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Volumn 143, Issue 5, 2013, Pages 597-605

Pomegranate polyphenols and extract inhibit nuclear factor of activated T-cell activity and microglial activation invitroand inatransgenic mouse model of alzheimer disease

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; DRINKING WATER; ELLAGIC ACID; POMEGRANATE EXTRACT; PRESENILIN 1; PUNICALAGIN; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84877006963     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.112.169516     Document Type: Article
Times cited : (122)

References (69)
  • 1
    • 0024821978 scopus 로고
    • A study of the morphology and distribution of amyloid beta protein immunoreactive plaque and related lesions in the brains of Alzheimer's disease and adult Down's syndrome
    • Ikeda S, Allsop D, Glenner GG. A study of the morphology and distribution of amyloid beta protein immunoreactive plaque and related lesions in the brains of Alzheimer's disease and adult Down's syndrome. Prog Clin Biol Res. 1989;317:313-23.
    • (1989) Prog Clin Biol Res , vol.317 , pp. 313-23
    • Ikeda, S.1    Allsop, D.2    Glenner, G.G.3
  • 3
    • 0023809230 scopus 로고
    • Alzheimer's disease: a double-labeling immunohistochemical study of senile plaques
    • Dickson DW, Farlo J, Davies P, Crystal H, Fuld P, Yen SH. Alzheimer's disease: a double-labeling immunohistochemical study of senile plaques. Am J Pathol. 1988;132:86-101.
    • (1988) Am J Pathol , vol.132 , pp. 86-101
    • Dickson, D.W.1    Farlo, J.2    Davies, P.3    Crystal, H.4    Fuld, P.5    Yen, S.H.6
  • 4
    • 0024436506 scopus 로고
    • Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
    • Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol. 1989;24:173-82.
    • (1989) J Neuroimmunol , vol.24 , pp. 173-82
    • Itagaki, S.1    McGeer, P.L.2    Akiyama, H.3    Zhu, S.4    Selkoe, D.5
  • 5
    • 0000920292 scopus 로고    scopus 로고
    • Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease
    • Du Yan S, Zhu H, Fu J, Yan SF, Roher A, TourtellotteWW, Rajavashisth T, Chen X, Godman GC, Stern D, et al. Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. Proc Natl Acad Sci USA. 1997;94: 5296-301.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5296-301
    • Du Yan, S.1    Zhu, H.2    Fu, J.3    Yan, S.F.4    Roher, A.5    Tourtellotte, W.W.6    Rajavashisth, T.7    Chen, X.8    Godman, G.C.9    Stern, D.10
  • 6
    • 0030210955 scopus 로고    scopus 로고
    • Beta-amyloid (25-35) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells
    • Meda L, Bernasconi S, Bonaiuto C, Sozzani S, Zhou D, Otvos L Jr, Mantovani A, Rossi F, Cassatella MA. Beta-amyloid (25-35) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells. J Immunol. 1996;157:1213-8.
    • (1996) J Immunol , vol.157 , pp. 1213-8
    • Meda, L.1    Bernasconi, S.2    Bonaiuto, C.3    Sozzani, S.4    Zhou, D.5    Otvos Jr, L.6    Mantovani, A.7    Rossi, F.8    Cassatella, M.A.9
  • 8
    • 61349164312 scopus 로고    scopus 로고
    • Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia
    • Sondag CM, Dhawan G, Combs CK. Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia. J Neuroinflammation. 2009;6:1.
    • (2009) J Neuroinflammation , vol.6 , pp. 1
    • Sondag, C.M.1    Dhawan, G.2    Combs, C.K.3
  • 9
  • 10
    • 84861314593 scopus 로고    scopus 로고
    • Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease.
    • Jaturapatporn D, Isaac MG, McCleery J, Tabet N. Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease. Cochrane Database Syst Rev. 2012;2:CD006378.
    • (2012) Cochrane Database Syst Rev. , vol.2
    • Jaturapatporn, D.1    Isaac, M.G.2    McCleery, J.3    Tabet, N.4
  • 12
    • 80053383308 scopus 로고    scopus 로고
    • Effects of nonsteroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial
    • Leoutsakos JM, Muthen BO, Breitner JC, Lyketsos CG. Effects of nonsteroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial. Int J Geriatr Psychiatry. 2012;27:364-74.
    • (2012) Int J Geriatr Psychiatry , vol.27 , pp. 364-74
    • Leoutsakos, J.M.1    Muthen, B.O.2    Breitner, J.C.3    Lyketsos, C.G.4
  • 13
    • 0025077080 scopus 로고
    • Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain
    • Styren SD, Civin WH, Rogers J. Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain. Exp Neurol. 1990;110:93-104.
    • (1990) Exp Neurol. , vol.110 , pp. 93-104
    • Styren, S.D.1    Civin, W.H.2    Rogers, J.3
  • 14
    • 0023633015 scopus 로고
    • Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR.
    • McGeer PL, Itagaki S, Tago H, McGeer EG. Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR. Neurosci Lett. 1987;79: 195-200.
    • (1987) Neurosci Lett. , vol.79 , pp. 195-200
    • McGeer, P.L.1    Itagaki, S.2    Tago, H.3    McGeer, E.G.4
  • 15
    • 0030973579 scopus 로고    scopus 로고
    • Transcription factors of the NFAT family: regulation and function
    • Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol. 1997;15:707-47.
    • (1997) Annu Rev Immunol , vol.15 , pp. 707-47
    • Rao, A.1    Luo, C.2    Hogan, P.G.3
  • 16
    • 0033594887 scopus 로고    scopus 로고
    • NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun
    • Lopez-Rodríguez C, Aramburu J, Rakeman AS, Rao A. NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. Proc Natl Acad Sci USA. 1999;96:7214-9.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7214-9
    • Lopez-rodríguez, C.1    Aramburu, J.2    Rakeman, A.S.3    Rao, A.4
  • 17
    • 20644466433 scopus 로고    scopus 로고
    • NFAT proteins: key regulators of T-cell development and function.
    • Macian F. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol. 2005;5:472-84.
    • (2005) Nat Rev Immunol. , vol.5 , pp. 472-84
    • Macian, F.1
  • 19
    • 0037806030 scopus 로고    scopus 로고
    • Neurotrophins and netrins require calcineurin/NFATsignaling to stimulate outgrowth of embryonic axons
    • Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR.Neurotrophins and netrins require calcineurin/NFATsignaling to stimulate outgrowth of embryonic axons. Cell. 2003;113:657-70.
    • (2003) Cell , vol.113 , pp. 657-70
    • Graef, I.A.1    Wang, F.2    Charron, F.3    Chen, L.4    Neilson, J.5    Tessier-lavigne, M.6    Crabtree, G.R.7
  • 20
    • 41149179522 scopus 로고    scopus 로고
    • Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS.
    • Luoma JI, Zirpel L. Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS. J Neurosci. 2008;28:3159-69.
    • (2008) J Neurosci. , vol.28 , pp. 3159-69
    • Luoma, J.I.1    Zirpel, L.2
  • 23
    • 52049094598 scopus 로고    scopus 로고
    • Interleukin-1beta-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/NFAT activity
    • Sama MA, Mathis DM, Furman JL, Abdul HM, Artiushin IA, Kraner SD, Norris CM. Interleukin-1beta-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/NFAT activity. J Biol Chem. 2008;283:21953-64.
    • (2008) J Biol Chem , vol.283 , pp. 21953-64
    • Sama, M.A.1    Mathis, D.M.2    Furman, J.L.3    Abdul, H.M.4    Artiushin, I.A.5    Kraner, S.D.6    Norris, C.M.7
  • 25
    • 77954755219 scopus 로고    scopus 로고
    • Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated T cells)
    • Nagamoto-Combs K, Combs CK. Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated T cells). J Neurosci. 2010;30:9641-6.
    • (2010) J Neurosci , vol.30 , pp. 9641-6
    • Nagamoto-combs, K.1    Combs, C.K.2
  • 26
    • 0033531791 scopus 로고    scopus 로고
    • P2X7/P2Z purinoreceptormediated activation of transcription factor NFAT in microglial cells
    • Ferrari D, Stroh C, Schulze-Osthoff K. P2X7/P2Z purinoreceptormediated activation of transcription factor NFAT in microglial cells. J Biol Chem. 1999;274:13205-10.
    • (1999) J Biol Chem , vol.274 , pp. 13205-10
    • Ferrari, D.1    Stroh, C.2    Schulze-osthoff, K.3
  • 27
    • 57249111810 scopus 로고    scopus 로고
    • Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT
    • Kataoka A, Tozaki-Saitoh H, Koga Y, Tsuda M, Inoue K. Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT. J Neurochem. 2009;108:115-25.
    • (2009) J Neurochem , vol.108 , pp. 115-25
    • Kataoka, A.1    Tozaki-saitoh, H.2    Koga, Y.3    Tsuda, M.4    Inoue, K.5
  • 28
    • 0035971436 scopus 로고    scopus 로고
    • Partners in transcription: NFAT and AP-1
    • Macián F, Lopez-Rodriguez C, Rao A. Partners in transcription: NFAT and AP-1. Oncogene. 2001;20:2476-89.
    • (2001) Oncogene , vol.20 , pp. 2476-89
    • Macián, F.1    Lopez-rodriguez, C.2    Rao, A.3
  • 29
    • 0025736529 scopus 로고
    • Comparison of the effects of FK-506, cyclosporin A and rapamycin on IL-2 production
    • Henderson DJ, Naya I, Bundick RV, Smith GM, Schmidt JA. Comparison of the effects of FK-506, cyclosporin A and rapamycin on IL-2 production. Immunology. 1991;73:316-21.
    • (1991) Immunology , vol.73 , pp. 316-21
    • Henderson, D.J.1    Naya, I.2    Bundick, R.V.3    Smith, G.M.4    Schmidt, J.A.5
  • 31
    • 68049109460 scopus 로고    scopus 로고
    • The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins
    • Mohebbi N, Mihailova M, Wagner CA. The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins. Am J Physiol Renal Physiol. 2009;297:F499-509.
    • (2009) Am J Physiol Renal Physiol , vol.297
    • Mohebbi, N.1    Mihailova, M.2    Wagner, C.A.3
  • 32
    • 11144347825 scopus 로고    scopus 로고
    • Discovery of small-molecule inhibitors of the NFAT-calcineurin interaction by competitive highthroughput fluorescence polarization screening
    • Roehrl MH, Wang JY, Wagner G. Discovery of small-molecule inhibitors of the NFAT-calcineurin interaction by competitive highthroughput fluorescence polarization screening. Biochemistry. 2004;43: 16067-75.
    • (2004) Biochemistry , vol.43 , pp. 16067-75
    • Roehrl, M.H.1    Wang, J.Y.2    Wagner, G.3
  • 33
    • 27844549820 scopus 로고    scopus 로고
    • Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site
    • Kang S, Li H, Rao A, Hogan PG. Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site. J Biol Chem. 2005;280:37698-706.
    • (2005) J Biol Chem , vol.280 , pp. 37698-706
    • Kang, S.1    Li, H.2    Rao, A.3    Hogan, P.G.4
  • 37
    • 40549129366 scopus 로고    scopus 로고
    • Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling
    • Cho HJ, Jin SM, Youn HD, Huh K, Mook-Jung I. Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling. Aging Cell. 2008;7: 137-47.
    • (2008) Aging Cell , vol.7 , pp. 137-47
    • Cho, H.J.1    Jin, S.M.2    Youn, H.D.3    Huh, K.4    Mook-jung, I.5
  • 38
    • 0037219635 scopus 로고    scopus 로고
    • Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice
    • Cerdá B, Llorach R, Ceron JJ, Espin JC, Tomas-Barberan FA. Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. Eur J Nutr. 2003;42:18-28.
    • (2003) Eur J Nutr , vol.42 , pp. 18-28
    • Cerdá, B.1    Llorach, R.2    Ceron, J.J.3    Espin, J.C.4    Tomas-barberan, F.A.5
  • 39
    • 33749494522 scopus 로고    scopus 로고
    • Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours
    • Seeram NP, Henning SM, Zhang Y, Suchard M, Li Z, Heber D. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. J Nutr. 2006;136:2481-5.
    • (2006) J Nutr , vol.136 , pp. 2481-5
    • Seeram, N.P.1    Henning, S.M.2    Zhang, Y.3    Suchard, M.4    Li, Z.5    Heber, D.6
  • 40
    • 80051855181 scopus 로고    scopus 로고
    • Pomegranate phenolics from the peels, arils, and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein E-deficient (E 0) mice and in vitro in cultured macrophages and lipoproteins
    • Aviram M, Volkova N, Coleman R, Dreher M, Reddy MK, Ferreira D, Rosenblat M. Pomegranate phenolics from the peels, arils, and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein E-deficient (E 0) mice and in vitro in cultured macrophages and lipoproteins. J Agric Food Chem. 2008;56:1148-57.
    • (2008) J Agric Food Chem. , vol.56 , pp. 1148-1157
    • Aviram, M.1    Volkova, N.2    Coleman, R.3    Dreher, M.4    Reddy, M.K.5    Ferreira, D.6    Rosenblat, M.7
  • 42
    • 4444365417 scopus 로고    scopus 로고
    • Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.)
    • Seeram NP, Lee R, Heber D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clin Chim Acta. 2004;348:63-8.
    • (2004) juice. Clin Chim Acta , vol.348 , pp. 63-68
    • Seeram, N.P.1    Lee, R.2    Heber, D.3
  • 43
    • 33751260936 scopus 로고    scopus 로고
    • Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers
    • Mertens-Talcott SU, Jilma-Stohlawetz P, Rios J, Hingorani L, Derendorf H. Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers. J Agric Food Chem. 2006;54:8956-61.
    • (2006) J Agric Food Chem , vol.54 , pp. 8956-8961
    • Mertens-talcott, S.U.1    Jilma-stohlawetz, P.2    Rios, J.3    Hingorani, L.4    Derendorf, H.5
  • 45
    • 0038284925 scopus 로고    scopus 로고
    • Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic
    • Cerdá B, Ceron JJ, Tomas-Barberan FA, Espin JC. Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic. J Agric Food Chem. 2003;51: 3493-501.
    • (2003) J Agric Food Chem , vol.51 , pp. 3493-3501
    • Cerdá, B.1    Ceron, J.J.2    Tomas-barberan, F.A.3    Espin, J.C.4
  • 46
    • 84861805073 scopus 로고    scopus 로고
    • Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer's disease
    • Dhawan G, Combs CK. Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer's disease. J Neuroinflammation. 2012;9:117.
    • (2012) J Neuroinflammation , vol.9 , pp. 117
    • Dhawan, G.1    Combs, C.K.2
  • 47
    • 33646841989 scopus 로고    scopus 로고
    • Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner
    • Floden AM, Combs CK. Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner. J Neurosci. 2006;26:4644-8.
    • (2006) J Neurosci. , vol.26 , pp. 4644-4648
    • Floden, A.M.1    Combs, C.K.2
  • 48
    • 33244454723 scopus 로고    scopus 로고
    • Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells
    • Adams LS, Seeram NP, Aggarwal BB, Takada Y, Sand D, Heber D. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem. 2006;54:980-5.
    • (2006) J Agric Food Chem , vol.54 , pp. 980-5
    • Adams, L.S.1    Seeram, N.P.2    Aggarwal, B.B.3    Takada, Y.4    Sand, D.5    Heber, D.6
  • 50
    • 79960440726 scopus 로고    scopus 로고
    • Punica granatum protects against oxidative stress in PC12 cells and oxidative stress-induced Alzheimer's symptoms in mice
    • Choi SJ, Lee JH, Heo HJ, Cho HY, Kim HK, Kim CJ, Kim MO, Suh SH, Shin DH. Punica granatum protects against oxidative stress in PC12 cells and oxidative stress-induced Alzheimer's symptoms in mice. J Med Food. 2011;14:695-701.
    • (2011) J Med Food , vol.14 , pp. 695-701
    • Choi, S.J.1    Lee, J.H.2    Heo, H.J.3    Cho, H.Y.4    Kim, H.K.5    Kim, C.J.6    Kim, M.O.7    Suh, S.H.8    Shin, D.H.9
  • 51
    • 40549091931 scopus 로고    scopus 로고
    • Comparison of antioxidant potency of commonly consumedpolyphenol-rich beverages in the United States
    • Seeram NP, Aviram M, Zhang Y, Henning SM, Feng L, Dreher M, Heber D. Comparison of antioxidant potency of commonly consumedpolyphenol-rich beverages in the United States. J Agric Food Chem. 2008;56:1415-22.
    • (2008) J Agric Food Chem , vol.56 , pp. 1415-22
    • Seeram, N.P.1    Aviram, M.2    Zhang, Y.3    Henning, S.M.4    Feng, L.5    Dreher, M.6    Heber, D.7
  • 52
    • 79953249592 scopus 로고    scopus 로고
    • Comparison of the polyphenolic composition and antioxidant activity of European commercial fruit juices
    • Borges G, Mullen W, Crozier A. Comparison of the polyphenolic composition and antioxidant activity of European commercial fruit juices. Food Funct. 2010;1:73-83.
    • (2010) Food Funct , vol.1 , pp. 73-83
    • Borges, G.1    Mullen, W.2    Crozier, A.3
  • 53
    • 84864747637 scopus 로고    scopus 로고
    • Anti-inflammatory effects of pomegranate (Punica granatum L.) husk ellagitannins in Caco-2 cells, an in vitro model of human intestine
    • Hollebeeck S, Winand J, Herent MF, During A, Leclercq J, Larondelle Y, Schneider YJ. Anti-inflammatory effects of pomegranate (Punica granatum L.) husk ellagitannins in Caco-2 cells, an in vitro model of human intestine. Food Funct. 2012;3:875-85.
    • (2012) Food Funct , vol.3 , pp. 875-85
    • Hollebeeck, S.1    Winand, J.2    Herent, M.F.3    During, A.4    Leclercq, J.5    Larondelle, Y.6    Schneider, Y.J.7
  • 54
    • 78650882960 scopus 로고    scopus 로고
    • Pomegranate juice protects macrophages from triglyceride accumulation: inhibitory effect on DGAT1 activity and on triglyceride biosynthesis
    • Rosenblat M, Aviram M. Pomegranate juice protects macrophages from triglyceride accumulation: inhibitory effect on DGAT1 activity and on triglyceride biosynthesis. Ann Nutr Metab. 2011;58:1-9.
    • (2011) Ann Nutr Metab , vol.58 , pp. 1-9
    • Rosenblat, M.1    Aviram, M.2
  • 55
    • 0033258057 scopus 로고    scopus 로고
    • Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats
    • Lin CC, Hsu YF, Lin TC. Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats. Am J Chin Med. 1999;27:371-6.
    • (1999) Am J Chin Med , vol.27 , pp. 371-6
    • Lin C.C.Hsu, Y.F.1    Lin, T.C.2
  • 56
    • 77956196994 scopus 로고    scopus 로고
    • NF-kappaB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts
    • González-Sarrías A, Larrosa M, Tomas-Barberan FA, Dolara P, Espin JC. NF-kappaB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts. Br J Nutr. 2010;104:503-12.
    • (2010) Br J Nutr , vol.104 , pp. 503-12
    • González-sarrías, A.1    Larrosa, M.2    Tomas-barberan, F.A.3    Dolara, P.4    Espin, J.C.5
  • 57
    • 37349020231 scopus 로고    scopus 로고
    • Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size
    • Heber D, Seeram NP, Wyatt H, Henning SM, Zhang Y, Ogden LG, Dreher M, Hill JO. Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. J Agric Food Chem. 2007;55:10050-4.
    • (2007) J Agric Food Chem , vol.55 , pp. 10050-4
    • Heber, D.1    Seeram, N.P.2    Wyatt, H.3    Henning, S.M.4    Zhang, Y.5    Ogden, L.G.6    Dreher, M.7    Hill, J.O.8
  • 58
    • 79951618330 scopus 로고    scopus 로고
    • Consumption of polyphenolic-rich beverages (mostly pomegranate and black currant juices) by healthy subjects for a short term increased serum antioxidant status, and the serum's ability to attenuate macrophage cholesterol accumulation
    • Rosenblat M, Volkova N, Attias J, Mahamid R, Aviram M. Consumption of polyphenolic-rich beverages (mostly pomegranate and black currant juices) by healthy subjects for a short term increased serum antioxidant status, and the serum's ability to attenuate macrophage cholesterol accumulation. Food Funct. 2010;1:99-109.
    • (2010) Food Funct , vol.1 , pp. 99-109
    • Rosenblat, M.1    Volkova, N.2    Attias, J.3    Mahamid, R.4    Aviram, M.5
  • 59
    • 70349215202 scopus 로고    scopus 로고
    • Absence of pomegranate ellagitannins in the majority of commercial pomegranate extracts: implications for standardization and quality control
    • Zhang Y, Wang D, Lee RP, Henning SM, Heber D. Absence of pomegranate ellagitannins in the majority of commercial pomegranate extracts: implications for standardization and quality control. J Agric Food Chem. 2009;57:7395-400.
    • (2009) J Agric Food Chem , vol.57 , pp. 7395-400
    • Zhang, Y.1    Wang, D.2    Lee, R.P.3    Henning, S.M.4    Heber, D.5
  • 60
    • 70349325799 scopus 로고    scopus 로고
    • The effect of pomegranate (Punica granatum L.) byproducts and ellagitannins on the growth of human gut bacteria
    • Bialonska D, Kasimsetty SG, Schrader KK, Ferreira D. The effect of pomegranate (Punica granatum L.) byproducts and ellagitannins on the growth of human gut bacteria. J Agric Food Chem. 2009;57:8344-9.
    • (2009) J Agric Food Chem , vol.57 , pp. 8344-9
    • Bialonska, D.1    Kasimsetty, S.G.2    Schrader, K.K.3    Ferreira, D.4
  • 62
    • 67649646708 scopus 로고    scopus 로고
    • Transport behavior of ellagic acid of pomegranate leaf tannins and its correlation with total cholesterol alteration in HepG2 cells
    • Lan J, Lei F, Hua L,Wang Y, Xing D, Du L. Transport behavior of ellagic acid of pomegranate leaf tannins and its correlation with total cholesterol alteration in HepG2 cells. Biomed Chromatogr. 2009;23:531-6.
    • (2009) Biomed Chromatogr , vol.23 , pp. 531-6
    • Lan, J.1    Lei, F.2    Hua, L.3    Wang, Y.4    Xing, D.5    Du, L.6
  • 63
    • 4544345237 scopus 로고    scopus 로고
    • The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans
    • Cerdá B, Espin JC, Parra S, Martinez P, Tomas-Barberan FA. The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans. Eur J Nutr. 2004;43:205-20.
    • (2004) Eur J Nutr , vol.43 , pp. 205-20
    • Cerdá, B.1    Espin, J.C.2    Parra, S.3    Martinez, P.4    Tomas-barberan, F.A.5
  • 64
    • 22544459923 scopus 로고    scopus 로고
    • Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds
    • Cerdá B, Periago P, Espin JC, Tomas-Barberan FA. Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds. J Agric Food Chem. 2005;53: 5571-6.
    • (2005) J Agric Food Chem , vol.53 , pp. 5571-5576
    • Cerdá, B.1    Periago, P.2    Espin, J.C.3    Tomas-barberan, F.A.4
  • 65
    • 38549178015 scopus 로고    scopus 로고
    • Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration
    • Tobinick EL, Gross H. Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration. J Neuroinflammation. 2008;5:2.
    • (2008) J Neuroinflammation , vol.5 , pp. 2
    • Tobinick, E.L.1    Gross, H.2
  • 66
    • 84867070961 scopus 로고    scopus 로고
    • Brain protection from stroke with intravenous TNFalpha decoy receptor-Trojan horse fusion protein
    • Sumbria RK, Boado RJ, Pardridge WM. Brain protection from stroke with intravenous TNFalpha decoy receptor-Trojan horse fusion protein. J Cereb Blood Flow Metab. 2012.
    • (2012) J Cereb Blood Flow Metab
    • Sumbria, R.K.1    Boado, R.J.2    Pardridge, W.M.3
  • 67
    • 36448961998 scopus 로고    scopus 로고
    • Immunomodulatory effects of etanercept in a model of brain injury act through attenuation of the acute-phase response
    • Campbell SJ, Jiang Y, Davis AE, Farrands R, Holbrook J, Leppert D, Anthony DC. Immunomodulatory effects of etanercept in a model of brain injury act through attenuation of the acute-phase response. J Neurochem. 2007;103:2245-55.
    • (2007) J Neurochem , vol.103 , pp. 2245-55
    • Campbell, S.J.1    Jiang, Y.2    Davis, A.E.3    Farrands, R.4    Holbrook, J.5    Leppert, D.6    Anthony, D.C.7
  • 68
    • 80052956995 scopus 로고    scopus 로고
    • Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB
    • Taoufik E, Tseveleki V, Chu SY, Tselios T, Karin M, Lassmann H, Szymkowski DE, Probert L. Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB. Brain. 2011;134:2722-35.
    • (2011) Brain , vol.134 , pp. 2722-35
    • Taoufik, E.1    Tseveleki, V.2    Chu, S.Y.3    Tselios, T.4    Karin, M.5    Lassmann, H.6    Szymkowski, D.E.7    Probert, L.8


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