Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating bim protein

Journal of Biological Chemistry

Volumn 287, Issue 39, 2012, Pages 32307-32311

  Liu, Lei ^a   Arun, Anirudh ^a   Ellis, Lakia ^a   Peritore, Carina ^a   Donmez, Gizem ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE-RELATED DISEASE; BENEFICIAL EFFECTS; CLINICAL FEATURES; DEACETYLASE; DOPAMINERGIC PATHWAYS; NEURODEGENERATION; PARKINSON DISEASE; PROTEIN LEVEL; SIRTUIN; SYSTEMIC ADMINISTRATION;

ACETYLATION; PROTEINS; RNA;

CELL DEATH;

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; BIM PROTEIN; RNA; SIRTUIN 2; TRANSCRIPTION FACTOR FKHRL1;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEACETYLATION; GENE; GENE DELETION; MOUSE; NERVE DEGENERATION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIRT2 GENE;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ACETYLATION; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MPTP POISONING; NERVE TISSUE PROTEINS; NEUROTOXINS; PARKINSON DISEASE, SECONDARY; PROTO-ONCOGENE PROTEINS; SIRTUIN 2; STRIATONIGRAL DEGENERATION; SUBSTANTIA NIGRA;

EID: 84866556460     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C112.403048     Document Type: Article

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