메뉴 건너뛰기




Volumn 4, Issue 4, 2009, Pages 297-307

Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin

Author keywords

Glutathione; Memory; Microglia; Nrf2; Oxidative stress

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; FISETIN; GLUTATHIONE; PROTEASOME; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; ROLIPRAM;

EID: 71949125029     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-009-0142-5     Document Type: Review
Times cited : (76)

References (96)
  • 1
    • 52049102256 scopus 로고    scopus 로고
    • Structural requirement for the flavonoid fisetin in inhibiting fibril formation of amyloid β protein
    • 10.1016/j.neulet.2008.08.052 18761054 1:CAS:528:DC%2BD1cXhtFersb%2FK
    • T Akaishi T Morimoto M Shibao S Watanabe K Sakai-Kato N Utsunomiya-Tate K Abe 2008 Structural requirement for the flavonoid fisetin in inhibiting fibril formation of amyloid β protein Neurosci Lett 444 280 285 10.1016/j.neulet.2008.08.052 18761054 1:CAS:528:DC%2BD1cXhtFersb%2FK
    • (2008) Neurosci Lett , vol.444 , pp. 280-285
    • Akaishi, T.1    Morimoto, T.2    Shibao, M.3    Watanabe, S.4    Sakai-Kato, K.5    Utsunomiya-Tate, N.6    Abe, K.7
  • 2
    • 0033850592 scopus 로고    scopus 로고
    • Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL and cholesterol concentration
    • 10958819 1:CAS:528:DC%2BD3cXmsVWlu7g%3D
    • Y Arai S Watanabe M Kimira K Shimoi R Mochizuki N Kinae 2000 Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL and cholesterol concentration J Nutr 130 2243 2250 10958819 1:CAS:528:DC%2BD3cXmsVWlu7g%3D
    • (2000) J Nutr , vol.130 , pp. 2243-2250
    • Arai, Y.1    Watanabe, S.2    Kimira, M.3    Shimoi, K.4    Mochizuki, R.5    Kinae, N.6
  • 3
    • 62249096975 scopus 로고    scopus 로고
    • Glutathione dysregulation and the etiology and progression of human diseases
    • 10.1515/BC.2009.033 19166318 1:CAS:528:DC%2BD1MXivFeis7w%3D
    • N Ballatori SM Krance S Notenboom S Shi K Tieu CL Hammond 2009 Glutathione dysregulation and the etiology and progression of human diseases Biol Chem 390 191 214 10.1515/BC.2009.033 19166318 1:CAS:528: DC%2BD1MXivFeis7w%3D
    • (2009) Biol Chem , vol.390 , pp. 191-214
    • Ballatori, N.1    Krance, S.M.2    Notenboom, S.3    Shi, S.4    Tieu, K.5    Hammond, C.L.6
  • 4
    • 0032426667 scopus 로고    scopus 로고
    • Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
    • DOI 10.1073/pnas.95.25.15020
    • M Barad R Bourtchouladze DG Winder H Golan E Kandel 1998 Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory Proc Natl Acad Sci USA 95 15020 15025 10.1073/pnas.95.25.15020 9844008 1:CAS:528:DyaK1cXotVGls7o%3D (Pubitemid 29003749)
    • (1998) Proceedings of the National Academy of Sciences of the United States of America , vol.95 , Issue.25 , pp. 15020-15025
    • Barad, M.1    Bourtchouladze, R.2    Winder, D.G.3    Golan, H.4    Kandel, E.5
  • 5
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
    • 10.1073/pnas.87.4.1620 2154753 1:CAS:528:DyaK3cXhvFegsb4%3D
    • JS Beckman TW Beckman J Chen PA Marshall BA Freeman 1990 Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide Proc Natl Acad Sci USA 87 1620 1624 10.1073/pnas.87.4.1620 2154753 1:CAS:528:DyaK3cXhvFegsb4%3D
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1620-1624
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3    Marshall, P.A.4    Freeman, B.A.5
  • 6
    • 0026439963 scopus 로고
    • Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite
    • 10.1016/0003-9861(92)90432-V 1416975 1:CAS:528:DyaK3sXhvVCjtQ%3D%3D
    • JS Beckman H Ischiropoulos L Zhu M van der Woerd C Smith J Chen J Harrison JC Martin M Tsai 1992 Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite Arch Biochem Biophys 298 438 445 10.1016/0003-9861(92)90432-V 1416975 1:CAS:528:DyaK3sXhvVCjtQ%3D%3D
    • (1992) Arch Biochem Biophys , vol.298 , pp. 438-445
    • Beckman, J.S.1    Ischiropoulos, H.2    Zhu, L.3    Van Der Woerd, M.4    Smith, C.5    Chen, J.6    Harrison, J.7    Martin, J.C.8    Tsai, M.9
  • 7
    • 0031916984 scopus 로고    scopus 로고
    • The free radical theory of aging matures
    • 9562038 1:CAS:528:DyaK1cXislakurg%3D
    • KB Beckman BN Ames 1998 The free radical theory of aging matures Physiol Rev 78 547 581 9562038 1:CAS:528:DyaK1cXislakurg%3D
    • (1998) Physiol Rev , vol.78 , pp. 547-581
    • Beckman, K.B.1    Ames, B.N.2
  • 8
    • 11344262265 scopus 로고    scopus 로고
    • Ubiquitin-proteasome system and Parkinson's diseases
    • DOI 10.1016/j.expneurol.2004.08.021, PII S0014488604003176, Neuroplasticity of the Central Nervous System
    • R Betarbet TB Sherer JT Greenamyre 2005 Ubiquitin-proteasome system and Parkinson's disease Exp Neurol 191 S17 S27 10.1016/j.expneurol.2004.08.021 15629758 1:CAS:528:DC%2BD2MXks1ag (Pubitemid 40075408)
    • (2005) Experimental Neurology , vol.191 , Issue.SUPPL. 1
    • Betarbet, R.1    Sherer, T.B.2    Greenamyre, J.T.3
  • 9
    • 34347215149 scopus 로고    scopus 로고
    • Object recognition in rats and mice: A non-trial non-matching-to-sample learning task to study 'recognition memory'
    • 10.1038/nprot.2006.205 17406415
    • RA Bevins J Besheer 2006 Object recognition in rats and mice: a non-trial non-matching-to-sample learning task to study 'recognition memory' Nat Protoc 1 1306 1311 10.1038/nprot.2006.205 17406415
    • (2006) Nat Protoc , vol.1 , pp. 1306-1311
    • Bevins, R.A.1    Besheer, J.2
  • 10
    • 0038206578 scopus 로고    scopus 로고
    • Gene microarrays in hippocampal aging: Statistical profiling identifies novel processes correlated with cognitive impairment
    • 12736351 1:CAS:528:DC%2BD3sXjslGnu7g%3D
    • EM Blalock K-C Chen K Sharrow JP Herman NM Porter TC Foster PW Landfield 2003 Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment J Neurosci 23 3807 3819 12736351 1:CAS:528:DC%2BD3sXjslGnu7g%3D
    • (2003) J Neurosci , vol.23 , pp. 3807-3819
    • Blalock, E.M.1    Chen, K.-C.2    Sharrow, K.3    Herman, J.P.4    Porter, N.M.5    Foster, T.C.6    Landfield, P.W.7
  • 11
    • 0027476024 scopus 로고
    • A synaptic model of memory: Long-term potentiation in the hippocampus
    • DOI 10.1038/361031a0
    • TVP Bliss GL Collingridge 1993 A synaptic model of memory: long-term potentiation in the hippocampus Nature 361 31 39 10.1038/361031a0 8421494 1:CAS:528:DyaK3sXntlOntw%3D%3D (Pubitemid 23020772)
    • (1993) Nature , vol.361 , Issue.6407 , pp. 31-39
    • Bliss, T.V.P.1    Collingridge, G.L.2
  • 12
    • 44449133306 scopus 로고    scopus 로고
    • Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons
    • DOI 10.1016/j.brainres.2007.10.077, PII S0006899307026054
    • J Burdo D Schubert P Maher 2008 Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical cultures Brain Res 1189 12 22 10.1016/j.brainres.2007.10.077 18048013 1:CAS:528:DC%2BD1cXlt1eqtA%3D%3D (Pubitemid 351842547)
    • (2008) Brain Research , vol.1189 , Issue.1 , pp. 12-22
    • Burdo, J.1    Schubert, D.2    Maher, P.3
  • 13
    • 22144467379 scopus 로고    scopus 로고
    • The many faces of CREB
    • DOI 10.1016/j.tins.2005.06.005, PII S016622360500158X
    • WA Carlezon RS Duman EJ Nestler 2005 The many faces of CREB Trends Neurosci 28 436 445 10.1016/j.tins.2005.06.005 15982754 1:CAS:528: DC%2BD2MXmsVOhtLk%3D (Pubitemid 40982557)
    • (2005) Trends in Neurosciences , vol.28 , Issue.8 , pp. 436-445
    • Carlezon Jr., W.A.1    Duman, R.S.2    Nestler, E.J.3
  • 15
    • 0034672595 scopus 로고    scopus 로고
    • Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein
    • 11118612 1:CAS:528:DC%2BD3cXoslGmsrg%3D
    • JY Chan M Kwong 2000 Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein Biochim Biophys Acta 1517 19 26 11118612 1:CAS:528:DC%2BD3cXoslGmsrg%3D
    • (2000) Biochim Biophys Acta , vol.1517 , pp. 19-26
    • Chan, J.Y.1    Kwong, M.2
  • 16
    • 2942568014 scopus 로고    scopus 로고
    • Dietary chemopreventive compounds and ARE/EpRE signaling
    • DOI 10.1016/j.freeradbiomed.2004.03.015, PII S089158490400276X
    • C Chen ANT Kong 2004 Dietary chemopreventive compounds and ARE/EpRE signaling Free Radic Biol Med 36 1505 1516 10.1016/j.freeradbiomed.2004.03.015 15182853 1:CAS:528:DC%2BD2cXkslWksL8%3D (Pubitemid 38746559)
    • (2004) Free Radical Biology and Medicine , vol.36 , Issue.12 , pp. 1505-1516
    • Chen, C.1    Kong, A.-N.T.2
  • 17
    • 33646578517 scopus 로고    scopus 로고
    • Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells
    • DOI 10.1016/j.tox.2006.03.007, PII S0300483X06001594
    • TJ Chen JY Jeng CW Lin CY Wu YC Chen 2006 Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells Toxicology 223 113 126 10.1016/j.tox.2006.03.007 16647178 1:CAS:528:DC%2BD28XkvVyntr4%3D (Pubitemid 43728620)
    • (2006) Toxicology , vol.223 , Issue.1-2 , pp. 113-126
    • Chen, T.-J.1    Jeng, J.-Y.2    Lin, C.-W.3    Wu, C.-Y.4    Chen, Y.-C.5
  • 18
    • 34447565153 scopus 로고    scopus 로고
    • The 5-lipoxygenase enzymatic pathway in the mouse brain: Young versus old
    • DOI 10.1016/j.neurobiolaging.2006.06.007, PII S0197458006002193
    • CM Chinnici Y Yao D Practico 2007 The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old Neurobiol Aging 28 1457 1462 10.1016/j.neurobiolaging.2006.06.007 16930777 1:CAS:528:DC%2BD2sXotlahsLk%3D (Pubitemid 47081230)
    • (2007) Neurobiology of Aging , vol.28 , Issue.9 , pp. 1457-1462
    • Chinnici, C.M.1    Yao, Y.2    Pratico, D.3
  • 19
    • 2942618660 scopus 로고    scopus 로고
    • The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders
    • 10.1016/S0166-2236(00)01998-6 11881748 1:CAS:528:DC%2BD3MXovFejsbg%3D
    • KKK Chung VL Dawson TM Dawson 2001 The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders Trends Neurosci 24 S7 S14 10.1016/S0166-2236(00)01998-6 11881748 1:CAS:528: DC%2BD3MXovFejsbg%3D
    • (2001) Trends Neurosci , vol.24
    • Chung, K.K.K.1    Dawson, V.L.2    Dawson, T.M.3
  • 20
    • 11244309014 scopus 로고    scopus 로고
    • Proteolysis: From the lysosome to ubiquitin and the proteasome
    • DOI 10.1038/nrm1552
    • A Ciechanover 2005 Proteolysis: from the lysosome to ubiquitin and the proteasome Nat Rev Mol Cell Biol 6 79 86 10.1038/nrm1552 15688069 1:CAS:528:DC%2BD2MXlvVWr (Pubitemid 40064901)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.1 , pp. 79-86
    • Ciechanover, A.1
  • 21
    • 0141987860 scopus 로고    scopus 로고
    • The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg
    • DOI 10.1016/S0896-6273(03)00606-8
    • A Ciechanover P Brundin 2003 The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg Neuron 40 427 446 10.1016/S0896-6273(03)00606-8 14556719 1:CAS:528:DC%2BD3sXosFCqs70%3D (Pubitemid 37244106)
    • (2003) Neuron , vol.40 , Issue.2 , pp. 427-446
    • Ciechanover, A.1    Brundin, P.2
  • 22
    • 54249124166 scopus 로고    scopus 로고
    • Aging, microglial priming, and the discordant central inflammatory response to signals from the peripheral immune system
    • 10.1189/jlb.0208108 18495785 1:CAS:528:DC%2BD1cXht1amsbrE
    • RN Dilger RW Johnson 2008 Aging, microglial priming, and the discordant central inflammatory response to signals from the peripheral immune system J Leukoc Biol 84 932 939 10.1189/jlb.0208108 18495785 1:CAS:528:DC%2BD1cXht1amsbrE
    • (2008) J Leukoc Biol , vol.84 , pp. 932-939
    • Dilger, R.N.1    Johnson, R.W.2
  • 23
    • 0035451913 scopus 로고    scopus 로고
    • Proteasomes and proteasome inhibition in the central nervous system
    • DOI 10.1016/S0891-5849(01)00635-9, PII S0891584901006359
    • Q Ding JN Keller 2001 Proteasomes and proteasome inhibition in the central nervous system Free Radic Biol Med 31 574 584 10.1016/S0891-5849(01) 00635-9 11522442 1:CAS:528:DC%2BD3MXmtV2ltbg%3D (Pubitemid 32777858)
    • (2001) Free Radical Biology and Medicine , vol.31 , Issue.5 , pp. 574-584
    • Ding, Q.1    Keller, J.N.2
  • 24
    • 24144473653 scopus 로고    scopus 로고
    • Oxidative and antioxidative potential of brain microglial cells
    • DOI 10.1089/ars.2005.7.1223
    • R Dringen 2005 Oxidative and antioxidative potential of brain microglial cells Antioxid Redox Signal 7 1223 1233 10.1089/ars.2005.7.1223 16115027 1:CAS:528:DC%2BD2MXos1ert70%3D (Pubitemid 41232519)
    • (2005) Antioxidants and Redox Signaling , vol.7 , Issue.9-10 , pp. 1223-1233
    • Dringen, R.1
  • 25
    • 34249104544 scopus 로고    scopus 로고
    • Oxidative stress and aberrant signaling in aging and cognitive decline
    • DOI 10.1111/j.1474-9726.2007.00294.x
    • W Droge HM Schipper 2007 Oxidative stress and aberrant signaling in aging and cognitive decline Aging Cell 6 361 370 10.1111/j.1474-9726.2007.00294.x 17517043 1:CAS:528:DC%2BD2sXntVOjsrw%3D (Pubitemid 46785141)
    • (2007) Aging Cell , vol.6 , Issue.3 , pp. 361-370
    • Droge, W.1    Schipper, H.M.2
  • 26
    • 0033565586 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neuronal damage
    • 10407030 1:CAS:528:DyaK1MXksVyktb8%3D
    • MJL Eliasson Z Huang RJ Ferrante M Sasamata ME Molliver SH Snyder MA Moskowitz 1999 Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neuronal damage J Neurosci 19 5910 5918 10407030 1:CAS:528:DyaK1MXksVyktb8%3D
    • (1999) J Neurosci , vol.19 , pp. 5910-5918
    • Eliasson, M.J.L.1    Huang, Z.2    Ferrante, R.J.3    Sasamata, M.4    Molliver, M.E.5    Snyder, S.H.6    Moskowitz, M.A.7
  • 27
    • 60549086571 scopus 로고    scopus 로고
    • Aging: An important factor for the pathogenesis of neurodegenerative diseases
    • 10.1016/j.mad.2008.11.006 19071157 1:CAS:528:DC%2BD1MXisFWhtLY%3D
    • T Farooqui AA Farooqui 2008 Aging: an important factor for the pathogenesis of neurodegenerative diseases Mech Ageing Dev 130 203 215 10.1016/j.mad.2008.11.006 19071157 1:CAS:528:DC%2BD1MXisFWhtLY%3D
    • (2008) Mech Ageing Dev , vol.130 , pp. 203-215
    • Farooqui, T.1    Farooqui, A.A.2
  • 28
    • 42049114647 scopus 로고    scopus 로고
    • 5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease
    • 10.1096/fj.07-9131.com 17998412 1:CAS:528:DC%2BD1cXktlWntr0%3D
    • O Firuzi J Zhuo CM Chinnici T Wisniewski D Pratico 2008 5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease FASEB J 22 1169 1178 10.1096/fj.07-9131.com 17998412 1:CAS:528:DC%2BD1cXktlWntr0%3D
    • (2008) FASEB J , vol.22 , pp. 1169-1178
    • Firuzi, O.1    Zhuo, J.2    Chinnici, C.M.3    Wisniewski, T.4    Pratico, D.5
  • 29
    • 33747463996 scopus 로고    scopus 로고
    • Microglia biology in health and disease
    • DOI 10.1007/s11481-006-9015-5
    • GA Garden T Moller 2006 Microglia biology in health and disease J Neuroimmune Pharmacol 1 127 137 10.1007/s11481-006-9015-5 18040779 (Pubitemid 44257488)
    • (2006) Journal of Neuroimmune Pharmacology , vol.1 , Issue.2 , pp. 127-137
    • Garden, G.A.1    Moller, T.2
  • 30
    • 0018666729 scopus 로고
    • Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)
    • 38242 1:CAS:528:DyaE1MXlvVOhu70%3D
    • OW Griffith A Meister 1979 Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine) J Biol Chem 254 7558 7560 38242 1:CAS:528:DyaE1MXlvVOhu70%3D
    • (1979) J Biol Chem , vol.254 , pp. 7558-7560
    • Griffith, O.W.1    Meister, A.2
  • 31
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • 1:STN:280:DyaG28%2FosVygsw%3D%3D
    • D Harman 1956 Aging: a theory based on free radical and radiation chemistry J Gernontol 11 298 300 1:STN:280:DyaG28%2FosVygsw%3D%3D
    • (1956) J Gernontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 32
    • 0036774226 scopus 로고    scopus 로고
    • Flavonoid antioxidants: Chemistry, metabolism and structure-activity relationships
    • DOI 10.1016/S0955-2863(02)00208-5, PII S0955286302002085
    • KE Heim AR Tagliaferro DJ Bobilya 2002 Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships J Nutr Biochem 13 572 584 10.1016/S0955-2863(02)00208-5 12550068 1:CAS:528:DC%2BD38XotVeqs7s%3D (Pubitemid 35246546)
    • (2002) Journal of Nutritional Biochemistry , vol.13 , Issue.10 , pp. 572-584
    • Heim, K.E.1    Tagliaferro, A.R.2    Bobilya, D.J.3
  • 34
    • 0035374431 scopus 로고    scopus 로고
    • Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation
    • 11351248 1:CAS:528:DC%2BD3MXktlCjs7w%3D
    • D-X Hou M Fukuda JA Johnson K Miyamori M Ushikai M Fujii 2001 Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation Int J Oncol 18 1175 1179 11351248 1:CAS:528:DC%2BD3MXktlCjs7w%3D
    • (2001) Int J Oncol , vol.18 , pp. 1175-1179
    • Hou, D.-X.1    Fukuda, M.2    Johnson, J.A.3    Miyamori, K.4    Ushikai, M.5    Fujii, M.6
  • 35
    • 0026485192 scopus 로고
    • Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
    • 10.1016/0003-9861(92)90431-U 1416974 1:CAS:528:DyaK38XmtVOrs7s%3D
    • H Ischiropoulos L Zhu J Chen M Tsai JC Martin CD Smith JS Beckman 1992 Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase Arch Biochem Biophys 298 431 437 10.1016/0003-9861(92)90431-U 1416974 1:CAS:528:DyaK38XmtVOrs7s%3D
    • (1992) Arch Biochem Biophys , vol.298 , pp. 431-437
    • Ischiropoulos, H.1    Zhu, L.2    Chen, J.3    Tsai, M.4    Martin, J.C.5    Smith, C.D.6    Beckman, J.S.7
  • 36
    • 0035865819 scopus 로고    scopus 로고
    • Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms
    • DOI 10.1016/S0891-5849(00)00498-6, PII S0891584900004986
    • K Ishige D Schubert Y Sagara 2001 Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms Free Radic Biol Med 30 433 446 10.1016/S0891-5849(00)00498-6 11182299 1:CAS:528:DC%2BD3MXhtFegsbc%3D (Pubitemid 32155542)
    • (2001) Free Radical Biology and Medicine , vol.30 , Issue.4 , pp. 433-446
    • Ishige, K.1    Schubert, D.2    Sagara, Y.3
  • 37
    • 0034717329 scopus 로고    scopus 로고
    • Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
    • DOI 10.1074/jbc.275.21.16023
    • T Ishii K Itoh S Takahashi H Sato T Yanagawa K Yasutake S Bannai M Yamamoto 2000 Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages J Biol Chem 275 16023 16029 10.1074/jbc.275.21.16023 10821856 1:CAS:528:DC%2BD3cXjvFaisbc%3D (Pubitemid 30366908)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.21 , pp. 16023-16029
    • Ishii, T.1    Itoh, K.2    Takahashi, S.3    Sato, H.4    Yanagawa, T.5    Katoh, Y.6    Bannai, S.7    Yamamoto, M.8
  • 38
    • 4444280871 scopus 로고    scopus 로고
    • What turns CREB on?
    • DOI 10.1016/j.cellsig.2004.05.001, PII S0898656804000804
    • M Johannessen MP Delghandi U Moens 2004 What turns CREB on? Cell Signal 16 1211 1227 10.1016/j.cellsig.2004.05.001 15337521 1:CAS:528: DC%2BD2cXntFSmur0%3D (Pubitemid 39165450)
    • (2004) Cellular Signalling , vol.16 , Issue.11 , pp. 1211-1227
    • Johannessen, M.1    Delghandi, M.P.2    Moens, U.3
  • 39
    • 0033568849 scopus 로고    scopus 로고
    • Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation
    • 10479711 1:CAS:528:DyaK1MXlvFahu7c%3D
    • JA Joseph B Shukitt-Hale NA Denisova D Bielinski A Martin JJ McEwen PC Bickford 1999 Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation J Neurosci 19 8114 8121 10479711 1:CAS:528: DyaK1MXlvFahu7c%3D
    • (1999) J Neurosci , vol.19 , pp. 8114-8121
    • Joseph, J.A.1    Shukitt-Hale, B.2    Denisova, N.A.3    Bielinski, D.4    Martin, A.5    McEwen, J.J.6    Bickford, P.C.7
  • 40
    • 0033972037 scopus 로고    scopus 로고
    • Possible involvement of proteasome inhibition in aging: Implications for oxidative stress
    • DOI 10.1016/S0047-6374(99)00101-3, PII S0047637499001013
    • JN Keller KB Hanni WR Markesbery 2000 Possible involvement of proteasome inhibition in aging: implications for oxidative stress Mech Ageing Dev 113 61 70 10.1016/S0047-6374(99)00101-3 10708250 1:CAS:528:DC%2BD3cXltVemsQ%3D%3D (Pubitemid 30050671)
    • (2000) Mechanisms of Ageing and Development , vol.113 , Issue.1 , pp. 61-70
    • Keller, J.N.1    Hanni, K.B.2    Markesbery, W.R.3
  • 41
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • DOI 10.1146/annurev.pharmtox.46.120604.141046
    • TW Kensler N Wakabayashi S Biswal 2007 Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway Annu Rev Pharmacol Toxicol 47 89 116 10.1146/annurev.pharmtox.46.120604.141046 16968214 1:CAS:528:DC%2BD2sXit1altrg%3D (Pubitemid 46272125)
    • (2007) Annual Review of Pharmacology and Toxicology , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 42
    • 27744563958 scopus 로고    scopus 로고
    • Effects of naturally occurring compounds on fibril formation and oxidative stress of β-amyloid
    • 10.1021/jf051985c 16248550 1:CAS:528:DC%2BD2MXhtVCltr7K
    • H Kim B-S Park K-G Lee CY Choi SS Jang Y-H Kim S-E Lee 2005 Effects of naturally occurring compounds on fibril formation and oxidative stress of β-amyloid J Agric Food Chem 53 8537 8541 10.1021/jf051985c 16248550 1:CAS:528:DC%2BD2MXhtVCltr7K
    • (2005) J Agric Food Chem , vol.53 , pp. 8537-8541
    • Kim, H.1    Park, B.-S.2    Lee, K.-G.3    Choi, C.Y.4    Jang, S.S.5    Kim, Y.-H.6    Lee, S.-E.7
  • 43
    • 0034864799 scopus 로고    scopus 로고
    • Proteasome inhibitors: From research tools to drug candidates
    • DOI 10.1016/S1074-5521(01)00056-4, PII S1074552101000564
    • AF Kisselev AL Goldberg 2001 Proteasome inhibitors: from research tools to drug candidates Chem Biol 8 739 758 10.1016/S1074-5521(01)00056-4 11514224 1:CAS:528:DC%2BD3MXmtV2ku7g%3D (Pubitemid 32752454)
    • (2001) Chemistry and Biology , vol.8 , Issue.8 , pp. 739-758
    • Kisselev, A.F.1    Goldberg, A.L.2
  • 44
    • 33744899830 scopus 로고    scopus 로고
    • Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathway
    • DOI 10.1016/j.bbrc.2006.05.043, PII S0006291X06010424
    • M-K Kwak TW Kensler 2006 Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathway Biochem Biophys Res Commun 345 1350 1357 10.1016/j.bbrc.2006.05.043 16723119 1:CAS:528:DC%2BD28Xltl2gsrs%3D (Pubitemid 43841827)
    • (2006) Biochemical and Biophysical Research Communications , vol.345 , Issue.4 , pp. 1350-1357
    • Kwak, M.-K.1    Kensler, T.W.2
  • 45
    • 0242721624 scopus 로고    scopus 로고
    • Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway
    • DOI 10.1128/MCB.23.23.8786-8794.2003
    • M-K Kwak N Wakabayashi JL Greenlaw M Yamamoto TW Kensler 2003 Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway Mol Cell Biol 23 8786 9794 10.1128/MCB.23.23.8786-8794.2003 14612418 1:CAS:528:DC%2BD3sXptFaitrs%3D (Pubitemid 37433379)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.23 , pp. 8786-8794
    • Kwak, M.-K.1    Wakabayashi, N.2    Greenlaw, J.L.3    Yamamoto, M.4    Kensler, T.W.5
  • 46
    • 34249727213 scopus 로고    scopus 로고
    • Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: Enhanced activity for degradation of abnormal protein
    • DOI 10.1016/j.lfs.2007.04.014, PII S0024320507003001
    • M-K Kwak B Huang H Chang J-A Kim TW Kensler 2007 Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein Life Sci 80 2411 2420 10.1016/j.lfs.2007.04.014 17521679 1:CAS:528: DC%2BD2sXmtVehsLo%3D (Pubitemid 46824133)
    • (2007) Life Sciences , vol.80 , Issue.26 , pp. 2411-2420
    • Kwak, M.-K.1    Huang, B.2    Chang, H.3    Kim, J.-A.4    Kensler, T.W.5
  • 47
    • 0037424262 scopus 로고    scopus 로고
    • Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway: Identification of novel gene clusters for cell survival
    • DOI 10.1074/jbc.M211898200
    • M-K Kwak N Wakabayashi K Itoh H Motohashi M Yamamoto TW Kensler 2003 Modulation of gene expression by cancer chemopreventative dithiolethiones through the Keap1-Nrf2 pathway J Biol Chem 278 8135 8145 10.1074/jbc.M211898200 12506115 1:CAS:528:DC%2BD3sXhsF2iu7k%3D (Pubitemid 36800555)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.10 , pp. 8135-8145
    • Kwak, M.-K.1    Wakabayashi, N.2    Itoh, K.3    Motohashi, H.4    Yamamoto, M.5    Kensler, T.W.6
  • 49
    • 0026095778 scopus 로고
    • Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives
    • 10.1016/0006-2952(91)90501-U 1656994 1:CAS:528:DyaK38Xjsl0%3D
    • MJ Laughton PJ Evans MA Moroney JRS Hoult B Halliwell 1991 Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives Biochem Pharmacol 42 1673 1681 10.1016/0006-2952(91)90501-U 1656994 1:CAS:528:DyaK38Xjsl0%3D
    • (1991) Biochem Pharmacol , vol.42 , pp. 1673-1681
    • Laughton, M.J.1    Evans, P.J.2    Moroney, M.A.3    Hoult, J.R.S.4    Halliwell, B.5
  • 50
    • 0036570038 scopus 로고    scopus 로고
    • Down-regulation of γ-glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging
    • DOI 10.1002/jnr.10217
    • R-M Liu 2002 Down-regulation of γ-glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging J Neurosci Res 68 344 351 10.1002/jnr.10217 12111865 1:CAS:528:DC%2BD38XjslSis78%3D (Pubitemid 34462540)
    • (2002) Journal of Neuroscience Research , vol.68 , Issue.3 , pp. 344-351
    • Liu, R.-M.1
  • 51
    • 0034652426 scopus 로고    scopus 로고
    • Age-associated decline in γ-glutamylcysteine synthetase gene expression in rats
    • DOI 10.1016/S0891-5849(99)00269-5, PII S0891584999002695
    • R-M Liu J Choi 2000 Age-associated decline in γ-glutamylcysteine synthetase gene expression in rats Free Radic Biol Med 28 566 574 10.1016/S0891-5849(99)00269-5 10719238 1:CAS:528:DC%2BD3cXhslaksbw%3D (Pubitemid 30136038)
    • (2000) Free Radical Biology and Medicine , vol.28 , Issue.4 , pp. 566-574
    • Liu, R.-M.1    Choi, J.2
  • 52
    • 3042631024 scopus 로고    scopus 로고
    • Gene regulation and DNA damage in the ageing human brain
    • DOI 10.1038/nature02661
    • T Lu Y Pan S-Y Kao C Li I Kohane J Chan BA Yankner 2004 Gene regulation and DNA damage in the ageing human brain Nature 429 883 891 10.1038/nature02661 15190254 1:CAS:528:DC%2BD2cXltVKltLY%3D (Pubitemid 38843301)
    • (2004) Nature , vol.429 , Issue.6994 , pp. 883-891
    • Lu, T.1    Pan, Y.2    Kao, S.-Y.3    Li, C.4    Kohane, I.5    Chan, J.6    Yankner, B.A.7
  • 53
    • 23644432822 scopus 로고    scopus 로고
    • The effects of stress and aging on glutathione metabolism
    • DOI 10.1016/j.arr.2005.02.005, PII S1568163705000103, Stress, Neuropeptides and Age-Related Diseases
    • P Maher 2005 The effects of stress and aging on glutathione metabolism Ageing Res Rev 4 288 314 10.1016/j.arr.2005.02.005 15936251 1:CAS:528: DC%2BD2MXhtVyhsb3O (Pubitemid 41114862)
    • (2005) Ageing Research Reviews , vol.4 , Issue.2 , pp. 288-314
    • Maher, P.1
  • 54
    • 33749255399 scopus 로고    scopus 로고
    • A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives
    • DOI 10.1080/10715760600672509, PII W1255U116263V742, Polyphenols and Health
    • P Maher 2006 A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives Free Radic Res 40 1105 1111 10.1080/10715760600672509 17015255 1:CAS:528:DC%2BD28XhtVymurjL (Pubitemid 44480551)
    • (2006) Free Radical Research , vol.40 , Issue.10 , pp. 1105-1111
    • Maher, P.1
  • 55
    • 42649103288 scopus 로고    scopus 로고
    • Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanism
    • 10.1016/j.bcp.2008.02.008 18359006 1:CAS:528:DC%2BD1cXlsFOmsLs%3D
    • P Maher 2008 Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanism Biochem Pharmacol 75 1994 2006 10.1016/j.bcp.2008.02.008 18359006 1:CAS:528:DC%2BD1cXlsFOmsLs%3D
    • (2008) Biochem Pharmacol , vol.75 , pp. 1994-2006
    • Maher, P.1
  • 56
    • 33644793240 scopus 로고    scopus 로고
    • Flavonoids protect retinal ganglion cells from oxidative stress-induced death
    • DOI 10.1167/iovs.05-0397
    • P Maher A Hanneken 2005 Flavonoids protect retinal ganglion cells from oxidative stress-induced death Invest Ophthalmol Vis Sci 46 4796 4803 10.1167/iovs.05-0397 16303981 (Pubitemid 44264586)
    • (2005) Investigative Ophthalmology and Visual Science , vol.46 , Issue.12 , pp. 4796-4803
    • Maher, P.1    Hanneken, A.2
  • 58
    • 34548855340 scopus 로고    scopus 로고
    • A novel approach to screening for new neuroprotective compounds for the treatment of stroke
    • DOI 10.1016/j.brainres.2007.07.061, PII S0006899307018094
    • P Maher KF Salgado JA Zivin PA Lapchak 2007 A novel approach to screening for new neuroprotective compounds for the treatment of stroke Brain Res 1173 117 125 10.1016/j.brainres.2007.07.061 17765210 1:CAS:528:DC%2BD2sXhtFSnu77F (Pubitemid 47449689)
    • (2007) Brain Research , vol.1173 , Issue.1 , pp. 117-125
    • Maher, P.1    Salgado, K.F.2    Zivin, J.A.3    Lapchak, P.A.4
  • 59
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • 15640486 1:CAS:528:DC%2BD2MXlvFKltA%3D%3D
    • C Manach G Williamson C Morand A Scalbert C Remesy 2005 Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies Am J Clin Nutr 81 230S 242S 15640486 1:CAS:528:DC%2BD2MXlvFKltA%3D%3D
    • (2005) Am J Clin Nutr , vol.81
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Remesy, C.5
  • 60
    • 0035430282 scopus 로고    scopus 로고
    • Transcriptional regulation by the phosphorylation-dependent factor creb
    • DOI 10.1038/35085068
    • B Mayr M Montminy 2001 Transcriptional regulation by the phosphorylation-dependent factor CREB Nat Rev Mol Cell Biol 2 599 609 10.1038/35085068 11483993 1:CAS:528:DC%2BD3MXlvVOqs70%3D (Pubitemid 33674011)
    • (2001) Nature Reviews Molecular Cell Biology , vol.2 , Issue.8 , pp. 599-609
    • Mayr, B.1    Montminy, M.2
  • 61
    • 0020972417 scopus 로고
    • 10.1146/annurev.bi.52.070183.003431 6137189 1:CAS:528:DyaL3sXkvVektbs%3D
    • A Meister ME Anderson 1983 Glutathione Ann Rev Biochem 52 711 760 10.1146/annurev.bi.52.070183.003431 6137189 1:CAS:528:DyaL3sXkvVektbs%3D
    • (1983) Glutathione Ann Rev Biochem , vol.52 , pp. 711-760
    • Meister, A.1    Anderson, M.E.2
  • 62
    • 0033637140 scopus 로고    scopus 로고
    • The effects of flavonoids on mammalian cells: Implications for inflammation, heart disease and cancer
    • 11121513 1:CAS:528:DC%2BD3MXislWktw%3D%3D
    • E Middleton C Kandaswami TC Theoharides 2000 The effects of flavonoids on mammalian cells: implications for inflammation, heart disease and cancer Pharmacol Rev 52 673 751 11121513 1:CAS:528:DC%2BD3MXislWktw%3D%3D
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton, E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 63
    • 0842326603 scopus 로고    scopus 로고
    • Age-related changes in glutathione availability and skeletal muscle carbonyl content in healthy rats
    • DOI 10.1016/j.exger.2003.10.014
    • L Mosoni D Breuille C Buffiere C Obled PP Mirand 2004 Age-related changes in glutathione availability and skeletal carbonyl content in healthy rats Exp Gerontol 39 203 210 10.1016/j.exger.2003.10.014 15036413 1:CAS:528: DC%2BD2cXptFeruw%3D%3D (Pubitemid 38169411)
    • (2004) Experimental Gerontology , vol.39 , Issue.2 , pp. 203-210
    • Mosoni, L.1    Breuille, D.2    Buffiere, C.3    Obled, C.4    Mirand, P.P.5
  • 65
    • 0036489186 scopus 로고    scopus 로고
    • Flavonoids increase the intracellular glutathione level by transactivation of the γ-glutamylcysteine synthetase catalytical subunit promoter
    • DOI 10.1016/S0891-5849(01)00812-7, PII S0891584901008127
    • MCW Myhrstad H Carlsen O Nordstrom R Blomhoff JO Moskaug 2002 Flavonoids increase the intracellular glutathione level by transactivation of the γ-glutamylcysteine synthetase catalytical subunit promoter Free Radic Biol Med 32 386 393 10.1016/S0891-5849(01)00812-7 11864778 1:CAS:528: DC%2BD38XhsFWns74%3D (Pubitemid 34178348)
    • (2002) Free Radical Biology and Medicine , vol.32 , Issue.5 , pp. 386-393
    • Myhrstad, M.C.W.1    Carlsen, H.2    Nordstrom, O.3    Blomhoff, R.4    Moskaug, J.O.5
  • 66
    • 0037763721 scopus 로고    scopus 로고
    • Regulatory mechanisms controlling gene expression mediated by the antioxidant response element
    • DOI 10.1146/annurev.pharmtox.43.100901.140229
    • T Nguyen PJ Sherratt CB Pickett 2003 Regulatory mechanisms controlling gene expression mediated by the antioxidant response element Annu Rev Pharmacol Toxicol 43 233 260 10.1146/annurev.pharmtox.43.100901.140229 12359864 1:CAS:528:DC%2BD3sXitFWqsbY%3D (Pubitemid 37372641)
    • (2003) Annual Review of Pharmacology and Toxicology , vol.43 , pp. 233-260
    • Nguyen, T.1    Sherratt, P.J.2    Pickett, C.B.3
  • 67
    • 0035871677 scopus 로고    scopus 로고
    • Effects of aging on the susceptibility to the toxic effects of cyclosporin A in rats. Changes in liver glutathione and antioxidant enzymes
    • DOI 10.1016/S0891-5849(01)00471-3, PII S0891584901004713
    • J Palomero AI Galan ME Munoz MJ Tunon J Gonzalez-Gallego R Jimenez 2001 Effects of aging on the susceptibility to the toxic effects of cyclosporin A in rats. Changes in liver glutathione and antioxidant enzymes Free Radic Biol Med 30 836 845 10.1016/S0891-5849(01)00471-3 11295526 1:CAS:528:DC%2BD3MXisF2qurs%3D (Pubitemid 32289261)
    • (2001) Free Radical Biology and Medicine , vol.30 , Issue.8 , pp. 836-845
    • Palomero, J.1    Galan, A.I.2    Muoz, M.E.3    Tuon, M.J.4    Gonzalez-Gallego, J.5    Jimenez, R.6
  • 68
    • 33747885659 scopus 로고    scopus 로고
    • Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders
    • DOI 10.1016/j.brainresrev.2006.02.002, PII S0165017306000117
    • JW Phillis LA Horrocks AA Farooqui 2006 Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders Brain Res Rev 52 201 243 10.1016/j.brainresrev.2006.02.002 16647138 1:CAS:528:DC%2BD28XptFCit7k%3D (Pubitemid 44291802)
    • (2006) Brain Research Reviews , vol.52 , Issue.2 , pp. 201-243
    • Phillis, J.W.1    Horrocks, L.A.2    Farooqui, A.A.3
  • 69
    • 37549040537 scopus 로고    scopus 로고
    • Metabolism and bioavailability of flavonoids in chemoprevention: Current analytical strategies and future prospects
    • 10.1021/mp700116u 18052086 1:CAS:528:DC%2BD2sXhtlKqtb3J
    • JK Prasain S Barnes 2007 Metabolism and bioavailability of flavonoids in chemoprevention: current analytical strategies and future prospects Mol Pharm 4 846 864 10.1021/mp700116u 18052086 1:CAS:528:DC%2BD2sXhtlKqtb3J
    • (2007) Mol Pharm , vol.4 , pp. 846-864
    • Prasain, J.K.1    Barnes, S.2
  • 70
    • 0025730414 scopus 로고
    • Peroxynitrite oxidation of sulfhydryls. the cytotoxic potential of superoxide and nitric oxide
    • 1847917 1:CAS:528:DyaK3MXhsFyku7Y%3D
    • R Radi JS Beckman KM Bush BA Freeman 1991 Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide J Biol Chem 266 4244 4250 1847917 1:CAS:528:DyaK3MXhsFyku7Y%3D
    • (1991) J Biol Chem , vol.266 , pp. 4244-4250
    • Radi, R.1    Beckman, J.S.2    Bush, K.M.3    Freeman, B.A.4
  • 71
    • 0025861082 scopus 로고
    • Age-related cysteine uptake as rate limiting in glutathione synthesis and glutathione half-life in the cultured human lens
    • 10.1016/0014-4835(91)90075-P 1915676 1:CAS:528:DyaK3MXlvVSitb4%3D
    • WB Rathbun DL Murray 1991 Age-related cysteine uptake as rate limiting in glutathione synthesis and glutathione half-life in the cultured human lens Exp Eye Res 53 205 212 10.1016/0014-4835(91)90075-P 1915676 1:CAS:528: DyaK3MXlvVSitb4%3D
    • (1991) Exp Eye Res , vol.53 , pp. 205-212
    • Rathbun, W.B.1    Murray, D.L.2
  • 72
    • 0041326831 scopus 로고    scopus 로고
    • Effects of age and caloric restriction on glutathione redox state in mice
    • DOI 10.1016/S0891-5849(03)00388-5
    • I Rebrin S Kamzalov RS Sohal 2003 Effects of age and caloric restriction on glutathione redox status in mice Free Radic Biol Med 35 626 635 10.1016/S0891-5849(03)00388-5 12957655 1:CAS:528:DC%2BD3sXmvV2rtrw%3D (Pubitemid 37101130)
    • (2003) Free Radical Biology and Medicine , vol.35 , Issue.6 , pp. 626-635
    • Rebrin, I.1    Kamzalov, S.2    Sohal, R.S.3
  • 73
    • 15844374508 scopus 로고    scopus 로고
    • Some aspects of the in vivo neuroprotective capacity of flavonoids: Bioavailability and structure-activity relationship
    • 10.1007/BF03033450 15639786
    • F Rivera J Urbanavicius E Gervaz A Morquio F Dajas 2004 Some aspects of the in vivo neuroprotective capacity of flavonoids: bioavailability and structure-activity relationship Neurotox Res 6 543 553 10.1007/BF03033450 15639786
    • (2004) Neurotox Res , vol.6 , pp. 543-553
    • Rivera, F.1    Urbanavicius, J.2    Gervaz, E.3    Morquio, A.4    Dajas, F.5
  • 74
    • 33747494572 scopus 로고    scopus 로고
    • Microglia as a pharmacological target in infectious and inflammatory diseases of the brain
    • DOI 10.1007/s11481-006-9012-8
    • RB Rock PK Peterson 2006 Microglia as a pharmacological target in infectious and inflammatory diseases on the brain J Neuroimmune Pharmacol 1 117 126 10.1007/s11481-006-9012-8 18040778 (Pubitemid 44257487)
    • (2006) Journal of Neuroimmune Pharmacology , vol.1 , Issue.2 , pp. 117-126
    • Rock, R.B.1    Peterson, P.K.2
  • 75
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: Bioavailability, metabolic effects, and safety
    • DOI 10.1146/annurev.nutr.22.111401.144957
    • JA Ross CM Kasum 2002 Dietary flavonoids: bioavailability, metabolic effects, and safety Annu Rev Nutr 22 19 34 10.1146/annurev.nutr.22.111401.144957 12055336 1:CAS:528:DC%2BD38XmtF2ht7o%3D (Pubitemid 35221452)
    • (2002) Annual Review of Nutrition , vol.22 , pp. 19-34
    • Ross, J.A.1    Kasum, C.M.2
  • 76
    • 4444360215 scopus 로고    scopus 로고
    • Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation
    • DOI 10.1111/j.1471-4159.2004.02563.x
    • Y Sagara J Vahnnasy P Maher 2004 Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation J Neurochem 90 1144 1155 10.1111/j.1471-4159.2004.02563.x 15312169 1:CAS:528:DC%2BD2cXns1Sru7c%3D (Pubitemid 39167347)
    • (2004) Journal of Neurochemistry , vol.90 , Issue.5 , pp. 1144-1155
    • Sagara, Y.1    Vanhnasy, J.2    Maher, P.3
  • 77
    • 0036082232 scopus 로고    scopus 로고
    • Alterations in oxidative stress scavenger system in aging rat brain and lymphocytes
    • DOI 10.1023/A:1015643107449
    • SK Sandhu G Kaur 2002 Alterations in oxidative stress scavenger system in aging rat brain and lymphocytes Biogerontology 3 161 173 10.1023/A: 1015643107449 12075135 1:CAS:528:DC%2BD38XltlSrtb8%3D (Pubitemid 34678894)
    • (2002) Biogerontology , vol.3 , Issue.3 , pp. 161-173
    • Sandhu, S.K.1    Kaur, G.2
  • 78
    • 0033597349 scopus 로고    scopus 로고
    • Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins
    • DOI 10.1074/jbc.274.17.11455
    • H Sato M Tamba T Ishii S Bannai 1999 Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins J Biol Chem 274 11455 11458 10.1074/jbc.274.17.11455 10206947 1:CAS:528:DyaK1MXislGmtLk%3D (Pubitemid 29197795)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.17 , pp. 11455-11458
    • Sato, H.1    Tamba, M.2    Ishii, T.3    Bannai, S.4
  • 79
    • 40449121975 scopus 로고    scopus 로고
    • Effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases
    • DOI 10.1159/000113717
    • M Sawada H Sawada T Nagatsu 2008 Effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases Neurodegener Dis 5 254 256 10.1159/000113717 18322405 1:CAS:528:DC%2BD1cXjs1Whur4%3D (Pubitemid 351347865)
    • (2008) Neurodegenerative Diseases , vol.5 , Issue.3-4 , pp. 254-256
    • Sawada, M.1    Sawada, H.2    Nagatsu, T.3
  • 80
    • 59849123367 scopus 로고    scopus 로고
    • Metabolism and pharmacokinetics of 3, 3′, 4′, 7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites
    • 10.1021/jf802378q 19090755 1:CAS:528:DC%2BD1cXhsFWhsLzO
    • C-S Shia S-Y Tsai S-C Kuo Y-C Hou P-DL Chao 2009 Metabolism and pharmacokinetics of 3, 3′, 4′, 7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites J Agric Food Chem 57 83 89 10.1021/jf802378q 19090755 1:CAS:528:DC%2BD1cXhsFWhsLzO
    • (2009) J Agric Food Chem , vol.57 , pp. 83-89
    • Shia, C.-S.1    Tsai, S.-Y.2    Kuo, S.-C.3    Hou, Y.-C.4    P-Dl, C.5
  • 81
    • 34249279788 scopus 로고    scopus 로고
    • Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging
    • DOI 10.1016/j.neurobiolaging.2006.05.031, PII S0197458006001928
    • B Shukitt-Hale AN Carey D Jenkins BM Rabin J Joseph 2007 Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging Neurobiol Aging 28 1187 1194 10.1016/j.neurobiolaging.2006. 05.031 16837106 1:CAS:528:DC%2BD2sXmtVahs7w%3D (Pubitemid 46810061)
    • (2007) Neurobiology of Aging , vol.28 , Issue.8 , pp. 1187-1194
    • Shukitt-Hale, B.1    Carey, A.N.2    Jenkins, D.3    Rabin, B.M.4    Joseph, J.A.5
  • 83
    • 33745139199 scopus 로고    scopus 로고
    • Tocopherol-mediated modulation of age-related changes in microglial cells: Turnover of extracellular oxidized protein material
    • DOI 10.1016/j.freeradbiomed.2006.02.011, PII S0891584906001183
    • A Stolzing R Widmer T Jung P Voss T Grune 2006 Tocopherol-mediated modulation of age-related changes in microglial cells: turnover of extracellular oxidized material Free Radic Biol Med 40 2126 2135 10.1016/j.freeradbiomed. 2006.02.011 16785026 1:CAS:528:DC%2BD28XlvF2htbc%3D (Pubitemid 43903100)
    • (2006) Free Radical Biology and Medicine , vol.40 , Issue.12 , pp. 2126-2135
    • Stolzing, A.1    Widmer, R.2    Jung, T.3    Voss, P.4    Grune, T.5
  • 85
    • 34347361698 scopus 로고    scopus 로고
    • Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-κB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IκBα kinase activation
    • DOI 10.1124/mol.107.034512
    • B Sung MK Pandey BB Aggarwal 2007 Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkBa kinase activation Mol Pharmacol 71 1703 1714 10.1124/mol.107.034512 17387141 1:CAS:528:DC%2BD2sXmt1Wqur4%3D (Pubitemid 47010923)
    • (2007) Molecular Pharmacology , vol.71 , Issue.6 , pp. 1703-1714
    • Sung, B.1    Pandey, M.K.2    Aggarwal, B.B.3
  • 86
    • 0035756761 scopus 로고    scopus 로고
    • Oxytosis: A novel form of programmed cell death
    • 10.2174/1568026013394741 11895126 1:CAS:528:DC%2BD3MXos1aitrc%3D
    • S Tan D Schubert P Maher 2001 Oxytosis: a novel form of programmed cell death Curr Top Med Chem 1 497 506 10.2174/1568026013394741 11895126 1:CAS:528:DC%2BD3MXos1aitrc%3D
    • (2001) Curr Top Med Chem , vol.1 , pp. 497-506
    • Tan, S.1    Schubert, D.2    Maher, P.3
  • 87
    • 0032825876 scopus 로고    scopus 로고
    • Neurodegenerative disorders: The role of peroxynitrite
    • DOI 10.1016/S0165-0173(99)00014-4, PII S0165017399000144
    • F Torreilles S Salman-Tabcheh M Guerin J Torreilles 1999 Neurodegenerative disorders: the role of peroxynitrite Brain Res Brain Res Rev 30 153 163 10.1016/S0165-0173(99)00014-4 10525172 1:CAS:528:DyaK1MXmsFejsbs%3D (Pubitemid 29440938)
    • (1999) Brain Research Reviews , vol.30 , Issue.2 , pp. 153-163
    • Torreilles, F.1    Salman-Tabcheh, S.2    Guerin, M.-C.3    Torreilles, J.4
  • 88
    • 0037392348 scopus 로고    scopus 로고
    • Targeting the CREB pathway for memory enhancers
    • 10.1038/nrd1061 12669026 1:CAS:528:DC%2BD3sXisFWktrw%3D
    • T Tully R Bourtchouladze R Scott J Tallman 2003 Targeting the CREB pathway for memory enhancers Nat Rev Drug Discov 2 267 277 10.1038/nrd1061 12669026 1:CAS:528:DC%2BD3sXisFWktrw%3D
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 267-277
    • Tully, T.1    Bourtchouladze, R.2    Scott, R.3    Tallman, J.4
  • 89
    • 0035798831 scopus 로고    scopus 로고
    • Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin
    • DOI 10.1016/S0378-4274(00)00302-7, PII S0378427400003027
    • LG Valerio JK Kepa GV Pickwell LC Quattrochi 2001 Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin Toxicol Lett 119 49 57 10.1016/S0378-4274(00)00302-7 11275421 1:CAS:528:DC%2BD3MXitF2lurs%3D (Pubitemid 32244058)
    • (2001) Toxicology Letters , vol.119 , Issue.1 , pp. 49-57
    • Valerio Jr., L.G.1    Kepa, J.K.2    Pickwell, G.V.3    Quattrochi, L.C.4
  • 91
    • 33846461062 scopus 로고    scopus 로고
    • Morris water maze: Procedures for assessing spatial and related forms of learning and memory
    • 10.1038/nprot.2006.116 17406317
    • CV Vorhees MT Williams 2006 Morris water maze: procedures for assessing spatial and related forms of learning and memory Nat Protoc 1 848 858 10.1038/nprot.2006.116 17406317
    • (2006) Nat Protoc , vol.1 , pp. 848-858
    • Vorhees, C.V.1    Williams, M.T.2
  • 93
    • 11144249849 scopus 로고    scopus 로고
    • Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier
    • DOI 10.1016/j.ijpharm.2004.10.007, PII S0378517304006192
    • Q Wang JD Rager K Weinstein PS Kardos GL Dobson J Li IJ Hidalgo 2005 Evaluation of the MDR-MDCK cell line as a permeability screen for the blood brain barrier Int J Pharm 288 349 359 10.1016/j.ijpharm.2004.10.007 15620875 1:CAS:528:DC%2BD2cXhtFGhurvE (Pubitemid 40038588)
    • (2005) International Journal of Pharmaceutics , vol.288 , Issue.2 , pp. 349-359
    • Wang, Q.1    Rager, J.D.2    Weinstein, K.3    Kardos, P.S.4    Dobson, G.L.5    Li, J.6    Hidalgo, I.J.7
  • 94
    • 41749110458 scopus 로고    scopus 로고
    • The aging brain
    • 10.1146/annurev.pathmechdis.2.010506.092044 1:CAS:528: DC%2BD1cXjsFers7o%3D
    • BA Yankner T Lu P Loerch 2008 The aging brain Annu Rev Pathol Mech Dis 3 41 66 10.1146/annurev.pathmechdis.2.010506.092044 1:CAS:528:DC%2BD1cXjsFers7o%3D
    • (2008) Annu Rev Pathol Mech Dis , vol.3 , pp. 41-66
    • Yankner, B.A.1    Lu, T.2    Loerch, P.3
  • 95
    • 18844418175 scopus 로고    scopus 로고
    • Proteasomal activity in brain differs between species and brain regions and changes with age
    • DOI 10.1016/j.mad.2005.01.008, PII S0047637405000448
    • B-Y Zeng AD Medhurst M Jackson S Rose P Jenner 2005 Proteasomal activity in brain differs between species and brain regions and changes with age Mech Ageing Dev 126 760 766 10.1016/j.mad.2005.01.008 15888331 1:CAS:528: DC%2BD2MXktVKqsbk%3D (Pubitemid 40693300)
    • (2005) Mechanisms of Ageing and Development , vol.126 , Issue.6-7 , pp. 760-766
    • Zeng, B.-Y.1    Medhurst, A.D.2    Jackson, M.3    Rose, S.4    Jenner, P.5
  • 96
    • 39149120805 scopus 로고    scopus 로고
    • Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity
    • 10.1016/j.intimp.2007.12.012 18279803 1:CAS:528:DC%2BD1cXitVGhsL4%3D
    • LT Zheng J Ock B-M Kwon K Suk 2008 Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity Int Immunopharmacol 8 484 494 10.1016/j.intimp.2007.12.012 18279803 1:CAS:528:DC%2BD1cXitVGhsL4%3D
    • (2008) Int Immunopharmacol , vol.8 , pp. 484-494
    • Zheng, L.T.1    Ock, J.2    Kwon, B.-M.3    Suk, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.