Changes of telomere length with aging

Geriatrics and Gerontology International

Volumn 10, Issue SUPPL. 1, 2010, Pages

  Takubo, Kaiyo ^a,b   Aida, Junko ^a,b   Izumiyama Shimomura, Naotaka ^a   Ishikawa, Naoshi ^a   Sawabe, Motoji ^a,b   Kurabayashi, Rie ^c   Shiraishi, Hiroaki ^a,d   Arai, Tomio ^a,b   Nakamura, Ken Ichi ^a  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b Tokyo Metropolitan Institute of Gerontology   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Brain; Breast; Heart; Human aging; Kidney; Liver; Q FISH; Stomach; Telomere; Tongue

Indexed keywords

ADULT; AGED; AGING; BRAIN; BREAST CARCINOMA; CANCER CELL; CHROMOSOME ANALYSIS; CHROMOSOME REARRANGEMENT; DNA DEGRADATION; ENDOTHELIUM CELL; ESOPHAGUS MUCOSA; FEMALE; FIBROBLAST; FLUORESCENCE IN SITU HYBRIDIZATION; GLIA; HEART MUSCLE; HUMAN; HUMAN TISSUE; LIVER CELL; MAMMARY GLAND; MITOSIS; NERVE CELL; PRIORITY JOURNAL; REVIEW; SOUTHERN BLOTTING; STOMACH MUCOSA; TELOMERE; TONGUE; VISCERAL METASTASIS; BREAST; CHEMISTRY; CYTOLOGY; FLOW CYTOMETRY; GENETICS; IMAGE PROCESSING; PHYSIOLOGY; PROCEDURES; STOMACH; ULTRASTRUCTURE;

AGING; BLOTTING, SOUTHERN; BREAST; FEMALE; FLOW CYTOMETRY; GASTRIC MUCOSA; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IN SITU HYBRIDIZATION, FLUORESCENCE; STOMACH; TELOMERE; TONGUE;

EID: 77954687175     PISSN: 14441586     EISSN: 14470594     Source Type: Journal    
DOI: 10.1111/j.1447-0594.2010.00605.x     Document Type: Review

References (59)

1. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965, 37:614-636.
2. Moyzis RK, Buckingham JM, Cram LS. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA 1988, 85:6622-6626.
3. Blackburn EH. Structure and function of telomeres. Nature 1991, 350:569-573.
4. Levy MZ, Allsopp RC, Futcher AB. Telomere end-replication problem and cell aging. J Mol Biol 1992, 225:951-960.
5. Blackburn EH. Structure and function of telomeres. Nature 1991, 350:569-573.
6. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990, 345:458-460.
7. Vaziri H, Schaechter F, Uchida I. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 1993, 52:661-667.
8. Takubo K, Nakamura K, Izumiyama N. Telomere shortening with aging in human liver. J Gerontol A Biol Sci 2000, B533-BB536.
9. Takubo K, Nakamura K, Izumiyama N. Telomere shortening with aging in human esophageal mucosa. Age 1999, 22:95-99.
10. Furugori E, Hirayama R, Nakamura K. Telomere shortening in gastric carcinoma with aging despite telomerase activation. J Cancer Res Clin Oncol 2000, 126:481-485.
11. Nakamura K, Furugori E, Esaki Y. Correlation of telomere lengths in normal and cancers tissue in the large bowel. Cancer Lett 2000, 158:179-184.
12. Cameron IL. Cell renewal in the organs and tissues of the nongrowing adult mouse. Tex Rep Biol Med 1970, 28:203-248.
13. Hastie ND, Dempster M, Dunlop MG. Telomere reduction in human colorectal carcinoma and with ageing. Nature 1990, 346:866-868.
14. Allsopp RC, Vaziri H, Patterson C. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 1992, 89:10114-10118.
15. Hiyama E, Hiyama K, Tatsumoto N. Telomerase activity in human intestine. Int J Oncol 1996, 9:453-458.
16. Lindsey J, McGill NI, Lindsey LA. In vivo loss of telomeric repeats with age in humans. Mutat Res 1991, 256:45-48.
17. Chang E, Harley CB. Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci USA 1995, 92:11190-11194.
18. Aikata H, Takaishi H, Kawakami Y. Telomere reduction in human liver tissues with age and chronic inflammation. Exp Cell Res 2000, 256:578-582.
19. Melk A, Ramassar V, Helms LMH. Telomere shortening in kidneys with age. J Am Soc Nephrol 2000, 11:444-453.
20. Slagboom PE, Droog S, Boomsma DI. Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 1994, 55:876-882.
21. Iwama H, Ohyashiki K, Ohyashiki JH. Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals. Hum Genet 1998, 102:397-402.
22. Son NH, Murray S, Yanovski J. Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age. J Immunol 2000, 165:1191-1196.
23. Nakamura K, Takubo K, Izumiyama-Shimomura N. Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older. Exp Gerontol 2007, 42:944-950.
24. Ishii A, Nakamura K, Kishimoto H. Telomere shortening with aging in the human pancreas. Exp Gerontol 2006, 41:882-886.
25. Eastwood GL. Gastrointestinal epithelial renewal. Gastroenterology 1977, 72:962-975.
26. McLean AR, Michie CA. In vivo estimates of division and death rates of human T lymphocytes. Proc Natl Acad Sci USA 1995, 92:3707-3711.
27. Freitas AA, Rocha B, Coutinho AA. Lymphocyte population kinetics in the mouse. Immunol Rev 1986, 91:5-37.
28. Zajicek G, Oren R, Weinreb M. The streaming liver. Liver 1985, 5:293-300.
29. Niida H, Shinkai Y, Hande MP. Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA. Mol Cell Biol 2000, 20:4115-4127.
30. Bachor C, Bachor OA, Boukamp P. Telomerase is active in normal gastrointestinal mucosa and not up-regulated in precancerous lesions. J Cancer Res Clin Oncol 1999, 125:453-460.
31. Counter CM, Gupta J, Harley CB. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 1995, 85:2315-2320.
32. Kim NW, Piatyszek MA, Prowse KR. Specific association of human telomerase activity with immortal cells and cancer. Science 1994, 266:2011-2015.
33. Aida J, Izumiyama-Shimomura N, Nakamura K. Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium. Exp Gerontol 2008, 43:833-839.
34. Aida J, Izumiyama-Shimomura N, Nakamura K. Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method. Hum Pathol 2007, 38:1192-1200.
35. Xia HH-X, Talley NJ. Apoptosis in gastric epithelium induced by Helicobacter pylori infection: implications in gastric carcinogenesis. Am J Gastroenterol 2001, 96:16-26.
36. Kountouras J, Zavos C, Chatzopoulos D. New concepts of molecular biology on gastric carcinogenesis. Hepatogastroenterology 2005, 52:1305-1312.
37. Kuniyasu H, Kitadai Y, Mieno H. Helicobacter pylori infection is closely associated with telomere reduction in gastric mucosa. Oncology 2003, 65:275-282.
38. Kameshima H, Yagihashi A, Yajima T. Helicobacter pylori infection: augmentation of telomerase activity in cancer and noncancerous tissues. World J Surg 2000, 24:1243-1249.
39. Maruyama Y, Hanai H, Fujita M. Telomere length and telomerase activity in carcinogenesis of the stomach. Jpn J Clin Oncol 1997, 27:216-220.
40. Kang MK, Kameta A, Shin KH. Senescence occurs with hTERT repression and limited telomere shortening in human oral keratinocytes cultured with feeder cells. J Cell Physiol 2004, 199:364-370.
41. Nakamura K, Izumiyama-Shimomura N, Sawabe M. Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium. J Invest Dermatol 2002, 119:1014-1019.
42. Meeker AK, Hicks JL, Iacobuzio-Donahue CA. Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin Cancer Res 2004, 10:3317-3326.
43. Flores I, Canela A, Vera E. The longest telomeres: a general signature of adult stem cell compartments. Genes Dev 2008, 22:654-667.
44. Robertson JD, Gale RE, Wynn RF. Dynamics of telomere shortening in neutrophils and T lymphocytes during ageing and the relationship to skewed X chromosome inactivation patterns. Br J Haematol 2000, 109:272-279.
45. Kang MK, Swee J, Kim RH. The telomeric length and heterogeneity decrease with age in normal human oral keratinocytes. Mech Ageing Dev 2002, 123:585-592.
46. Takeda T, Sugihara K, Hirayama Y. Immunohistological evaluation of Ki-67, p63, CK19 and p53 expression in oral epithelial dysplasias. J Oral Pathol Med 2006, 35:369-375.
47. Seery JP, Watt FM. Asymmetric stem-cell divisions define the architecture of human oesophageal epithelium. Curr Biol 2000, 10:1447-1450.
48. Takubo K, Izumiyama-Shimomura N, Honma N. Telomere lengths are characteristic in each human individual. Exp Gerontol 2002, 37:523-531.
49. Kang MK, Kameta A, Baluda MA. Telomere shortening does not occur during postmaturational aging in situ in normal human oral fibroblasts. Mech Ageing Dev 2003, 124:873-876.
50. Odagiri E, Kanda N, Jibiki K. Reduction of telomeric length and c-erbB-2 gene amplification in human breast cancer, fibroadenoma, and gynecomastia. Relationship to histologic grade and clinical parameters. Cancer 1994, 73:2978-2984.
51. Rogalla P, Rohen C, Bonk U. Telomeric repeat fragment lengths are not correlated to histological grading in 85 breast cancers. Cancer Lett 1996, 106:155-161.
52. Fordyce CA, Heaphy CM, Bisoffi M. Telomere content correlates with stage and prognosis in breast cancer. Breast Cancer Res Treat 2006, 99:193-202.
53. Kurabayashi R, Takubo K, Aida J. Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts. Hum Pathol 39:1647-1655.
54. Schwartz DC, Cantor CR. Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis. Cell 1984, 37:67-75.
55. Blouin A, Bolender RP, Weibel ER. Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. J Cell Biol 1977, 72:441-455.
56. Lansdorp PM, Verwoerd NP, van de Rijke FM. Heterogeneity in telomere length of human chromosomes. Hum Mol Genet 1996, 5:685-691.
57. Martens UM, Zijlmans JMJM, Poon SSS. Short telomeres on human chromosome 17p. Nat Genet 1998, 18:76-80.
58. Kammori M, Izumiyama N, Nakamura K. Telomere metabolism and diagnostic demonstration of telomere measurement in the human esophagus for distinguishing benign from malignant tissue by tissue quantitative fluorescence in situ hybridization. Oncology 2006, 71:430-436.
59. Ohashi M, Aizawa S, Ooka H. A new human diploid cell strain, TIG-1, for the research on cellular aging. Exp Gerontol 1980, 15:121-133.