Extending healthy life span-from yeast to humans

Science

Volumn 328, Issue 5976, 2010, Pages 321-326

  Fontana, Luigi ^a,b   Partridge, Linda ^c   Longo, Valter D ^d  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Division of Nutrition and Aging   (Italy)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE KINASE; ADENYLATE CYCLASE; ADIPONECTIN; C REACTIVE PROTEIN; CHOLESTEROL; CYCLIC AMP DEPENDENT PROTEIN KINASE; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; INSULIN; LIOTHYRONINE; PROTEIN SERINE THREONINE KINASE; RAS PROTEIN; S6 KINASE; SOMATOMEDIN; SUPEROXIDE DISMUTASE; TARGET OF RAPAMYCIN KINASE; TESTOSTERONE; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR FOXO;

CANCER; CARDIOVASCULAR DISEASE; DIABETES; DIET; FOOD INTAKE; GENETIC VARIATION; HEALTH STATUS; HORMONE; LONGEVITY; MUTATION; PATHOLOGY; PRIMATE; PUBLIC HEALTH; RODENT; YEAST;

AGING; AMENORRHEA; ARTERY INTIMA PROLIFERATION; BLOOD PRESSURE; BRAIN ATROPHY; CAENORHABDITIS ELEGANS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DIABETES MELLITUS; DIET RESTRICTION; DILUTION; DROSOPHILA; ENZYME ACTIVATION; EVOLUTION; FERTILITY; FOOD INTAKE; GENE DELETION; GENETIC SCREENING; GENETIC VARIABILITY; GRAY MATTER; GROWTH; HEALTH; HEALTH HAZARD; HEALTH PROMOTION; HEART LEFT VENTRICLE FAILURE; HUMAN; IMMUNE DEFICIENCY; INFERTILITY; INFLAMMATION; INSULIN RESISTANCE; LIFESPAN; METABOLISM; MUSCLE ATROPHY; MUTATION; NEOPLASM; NONHUMAN; NUTRIENT CONTENT; OBESITY; OSTEOPOROSIS; OXIDATIVE STRESS; PRIMARY PREVENTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RECEPTOR BINDING; REPRODUCTION; REVIEW; SIGNAL TRANSDUCTION; STARVATION; SURVIVAL; YEAST;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; CALORIC RESTRICTION; DROSOPHILA; EATING; HAPLORHINI; HUMANS; LONGEVITY; MICE; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

MACACA MULATTA; RODENTIA;

EID: 77951176737     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1172539     Document Type: Review

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70. We thank M. Wei for careful reading of the manuscript. This work was supported in part by a grant from the American Federation for Aging Research, Bakewell Foundation, and by NIH grants AG20642, AG025135, and GM075308 (to v.D.L). Support was also provided by the National Center for Research Resources (grant UL1 RR024992) and the National Institute of Diabetes and Digestive and Kidney Diseases (grant P30DK056341); by grants from lstituto Superiore di Sanità/National Institutes of Health Collaboration Program, Ministero della Salute, the Longer Life Foundation (an RGA/ Washington University Partnership), and the Bakewell Foundation; and by a donation from the Scott and Annie Appleby Charitable Trust (to L.F.).