Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 18, 1997, Pages 9866-9868

  Smith, Mark A ^a   Harris, Peggy L R ^a   Sayre, Lawrence M ^a   Perry, George ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFEROXAMINE; FREE RADICAL; HISTIDINE; HYDROGEN PEROXIDE; IRON;

AGED; ALZHEIMER DISEASE; ARTICLE; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; NEUROFIBRILLARY TANGLE; OXIDATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; SENILE PLAQUE;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; FREE RADICALS; HIPPOCAMPUS; HISTOCYTOCHEMISTRY; HUMANS; IRON; MIDDLE AGED; OXIDATION-REDUCTION;

EID: 0030885482     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.18.9866     Document Type: Article

References (26)

1. Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A. & Markesbery, W. R. (1991) Proc. Natl. Acad. Sci. USA 88, 10540-10543.
2. Pappolla, M. A., Omar, R. A., Kim, K. S. & Robakis, N. K. (1992) Am. J. Pathol. 140, 621-628.
3. Smith, M. A., Kutty, R. K., Richey, P. L., Van, S.-D., Stern, D., Chader, G. J., Wiggert, B., Petersen, R. B. & Perry, G. (1994) Am. J. Pathol 145, 42-47.
4. Smith, M. A., Sayre, L. M., Monnier, V. M. & Perry, G. (1995) Trends Neurosci. 18, 172-176.
5. Smith, M. A., Perry, G., Richey, P. L., Sayre, L. M., Anderson, V. E., Beal, M. F. & Kowall, N. (1996) Nature (London) 382, 120-121.
6. Connor, J. R., Menzies, S. L., St. Martin, S. M. & Mufson, E. J. (1992) J. Neurosci. Res. 31, 75-83.
7. Connor, J. R., Snyder, B. S., Beard, J. L., Fine, R. E. & Mufson, E. J. (1992) J. Neurosci. Res. 31, 327-335.
8. Good, P. F., Perl, D. P., Bierer, L. M. & Schmeidler, J. (1992) Ann. Neurol. 31, 286-292.
9. Thompson, C. M., Markesbery, W. R., Ehmann, W. D., Mao, Y.-X. & Vance, D. E. (1988) Neurotoxicology 9, 1-7.
10. Perls, M. (1867) Virchows Arch. Pathol. Anat. 39, 42.
11. Virchow, R. (1847) Virchows Arch. Pathol. Anat. 1, 379.
12. Nguyen-Legros, J., Bizot, J., Bolesse, M. & Pulicani, J. P. (1980) Histochemistry 66, 239-244.
13. Perry, G., Siedlak, S. L., Richey, P., Kawai, M., Cras, P., Kalaria, R. N., Galloway, P. G., Miriam Scardina, J., Cordell, B., Greenberg, B. D., Ledbetter, S. R. & Gambetti, P. (1991) J. Neurosci. 11, 3679-3683.
14. DeWitt, D. A., Richey, P. L., Praprotnik, D., Silver, J. & Perry, G. (1994) Brain Res. 656, 205-209.
15. Smith, M. A., Siedlak, S. L., Richey, P. L., Mulvihill, P., Ghiso, J., Frangione, B., Tagliavini, F., Giaccone, G., Bugiani, O., Praprotnik, D., Kalaria, R. N. & Perry, G. (1995) Nat. Med. 1, 365-369.
16. Badet-Denisot, M.-A. & Badet, B. (1992) Arch. Biochem. Biophys. 292, 475-478.
17. Secundo, F., Carrea, G., D'Arrigo, P. & Servi, S. (1996) Biochemistry 35, 9631-9636.
18. Grundke-Iqbal, I., Fleming, J., Tung, Y. C., Lassmann, H., Iqbal, K. & Joshi, J. G. (1990) Acta Neuropathol. 81, 105-110.
19. Leong, L. M., Tan, B. H. & Ho, K. K. (1992) Anal. Biochem. 207, 317-320.
20. Kawamata, T., Tooyama, I., Yamada, T., Walker, D. G. & McGeer, P. L. (1993) Am. J. Pathol. 142, 1574-1585.
21. Bush, A. I., Pettingell, W. H., Multhaup, G., de Paradis, M., Vonsattel, J. P., Gusella, J. F., Beyreuther, K., Masters, C. L. & Tanzi, R. E. (1994) Science 265, 1464-1467.
22. Miyata, M. & Smith, J. D. (1996) Nat. Genet. 14, 55-61.
23. Spiro, T. G. & Saltman, P. (1974) in Iron in Biochemistry and Medicine, eds. Jacobs, A. & Worwood, M. (Academic, London), pp. 1-28.
24. May, P. M. & Williams, D. R. (1980) Iron Biochem. Med. 2, 1-28.
25. Smith, M. A., Harris, P. L. R., Sayre, L. M., Beckman, J. S. & Perry, G. (1997) J. Neurosci. 17, 2653-2657.
26. Kennard, M. L., Feldman, H., Yamada, T. & Jefferies, W. A. (1996) Nat. Med. 2, 1230-1235.