Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice

Journal of Biological Chemistry

Volumn 287, Issue 9, 2012, Pages 6912-6927

  Mori, Takashi ^a   Rezai Zadeh, Kavon ^b   Koyama, Naoki ^a   Arendash, Gary W ^c,d   Yamaguchi, Haruyasu ^e   Kakuda, Nobuto ^f   Horikoshi Sakuraba, Yuko ^f   Tan, Jun ^d,g   Town, Terrence ^b,h  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c Florida Alzheimer's Disease Research Center   (United States)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

^e GUNMA UNIVERSITY   (Japan)

^f Immuno Biological Laboratories Co Ltd   (Japan)

^g UNIVERSITY OF SOUTH FLORIDA   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID DEPOSITS; AMYLOID PLAQUES; AMYLOID PRECURSOR PROTEINS; COGNITIVE FUNCTIONS; COGNITIVE IMPAIRMENT; DIETARY SUPPLEMENTATION; IN-VITRO; MOUSE MODELS; MUTANT HUMAN; NATURALLY OCCURRING; NEUROINFLAMMATION; NEURON-LIKE CELLS; POLYPHENOLS; PROTEIN STABILITY; SECRETASES; SPATIAL REFERENCE; TANNIC ACID; TRANS-GENES; TRANSGENIC MICE; TRANSGENICS;

BRAIN; DISEASES; GLYCOPROTEINS; OBJECT RECOGNITION; OLIGOMERS; PATHOLOGY; PHENOLS; PROTEINS;

MAMMALS;

ALPHA SECRETASE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; BETA SECRETASE INHIBITOR; MUTANT PROTEIN; NUTRACEUTICAL; OLIGOMER; PRESENILIN 1; TANNIN;

ALZHEIMER DISEASE; AMYLOID PLAQUE; AMYLOIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTOSIS; CARBOXY TERMINAL SEQUENCE; CEREBRAL AMYLOIDOSIS; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE MODEL; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STABILITY; FEMALE; GENDER; HYPERACTIVITY; IN VITRO STUDY; INFLAMMATION; MALE; MICROGLIA; MICROGLIOSIS; MOUSE; NEUROINFLAMMATION; NONHUMAN; OBJECT RECOGNITION; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RECOGNITION; REFERENCE MEMORY; SPATIAL MEMORY; TRANSGENE; TRANSGENIC MOUSE; TREATMENT DURATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELL LINE; CEREBRAL AMYLOID ANGIOPATHY; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ENCEPHALITIS; FEMALE; GLIOSIS; HUMANS; MALE; MAZE LEARNING; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; PEPTIDE FRAGMENTS; TANNINS;

MURINAE; MUS; MUS MUSCULUS;

EID: 84857497814     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.294025     Document Type: Article

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