOI 10.1056/NEJMoa044537
-
J.P. Després, A. Golay, L. Sjöström Rimonabant in Obesity-Lipids Study Group Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia N. Engl. J. Med. 353 2005 2121 2134 (Pubitemid 41653104)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.20
, pp. 2121-2134
-
-
Despres, J.-P.1
Golay, A.2
Sjostrom, L.3
-
12
-
-
30644473109
-
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
-
DOI 10.1016/j.neuron.2005.12.021, PII S0896627305011347
-
H. Dhillon, J.M. Zigman, C. Ye, C.E. Lee, R.A. McGovern, V. Tang, C.D. Kenny, L.M. Christiansen, R.D. White, and E.A. Edelstein Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis Neuron 49 2006 191 203 (Pubitemid 43089637)
-
(2006)
Neuron
, vol.49
, Issue.2
, pp. 191-203
-
-
Dhillon, H.1
Zigman, J.M.2
Ye, C.3
Lee, C.E.4
McGovern, R.A.5
Tang, V.6
Kenny, C.D.7
Christiansen, L.M.8
White, R.D.9
Edelstein, E.A.10
Coppari, R.11
Balthasar, N.12
Cowley, M.A.13
Chua Jr., S.14
Elmquist, J.K.15
Lowell, B.B.16
-
13
-
-
43249100162
-
Targeting the endocannabinoid system: To enhance or reduce?
-
DOI 10.1038/nrd2553, PII NRD2553
-
V. Di Marzo Targeting the endocannabinoid system: to enhance or reduce? Nature Reviews Drug Discovery 7 2008 438 455 (Pubitemid 351649182)
-
(2008)
Nature Reviews Drug Discovery
, vol.7
, Issue.5
, pp. 438-455
-
-
Di Marzo, V.1
-
14
-
-
77955046461
-
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
-
G. Donmez, D. Wang, D.E. Cohen, and L. Guarente SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10 Cell 142 2010 320 332
-
(2010)
Cell
, vol.142
, pp. 320-332
-
-
Donmez, G.1
Wang, D.2
Cohen, D.E.3
Guarente, L.4
-
15
-
-
33847319765
-
Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons
-
P.J. Enriori, A.E. Evans, P. Sinnayah, E.E. Jobst, L. Tonelli-Lemos, S.K. Billes, M.M. Glavas, B.E. Grayson, M. Perello, and E.A. Nillni Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons Cell Metab. 5 2007 181 194
-
(2007)
Cell Metab.
, vol.5
, pp. 181-194
-
-
Enriori, P.J.1
Evans, A.E.2
Sinnayah, P.3
Jobst, E.E.4
Tonelli-Lemos, L.5
Billes, S.K.6
Glavas, M.M.7
Grayson, B.E.8
Perello, M.9
Nillni, E.A.10
-
16
-
-
0035282983
-
Fos expression in orexin neurons varies with behavioral state
-
I.V. Estabrooke, M.T. McCarthy, E. Ko, T.C. Chou, R.M. Chemelli, M. Yanagisawa, C.B. Saper, and T.E. Scammell Fos expression in orexin neurons varies with behavioral state J. Neurosci. 21 2001 1656 1662 (Pubitemid 32182206)
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.5
, pp. 1656-1662
-
-
Estabrooke, I.V.1
McCarthy, M.T.2
Ko, E.3
Chou, T.C.4
Chemelli, R.M.5
Yanagisawa, M.6
Saper, C.B.7
Scammell, T.E.8
-
17
-
-
44849096876
-
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
-
R. Firestein, G. Blander, S. Michan, P. Oberdoerffer, S. Ogino, J. Campbell, A. Bhimavarapu, S. Luikenhuis, R. de Cabo, and C. Fuchs The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth PLoS ONE 3 2008 e2020
-
(2008)
PLoS ONE
, vol.3
, pp. 2020
-
-
Firestein, R.1
Blander, G.2
Michan, S.3
Oberdoerffer, P.4
Ogino, S.5
Campbell, J.6
Bhimavarapu, A.7
Luikenhuis, S.8
De Cabo, R.9
Fuchs, C.10
-
18
-
-
34247259630
-
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α
-
DOI 10.1038/sj.emboj.7601633, PII 7601633
-
Z. Gerhart-Hines, J.T. Rodgers, O. Bare, C. Lerin, S.H. Kim, R. Mostoslavsky, F.W. Alt, Z. Wu, and P. Puigserver Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha EMBO J. 26 2007 1913 1923 (Pubitemid 46624046)
-
(2007)
EMBO Journal
, vol.26
, Issue.7
, pp. 1913-1923
-
-
Gerhart-Hines, Z.1
Rodgers, J.T.2
Bare, O.3
Lerin, C.4
Kim, S.-H.5
Mostoslavsky, R.6
Alt, F.W.7
Wu, Z.8
Puigserver, P.9
-
19
-
-
77949887506
-
Mammalian sirtuins: Biological insights and disease relevance
-
M.C. Haigis, and D.A. Sinclair Mammalian sirtuins: biological insights and disease relevance Annu. Rev. Pathol. 5 2010 253 295
-
(2010)
Annu. Rev. Pathol.
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
20
-
-
77950264425
-
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility
-
J.W. Hill, C.F. Elias, M. Fukuda, K.W. Williams, E.D. Berglund, W.L. Holland, Y.R. Cho, J.C. Chuang, Y. Xu, and M. Choi Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility Cell Metab. 11 2010 286 297
-
(2010)
Cell Metab.
, vol.11
, pp. 286-297
-
-
Hill, J.W.1
Elias, C.F.2
Fukuda, M.3
Williams, K.W.4
Berglund, E.D.5
Holland, W.L.6
Cho, Y.R.7
Chuang, J.C.8
Xu, Y.9
Choi, M.10
-
21
-
-
0027295482
-
Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression
-
DOI 10.1210/me.7.7.852
-
Y. Ikeda, D.S. Lala, X. Luo, E. Kim, M.P. Moisan, and K.L. Parker Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression Molecular Endocrinology 7 1993 852 860 (Pubitemid 23220635)
-
(1993)
Molecular Endocrinology
, vol.7
, Issue.7
, pp. 852-860
-
-
Ikeda, Y.1
Lala, D.S.2
Luo, X.3
Kim, E.4
Moisan, M.-P.5
Parker, K.L.6
-
22
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
DOI 10.1038/35001622
-
S. Imai, C.M. Armstrong, M. Kaeberlein, and L. Guarente Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase Nature 403 2000 795 800 (Pubitemid 30111843)
-
(2000)
Nature
, vol.403
, Issue.6771
, pp. 795-800
-
-
Imai, S.-I.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
23
-
-
77956284607
-
Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects
-
SCOUT Investigators
-
W.P. James, I.D. Caterson, W. Coutinho, N. Finer, L.F. Van Gaal, A.P. Maggioni, C. Torp-Pedersen, A.M. Sharma, G.M. Shepherd, R.A. Rode, C.L. Renz SCOUT Investigators Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects N. Engl. J. Med. 363 2010 905 917
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 905-917
-
-
James, W.P.1
Caterson, I.D.2
Coutinho, W.3
Finer, N.4
Van Gaal, L.F.5
Maggioni, A.P.6
Torp-Pedersen, C.7
Sharma, A.M.8
Shepherd, G.M.9
Rode, R.A.10
Renz, C.L.11
-
24
-
-
34447308268
-
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
-
DOI 10.1038/sj.emboj.7601758, PII 7601758
-
D. Kim, M.D. Nguyen, M.M. Dobbin, A. Fischer, F. Sananbenesi, J.T. Rodgers, I. Delalle, J.A. Baur, G. Sui, and S.M. Armour SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis EMBO J. 26 2007 3169 3179 (Pubitemid 47057498)
-
(2007)
EMBO Journal
, vol.26
, Issue.13
, pp. 3169-3179
-
-
Kim, D.1
Nguyen, M.D.2
Dobbin, M.M.3
Fischer, A.4
Sananbenesi, F.5
Rodgers, J.T.6
Delalle, I.7
Baur, J.A.8
Sui, G.9
Armour, S.M.10
Puigserver, P.11
Sinclair, D.A.12
Tsai, L.-H.13
-
25
-
-
34848872799
-
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
-
DOI 10.1172/JCI31021
-
J.Y. Kim, E. van de Wall, M. Laplante, A. Azzara, M.E. Trujillo, S.M. Hofmann, T. Schraw, J.L. Durand, H. Li, and G. Li Obesity-associated improvements in metabolic profile through expansion of adipose tissue J. Clin. Invest. 117 2007 2621 2637 (Pubitemid 47494363)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.9
, pp. 2621-2637
-
-
Kim, J.-Y.1
Van De Wall, E.2
Laplante, M.3
Azzara, A.4
Trujillo, M.E.5
Hofmann, S.M.6
Schraw, T.7
Durand, J.L.8
Li, H.9
Li, G.10
Jelicks, L.A.11
Mehler, M.F.12
Hui, D.Y.13
Deshaies, Y.14
Shulman, G.I.15
Schwartz, G.J.16
Scherer, P.E.17
-
26
-
-
33845399894
-
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
-
DOI 10.1016/j.cell.2006.11.013, PII S0092867406014280
-
M. Lagouge, C. Argmann, Z. Gerhart-Hines, H. Meziane, C. Lerin, F. Daussin, N. Messadeq, J. Milne, P. Lambert, and P. Elliott Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha Cell 127 2006 1109 1122 (Pubitemid 44894520)
-
(2006)
Cell
, vol.127
, Issue.6
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
Geny, B.11
Laakso, M.12
Puigserver, P.13
Auwerx, J.14
-
27
-
-
23244458439
-
Medicine: Regulation of blood glucose by hypothalamic pyruvate metabolism
-
DOI 10.1126/science.1112085
-
T.K. Lam, R. Gutierrez-Juarez, A. Pocai, and L. Rossetti Regulation of blood glucose by hypothalamic pyruvate metabolism Science 309 2005 943 947 (Pubitemid 41099933)
-
(2005)
Science
, vol.309
, Issue.5736
, pp. 943-947
-
-
Lam, T.K.T.1
Gutierrez-Juarez, R.2
Pocai, A.3
Rossetti, L.4
-
28
-
-
0028303959
-
A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
-
DOI 10.1016/0092-8674(94)90211-9
-
X. Luo, Y. Ikeda, and K.L. Parker A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation Cell 77 1994 481 490 (Pubitemid 24153989)
-
(1994)
Cell
, vol.77
, Issue.4
, pp. 481-490
-
-
Luo, X.1
Ikeda, Y.2
Parker, K.L.3
-
29
-
-
34250788809
-
AKT/PKB Signaling: Navigating Downstream
-
DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
-
B.D. Manning, and L.C. Cantley AKT/PKB signaling: navigating downstream Cell 129 2007 1261 1274 (Pubitemid 46962095)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
30
-
-
61749094289
-
Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
-
C.E. McCurdy, J.M. Bishop, S.M. Williams, B.E. Grayson, M.S. Smith, J.E. Friedman, and K.L. Grove Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates J. Clin. Invest. 119 2009 323 335
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 323-335
-
-
McCurdy, C.E.1
Bishop, J.M.2
Williams, S.M.3
Grayson, B.E.4
Smith, M.S.5
Friedman, J.E.6
Grove, K.L.7
-
31
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
DOI 10.1038/nature06261, PII NATURE06261
-
J.C. Milne, P.D. Lambert, S. Schenk, D.P. Carney, J.J. Smith, D.J. Gagne, L. Jin, O. Boss, R.B. Perni, and C.B. Vu Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes Nature 450 2007 712 716 (Pubitemid 350207685)
-
(2007)
Nature
, vol.450
, Issue.7170
, pp. 712-716
-
-
Milne, J.C.1
Lambert, P.D.2
Schenk, S.3
Carney, D.P.4
Smith, J.J.5
Gagne, D.J.6
Jin, L.7
Boss, O.8
Perni, R.B.9
Vu, C.B.10
Bemis, J.E.11
Xie, R.12
Disch, J.S.13
Ng, P.Y.14
Nunes, J.J.15
Lynch, A.V.16
Yang, H.17
Galonek, H.18
Israelian, K.19
Choy, W.20
Iffland, A.21
Lavu, S.22
Medvedik, O.23
Sinclair, D.A.24
Olefsky, J.M.25
Jirousek, M.R.26
Elliott, P.J.27
Westphal, C.H.28
more..
-
32
-
-
0032971214
-
Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats
-
DOI 10.2337/diabetes.48.2.287
-
Y. Minokoshi, M.S. Haque, and T. Shimazu Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats Diabetes 48 1999 287 291 (Pubitemid 29061100)
-
(1999)
Diabetes
, vol.48
, Issue.2
, pp. 287-291
-
-
Minokoshi, Y.1
Haque, M.S.2
Shimazu, T.3
-
33
-
-
12344279952
-
Genetic factors in type 2 diabetes: The end of the beginning?
-
DOI 10.1126/science.1104346
-
S. O'Rahilly, I. Barroso, and N.J. Wareham Genetic factors in type 2 diabetes: the end of the beginning? Science 307 2005 370 373 (Pubitemid 40139970)
-
(2005)
Science
, vol.307
, Issue.5708
, pp. 370-373
-
-
O'Rahilly, S.1
Barroso, I.2
Wareham, N.J.3
-
34
-
-
56749156405
-
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
-
P. Oberdoerffer, S. Michan, M. McVay, R. Mostoslavsky, J. Vann, S.K. Park, A. Hartlerode, J. Stegmuller, A. Hafner, and P. Loerch SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging Cell 135 2008 907 918
-
(2008)
Cell
, vol.135
, pp. 907-918
-
-
Oberdoerffer, P.1
Michan, S.2
McVay, M.3
Mostoslavsky, R.4
Vann, J.5
Park, S.K.6
Hartlerode, A.7
Stegmuller, J.8
Hafner, A.9
Loerch, P.10
-
35
-
-
0000293983
-
Reciprocal Activities of the Ventromedial and Lateral Hypothalamic Areas of Cats
-
Y. Oomura, K. Kimura, H. Ooyama, T. Maeno, M. Iki, and M. Kuniyoshi Reciprocal Activities of the Ventromedial and Lateral Hypothalamic Areas of Cats Science 143 1964 484 485
-
(1964)
Science
, vol.143
, pp. 484-485
-
-
Oomura, Y.1
Kimura, K.2
Ooyama, H.3
Maeno, T.4
Iki, M.5
Kuniyoshi, M.6
-
36
-
-
77950246109
-
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
-
M. Pacholec, J.E. Bleasdale, B. Chrunyk, D. Cunningham, D. Flynn, R.S. Garofalo, D. Griffith, M. Griffor, P. Loulakis, B. Pabst, X. Qiu, and B. Stockman SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1 J. Biol. Chem. 285 2010 8340 8351
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 8340-8351
-
-
Pacholec, M.1
Bleasdale, J.E.2
Chrunyk, B.3
Cunningham, D.4
Flynn, D.5
Garofalo, R.S.6
Griffith, D.7
Griffor, M.8
Loulakis, P.9
Pabst, B.10
Qiu, X.11
Stockman, B.12
-
37
-
-
34548604499
-
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
-
DOI 10.1038/nature06098, PII NATURE06098
-
L.E. Parton, C.P. Ye, R. Coppari, P.J. Enriori, B. Choi, C.Y. Zhang, C. Xu, C.R. Vianna, N. Balthasar, and C.E. Lee Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity Nature 449 2007 228 232 (Pubitemid 47402365)
-
(2007)
Nature
, vol.449
, Issue.7159
, pp. 228-232
-
-
Parton, L.E.1
Ye, C.P.2
Coppari, R.3
Enriori, P.J.4
Choi, B.5
Zhang, C.-Y.6
Xu, C.7
Vianna, C.R.8
Balthasar, N.9
Lee, C.E.10
Elmquist, J.K.11
Cowley, M.A.12
Lowell, B.B.13
-
38
-
-
47749128879
-
Sirt1 protects against high-fat diet-induced metabolic damage
-
DOI 10.1073/pnas.0802917105
-
P.T. Pfluger, D. Herranz, S. Velasco-Miguel, M. Serrano, and M.H. Tschöp Sirt1 protects against high-fat diet-induced metabolic damage Proc. Natl. Acad. Sci. USA 105 2008 9793 9798 (Pubitemid 352031379)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.28
, pp. 9793-9798
-
-
Pfluger, P.T.1
Herranz, D.2
Velasco-Miguel, S.3
Serrano, M.4
Tschop, M.H.5
-
39
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
-
DOI 10.1038/nature02583
-
F. Picard, M. Kurtev, N. Chung, A. Topark-Ngarm, T. Senawong, R. Machado De Oliveira, M. Leid, M.W. McBurney, and L. Guarente Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma Nature 429 2004 771 776 (Pubitemid 38833129)
-
(2004)
Nature
, vol.429
, Issue.6993
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
Topark-Ngarm, A.4
Senawong, T.5
De Oliveira, R.M.6
Leid, M.7
McBurney, M.W.8
Guarente, L.9
-
40
-
-
17844379717
-
ATP channels control hepatic glucose production
-
DOI 10.1038/nature03439
-
A. Pocai, T.K. Lam, R. Gutierrez-Juarez, S. Obici, G.J. Schwartz, J. Bryan, L. Aguilar-Bryan, and L. Rossetti Hypothalamic K(ATP) channels control hepatic glucose production Nature 434 2005 1026 1031 (Pubitemid 40586051)
-
(2005)
Nature
, vol.434
, Issue.7036
, pp. 1026-1031
-
-
Pocal, A.1
Lam, T.K.T.2
Gutierrez-Juarez, R.3
Obici, S.4
Schwartz, G.J.5
Bryan, J.6
Aguilar-Bryan, L.7
Rossetti, L.8
-
41
-
-
63449112017
-
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
-
A. Purushotham, T.T. Schug, Q. Xu, S. Surapureddi, X. Guo, and X. Li Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation Cell Metab. 9 2009 327 338
-
(2009)
Cell Metab.
, vol.9
, pp. 327-338
-
-
Purushotham, A.1
Schug, T.T.2
Xu, Q.3
Surapureddi, S.4
Guo, X.5
Li, X.6
-
42
-
-
33746824192
-
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of alzheimer disease amyloid neuropathology by calorie restriction
-
DOI 10.1074/jbc.M602909200
-
W. Qin, T. Yang, L. Ho, Z. Zhao, J. Wang, L. Chen, W. Zhao, M. Thiyagarajan, D. MacGrogan, and J.T. Rodgers Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction J. Biol. Chem. 281 2006 21745 21754 (Pubitemid 44181878)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.31
, pp. 21745-21754
-
-
Qin, W.1
Yang, T.2
Ho, L.3
Zhao, Z.4
Wang, J.5
Chen, L.6
Zhao, W.7
Thiyagarajan, M.8
MacGrogan, D.9
Rodgers, J.T.10
Puigserver, P.11
Sadoshima, J.12
Deng, H.13
Pedrini, S.14
Gandy, S.15
Sauve, A.A.16
Pasinetti, G.M.17
-
43
-
-
77952875980
-
Pharmacological manipulations of CNS sirtuins: Potential effects on metabolic homeostasis
-
G. Ramadori, and R. Coppari Pharmacological manipulations of CNS sirtuins: potential effects on metabolic homeostasis Pharmacol. Res. 62 2010 48 54
-
(2010)
Pharmacol. Res.
, vol.62
, pp. 48-54
-
-
Ramadori, G.1
Coppari, R.2
-
44
-
-
54049158932
-
Brain SIRT1: Anatomical distribution and regulation by energy availability
-
G. Ramadori, C.E. Lee, A.L. Bookout, S. Lee, K.W. Williams, J. Anderson, J.K. Elmquist, and R. Coppari Brain SIRT1: anatomical distribution and regulation by energy availability J. Neurosci. 28 2008 9989 9996
-
(2008)
J. Neurosci.
, vol.28
, pp. 9989-9996
-
-
Ramadori, G.1
Lee, C.E.2
Bookout, A.L.3
Lee, S.4
Williams, K.W.5
Anderson, J.6
Elmquist, J.K.7
Coppari, R.8
-
45
-
-
71949100263
-
Central Administration of Resveratrol Improves Diet-Induced Diabetes
-
G. Ramadori, L. Gautron, T. Fujikawa, C.R. Vianna, J.K. Elmquist, and R. Coppari Central Administration of Resveratrol Improves Diet-Induced Diabetes Endocrinology 150 2009 5326 5333
-
(2009)
Endocrinology
, vol.150
, pp. 5326-5333
-
-
Ramadori, G.1
Gautron, L.2
Fujikawa, T.3
Vianna, C.R.4
Elmquist, J.K.5
Coppari, R.6
-
46
-
-
77956644726
-
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
-
G. Ramadori, T. Fujikawa, M. Fukuda, J. Anderson, D.A. Morgan, R. Mostoslavsky, R.C. Stuart, M. Perello, C.R. Vianna, and E.A. Nillni SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity Cell Metab. 12 2010 78 87
-
(2010)
Cell Metab.
, vol.12
, pp. 78-87
-
-
Ramadori, G.1
Fujikawa, T.2
Fukuda, M.3
Anderson, J.4
Morgan, D.A.5
Mostoslavsky, R.6
Stuart, R.C.7
Perello, M.8
Vianna, C.R.9
Nillni, E.A.10
-
47
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
-
DOI 10.1038/nature03354
-
J.T. Rodgers, C. Lerin, W. Haas, S.P. Gygi, B.M. Spiegelman, and P. Puigserver Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 Nature 434 2005 113 118 (Pubitemid 40349395)
-
(2005)
Nature
, vol.434
, Issue.7029
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
48
-
-
70449927248
-
Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system
-
T. Shiuchi, M.S. Haque, S. Okamoto, T. Inoue, H. Kageyama, S. Lee, C. Toda, A. Suzuki, E.S. Bachman, and Y.B. Kim Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system Cell Metab. 10 2009 466 480
-
(2009)
Cell Metab.
, vol.10
, pp. 466-480
-
-
Shiuchi, T.1
Haque, M.S.2
Okamoto, S.3
Inoue, T.4
Kageyama, H.5
Lee, S.6
Toda, C.7
Suzuki, A.8
Bachman, E.S.9
Kim, Y.B.10
-
49
-
-
27744457512
-
Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting
-
DOI 10.1038/nn1550, PII N1550
-
S.M. Sternson, G.M. Shepherd, and J.M. Friedman Topographic mapping of VMH - > arcuate nucleus microcircuits and their reorganization by fasting Nat. Neurosci. 8 2005 1356 1363 (Pubitemid 41630424)
-
(2005)
Nature Neuroscience
, vol.8
, Issue.10
, pp. 1356-1363
-
-
Sternson, S.M.1
Shepherd, G.M.G.2
Friedman, J.M.3
-
50
-
-
0025942149
-
Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats
-
M. Sudo, Y. Minokoshi, and T. Shimazu Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats Am. J. Physiol. 261 1991 E298 E303
-
(1991)
Am. J. Physiol.
, vol.261
-
-
Sudo, M.1
Minokoshi, Y.2
Shimazu, T.3
-
51
-
-
0024229140
-
Diet-induced type II diabetes in C57BL/6J mice
-
R.S. Surwit, C.M. Kuhn, C. Cochrane, J.A. McCubbin, and M.N. Feinglos Diet-induced type II diabetes in C57BL/6J mice Diabetes 37 1988 1163 1167 (Pubitemid 19035045)
-
(1988)
Diabetes
, vol.37
, Issue.9
, pp. 1163-1167
-
-
Surwit, R.S.1
Kuhn, C.M.2
Cochrane, C.3
McCubbin, J.A.4
Feinglos, M.N.5
-
52
-
-
0042697384
-
Weight gain profiles of new anti-psychotics: Public health consequences
-
DOI 10.1046/j.1467-789X.2003.00105.x
-
S. Tardieu, J. Micallef, S. Gentile, and O. Blin Weight gain profiles of new anti-psychotics: public health consequences Obes. Rev. 4 2003 129 138 (Pubitemid 36950575)
-
(2003)
Obesity Reviews
, vol.4
, Issue.3
, pp. 129-138
-
-
Tardieu, S.1
Micallef, J.2
Gentile, S.3
Blin, O.4
-
53
-
-
34247616021
-
Synaptic Glutamate Release by Ventromedial Hypothalamic Neurons Is Part of the Neurocircuitry that Prevents Hypoglycemia
-
DOI 10.1016/j.cmet.2007.04.001, PII S1550413107000964
-
Q. Tong, C. Ye, R.J. McCrimmon, H. Dhillon, B. Choi, M.D. Kramer, J. Yu, Z. Yang, L.M. Christiansen, and C.E. Lee Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia Cell Metab. 5 2007 383 393 (Pubitemid 46667758)
-
(2007)
Cell Metabolism
, vol.5
, Issue.5
, pp. 383-393
-
-
Tong, Q.1
Ye, C.2
McCrimmon, R.J.3
Dhillon, H.4
Choi, B.5
Kramer, M.D.6
Yu, J.7
Yang, Z.8
Christiansen, L.M.9
Lee, C.E.10
Choi, C.S.11
Zigman, J.M.12
Shulman, G.I.13
Sherwin, R.S.14
Elmquist, J.K.15
Lowell, B.B.16
-
54
-
-
50249120768
-
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
-
Q. Tong, C.P. Ye, J.E. Jones, J.K. Elmquist, and B.B. Lowell Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance Nature Neuroscience 11 2008 998 1000
-
(2008)
Nature Neuroscience
, vol.11
, pp. 998-1000
-
-
Tong, Q.1
Ye, C.P.2
Jones, J.E.3
Elmquist, J.K.4
Lowell, B.B.5
-
55
-
-
78650839802
-
A treasure trove of hypothalamic neurocircuitries governing body weight homeostasis
-
C.R. Vianna, and R. Coppari A treasure trove of hypothalamic neurocircuitries governing body weight homeostasis Endocrinology 152 2011 11 18
-
(2011)
Endocrinology
, vol.152
, pp. 11-18
-
-
Vianna, C.R.1
Coppari, R.2
-
56
-
-
36048991085
-
Physiology. An integrative view of obesity
-
B.E. Wisse, F. Kim, and M.W. Schwartz Physiology. An integrative view of obesity Science 318 2007 928 929
-
(2007)
Science
, vol.318
, pp. 928-929
-
-
Wisse, B.E.1
Kim, F.2
Schwartz, M.W.3
-
57
-
-
77956627976
-
PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis
-
Y. Xu, J.W. Hill, M. Fukuda, L. Gautron, J.W. Sohn, K.W. Kim, C.E. Lee, M.J. Choi, D.A. Lauzon, and H. Dhillon PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis Cell Metab. 12 2010 88 95
-
(2010)
Cell Metab.
, vol.12
, pp. 88-95
-
-
Xu, Y.1
Hill, J.W.2
Fukuda, M.3
Gautron, L.4
Sohn, J.W.5
Kim, K.W.6
Lee, C.E.7
Choi, M.J.8
Lauzon, D.A.9
Dhillon, H.10
-
58
-
-
54349113070
-
Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight
-
R. Zhang, H. Dhillon, H. Yin, A. Yoshimura, B.B. Lowell, E. Maratos-Flier, and J.S. Flier Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight Endocrinology 149 2008 5654 5661
-
(2008)
Endocrinology
, vol.149
, pp. 5654-5661
-
-
Zhang, R.1
Dhillon, H.2
Yin, H.3
Yoshimura, A.4
Lowell, B.B.5
Maratos-Flier, E.6
Flier, J.S.7
|