Cocoa polyphenols inhibit phorbol ester-induced superoxide anion formation in cultured HL-60 cells and expression of cyclooxygenase-2 and activation of NF-κB and MAPKs in mouse skin in vivo

Journal of Nutrition

Volumn 136, Issue 5, 2006, Pages 1150-1155

  Ki, Won Lee ^a   Kundu, Joydeb Kumar ^a   Sue, Ok Kim ^a   Chun, Kyung Soo ^a   Hyong, Joo Lee ^a   Surh, Young Joon ^a  

^a Seoul National University   (South Korea)

Author keywords

Antiinflammation; Cocoa polyphenols; Cyclooxygenase 2; Mouse skin; Nuclear factor B

Indexed keywords

COCOA POLYPHENOL; CYCLOOXYGENASE 2; FLAVONOID; FREE RADICAL; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; POLYPHENOL DERIVATIVE; SCAVENGER; SUPEROXIDE; UNCLASSIFIED DRUG; XANTHINE OXIDASE; XANTHINE OXIDASE INHIBITOR;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CACAO; CELL STRAIN HL 60; CONTROLLED STUDY; DNA BINDING; DRUG ACTIVITY; DRUG INHIBITION; EDEMA; ENZYME PHOSPHORYLATION; FEMALE; IN VIVO CULTURE; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SKIN;

THEOBROMA CACAO;

EID: 33646420331     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.5.1150     Document Type: Article

References (42)

1. Surh Y-J. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer. 2003;3:768-80.
2. Chen C, Kong AN. Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects. Trends Pharmacol Sci. 2005;26:318-26.
3. Fraga CG. Cocoa, diabetes, and hypertension: should we eat more chocolate? Am J Clin Nutr. 2005;81:541-2.
4. Arteel GE, Sies H. Reactions of peroxynitrite with cocoa procyanidin oligomers. FEBS Lett. 1999;462:167-70.
5. Carnesecchi S, Schneider Y, Lazarus SA, Coehlo D, Gosse F, Raul F. Flavanols and procyanidins of cocoa and chocolate inhibit growth and polyamine biosynthesis of human colonic cancer cells. Cancer Lett. 2002;175:147-55.
6. Lee KW, Kim YJ, Lee HJ, Lee CY. Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. J Agric Food Chem. 2003;51:7292-5.
7. Serafini M, Bugianesi R, Maiani G, Valtuena S, Santis SD, Crozier A. Plasma antioxidants from chocolate. Nature. 2003;424:1013.
8. Vinson JA, Proch J, Zubik L. Phenol antioxidant quantity and quality in foods: cocoa, dark chocolate, and milk chocolate. J Agric Food Chem. 1999;47:4821-4.
9. Osakabe N, Yasuda A, Natsume M, Takizawa T, Terao J, Kondo K. Catechins and their oligomers linked by C4 → C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro. Exp Biol Med. 2002;227:51-6.
10. Schewe T, Kuhn H, Sies H. Flavonoids of cocoa inhibit recombinant human 5-lipoxygenase. J Nutr. 2002;132:1825-9.
11. Yamagishi M, Natsume M, Osakabe N, Nakamura H, Furukawa F, Imazawa T, Nishikawa A, Hirose M. Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats. Cancer Lett. 2002;185:123-30.
12. Yamagishi M, Natsume M, Osakabe N, Okazaki K, Furukawa F, Imazawa T, Nishikawa A, Hirose M. Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model. Cancer Lett. 2003;191:49-57.
13. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420:860-7.
14. Halliday GM. Inflammation, gene mutation and photoimmunosuppression in response to UVR-induced oxidative damage contributes to photocarcinogenesis. Mutat Res. 2005;571:107-20.
15. Kundu JK, Surh YJ. Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals. Mutat Res. 2005;591:123-46.
16. Cerutti PA. Prooxidant states and tumor promotion. Science. 1985;227:375-81.
17. Marnett LJ. Peroxyl free radicals: potential mediators of tumor initiation and promotion. Carcinogenesis. 1987;8:1365-73.
18. Reiners JJ, Pence BC, Barcus MC, Cantu AR. 12-O-tetradecanoylphorbol-13- acetate-dependent induction of xanthine dehydrogenase and conversion to xanthine oxidase in murine epidermis. Cancer Res. 1987;47:1775-9.
19. Muller-Decker K, Neufang G, Berger I, Neumann M, Marks F, Furstenberger G. Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis. Proc Natl Acad Sci USA. 2002;99:12483-8.
20. Tiano HF, Loftin CD, Akunda J, Lee CA, Spalding J, Sessoms A, Dunson DB, Rogan EG, Morham SG, et al. Deficiency of either cyclooxygenase (COX-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res. 2002;62:3395-401.
21. Zhi YH, Liu RS, Song MM, Tian Y, Long J, Tu W, Guo RX. Cyclooxygenase-2 promotes angiogenesis by increasing vascular endothelial growth factor and predicts prognosis in gallbladder carcinoma. World J Gastroenterol. 2005;11:3724-8.
22. Chun K-S, Kim SH, Song YS, Surh Y-J. Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin. Carcinogenesis. 2004;25:713-22.
23. Kim Y, Fischer SM. Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/enhancer-binding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissues. J Biol Chem. 1998;273:27686-94.
24. Surh YJ, Kundu JK. Signal transduction network leading to COX-2 induction: a road map in search of cancer chemopreventives. Arch Pharm Res. 2005;28:1-15.
25. Chang MS, Chen BC, Yu MT, Sheu JR, Chen TF, Lin CH. Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways. Cell Signal. 2005;17:299-310.
26. Chun K-S, Keum YS, Han SS, Song YS, Kim SH, Surh Y-J. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. Carcinogenesis. 2003;24:1515-24.
27. Zhishen J, Mengcheng T, Jianming W. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 1999;64:555-9.
28. Kim DO, Lee KW, Lee HJ, Lee CY. Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. J Agric Food Chem. 2002;50:3713-7.
29. van den Berg R, Haenen GRMM, van den Berg H, Bast A. Applicability of an improved Trolox equivalent antioxidant capacity (TEAC). assay for evaluation of antioxidant capacity measurements of mixtures. Food Chem. 1999;66:511-7.
30. Brand-Williams W, Cuvelier ME, Berset C. Use of a free radical method to evaluate antioxidant activity. Lebensm Wissu Technol. 1995;28:25-30.
31. Gotoh N, Niki E. Rates of interactions of superoxide with vitamin E, vitamin C and related compounds as measured by chemiluminescence. Biochim Biophys Acta. 1992;1115:201-7.
32. Nakamura Y, Murakami A, Ohto Y, Torikai K, Tanaka T, Ohigashi H. Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1′-acetoxychavicol acetate. Cancer Res. 1998;58:4832-39.
33. Kundu JK, Na HK, Chun K-S, Kim YK, Lee SJ, Lee SS, Lee OS, Sim YC, Surh Y-J. Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells. J Nutr. 2003;133:3805S-10S.
34. Kim SO, Kundu JK, Shin YK, Park JH, Cho MH, Kim TY, Surh YJ. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Oncogene. 2005;24:2558-67.
35. Wang HQ, Kim MP, Tiano HF, Langenbach R, Smart RC. Protein kinase C-alpha coordinately regulates cytosolic phospholipase A(2) activity and the expression of cyclooxygenase-2 through different mechanisms in mouse keratinocytes. Mol Pharmacol. 2001;59:860-6.
36. Klaunig JE. Chemopreventive effects of green tea components on hepatic carcinogenesis. Prev Med. 1992;21:510-9.
37. Wei H, Bowen R, Cai Q, Barnes S, Wang Y. Antioxidant and antipromotional effects of the soybean isoflavone genistein. Proc Soc Exp Biol Med. 1995;208:124-30.
38. Philip M, Rowley DA, Schreiber H. Inflammation as a tumor promoter in cancer induction. Semin Cancer Biol. 2004;14:433-9.
39. Chun KS, Surh YJ. Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. Biochem Pharmacol. 2004;68:1089-100.
40. Manach C, Scalbert A, Morand C, Remesy C, Jimenez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;79:727-47.
41. Manach C, Morand C, Gil-Izquierdo A, Bouteloup-Demange C, Remesy C. Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. Eur J Clin Nutr. 2003;57:235-42.
42. Silberberg M, Morand C, Mathevon T, Besson C, Manach C, Scalbert A, Remesy C. The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites. Eur J Nutr. 2006;45:88-96.